scholarly journals Prevalence of polycystic ovarian syndrome and its association with circulatory gonadotropins (luteinizing hormone and follicle-stimulating hormone) and prolactin in different reproductive age groups: A brief survey

2021 ◽  
Vol 2 ◽  
pp. 8
Author(s):  
Swastika Purohit ◽  
Seema Rai ◽  
Shubhada Kalvit
Keyword(s):  
Luteinizing Hormone ◽  
Polycystic Ovarian Syndrome ◽  
Follicle Stimulating Hormone ◽  
Age Groups ◽  
Reproductive Age ◽  
Age Group ◽  
Age Related ◽  
Circulatory Level ◽  
Ovarian Syndrome ◽  
Stimulating Hormone

Polycystic ovarian syndrome can affect fertility due to anovulatory cycles, luteal phase defects, hyperprolactinemia, and sex hormone imbalance, it remains untreated. The present study aims prevalence of polycystic ovarian disease (PCOD) of clinical/subclinical infertile women, different age groups and to analyze the association between circulatory level of gonadotropins, luteinizing hormone and follicle-stimulating hormone (LH and FSH) and prolactin (PRL) in polycystic ovary syndrome (PCOS) women of different reproductive age and its impact on fertility of women. The hormonal reports for LH, FSH, and PRL of 100 female patients were analyzed. Women suffering from oligomenorrhea and amenorrhea are given priority in this study. These samples were categorized into five different age groups of 15–20 years, 21–25 years, 26–30 years, 31–35 years, and 36–40 years. Obtained hormonal data of LH, FSH, and PRL were pooled and the average was taken to compare with the normal range of hormone. A significant age-dependent variation observed in circulatory serum levels of gonadotropins (LH and FSH) and PRL. The study reveals that the highest PCOD patients were observed in the age group of 21–25 years. Whereas, 30% to 15–20 years, 60% to 21–25 years, 40% to 26–30 years, 30 % to 31–35 years, and 20 % to 36–40 years of reproductive age group. Most affected population of PCOS women ranges in between 21 and 25 age groups, whereas the 36–40 age group was least affected. Age-related alteration in the circulatory level of PRL (hyperprolactinemia) and pulsatility of LH and FSH can be considered as the important factor regulating neuronal mechanisms of hypophyseal gonadal and peripheral endocrine feedback.

Reference intervals for follicle-stimulating hormone, luteinizing hormone and prolactin in children and young adults on the bioMérieux Mini-Vidas system

2007 ◽  
Vol 45 (4) ◽  
Author(s):  
Thu Koskas ◽  
Karamo Souaré ◽  
Tarik Ouahabi ◽  
Dominique Porquet ◽  
Didier Chevenne
Keyword(s):  
Luteinizing Hormone ◽  
Pediatric Population ◽  
Follicle Stimulating Hormone ◽  
Reference Intervals ◽  
Age Group ◽  
Pubertal Stage ◽  
Significant Difference ◽  
Class 1 ◽  
Children And Young Adults ◽  
Stimulating Hormone

AbstractWe measured serum follicle-stimulating hormone (FSH), luteinizing hormone (LH) and prolactin concentrations on a bioMérieux Mini Vidas system in a pediatric population ranging in age from 1 to 19 years. Reference intervals were established separately for females and males, with stratification by age group and by Tanner's pubertal stage. FSH values were higher in females than in males, and were lowest in both sexes of age class 2 (4–8 years), increasing thereafter to the upper limit for stage PIV (females) and stage PV (males). LH values showed a similar pattern of change: concentrations were lowest for class 1 (1–3 years) and class 2 (4–8 years), and highest for stage PII (females) and stage PV (males). No significant difference was observed according to gender. Prolactin values did not differ markedly according to gender or pubertal status.Clin Chem Lab Med 2007;45:541–5.

