Rickets and Metabolic Disorders

PEDIATRICS ◽  
1990 ◽  
Vol 85 (4) ◽  
pp. 624-625
Author(s):  
SINASI ÖZSOYLU ◽  
AYTEKIN BESIM
Keyword(s):  
Alkaline Phosphatase ◽  
Growth Plate ◽  
Metabolic Disorders ◽  
Short Report ◽  
Cell Disease ◽  
Mucolipidosis Ii ◽  
Calcium And Phosphorus ◽  
Phosphorus Levels

To the Editor.— The short report of Morrison and Kerr1 entitled "Growth Plate: Roentgenologic Findings in a Case of Tyrosinosis" deserves some comments. In addition to phenylketonuria and homocystinuria which were mentioned by the authors, roentgenologic bony changes were shown recently in a 5-month-old boy with mucolipidosis II (I-cell disease).2 Alkaline phosphatase was found to be elevated, and calcium and phosphorus levels were somewhat decreased in most of these cases. With the addition of roentgenologic findings one can be sure that all of these patients had rickets.

Rickets Associated With Long-Term Anticonvulsant Therapy

PEDIATRICS ◽  
1977 ◽  
Vol 60 (2) ◽  
pp. 261-262
Author(s):  
Francesca Severi ◽  
Maria Clara Gasparoni ◽  
Carla Martini
Keyword(s):  
Alkaline Phosphatase ◽  
Serum Alkaline Phosphatase ◽  
Anticonvulsant Therapy ◽  
Control Population ◽  
Calcium And Phosphorus ◽  
Phosphorus Levels ◽  
At Home

The study presented by Crosley et al. in the July 1975 issue of Pediatrics (page 52) is the first dealing with noninstitutionalized children. A significantly higher value of serum alkaline phosphatase was observed in treated children than in the control population, while calcium and phosphorus abnormalities were minimal in both groups. We concluded a study on the serum alkaline phosphatase, calcium, and phosphorus levels in noninstitutionalized children, including 50 who were from 3 to 14 years old and who were receiving long-term anticonvulsant therapy (either diphenylhydantoin, phenobarbital, or both for more than 12 months) and 57 age-matched controls, all living at home.

Rickets and Metabolic Disorders

PEDIATRICS ◽  
1990 ◽  
Vol 85 (4) ◽  
pp. 625-625
Author(s):  
STUART C. MORRISON ◽  
DOUGLAS S. KERR
Keyword(s):  
Alkaline Phosphatase ◽  
Serum Calcium ◽  
Metabolic Disorders ◽  
Normal Serum ◽  
X Rays ◽  
Elevated Alkaline Phosphatase ◽  
Normal Serum Calcium ◽  
Metabolic Data ◽  
Calcium And Phosphorus

In Reply.— We have reviewed the letter from Drs Ozsoylu and Besim and have reviewed the metabolic data from our patient with tyrosinosis to determine if there was evidence of rickets in our patient. At the time that the published x-rays were obtained, the patient had normal serum calcium and phosphorus. However, a month earlier, when the x-rays appeared normal apart from probable osteopenia, the patient did have persistent hypophosphatemia, 1.5 to 1.8 mg/dL (normal 4.0 to 6.0 mg/dL), and elevated alkaline phosphatase, 956 IU/L (normal 50 to 380 IU/L).

scholarly journals Effect of dietary calcium and phosphorus levels on growth, carcass characteristics and liver and kidney functions of growing Egyptian geese

2021 ◽  
pp. 101244
Author(s):  
Mahmoud Alagawany ◽  
Elwy Ali Ashour ◽  
Mohamed Soliman El-Kholy ◽  
Laila Ali Mohamed ◽  
Mohamed Ezzat Abd El-Hack
Keyword(s):  
Carcass Characteristics ◽  
Dietary Calcium ◽  
Liver And Kidney ◽  
Calcium And Phosphorus ◽  
Kidney Functions ◽  
Phosphorus Levels

scholarly journals Effect of Calcium and Phosphorus Levels on the Performance of Layers in Nigeria

1973 ◽  
Vol 52 (4) ◽  
pp. 1393-1398 ◽  
Author(s):  
Irene O. Kalango ◽  
A.A. Ademosun
Keyword(s):  
Calcium And Phosphorus ◽  
Phosphorus Levels

scholarly journals Impaired clearance of free cystine from lysosome-enriched granular fractions of I-cell-disease fibroblasts

1986 ◽  
Vol 237 (1) ◽  
pp. 9-15 ◽  
Author(s):  
F Tietze ◽  
L H Rome ◽  
J D Butler ◽  
G S Harper ◽  
W A Gahl
Keyword(s):  
Mutant Cell ◽  
Cell Types ◽  
Nephropathic Cystinosis ◽  
Cell Disease ◽  
Rapid Loss ◽  
Normal Cells ◽  
Cultured Fibroblasts ◽  
Carrier Mechanism ◽  
Mucolipidosis Ii

