Fundus Pigmentation in Retinopathy of Prematurity

PEDIATRICS ◽  
1996 ◽  
Vol 97 (3) ◽  
pp. 343-348 ◽  
Author(s):  
Tova Monos ◽  
Shirley D. Rosen ◽  
Michael Karplus ◽  
Yuval Yassur
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Confidence Interval ◽  
Retinopathy Of Prematurity ◽  
Protective Factor ◽  
Very Low Birth Weight ◽  
Ophthalmological Examination ◽  
Dark Pigmentation ◽  
Prospective Study Design ◽  
Fundus Pigmentation

Objective. A prospective study design was used to investigate the association between different degrees of fundus pigmentation and the incidence of retinopathy of prematurity (ROP) among very low birth weight infants in a large neonatal intensive care unit. Methods. The study group consisted of 161 infants weighing 1500 g or less at birth and included all infants born from 1988 to 1990 who survived at least 10 weeks. Presence or lack of any acute stage ROP was determined by weekly ophthalmological examination from the age of 4 weeks. The degree of fundus pigmentation was recorded for each infant during the first examination. Results. Infants with dark fundus pigmentation were found to be at half the risk of developing ROP as compared with the infants having light/medium fundus pigmentation (relative risk 0.5;95% confidence interval = 0.2-1.1). When controlling for birth weight, gestational age, length of oxygen therapy, and ethnic group in multivariate analysis, dark pigmentation was an independent and statistically significant protective factor (odds ratio = 0.09, 95% confidence interval = 0.02-0.6). None of the infants with Stage III ROP or higher had dark pigmentation. Conclusion. We speculate that large amounts of melanin in the retinal pigment epithelium or choroid may protect the dark-pigmented very low birth weight infant from developing ROP.

RISK PREDICTORS FOR THE DEVELOPMENT OF RETINOPATHY OF PREMATURITY IN VERY LOW BIRTH WEIGHT NEONATES

2017 ◽  
Vol 04 (01) ◽  
pp. 22-26
Author(s):  
Sheena Shreetal ◽  
S Sobhakumar ◽  
Reshmi Rhiju ◽  
Shreetal Rajan Nair
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Retinopathy Of Prematurity ◽  
Very Low Birth Weight ◽  
Risk Predictors

d-Penicillamine and Retinopathy of Prematurity

PEDIATRICS ◽  
1988 ◽  
Vol 82 (6) ◽  
pp. 951-952
Author(s):  
LAJOS LAKATOS
Keyword(s):  
Birth Weight ◽  
Vitamin E ◽  
Low Birth Weight ◽  
Retinopathy Of Prematurity ◽  
Very Low Birth Weight ◽  
Marked Decrease ◽  
Neonatal Period ◽  
Low Birth Weight Infants ◽  
Retrolental Fibroplasia ◽  
Clinical Observations

To the Editor.— The letter to the editor by Johnson et al1 and studies by others regarding vitamin E prophylaxis for retinopathy of prematurity suggest that further research into the prevention of retinopathy of prematurity should not be limited to vitamin E. On the basis of clinical observations we reported that d-penicillamine treatment in the neonatal period was associated with a marked decrease in the incidence of severe retrolental fibroplasia among the very low birth weight infants.2

scholarly journals High Blood Pressure during Pregnancy is not a Protective Factor for Preterm Infants with Very Low Birth Weight. A Case-Control Study

2017 ◽  
Vol 39 (04) ◽  
pp. 155-161 ◽  
Author(s):  
Annibal Sabino ◽  
Eduardo de Souza ◽  
Ana Goulart ◽  
Adriana Lima ◽  
Nelson Sass
Keyword(s):  
Blood Pressure ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Protective Factor ◽  
Case Control Study ◽  
Very Low Birth Weight ◽  
Case Control ◽  
World Health ◽  
Control Group ◽  
Control Study

Objective To evaluate whether the presence of maternal blood pressure reduces the risks of morbidity, perinatal mortality and morbidity at 24 months of age in very low birth weight infants (VLBWIs) compared with a control group. Methods A retrospective, observational, case-control study. Total 49 VLBWIs were allocated to the study group, called the maternal arterial hypertension group (AHG), and matched with 44 in the control group (CG). The infants were assessed during hospitalization and at 12 and 24 months corrected age at a specialized clinic. For the assessment of growth, the World Health Organization (WHO) Anthro software (Geneva, 2006) was used, and for the psychomotor assessment, the Denver II test was used. Results In relation to the antenatal variables, the infants of the AHG had more centralized circulation assessed by Doppler, received more corticosteroids and magnesium sulfate, and were born by cesarean section more frequently. In terms of the postnatal and in-hospital outcomes, the AHG had a higher gestational age at birth (30.7 versus 29.6 weeks) and a lower frequency of 5-minute Apgar scores of less than 7 (26.5% versus 52.3%). The CG had a higher rate of pulmonary dysplasia (30.2% versus 8.3%). There were no differences in terms of hospital mortality, complications, somatic growth and functional problems at 24 months of corrected age. Conclusion The presence of maternal hypertension, especially preeclampsia, was not a protective factor against morbidity, mortality and evolution in VLBWIs aged up to 24 months. Therefore, the clinical practice should be focused on prolonging the pregnancy for as long as possible in these conditions as well.

Postnatal Dexamethasone Treatment and Retinopathy of Prematurity in Very-Low-Birth-Weight Neonates

Neonatology ◽  
2001 ◽  
Vol 79 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Phillip S. Cuculich ◽  
Kellie A. DeLozier ◽  
Beverly G. Mellen ◽  
Jayant P. Shenai
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Retinopathy Of Prematurity ◽  
Very Low Birth Weight ◽  
Dexamethasone Treatment
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