scholarly journals Role of Coxiella burnetii in the development of fever of unknown origin: А mini review

2019 ◽  
Vol 22 (3) ◽  
pp. 251-265
Author(s):  
P. Genova-Kalou ◽  
S. Ivanova ◽  
A. Pavlova ◽  
K. Simeonov ◽  
D. Pencheva ◽  
...  
Keyword(s):  
Fever Of Unknown Origin ◽  
Clinical Presentation ◽  
Q Fever ◽  
Unknown Origin ◽  
Accurate Diagnosis ◽  
Diagnostic Methods ◽  
Molecular Diagnostic ◽  
Agricultural Systems ◽  
The World

Q fever is a widespread zoonosis throughout the world in the form of numerous natural and agricul-tural outbreaks. C. burnetii infects various hosts, including humans, ruminants and pets and in rare cases, reptiles, birds, and ticks. This bacterium is excreted in urine, milk, faeces, and birth products. In humans Q fever occurs as acute or chronic disease with diverse clinical presentation, as isolated cases and epidemics. It affects various organs and systems, and in pregnant women can cause miscar-riage or premature birth. Untreated Q fever can become chronic with adverse effects on patients. Diversity in the clinical picture in the absence of specific pathological syndrome often hinders accurate diagnosis and proper etiological significance. Therefore, improvement of diagnostic methods and in particular the development and introduction of new molecular diagnostic methods is the basis of effective therapeutic and prophylactic approach. Тhe purpose of the review is to renew the interest to Q fever – on one hand, because of its serious impact on human health and agricultural systems, and on the other, the ability for development and introduction of new molecular diagnostic methods.

The role of FDG PET/CT discovering the cause of fever of unknown origin

2012 ◽  
Vol 153 (6) ◽  
pp. 227-231
Author(s):  
Bernadett Szűcs ◽  
Edit Nagy ◽  
Stefan Talev ◽  
Ildikó Garai ◽  
László Galuska
Keyword(s):  
Case Report ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Diagnostic Procedures ◽  
Clinical Problem ◽  
Diagnostic Techniques ◽  
Diagnostic Methods ◽  
Pet Ct ◽  
Fdg Pet Ct

The fever of unknown origin from time to time constitutes a serious clinical problem and nearly all diagnostic methods are involved to discover urgently its cause. According to literature data 18F-fluoro-deoxyglucose PET/CT was successful in 25-70% of cases even in patients without any positive findings with conventional diagnostic techniques. The Hungarian National Health Fund does not include fever of unknown origin in the list of reimbursed 18F-fluoro-deoxyglucose PET/CT indications. The authors try to illustrate the clinical problem with this case report. Fever of unknown origin persisted in a patient for a year, but conventional diagnostic procedures were unsuccessful to find the cause of the fever. Finally, 18F-fluoro-deoxyglucose PET/CT indicated a metabolically active focus between the pancreas tail and the spleen. After a long-lasting antibiotic therapy the patient became symptomfree. Orv. Hetil., 2012, 153, 227–231.

scholarly journals From autoimmune hepatitis to Q fever

2015 ◽  
Vol 10 (1) ◽  
pp. 58
Author(s):  
Davide Tizzani ◽  
Silvia Totaro ◽  
Valentina Laura Crudo ◽  
Andrea Viola ◽  
Vittorio Gallo ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Liver Biopsy ◽  
Autoimmune Hepatitis ◽  
Medical History ◽  
Coxiella Burnetii ◽  
Fever Of Unknown Origin ◽  
Clinical Presentation ◽  
Q Fever ◽  
Unknown Origin ◽  
Granulomatous Hepatitis

Q fever is an infectious disease caused by <em>Coxiella burnetii.</em> Its clinical presentation is often nonspecific and the serological diagnosis difficult to make, especially in the absence of specific and suspected medical history. This article presents a case of fever of unknown origin (FUO), interpreted as an autoimmune hepatitis, later proven by the liver biopsy to be a granulomatous hepatitis caused by <em>C. burnetii</em>. The approach to FUO, the features of granulomatous hepatitis and Q fever are presented and discussed.

