Aberrant posterior superior temporal sulcus functional connectivity and executive dysfunction in adolescents with internet gaming disorder

AbstractBackground and aimsThe clinical significance of Internet gaming disorder (IGD) is spreading worldwide, but its underlying neural mechanism still remains unclear. Moreover, the prevalence of IGD seems to be the highest in adolescents whose brains are in development. This study investigated the functional connectivity between large-scale intrinsic networks including default mode network, executive control network, and salience network. We hypothesized that adolescents with IGD would demonstrate different functional connectivity patterns among large-scale intrinsic networks, implying neurodevelopmental alterations, which might be associated with executive dysfunction.MethodsThis study included 17 male adolescents with Internet gaming disorder, and 18 age-matched male adolescents as healthy controls. Functional connectivity was examined using seed-to-voxel analysis and seed-to-seed analysis, with the nodes of large-scale intrinsic networks used as region of interests. Group independent component analysis was performed to investigate spatially independent network.ResultsWe identified aberrant functional connectivity of salience network and default mode network with the left posterior superior temporal sulcus (pSTS) in adolescents with IGD. Furthermore, functional connectivity between salience network and pSTS correlated with proneness to Internet addiction and self-reported cognitive problems. Independent component analysis revealed that pSTS was involved in social brain network.Discussion and conclusionsThe results imply that aberrant functional connectivity of social brain network with default mode network and salience network was identified in IGD that may be associated with executive dysfunction. Our results suggest that inordinate social stimuli during excessive online gaming leads to altered connections among large-scale networks during neurodevelopment of adolescents.

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The correlation between mood states and functional connectivity within the default mode network can differentiate Internet gaming disorder from healthy controls

Progress in Neuro-Psychopharmacology and Biological Psychiatry ◽

10.1016/j.pnpbp.2017.04.016 ◽

2017 ◽

Vol 77 ◽

pp. 185-193 ◽

Cited By ~ 10

Author(s):

Guangheng Dong ◽

Hui Li ◽

Lingxiao Wang ◽

Marc N. Potenza

Keyword(s):

Functional Connectivity ◽

Default Mode Network ◽

Internet Gaming Disorder ◽

Mood States ◽

Healthy Controls ◽

Gaming Disorder ◽

Default Mode ◽

Internet Gaming

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Altered functional connectivity in default mode network in Internet gaming disorder: Influence of childhood ADHD

Progress in Neuro-Psychopharmacology and Biological Psychiatry ◽

10.1016/j.pnpbp.2017.02.005 ◽

2017 ◽

Vol 75 ◽

pp. 135-141 ◽

Cited By ~ 10

Author(s):

Deokjong Lee ◽

Junghan Lee ◽

Jung Eun Lee ◽

Young-Chul Jung

Keyword(s):

Functional Connectivity ◽

Default Mode Network ◽

Internet Gaming Disorder ◽

Gaming Disorder ◽

Default Mode ◽

Childhood Adhd ◽

Internet Gaming

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Altered functional connectivity in default mode network in Internet gaming disorder with childhood ADHD

European Psychiatry ◽

10.1016/j.eurpsy.2017.02.314 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S346-S346

Author(s):

Y.C. Jung ◽

K. Namkoong

Keyword(s):