Ovulation induction by step-down administration of purified urinary follicle-stimulating hormone in patients with polycystic ovarian syndrome

1991 ◽  
Vol 55 (6) ◽  
pp. 1195-1196 ◽  
Author(s):  
Hideki Mizunuma ◽  
Takeshi Takagi ◽  
Kiyohiko Yamada ◽  
Kazumichi Andoh ◽  
Yosito Ibuki ◽  
...  
Keyword(s):  
Ovulation Induction ◽  
Polycystic Ovarian Syndrome ◽  
Follicle Stimulating Hormone ◽  
Step Down ◽  
Ovarian Syndrome ◽  
Stimulating Hormone

scholarly journals Mitigating effect of metformin on polycystic ovarian syndrome and insulin resistance in rats, and the mechanisms involved

2020 ◽  
Vol 19 (9) ◽  
pp. 1941-1946
Author(s):  
Lanyawen Hu ◽  
Baimiao Wang ◽  
Yingli Tao
Keyword(s):  
Insulin Resistance ◽  
Blood Sugar ◽  
Polycystic Ovarian Syndrome ◽  
Follicle Stimulating Hormone ◽  
Fasting Blood Glucose ◽  
Resistance Index ◽  
New Drugs ◽  
Fasting Blood Sugar ◽  
Ovarian Syndrome ◽  
Stimulating Hormone

Purpose: To study the effect of metformin on polycystic ovarian syndrome (PCOS) and insulin resistance (IR) in rats, and the mechanism involved.Methods: Eighty healthy female SD rats, aged 6 weeks, were selected. Three groups of rats were used: model, metformin + PI3K inhibitor, and metformin groups, with 20/group. Testosterone, leutenizing hormone (LH), and follicle-stimulating hormone (FSH) were assayed by enzyme-linkedassay (ELISA), while HOMA-IR was calculated from fasting blood sugar (FBG); the effect of metformin on the IR of PCOS rats was determined. The expressions of PI3K and AKT in ovaries and liver of rats in each group were assayed by Western blotting.Results: Fasting blood glucose, fasting insulin, and insulin resistance index were markedly higher in model than in control rats, and also significantly higher in inhibitor-treated rats than in metformin rats (p < 0.05). Relative to control, FSH level was higher, while levels of LH, LH/FSH ratio and testosterone in the metformin group were significantly lower (p < 0.05). The expression levels of PI3K and AKT in the ovary and liver were reduced in the inhibitor group, relative to the levels in metformin-treated rats (p < 0.05).Conclusion: Metformin mitigates PCOS-linked ovarian changes and IR in rats via PI3K/AKT route. These findings may be useful in the design of new drugs. Keywords: Metformin, Polycystic ovary syndrome, Leutenizing hormone, Insulin resistance, Fasting blood sugar, Follicle-stimulating hormone

scholarly journals Study on the Prevalence and Characteristics of Metabolic Syndrome in Women of Reproductive Age Group with Polycystic Ovarian Syndrome

2017 ◽  
Vol 9 (4) ◽  
pp. 341-347
Author(s):  
Rekha R Madusudhanan ◽  
Bindu Nambisan ◽  
Mayadevi Brahmanandan ◽  
Sreekumari Radha
Keyword(s):  
Metabolic Syndrome ◽  
Polycystic Ovarian Syndrome ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Reproductive Age ◽  
Age Group ◽  
Women Of Reproductive Age ◽  
Ovarian Syndrome ◽  
Reproductive Age Group