scholarly journals FDG-PET or PET/CT in Fever of Unknown Origin: The Diagnostic Role of Underlying Primary Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Nurhan Ergül ◽  
Tevfik Fikret Çermik
Keyword(s):  
Fdg Pet ◽  
Fever Of Unknown Origin ◽  
Inflammatory Diseases ◽  
Unknown Origin ◽  
Structural Analog ◽  
Diagnostic Methods ◽  
Pet Ct ◽  
Diagnostic Role ◽  
The Impact

Fever of unknown origin (FUO) is generally defined as a fever greater than 38.3°C on several occasions during a period longer than 3 weeks for which the etiology behind cannot be diagnosed at the end of at least 1 week hospital stay. Conventional diagnostic methods are still not adequate to reveal underlying reason in approximately 50% of patients with FUO. In patients with certain diagnosis, three major categories are infections, malignancies, and noninfectious inflammatory diseases. Fluoro-18-fluoro-2-deoxy-D:-glucose (FDG) is a structural analog of 2-deoxyglucose and accumulates in malignant tissues but also at sites of infection and inflammation. For this reason, FDG PET or PET/CT has great advantage in understanding of underlying pathology in assessment of FUO. However, till today, there are limited studies about the role of FDG PET or PET/CT in evaluation of FUO. In this paper, the impact of FDG PET or PET/CT in the diagnostic work-up of FUO is described by data obtained from literature review.

scholarly journals Questing one Brazilian query: reporting 16 cases of Q fever from Minas Gerais, Brazil

2006 ◽  
Vol 48 (1) ◽  
pp. 5-9 ◽  
Author(s):  
Paulo Sérgio Gonçalves da Costa ◽  
Marco Emilio Brigatte ◽  
Dirceu Bartolomeu Greco
Keyword(s):  
Phase I ◽  
Phase Ii ◽  
Fever Of Unknown Origin ◽  
Q Fever ◽  
Acute Infection ◽  
Case Series ◽  
Febrile Illness ◽  
Unknown Origin ◽  
Clinical Form ◽  
Chronic Q Fever

Q fever has been considered non-existing in Brazil where reports of clinical cases still cannot be found. This case-series of 16 patients is a result of a systematic search for such illness by means of clinical and serologic criteria. Serologic testing was performed by the indirect microimmunofluorescence technique using phase I/II C. burnetii antigens. Influenza-like syndrome was the most frequent clinical form (eight cases - 50%), followed by pneumonia, FUO (fever of unknown origin), mono-like syndrome (two cases - 12.5% each), lymphadenitis (one case - 6.3%) and spondylodiscitis associated with osteomyelitis (one case - 6.3%). The ages varied from four to 67 years old with a median of 43.5. All but one patient had positive serologic tests for phase II IgG whether or not associated with IgM positivity compatible with acute infection. One patient had both phase I and phase II IgG antibodies compatible with chronic Q fever. Seroconvertion was detected in 10 patients. Despite the known limitations of serologic diagnosis, the cases here reported should encourage Brazilian doctors to include Q fever as an indigenous cause of febrile illness.

THE ROLE OF LIVER BIOPSY IN ESTABLISHING DIAGNOSIS IN A PATIENT WITH FEVER OF UNKNOWN ORIGIN: REPORT OF A CASE

2011 ◽  
Vol 22 ◽  
pp. S52
Author(s):  
Fani Kyriakou ◽  
Nikolaos Nikolaou ◽  
Makrina Koutsouraki ◽  
Georgios Erotokritou ◽  
Ekaterini Parassi ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Fever Of Unknown Origin ◽  
Unknown Origin

scholarly journals Role of Multi Detector Computed Tomography Cervicocerebral Angiography in Evaluation of Patients with Stroke

2020 ◽  
Vol 8 (1) ◽  
pp. 93-99
Author(s):  
Balaji Varaprasad Mallula ◽  
Jithender Reddy Chintala ◽  
Srinadh Boppanna ◽  
S. Annapurna
Keyword(s):  
Prospective Observational Study ◽  
Hemorrhagic Stroke ◽  
Accurate Diagnosis ◽  
Age Group ◽  
Common Risk Factor ◽  
Female Ratio ◽  
The World ◽  
Male To Female ◽  
Multi Detector Computed Tomography

