scholarly journals Comparison of Dehydroepiandrosterone Sulfate to Free Testosterone and Luteinizing Hormone to Follicular Stimulating Hormone Ratios in Polycystic Ovarian Syndrome Women

2017 ◽  
Vol 3 (1) ◽  
pp. 32-36
Author(s):  
Manju Bala Pahwa ◽  
◽  
Menaka K ◽  
Anjali Gupta ◽  
Meenakshi .
Keyword(s):  
Luteinizing Hormone ◽  
Polycystic Ovarian Syndrome ◽  
Free Testosterone ◽  
Dehydroepiandrosterone Sulfate ◽  
Ovarian Syndrome ◽  
Follicular Stimulating Hormone ◽  
Stimulating Hormone

scholarly journals HIRSUTISM

2016 ◽  
Vol 23 (06) ◽  
pp. 741-745
Author(s):  
Muhammad Usman Anjum ◽  
Surriya Yasmin ◽  
Hashim Riaz ◽  
Syed Humayun Shah
Keyword(s):  
Large Scale ◽  
Polycystic Ovarian Syndrome ◽  
Free Testosterone ◽  
Descriptive Study ◽  
Drug Induced ◽  
True Prevalence ◽  
Idiopathic Hirsutism ◽  
The Common ◽  
Ovarian Syndrome ◽  
Follicular Stimulating Hormone

elf-esteem, psychological distress and cosmetic embarrassment. Objective: Tostudy the clinical, biochemical and etiological profile of patients with hirsutism in Abbottabad,Pakistan. Duration and place: This descriptive study was performed in Frontier Medical & DentalCollege, Abbottabad from January, 2015 to December, 2015. Methods: Fifty patients wereincluded in the study. Complete clinical assessment and abdominal and pelvic ultrasonographywas carried out. Ferriman and Gallwey score was used to assess the extent and pattern ofhirsutism. Endocrinological investigations performed in these patients included prolactin,testosterone, luteinizing and follicular stimulating hormone (LH, FSH), thyroid function testsand cortisol. Results: Fifty patients were included in the study. Their mean age was 28.30±5.83years. About 88% of the women were married and 70% were obese. The polycystic ovariansyndrome (58%) was diagnosed as the main cause of hirsutism followed by idiopathic hirsutism(38%) and drug-induced hirsutism (4%). Majority of patients, 50%, had hirsutism for 1-5 yearswhile 22% and 20% had hirsutism for 6-10 years and > 10 years respectively. The rate of infertilityamong hirsute women was 70% (35 cases), out of which, 24 (48%) cases had primary infertilitywhile 11 (22%) had secondary infertility. Most of the hirsuite patients, 26 (52%), presented withthe complaints of infertility and menstrual disturbances followed by infertility alone in 9 (18%)cases, hirsutism in 6 (12%) cases and menstrual irregularities in 5 (10%). The 60% of patientsbelonged to moderate category according to FG score, (FG score 17-24). The 26% belonged tomild category (FG score 8-16) and 14% belonged to severe category (FG score 25-30). About72% of our patients used treatment of any kind for their disease. The common hair removingpractices used by these patients included bleaching (22%), waxing (20%), epilation (20%),electrolysis (6%) and shaving (4%). Serum free testosterone levels were elevated in 44% of ourpatients, LH/FSH ratio was more than 2 in 42.1% patients and prolactin levels were raised in10% of the patients. Conclusion: Hirsutism is not uncommon in Pakistan. The most commoncause of hirsutism was polycystic ovarian syndrome and idiopathic hirsutism. There is a need toconduct large scale studies to determine the true prevalence and etiological profile of patientswith hirsutism.

scholarly journals Prevalence of polycystic ovarian syndrome and its association with circulatory gonadotropins (luteinizing hormone and follicle-stimulating hormone) and prolactin in different reproductive age groups: A brief survey

2021 ◽  
Vol 2 ◽  
pp. 8
Author(s):  
Swastika Purohit ◽  
Seema Rai ◽  
Shubhada Kalvit
Keyword(s):  
Luteinizing Hormone ◽  
Polycystic Ovarian Syndrome ◽  
Follicle Stimulating Hormone ◽  
Age Groups ◽  
Reproductive Age ◽  
Age Group ◽  
Age Related ◽  
Circulatory Level ◽  
Ovarian Syndrome ◽  
Stimulating Hormone

