IDIOPATHIC HYPOPROTEINEMIA

PEDIATRICS ◽  
1952 ◽  
Vol 9 (6) ◽  
pp. 729-735
Author(s):  
JAMES B. WYNGAARDEN ◽  
JOHN D. CRAWFORD ◽  
HARRIE R. CHAMBERLIN ◽  
WALTER F. LEVER
Keyword(s):  
Weight Gain ◽  
Renal Impairment ◽  
Plasma Protein ◽  
Protein Metabolism ◽  
Unusual Case ◽  
Gamma Globulin ◽  
Serum Sickness ◽  
Mild Asthma ◽  
Plasma Albumin ◽  
Acute Tonsillitis

A 3½ year old Negro boy with an obscure syndrome of inexplicable, transient, acquired hypoproteinemia, involving plasma albumin and especially gamma globulin, has been observed. Edema, oliguria and weight gain were noted 10 days following an attack of acute tonsillitis. Hypertension, renal impairment, proteinuria and hematuria were conspicuously absent, and an associated eosinophilia subsided as recovery progressed. Plasma protein regeneration was complete in 10 weeks. The patient has since developed mild asthma but has otherwise remained well. This appears to be an unusual case of transient derangement of plasma protein metabolism. Possible relationships to the syndromes of acute nephritis without proteinuria, nephrosis, serum sickness and idiopathic acquired hypoproteinemia are discussed.

Changes in the concentration of plasma proteins in intensively bred ewes

1977 ◽  
Vol 88 (2) ◽  
pp. 283-288 ◽  
Author(s):  
W. S. Mackie
Keyword(s):  
Plasma Protein ◽  
Plasma Volume ◽  
Plasma Proteins ◽  
Gamma Globulin ◽  
Total Plasma ◽  
Plasma Albumin ◽  
Total Plasma Protein ◽  
The Mean ◽  
Mean Concentration ◽  
Intensive Breeding

SUMMARYThe mean concentration of plasma albumin in 30 Finnish Landrace x Dorset Horn ewes subjected to intensive breeding decreased as the number of pregnancies increased from three to seven; it also changed significantly within a pregnancy. Gamma globulin concentration was not affected by the number of pregnancies but decreased significantly within a pregnancy. Total plasma protein was affected like albumin by the number and stage of pregnancy.Plasma volume increased by 23 % in the latter third of pregnancy.

Low Plasma Albumin Levels Are Associated with Increased Plasma Protein Glycation and HbA1c in Diabetes

2012 ◽  
Vol 11 (2) ◽  
pp. 1391-1396 ◽  
Author(s):  
Hemangi S. Bhonsle ◽  
Arvind M. Korwar ◽  
Sachin S. Kote ◽  
Sandeep B. Golegaonkar ◽  
Ashok D. Chougale ◽  
...  
Keyword(s):  
Plasma Protein ◽  
Protein Glycation ◽  
Plasma Albumin

scholarly journals Plasma Protein Metabolism

1971 ◽  
Vol 24 (8) ◽  
pp. 772-772
Author(s):  
J. R. Hobbs
Keyword(s):  
Plasma Protein ◽  
Protein Metabolism

scholarly journals Reduced Albumin Concentration Predicts Weight Gain and Higher Ad Libitum Energy Intake in Humans

2021 ◽  
Vol 12 ◽  
Author(s):  
Alessio Basolo ◽  
Takafumi Ando ◽  
Douglas C. Chang ◽  
Tim Hollstein ◽  
Jonathan Krakoff ◽  
...  
Keyword(s):  
Weight Gain ◽  
Energy Expenditure ◽  
Energy Intake ◽  
Fat Free Mass ◽  
Albumin Concentration ◽  
Plasma Albumin ◽  
Clinical Trial Registration ◽  
Ad Libitum ◽  
Intake Regulation

ObjectiveCirculating albumin is negatively associated with adiposity but whether it is associated with increased energy intake, lower energy expenditure or weight gain has not been examined.MethodsIn study 1 (n=238; 146 men), we evaluated whether fasting albumin concentration was associated with 24-h energy expenditure and ad libitum energy intake. In study 2 (n=325;167 men), we evaluated the association between plasma albumin and change in weight and body composition.ResultsAfter adjustment for known determinants of energy intake lower plasma albumin concentration was associated with greater total daily energy intake (β= 89.8 kcal/day per 0.1 g/dl difference in plasma albumin, p=0.0047). No associations were observed between plasma albumin concentrations and 24-h energy expenditure or 24-h respiratory quotient (p>0.2). Over 6 years, volunteers gained on average 7.5 ± 11.7 kg (p<0.0001). Lower albumin concentrations were associated with greater weight [β=3.53 kg, p=0.039 (adjusted for age, sex, follow up time), CI 0.16 to 6.21 per 1 g/dl difference albumin concentration] and fat mass (β=2.3 kg, p=0.022), respectively, but not with changes in fat free mass (p=0.06).ConclusionsLower albumin concentrations were associated with increased ad libitum food intake and weight gain, indicating albumin as a marker of energy intake regulation.Clinical Trial RegistrationClinicalTrials.gov, identifiers NCT00340132, NCT00342732.

Binding of calcium by human plasma proteins under simulated physiologic conditions

1964 ◽  
Vol 19 (2) ◽  
pp. 292-296 ◽  
Author(s):  
Irene R. Held ◽  
Smith Freeman
Keyword(s):  
Human Plasma ◽  
Plasma Proteins ◽  
Protein Concentration ◽  
Calcium Concentration ◽  
Gamma Globulin ◽  
Chloride Concentration ◽  
Total Calcium ◽  
Total Protein Concentration ◽  
Plasma Albumin

The binding of calcium to human plasma albumin, alpha, beta, and gamma globulins was studied with the aid of an ultracentrifuge. The amount of calcium bound to these separated proteins was determined in solutions with electrolyte concentrations and pH within physiological ranges. The total calcium concentration was 2.35–2.90 mm/liter H2O and the total protein concentration was 3.91–4.29 g/100 ml H2O. In these solutions no significant differences were found for the binding of calcium (expressed as mm Ca++ bound per gram protein) by albumin, alpha, and beta globulins; the average values obtained were, respectively, 0.016, 0.018, and 0.023. Significantly less calcium was bound by gamma globulin; 0.009 mm/gram. The pH was varied between 7.200–7.550 and the sodium chloride concentration between 114–157 mEq Na per liter. These changes did not measurably affect the amount of calcium bound to albumin. protein-bound calcium; ultracentrifugation and determination of protein-bound calcium; plasma globulin-bound calcium; plasma albumin-bound calcium Submitted on July 2, 1963

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