Hyperbilirubinemia in Low Birth Weight Infants and Outcome at 5 Years of Age

PEDIATRICS ◽  
1992 ◽  
Vol 89 (3) ◽  
pp. 359-364
Author(s):  
Margot van de Bor ◽  
Martina Ens-Dokkum ◽  
Anneke M. Schreuder ◽  
Sylvia Veen ◽  
Ronald Brand ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Intracranial Hemorrhage ◽  
Gestational Age ◽  
Odds Ratio ◽  
Total Bilirubin ◽  
Neonatal Period ◽  
Serum Total Bilirubin ◽  
Bilirubin Concentration ◽  
Total Bilirubin Concentration ◽  
The Relationship

The collaborative national survey on morbidity and mortality in preterm and small for gestational age infants in the Netherlands enrolled initially 1338 infants born in 1983. The relationship between maximal serum total bilirubin concentration in the neonatal period and neurodevelopmental outcome in the survivors of this cohort was studied. This relationship at the corrected age of 2 years was previously reported. A dose-response relationship between maximal serum total bilirubin concentration and risk of adverse outcome was observed in the 831 surviving children. The present study reassessed the relationship at the age of 5 years in 814 children. There was no significant difference in mean maximal serum total bilirubin concentration between the children with and without a handicap. This was confirmed by logistic regression analysis. After correction for seven suspected confounding factors (gestational age, birth weight, intracranial hemorrhage, ventriculomegaly, seizures, bronchopulmonary dysplasia, and socioeconomic status) the estimated odds ratio was 1.2 (confidence interval 0.89, 1.43) per 50 µmol/l increase of total bilirubin. However, in this analysis an interaction between bilirubin and intracranial hemorrhage was observed. Therefore, the cohort was divided into two groups according to the absence or presence of an intracranial hemorrhage. Logistic regression analysis including four suspected confounding factors (gestational age, ventriculomegaly. seizures, and socioeconomic status) was then again applied. In children who had suffered from an intracranial hemorrhage in the neonatal period the estimated odds ratio was 1.84 (confidence interval 1.08, 3.15) per 50 µmol/l increase of bilirubin. Similar results were obtained treating bilirubin as a categorized exposure. The odds ratio in children without a hemorrhage was 1.05 (confidence interval 0.80, 1.38), probably because of the small number of surviving handicapped children.

Hyperbilirubinemia in Preterm Infants and Neurodevelopmental Outcome at 2 Years of Age: Results of a National Collaborative Survey

PEDIATRICS ◽  
1989 ◽  
Vol 83 (6) ◽  
pp. 915-920
Author(s):  
Margot van de Bor ◽  
Thea M. van Zeben-van der Aa ◽  
S. Pauline Verloove-Vanhorick ◽  
Ronald Brand ◽  
Jan H. Ruys
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Total Bilirubin ◽  
Neurodevelopmental Outcome ◽  
Serum Total Bilirubin ◽  
Bilirubin Concentration ◽  
Total Bilirubin Concentration ◽  
Consistent Increase ◽  
The Relationship

As part of a prospective national survey of preterm and small for gestational age infants in the Netherlands, the relationship between maximal serum total bilirubin concentration in the neonatal period and neurodevelopmental outcome at the corrected age of 2 years was studied. Initially, 1,338 infants with a gestational age of less than 32 completed weeks and/or a birth weight of less than 1,500 g were enrolled in the study; 146 were subsequently excluded because of congenital malformations and 361 died during the study period. At the corrected age of 2 years, 831 children were available for follow-up. Children with minor and major handicaps had significantly greater maximal serum total bilirubin concentrations than children with a normal neurodevelopmental outcome (P = .02). A consistent increase in prevalence of handicaps was found for each 50-µmol/L (2.9 mg/dL) increase of maximal serum total bilirubin concentration. The handicaps consisted mainly of cerebral palsy. Logistic regression analysis involving seven suspected confounding factors (gestational age, birth weight, seizures, intracranial hemorrhage, respiratory distress syndrome, ventriculomegaly, and bronchopulmonary dysplasia) revealed that the odds ratio was 1.3. This indicates that, on a multiplicative scale, the risk of a handicap increased by 30% for each 50-µmol/L (2.9 mg/dL) increase of maximal serum total bilirubin concentration (P = .02). Further analysis treated bilirubin as a categorized exposure. A striking systematic increase was found, suggesting a causal relationship between maximal serum total bilirubin concentration and neurodevelopmental outcome.