Background: Stroke is the second single most common cause of death in the world causing approximately 6.7 million deaths each year. It has a greater disability impact on an individual than any other chronic disease. The aim of the study is to review the value of CTA in detection and evaluation of non-traumatic cervicocerebral vascular disease (stroke). Subjects & Methods: A prospective observational study conducted in the Department of Radiodiagnosis, Kamineni Hospitals, L.B. Nagar, Hyderabad over 60 patients during April 2016 to May 2017. Results: Out of 60 patients, 35(58.3%) patients had ischemic stroke, 25(41.6%) had hemorrhagic stroke. Overall stroke was seen mostly in the age group of 61-70 (28.3%) years, with a Male to female ratio of 3:2. Conclusion: Hypertension was the most common risk factor associated with this disease, followed by diabetes. CTA helps in accurate diagnosis, risk stratification and planning management protocols.

Infective endocarditis as a complication of longstanding ventriculoatrial (VA) shunt: the importance of suspicion and early investigation in patients with VA shunt and pyrexia of unknown origin

2021 ◽  
Vol 14 (1) ◽  
pp. e237161
Author(s):  
Rosa Sun ◽  
Richard Warwick ◽  
Stuart Harrisson ◽  
Nageswar Bandla
Keyword(s):  
Infective Endocarditis ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Early Investigation ◽  
Window Of Opportunity ◽  
Pyrexia Of Unknown Origin ◽  
Cerebrospinal Fluid Diversion ◽  
Prompt Diagnosis

Ventriculoatrial (VA) shunts are a method of cerebrospinal fluid diversion, which nowadays are infrequently seen in medical practice. Infective endocarditis (IE) can occur as rare complications of VA shunts, through the introduction of a foreign body close to the tricuspid valve. We report a case of infective endocarditis, that is, in a patient with VA shunt for congenital hydrocephalus. We present the case to highlight the importance of early investigation for IE in patients with fever of unknown origin and shunt in situ, as rapid deterioration can occur and be fatal. We also discuss past experience reported in the literature on the role of cardiothoracic intervention. Prompt diagnosis and early cardiothoracic referral for surgery are crucial, there may only be a narrow window of opportunity for intervention before patients develop fulminant sepsis.

Giant cell arteritis mimicking fever of unknown origin: potential diagnostic role of PET scan

2006 ◽  
Vol 95 (02) ◽  
pp. 390-392 ◽  
Author(s):  
Olivier Chavaillaz ◽  
Salah Gueddi ◽  
Sophia Taylor ◽  
Hans Stalder ◽  
Marc Righini
Keyword(s):  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Pet Scan ◽  
Diagnostic Role

scholarly journals Globalisation and mental disorders

2004 ◽  
Vol 184 (1) ◽  
pp. 10-20 ◽  
Author(s):  
Dinesh Bhugra ◽  
Anastasia Mastrogianni
Keyword(s):  
Cultural Competency ◽  
Clinical Presentation ◽  
Psychological Symptoms ◽  
Somatic Symptoms ◽  
Idioms Of Distress ◽  
Pathways To Care ◽  
Treatment Of Depression ◽  
The World ◽  
The Media

BackgroundGlobalisation is the process by which traditional boundaries of cultures are changing. Industrialisation, urbanisation and influence of the media are influencing idioms of distress across cultures.AimsTo discuss the role of globalisation, using the epidemiology, diagnosis, clinical presentation and treatment of depression across various cultures as an example.MethodRecent studies focusing on transcultural aspects of depression were reviewed and summarised.ResultsCultural, social and religious mores account for variations in the presentation of depression across cultures. Somatic symptoms are common presenting features throughout the world and may serve as cultural idioms of distress, but psychological symptoms can usually be found when probed. Feelings of guilt and suicide rates vary across cultures and depression may be underdiagnosed.ConclusionsTraining packages could enhance clinicians' cultural competency in multicultural settings. However, globalisation is likely to influence idioms of distress and pathways to care in ways that are difficult to predict.

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