Cultured fibroblasts from patients with I-cell disease (mucolipidosis II) accumulate excessive amounts of free cystine, similarly to cells from patients with nephropathic cystinosis, a disorder of lysosomal cystine transport. To clarify whether the intralysosomal accumulation of cystine in I-cell-disease fibroblasts was due to a defective disposal mechanism, we measured the rates of clearance of free [35S]cystine from intact normal, cystinotic and I-cell-disease fibroblasts. Loss of radioactivity from the two mutant cell types occurred slowly (t 1/2 = 500 min) compared with the rapid loss from normal cells (t 1/2 = 40 min). Lysosome-rich granular fractions isolated from three different cystine-loaded normal, cystinotic and I-cell-disease fibroblast strains were similarly examined for non-radioactive cystine egress. Normal granular fractions lost cystine rapidly (mean t 1/2 = 43 min), whereas cystinotic granular fractions did not lose any cystine (mean t 1/2 = infinity). I-cell-disease granular fractions displayed prolonged half-times for cystine disposal (mean = 108 min), suggesting that I-cell-disease fibroblasts, like cystinotic cells, possess a defective carrier mechanism for cystine transport.

Effect of Estrus Induction on Blood Biochemical and Mineral Profiles and Fertility Rate in Retained Fetal Membranes Affected and Normally Calved Riverine Buffaloes

2021 ◽  
Author(s):  
M. Selvaraju ◽  
K. Ganesh
Keyword(s):  
Blood Glucose ◽  
Total Protein ◽  
Fertility Rate ◽  
Fetal Membranes ◽  
Blood Biochemical ◽  
Group I ◽  
Mineral Mixture ◽  
Calcium Phosphorus ◽  
Calcium And Phosphorus ◽  
Phosphorus Levels

Background: Calving to conception interval is abnormally extended by the occurrence of retained fetal membranes (RFM) by altering the blood biochemical and mineral milieu in cows. Hence this experiment was conducted in RFM affected and normally calved (NC) buffaloes by inducing estrus with CIDR plus PGF2α protocol to study the blood biochemical and mineral profiles and to correlate them with fertility rate. Methods: Buffaloes (n=64) at 45-60 days postpartum including 32 treated for RFM and 32 NC from field were equally divided into groups I and II and groups III and IV, respectively. Buffaloes of groups I and III were initially dewormed and administered 35-50 g mineral mixture daily orally for 15 days in the concentrate feed. Then, buffaloes of all the groups were treated with CIDR plus PGF2α. After CIDR removal, all the buffaloes were artificially inseminated twice at 48 and 72 hrs. Blood was collected during different stages of treatment from all the buffaloes to assess the blood biochemical and mineral status. The animals returned to estrus following FTAI were again inseminated during subsequent estrus. Pregnancy diagnosis was done at 60 days post-AI and conception rates for induced estrus and overall of two cycles were calculated.Result: In all the groups, blood glucose, total protein, triglycerides, cholesterol and phosphorus levels increased from the time of selection to 10 days post-AI. There was an altered calcium phosphorus ratio in RFM affected buffaloes (1:1) at the time of selection. CIDR plus PGF2α protocol influenced the blood biochemical constituents and brought the calcium and phosphorus ratio as 2:1 and improved the fertility in riverine buffaloes. The overall conception rate was 62.50, 37.50, 87.50 and 75.00 per cent, in group I, II, III and IV buffaloes, respectively.

scholarly journals Status of metabolic processes in horses during spring period

2019 ◽  
pp. 88-91
Author(s):  
N. O. Kravchenko ◽  
L. V. Kovalenko ◽  
O. P. Rudenko ◽  
V. S. Boiko
Keyword(s):  
Metabolic Disorders ◽  
Average Rate ◽  
Inorganic Phosphorus ◽  
Metabolic Processes ◽  
Horse Breed ◽  
Spring Period ◽  
Γ Globulins ◽  
Horse Blood ◽  
Biochemical Indices ◽  
Phosphorus Levels

The purpose of these studies was to determine status of metabolic processes in clinically healthy horses of sport breeds in spring period. Blood samples for biochemical studies were collected from 12 clinically healthy 7–9 month-old stallions of Ukrainian horse breed at Dnipropetrovsk region equestrian club. Protein (albumin, globulin, urea and creatinine) and mineral (common calcium and inorganic phosphorus) metabolic statuses, level of glucose, vitamins A and E and acid, as well as activity of hepatospecific enzymes (ALT, AST and AP) were determined using common techniques. It has been found that common protein level was within the limits of physiologic norm, although the level of albumins was decreased at the average rate of 12.0%, and the level of β- and γ-globulins was increased at the average rates of 5.2 and 11.3% respectively. AST activity was decreased at the rate of 38.0% regarding to physiological norm. Thereby, urea and creatinine concentrations were within the referent levels. Hyperglycaemia was observed in 50.0% of tested animals with maximal excess at the rate of 44.0%. Also, decreasing of common calcium and inorganic phosphorus levels was determined at the rate of 16.0 and 58.6%, vitamins А and Е — at the rate of 64.0 and 48,6% respectively, in comparison to lower level of physiological norm. The average index of acid capacity reached maximal referent levels. At the same time, it was increased in 33.3% of animals. Therefore, detected changes in biochemical indices in horse blood evidence that various metabolic disorders progress in clinically healthy stallions at spring and may furtherly lead to the appearance of metabolic syndrome

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