Polycystic ovarian syndrome can affect fertility due to anovulatory cycles, luteal phase defects, hyperprolactinemia, and sex hormone imbalance, it remains untreated. The present study aims prevalence of polycystic ovarian disease (PCOD) of clinical/subclinical infertile women, different age groups and to analyze the association between circulatory level of gonadotropins, luteinizing hormone and follicle-stimulating hormone (LH and FSH) and prolactin (PRL) in polycystic ovary syndrome (PCOS) women of different reproductive age and its impact on fertility of women. The hormonal reports for LH, FSH, and PRL of 100 female patients were analyzed. Women suffering from oligomenorrhea and amenorrhea are given priority in this study. These samples were categorized into five different age groups of 15–20 years, 21–25 years, 26–30 years, 31–35 years, and 36–40 years. Obtained hormonal data of LH, FSH, and PRL were pooled and the average was taken to compare with the normal range of hormone. A significant age-dependent variation observed in circulatory serum levels of gonadotropins (LH and FSH) and PRL. The study reveals that the highest PCOD patients were observed in the age group of 21–25 years. Whereas, 30% to 15–20 years, 60% to 21–25 years, 40% to 26–30 years, 30 % to 31–35 years, and 20 % to 36–40 years of reproductive age group. Most affected population of PCOS women ranges in between 21 and 25 age groups, whereas the 36–40 age group was least affected. Age-related alteration in the circulatory level of PRL (hyperprolactinemia) and pulsatility of LH and FSH can be considered as the important factor regulating neuronal mechanisms of hypophyseal gonadal and peripheral endocrine feedback.

scholarly journals Recombinant Follicular Stimulating Hormone Plus Recombinant Luteinizing Hormone Versus Human Menopausal Gonadotropins- Does the Source of LH Bioactivity Affect Ovarian Stimulation Outcome?

2021 ◽  
Author(s):  
Michal Kirshenbaum ◽  
Or Gil ◽  
Jigal Haas ◽  
Ravit Nahum ◽  
Eran Zilberberg ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Ovarian Stimulation ◽  
Intracellular Signaling ◽  
Physiological Role ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Common Receptor ◽  
The Mean ◽  
Follicular Stimulating Hormone ◽  
Stimulating Hormone

Abstract Background: Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) activate distinct intracellular signaling cascades. However, due to their similar structure and common receptor, they are used interchangeably during ovarian stimulation (OS). This study aims to assess if the source of LH used during OS affects IVF outcome. Materials and methods: This was a cross sectional study of patients who underwent two consecutive IVF cycles, one included recombinant follicular stimulating hormone (FSH) plus recombinant LH [rFSH+rLH, (Pergoveris)] and the other included urinary hCG [highly purified hMG (HP-hMG), (Menopur)]. The OS protocol, except of the LH preparation, was identical in the two IVF cycles. Results: The rate of mature oocytes was not different between the treatment cycles (0.9 in the rFSH+rLH vs 0.8 in the HP-hMG, p=0.07). Nonetheless, the mean number of mature oocytes retrieved in the rFSH+rLH treatment cycles was higher compared to the HP-hMG treatment cycles (10 ± 5.8 vs 8.3 ±4.6, respectively, P=0.01). Likewise, the mean number of fertilized oocytes was higher in the rFSH+rLH cycles compared with the HP-hMG cycles (8.5 ± 5.9 vs 6.4 ± 3.6, respectively, p=0.05). There was no difference between the treatment cycles regarding the number of top-quality embryos, the ratio of top-quality embryos per number of oocytes retrieved or fertilized oocytes or the pregnancy rate. Conclusion: The differences in treatment outcome, derived by different LH preparations reflect the distinct physiological role of these molecules. Our findings may assist in tailoring a specific GT regimen when assembling an OS protocol.

scholarly journals Association of altered thyroid function and prolactin level in polycystic ovarian syndrome

2016 ◽  
Vol 45 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Marufa Mustari ◽  
MA Hasanat ◽  
Qamrul Hasan ◽  
Sadiqa Tuqan ◽  
Md Shah Emran ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Prolactin Level ◽  
Polycystic Ovarian Syndrome ◽  
Density Lipoprotein ◽  
Serum Testosterone ◽  
Thyroid Stimulating Hormone ◽  
Primary Infertility ◽  
Altered Thyroid ◽  
Ovarian Syndrome ◽  
Stimulating Hormone