Serum Total Bilirubin Concentration Is Inversely Correlated with Framingham Risk Score in Koreans

2012 ◽  
Vol 43 (4) ◽  
pp. 288-293 ◽  
Author(s):  
Kwang-Min Kim ◽  
Bom-Taeck Kim ◽  
Sat-Byul Park ◽  
Doo-Yeoun Cho ◽  
Sang Hyeon Je ◽  
...  
Keyword(s):  
Risk Score ◽  
Framingham Risk Score ◽  
Total Bilirubin ◽  
Serum Total Bilirubin ◽  
Bilirubin Concentration ◽  
Framingham Risk ◽  
Total Bilirubin Concentration

scholarly journals Association of Serum Total Bilirubin Concentration with Telomere Length: The National Health and Nutrition Examination Survey

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Lu Hao ◽  
Qiuyan Chen ◽  
Xi Chen ◽  
Qing Zhou
Keyword(s):  
Telomere Length ◽  
National Health ◽  
Large Scale ◽  
Total Bilirubin ◽  
Serum Total Bilirubin ◽  
Nutrition Examination Survey ◽  
Bilirubin Concentration ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
Total Bilirubin Concentration

Introduction. Mildly increased bilirubin concentration has a protective effect on oxidative stress–related diseases. However, it remains unknown whether elevated circulating bilirubin is associated with longer telomere length. The aim of this cross-sectional study was to examine the association between total bilirubin concentration and telomere length. Methods. We used the data from the National Health and Nutrition Examination Survey (NHANES) 1999-2002. The multivariable linear regression model was used to examine the association between total bilirubin concentration and telomere length. The nonlinear relationship was analyzed using a generalized additive model with the smoothing plot. Results. A total of 7818 participants with a mean age of 49.20 ± 18.82 years were included. Compared with the lowest concentration of total bilirubin (Q1), the highest quartile of total bilirubin concentration was associated with longer telomere length in male ( β = 0.04 , 95 CI%: 0.00, 0.07, P = 0.024 ) and female ( β = 0.04 , 95 CI%: 0.02, 0.04, P = 0.002 ). Furthermore, an inverted U-shaped relationship between total bilirubin and telomere length was found. On the left of turning points ( total   bilirubin < 0.5   mg / dL ), total bilirubin concentration was positively associated with telomere length ( β = 0.23 , 95 CI%: 0.14, 0.32, P < 0.001 ). However, the association between total bilirubin concentration and telomere length was not significant ( β = 0.01 , 95% CI: -0.01, 0.04, P = 0.346 ) above the turning point. Conclusion. This is the first evidence based on a nationally representative survey demonstrating a positive and nonlinear association between total bilirubin concentration and telomere length. Future large-scale prospective studies are warranted to confirm our findings.

scholarly journals Serum Concentration of Fluoride in Patients with Alcoholic Liver Cirrhosis from the Lublin Region in Eastern Poland

2021 ◽  
Vol 18 (3) ◽  
pp. 1115
Author(s):  
Andrzej Prystupa ◽  
Jarosław Sak ◽  
Paweł Kiciński ◽  
Agnieszka Stenzel-Bembenek ◽  
Anna Błażewicz
Keyword(s):  
Liver Cirrhosis ◽  
Liver Function ◽  
Serum Concentration ◽  
Total Bilirubin ◽  
Alcoholic Liver Cirrhosis ◽  
Serum Concentrations ◽  
Bilirubin Concentration ◽  
Severity Of Disease ◽  
Total Bilirubin Concentration ◽  
The Relationship

In view of previous reports, it is important to determine the relationship between liver function and the level of fluoride in the serum. The aim of this study was to investigate serum concentrations of fluoride in 72 patients with alcoholic liver cirrhosis, living in the region of Lublin (Eastern Poland) divided based on the severity of disease according to the Child-Turcotte-Pugh criteria. Higher plasma fluoride concentrations were associated with changes in liver related parameters. In all groups of analyzed patients with different stages of alcoholic liver cirrhosis, elevated levels of plasma fluoride and increased activities of both alanine aminotransferase (ALT) and total bilirubin concentration were shown.

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