Polymorphism and association of progesterone receptor gene with milk production and reproductive traits of rabbits

Using the PCR RFLP method polymorphism and three different genotypes (AA, AG and GG) were detected in the progesterone receptor gene (PGR) promoter in a local Slovak crossbred rabbit line. We have noted a slightly majority frequency of allele A (0.53) over allele G (0.47). Comparing the observed and expected genotype frequencies with the χ<sup>2</sup> test the results were statistically significant, which means the tested rabbit population was non-equilibrium. The best results and significantly highest milk production (P < 0.001) were recorded in the does of GG genotype compared to AA genotype. Other association studies aimed at the effect of genotypes on litter size showed the highest litter size and number of weaned rabbits per litter in GG genotype. A significantly higher (P < 0.05) average number of stillborn kits per litter was in the group of does with AA genotype (0.62) compared with GG genotype (0.34).

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Genetic variation of progesterone receptor gene and its association with reproductive traits in pig

JOURNAL OF HUNAN AGRICULTURAL UNIVERSITY ◽

10.3724/sp.j.1238.2013.00058 ◽

2014 ◽

Vol 39 (1) ◽

pp. 58-62

Author(s):

Shan-wen ZHANG ◽

Bin CHEN

Keyword(s):

Genetic Variation ◽

Progesterone Receptor ◽

Receptor Gene ◽

Reproductive Traits ◽

Progesterone Receptor Gene

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Identification of Single-Nucleotide Polymorphism in the Progesterone Receptor Gene and Its Association With Reproductive Traits in Rabbits

Genetics ◽

10.1534/genetics.108.090779 ◽

2008 ◽

Vol 180 (3) ◽

pp. 1699-1705 ◽

Cited By ~ 17

Author(s):

R. Peiró ◽

M. Merchán ◽

M. A. Santacreu ◽

M. J. Argente ◽

M. L. García ◽

...

Keyword(s):

Single Nucleotide Polymorphism ◽

Progesterone Receptor ◽

Receptor Gene ◽

Reproductive Traits ◽

Nucleotide Polymorphism ◽

Single Nucleotide ◽

Progesterone Receptor Gene

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PROLACTIN RECEPTOR GENE (PRLR) ROLE IN SWINE REPRODUCTION

Trakia Journal of Sciences ◽

10.15547/tjs.2019.01.012 ◽

2019 ◽

Vol 17 (1) ◽

pp. 75-80

Author(s):

Zh. Sabev

Keyword(s):

Receptor Gene ◽

Prolactin Receptor ◽

Reproductive Traits ◽

Biological Functions ◽

Chromosome 16 ◽

Porcine Chromosome ◽

Genotype Frequencies ◽

Litter Traits ◽

Pcr Rflp ◽

Prolactin Receptor Gene

PRLR gene has been studied as a candidate gene for litter size in swine because of prolactin biological functions and their association with reproduction. Prolactin receptor gene is mapped on porcine chromosome 16. The established PCR-RFLP polymorphism at PRLR locus demonstrated the presence of two alleles, А and В and three genotypes АА, АВ and ВВ. There were found different allele and genotype frequencies in different pig populations with variation of the effects of PRLR genotypes on litter traits. Additional studies should be done in specific breeds and populations to evaluate the association of existing PRLR locus polymorphism with reproductive traits before application of marker-assisted selection in these populations.

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Progesterone Receptor Gene Polymorphism Promoter Region +331G/A Increases Risk of Endometriosis

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v4i1.73 ◽

2016 ◽

pp. 52-56

Author(s):

Syifa Alkaf ◽

Aerul Chakra ◽

Usman Said ◽

Irsan Saleh

Keyword(s):

Progesterone Receptor ◽

Gene Polymorphism ◽

Promoter Region ◽

Receptor Gene ◽

Case Group ◽

Progesterone Receptor Gene ◽

Pcr Rflp ◽

Increase Risk ◽

Study Population ◽

Control Study

Objective: To identify relationship between progesterone receptor gene polymorphism promoter region +331G/A with the risk of endometriosis. Method: An observational case-control study. Population are women with endometriosis and/or adenomyosis who have been performed laparotomy/laparoscopy at Obstetrics and Gynecology Department Dr. Mohammad Hoesin General Hospital Palembang, January-November 2013. Subjects fulfilled inclusion criteria, given informed consent and performed blood sampling continued by PCRRFLP. Results were divided into A/A genotype (homozygote mutant), G/A (heterozygote mutant), and G/G (homozygote wild type). Data were analyzed by SPSS 21.0 version. Result: PCR-RFLP results for+331G/A genotype were 26 (54.1%) in case group and 14 (26.4%) in control. +331A/A genotype was not found in both groups. There was significant increase risk of endometriosis in women carrying genotype +331G/A to those with genotype +331G/G with OR 3.29 (p

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Advances on progesterone receptor gene

Hereditas (Beijing) ◽

10.3724/sp.j.1005.2008.01536 ◽

2009 ◽

Vol 30 (12) ◽

pp. 1536-1544

Author(s):

Bao-Yun ZHANG

Keyword(s):

Progesterone Receptor ◽

Receptor Gene ◽

Progesterone Receptor Gene

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Progesterone receptor (PROGINS) polymorphism and the risk of endometrial cancer development

International Journal of Gynecological Cancer ◽

10.1111/j.1525-1438.2006.00767.x ◽

2007 ◽

Vol 17 (1) ◽

pp. 229-232 ◽

Cited By ~ 18

Author(s):

M. G. Junqueira ◽

I. D.C.G. Da Silva ◽

N. C. Nogueira-De-Souza ◽

C. V. Carvalho ◽

D. B. Leite ◽

...

Keyword(s):

Endometrial Cancer ◽

Progesterone Receptor ◽

Receptor Gene ◽

Population Based ◽

Cancer Development ◽

Control Group ◽

Cancer Group ◽

Increased Risk ◽

Progesterone Receptor Gene ◽

Risk Modifier

The progesterone receptor gene (PROGINS) has been identified as a risk modifier for benign and malignant gynecological diseases. The present case-control study is to evaluate the role of the PROGINS polymorphisms, as risk factor, for endometrial cancer development and to investigate the association between these genetics variants and clinical/pathologic variables of endometrial cancer. PROGINS polymorphism was examined in a total of 121 patients with endometrial cancer and 282 population-based control subjects, all located at the same area in São Paulo, SP, Brazil. The genotyping of PROGINS polymorphism was determined by polymerase chain reaction. The frequencies of PROGINS polymorphism T1/T1, T1/T2, and T2/T2 were 82.6%, 14.9%, and 2.5% in the endometrial cancer patients and 78.4%, 21.6%, and 0% in the controls, respectively. The χ2 test showed a higher incidence of the T2/T2 genotype in the endometrial cancer group subjects, these results were statistically different (P= 0.012). However, due to the fact that there were no women in the control group showing homozygosis for the allele T2, the correct evaluation of odds ratio could not be properly calculated. Regarding the clinical and pathologic findings observed within the group of patients with endometrial cancer, there was significant correlation between T1/T2 genotype and the presence of myoma (P= 0.048). No correlations were observed among the other variables. These data suggest that the PROGINS polymorphism T2/T2 genotype might be associated with an increased risk of endometrial cancer.

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