ABSTRACT Introduction Polycystic ovarian syndrome (PCOS) is an endocrine disorder affecting all age groups and presenting with myriad problems like menstrual irregularities, hirsutism, anovulatory infertility, and long-term complications like diabetes, cardiovascular problems, etc. Aim Study was aimed at finding the prevalence, characteristics, and various risk factors of metabolic syndrome (MS) in reproductive age group in our hospital. Materials and methods Using statistical table, a sample size of 131 was calculated and patients were recruited as per inclusion criteria. Polycystic ovarian syndrome was diagnosed by the American Society for Reproductive Medicine (ASRM)/European Society of Human Reproduction and Embryology (ESHRE) criteria. After informed consent, a detailed history was obtained and physical examination was carried out to assess, body weight, height, body mass index (BMI), waist—hip ratio (WHR), and blood pressure (BP). Fasting blood glucose, triglycerides, and high-density lipoprotein (HDL) were measured for each woman Results Prevalence of MS in our study was 45.8%; 26.7% of patients had a combination of increased waist circumference, raised triglycerides, and low HDL; 55.2% of patients had a fasting blood sugar (FBS) levels more than 100 mg%. Age of the patient was a statistically significant risk factor of MS with 100% of patients in the age group of 35 to 39 presenting with MC. Body mass index was also a statistically significant risk factor with 82.6% with BMI > 30 having MC. Other important risk factors include a WHR more than 0.95, presence of diabetes in mother or sister, and presence of acanthosis; 71% of patients with WHR more than 0.95 had MC. Age of menarche, duration of menstrual cycles, and hirsutism showed no significant relationship. Conclusion An outstanding fact that emerged in this study was that 94% of women with PCOS had HDL values <50 mg/dL. And 58% had triglycerides more than 150 mg/dL. Hence, lifestyle modification and early intervention will hopefully spare long-term complication of PCOS. How to cite this article Madusudhanan RR, Nambisan B, Brahmanandan M, Radha S. Study on the Prevalence and Characteristics of Metabolic Syndrome in Women of Reproductive Age Group with Polycystic Ovarian Syndrome. J South Asian Feder Obst Gynae 2017;9(4):341-347.

Features of the functional state of the pituitary-ovarian systems in women with polycystic ovary syndrome at different periods of reproductive age

2020 ◽  
Vol 75 (6) ◽  
pp. 653-660
Author(s):  
O. V. Krusko ◽  
L. F. Sholokhov ◽  
L. V. Belenkaya ◽  
M. A. Rashidova ◽  
I. N. Danusevich ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Follicle Stimulating Hormone ◽  
Reproductive Age ◽  
Sex Steroid ◽  
Control Group ◽  
Ovary Syndrome ◽  
Steroid Binding ◽  
Stimulating Hormone

Background. PCOS is one of the most common endocrinological pathologies in women of reproductive age, manifested by a wide range of clinical manifestations. There are many unresolved issues related to the pathogenesis, diagnosis and treatment of this pathological condition in different periods of reproductive age. Aim the objective of the study was to identify the features of the functioning of the pituitary-ovarian system in women with PCOS at different periods of reproductive age. Methods. Study was performed in 20172019 at the FSPSI SCFHHRP, and involved women aged 1845 years. The study groups included women (a group of women with PCOS and a control group) in the follicular phase from 1 to 12 days of the menstrual cycle. As a result of the survey, a group of 44 women with PCOS and a group of 56 healthy women were formed. PCOS was diagnosed according to ESHRE/ASRM criteria (Rotterdam, 2003). Next, subgroups of women in early reproductive age from 35 to 45 years were formed: a group of women with PCOS (n = 29) and a control group (n = 22). And groups of women in late reproductive age from 35 to 45 years were formed: a group of women with PCOS (n = 15) and a control group (n = 34). Conducted: questionnaire survey, general and gynecological examination, ultrasound examination of the pelvic organs, laboratory tests, statistical data analysis. Results. In women with polycystic ovary syndrome of early reproductive age (1835 years), we detected an increase in the level of testosterone by 2 times, DHEA-S by 1.3 times, 17-OH-progesterone by 2 times, sex steroid-binding globulin by 1.4 times, in comparison with control group. The ratio of luteinizing hormone to follicle-stimulating hormone increased by 52%. In women with polycystic ovary syndrome of late reproductive age (3545 years), we detected an increase in the level of testosterone by 1.5 times, 17-OH-progesterone by 1.9 times, luteinizing hormone by 1.4 times, sex steroid-binding globulin by 1.6 times, in comparison with control group, without any significant differences in DHEA-S. At the same time, the ratio of luteinizing hormone to follicle-stimulating hormone increased by 60%. Conclusion. The hormonal profile of women with PCOS of early and late reproductive period is characterized by series of age-related changes in the pituitary-ovarian system, which should be taken into account in preventive and therapeutic measures.

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