Polycystic ovarian syndrome (PCOS) is a common disorder for female with fertile age. Along with other clinical and biochemical manifestations, thyroid function and prolactin level may be altered in patients with PCOS. This study aimed to evaluate the clinical and biochemical status, as well as alteration of thyroid stimulating hormone (TSH), prolactin (PRL) level in patients with PCOS. Present study comprised of 100 diagnosed PCOS patients according to revised Rotterdem Consensus criteria. All patients were studied for serum testosterone, LH (lutenizing hormone), FSH (follicle stimulating hormone), blood glucose, lipid profile as well as TSH, FT4 (free thyroxin) and prolactin level. Out of 100 PCOS patients 97 had hirsutism, 64 had acanthosis nigricans, where menstrual irregularities were in 94 patients. Diastolic blood pressure (74±1.1 vs. 77±0.9, mmHg; p=0.017), total cholesterol (163±5.3 vs. 193±6.2 mg/dl; p<0.001), low density lipoprotein (LDL, 104±3.7 vs. 124±4.9 mg/dl; p=0.002) and frequency of acanthosis (25% vs. 75%; p<0.001) were significantly higher among the patients having BMI>25 Kg/m2 than those of have ? 25 Kg/m2. Among the fertile women (n=53), 47% had primary and 41.5% had secondary infertility; whereas of the total patients, 21% had altered thyroid function and 6.1% had raised prolactin (PRL, ng/ml) level. Differences of TSH (4.1±3.6 vs. 3.5±6.8, mIU/L; p=0.725) was not significant; whereas level of PRL (13.87±6.9vs. 9.4±5.2 ng/ml; p=0.018) was significantly higher in the group of primary infertility. Hirsutism, menstrual disturbance and acanthosis were very common in PCOS. Both primary and secondary sterility were also commonly observed and PRL was higher in primary infertility. About one fifth of PCOS had altered thyroid function.Bangladesh Med J. 2016 Jan; 45 (1): 1-5

scholarly journals Study of cutaneous manifestations of polycystic ovarian syndrome

2020 ◽  
Vol 9 (4) ◽  
pp. 1627
Author(s):  
Sukhleen Kaur ◽  
Sunil K. Gupta ◽  
Sunil K. Juneja ◽  
Sukhjot Kaur ◽  
Monika Rani
Keyword(s):  
Insulin Resistance ◽  
Acanthosis Nigricans ◽  
Polycystic Ovarian Syndrome ◽  
Free Testosterone ◽  
Reproductive Age ◽  
Common Finding ◽  
Serum Prolactin ◽  
Endocrine Disorders ◽  
Cutaneous Manifestations ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is one of the most frequently encountered endocrine disorders that occurs in as many as 4 to 10% of women of reproductive age group. It presents with a series of skin changes including acne, hirsutism, seborrhea, androgenetic alopecia (AGA) and acanthosis nigricans. Aim of the study was to determine the prevalence and frequency of different cutaneous manifestations in PCOS patients and to correlate them with the degree of hormonal abnormalities.Methods: A total 100 patients with features of PCOS who presented to department of dermatology, gynecology (January 2018-December 2019) with cutaneous manifestations were recorded and diagnosis of PCOS was made using Rotterdam’s criteria. Pregnant women and diagnosed cases of any other endocrine disorder were excluded. Hirsutism was assessed using Ferriman-Gallwey score and AGA according to Ludwig’s classification. Serum hormonal profile including FSH, LH, prolactin, testosterone (free), DHEAS, TSH, FBS, fasting insulin were done. Insulin resistance was determined by calculating HOMA-IR score.Results: Among cutaneous manifestations of PCOS, hirsutism (85%) was the most common finding followed by acne (73%), seborrhea (50%), AGA (36%), acanthosis nigricans (29%) and acrochordons (9%). The most common hormonal abnormality was insulin resistance in 53% patients, followed by raised free testosterone in 19% and serum prolactin in 18% patients. A statistically significant association was present between AGA and insulin resistance, hirsutism and raised prolactin levels, seborrhea and raised body mass index (p < 0.05).Conclusions: Dermatological manifestations of PCOS play a significant role in making the diagnosis and constitute a substantial portion of the symptoms experienced by women with this syndrome.

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