PROLACTIN RECEPTOR GENE (PRLR) ROLE IN SWINE REPRODUCTION

PRLR gene has been studied as a candidate gene for litter size in swine because of prolactin biological functions and their association with reproduction. Prolactin receptor gene is mapped on porcine chromosome 16. The established PCR-RFLP polymorphism at PRLR locus demonstrated the presence of two alleles, А and В and three genotypes АА, АВ and ВВ. There were found different allele and genotype frequencies in different pig populations with variation of the effects of PRLR genotypes on litter traits. Additional studies should be done in specific breeds and populations to evaluate the association of existing PRLR locus polymorphism with reproductive traits before application of marker-assisted selection in these populations.

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Prolactin reeeptor gene polymorphism and its association with litter size in Polish Landrace

Archives Animal Breeding ◽

10.5194/aab-44-547-2001 ◽

2001 ◽

Vol 44 (5) ◽

pp. 547-552 ◽

Cited By ~ 3

Author(s):

M. Kmiec ◽

A. Dybus ◽

A. Terman

Keyword(s):

Gene Locus ◽

Prolactin Receptor ◽

Reproductive Traits ◽

Gene Marker ◽

Chromosome 16 ◽

Specific Primers ◽

Dna Mutations ◽

Pcr Rflp ◽

Left And Right ◽

Discrete Scale

Abstract. Prolactin reeeptor gene (PRLR), which is localized on chromosome 16 in pigs, is a candidate gene marker for reproductive traits. The experiment was aimed to detect the DNA mutations in that gene and to find probable relations between the genotype and some reproductive traits in Polish Landrace pigs 207 sows and 8 boars from pedigree herd were studied. The polymorphism in PRLR gene locus was detected using PCR-RFLP method, with specific primers and restriction enzyme Alul. Two different alleles were identified: PRLRA; PRLRB. The frequency of PRLRA was estimated at 0.44 and PRLRB – 0,56. In the studied population of pigs frequencies of genotypes AA, AB and BB were 0.247, 0.386 and 0.367, respectively. The relations between PRLR genotypes and teats number on the left and right body side, total number of teats, number of piglets in the litter and the age at the first parity were analyzed. All data were transformed from the discrete scale into the quantitative one. The analysis showed the significant dependencies (P ≤ 0,01) between the number of piglets in the first litter and genotype of prolactin receptor. Significantly greater number of piglets characterized the sows carrying AA genotype.

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Two tagSNPs in the prolactin receptor gene are associated with growth and litter traits in Boer and Macheng Black crossbred goats

Livestock Science ◽

10.1016/j.livsci.2016.10.002 ◽

2016 ◽

Vol 193 ◽

pp. 71-77 ◽

Cited By ~ 1

Author(s):

Qi Xiong ◽

Jin Chai ◽

Xiaofeng Li ◽

Xiaojun Suo ◽

Nian Zhang ◽

...

Keyword(s):

Receptor Gene ◽

Prolactin Receptor ◽

Litter Traits ◽

Prolactin Receptor Gene

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Porcine prolactin receptor genotypes and production and reproduction traits in Hungarian Large White and Landrace sows (Brief Report)

Archives Animal Breeding ◽

10.5194/aab-53-497-2010 ◽

2010 ◽

Vol 53 (4) ◽

pp. 497-499

Author(s):

K. Kovacs ◽

L. Fesus ◽

A. Zsolnai ◽

A. Nyiri ◽

I. Anton

Keyword(s):

Litter Size ◽

Receptor Gene ◽

Mammalian Species ◽

Prolactin Receptor ◽

Reproductive Traits ◽

Pituitary Hormone ◽

Chromosome 16 ◽

Large White ◽

Anterior Pituitary Hormone ◽

Reproduction Traits

Abstract. Prolactin is an anterior pituitary hormone involved in many endocrine activities and plays and essential role in reproduction. Its receptor (PRLR) was detected in various tissues including brain, ovary, placenta, an uterus in several mammalian species (BOLE-FEYSOT et al. 1998). Reproductive performance of sows is a crutial point in pig production with significant economic importance and may be estimated with the help of markers. Porcine prolactin receptor gene is said to be a candidate genetic marker for reproductive traits. It has been mapped to porcine chromosome 16 (Vincent et al. 1997). There is a C/G SNP in PRLR gene (KMIEC et al. 2001) at the position of 203 (GAN: U96306) which eliminates an AluI cleavage site. The effect of this polymorphism on litter size in various breeds has been estimated (VINCENT et al. 1998, ROTHSCHILD et al. 1998, VAN RENS et al. 2002, KMIEC and TERMAN, 2004, DRÖGEMÜLLER et al. 2001, KORWIN-KOSSAKOWSKA et al. 2003). The influence of the bovine hormone variant was also estimated (RATNA-KUMARI et al. 2008). The aim of the study was to estimate PRLR AluI polymorphism effects on litter size in Hungarian Large White (HLW) and Hungarian Landrace (HL) breeds.

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Polymorphism and association of progesterone receptor gene with milk production and reproductive traits of rabbits

Czech Journal of Animal Science ◽

10.17221/156/2020-cjas ◽

2020 ◽

Vol 65 (No. 9.) ◽

pp. 346-353

Author(s):

Lubomir Ondruska ◽

Vladimir Parkanyi ◽

Jan Rafay ◽

Alica Navratilova

Keyword(s):

Progesterone Receptor ◽

Milk Production ◽

Litter Size ◽

Association Studies ◽

Receptor Gene ◽

Reproductive Traits ◽

Genotype Frequencies ◽

Progesterone Receptor Gene ◽

Pcr Rflp ◽

Genotype A

Using the PCR RFLP method polymorphism and three different genotypes (AA, AG and GG) were detected in the progesterone receptor gene (PGR) promoter in a local Slovak crossbred rabbit line. We have noted a slightly majority frequency of allele A (0.53) over allele G (0.47). Comparing the observed and expected genotype frequencies with the χ<sup>2</sup> test the results were statistically significant, which means the tested rabbit population was non-equilibrium. The best results and significantly highest milk production (P < 0.001) were recorded in the does of GG genotype compared to AA genotype. Other association studies aimed at the effect of genotypes on litter size showed the highest litter size and number of weaned rabbits per litter in GG genotype. A significantly higher (P < 0.05) average number of stillborn kits per litter was in the group of does with AA genotype (0.62) compared with GG genotype (0.34).

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