Functional Connectivity ◽

Executive Control ◽

Default Mode Network ◽

Internet Gaming Disorder ◽

Brain Regions ◽

Posterior Cingulate Cortex ◽

Gaming Disorder ◽

Default Mode ◽

Childhood Adhd ◽

Internet Gaming

ObjectiveInternet gaming disorder (IGD) is a type of behavioral addiction characterized by abnormal executive control, leading to loss of control over excessive gaming. Attention deficit and hyperactivity disorder (ADHD) is one of the most common comorbid disorders in IGD, involving delayed development of the executive control system, which could predispose individuals to gaming addiction. We investigated the influence of childhood ADHD on neural network features of IGD.MethodsResting-state functional magnetic resonance imaging analysis was performed on 44 young, male IGD subjects with and without childhood ADHD and 19 age-matched, healthy male controls. Posterior cingulate cortex (PCC)-seeded connectivity was evaluated to assess abnormalities in default mode network (DMN) connectivity, which is associated with deficits in executive control.ResultsIGD subjects without childhood ADHD showed expanded functional connectivity (FC) between DMN-related regions (PCC, medial prefrontal cortex, thalamus) compared with controls. These subjects also exhibited expanded FC between the PCC and brain regions implicated in salience processing (anterior insula, orbitofrontal cortex) compared with IGD subjects with childhood ADHD. IGD subjects with childhood ADHD showed expanded FC between the PCC and cerebellum (crus II), a region involved in executive control. The strength of connectivity between the PCC and cerebellum (crus II) was positively correlated with self-reporting scales reflecting impulsiveness.ConclusionIndividuals with IGD showed altered PCC-based FC, the characteristics of which might be dependent upon history of childhood ADHD. Our findings suggest that altered neural networks for executive control in ADHD would be a predisposition for developing IGD.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Internet gaming disorder impacts gray matter structural covariance organization in the default mode network

Journal of Affective Disorders ◽

10.1016/j.jad.2021.03.077 ◽

2021 ◽

Author(s):

Shuaiyu Chen ◽

Min Wang ◽

Haohao Dong ◽

Lingxiao Wang ◽

Yuchao Jiang ◽

...

Keyword(s):

Gray Matter ◽

Default Mode Network ◽

Internet Gaming Disorder ◽

Gaming Disorder ◽

Structural Covariance ◽

Default Mode ◽

Internet Gaming

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Frequency Specific Effects of ApoE ε4 Allele on Resting-State Networks in Nondemented Elders

BioMed Research International ◽

10.1155/2017/9823501 ◽

2017 ◽

Vol 2017 ◽

pp. 1-8 ◽

Cited By ~ 7

Author(s):

Ying Liang ◽

Zhenzhen Li ◽

Jing Wei ◽

Chunlin Li ◽

Xu Zhang ◽

...

Keyword(s):

Functional Connectivity ◽

Frequency Band ◽

Default Mode Network ◽

Resting State ◽

Brain Network ◽

Salience Network ◽

Default Mode ◽

Specific Effects ◽

Network Time ◽

Time Courses

We applied resting-state functional magnetic resonance imaging (fMRI) to examine the Apolipoprotein E (ApoE) ε4 allele effects on functional connectivity of the default mode network (DMN) and the salience network (SN). Considering the frequency specific effects of functional connectivity, we decomposed the brain network time courses into two bands: 0.01–0.027 Hz and 0.027–0.08 Hz. All scans were acquired by the Alzheimer’s Disease Neuroscience Initiative (ADNI). Thirty-two nondemented subjects were divided into two groups based on the presence (n=16) or absence (n=16) of the ApoE ε4 allele. We explored the frequency specific effects of ApoE ε4 allele on the default mode network (DMN) and the salience network (SN) functional connectivity. Compared to ε4 noncarriers, the DMN functional connectivity of ε4 carriers was significantly decreased while the SN functional connectivity of ε4 carriers was significantly increased. Many functional connectivities showed significant differences at the lower frequency band of 0.01–0.027 Hz or the higher frequency band of 0.027–0.08 Hz instead of the typical range of 0.01–0.08 Hz. The results indicated a frequency dependent effect of resting-state signals when investigating RSNs functional connectivity.

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Altered coupling of default-mode, executive-control and salience networks in Internet gaming disorder

European Psychiatry ◽

10.1016/j.eurpsy.2017.06.012 ◽

2017 ◽

Vol 45 ◽

pp. 114-120 ◽

Cited By ~ 10

Author(s):

J.T. Zhang ◽

S.-S. Ma ◽

C.-G. Yan ◽

S. Zhang ◽

L. Liu ◽

...

Keyword(s):

Network Model ◽

Executive Control ◽

Large Scale ◽

Right Hemisphere ◽

Critical Role ◽

Internet Gaming Disorder ◽

Gaming Disorder ◽

Neural Basis ◽

Default Mode ◽

Internet Gaming

AbstractBackground:Recently, a triple-network model suggested the abnormal interactions between the executive-control network (ECN), default-mode network (DMN) and salience network (SN) are important characteristics of addiction, in which the SN plays a critical role in allocating attentional resources toward the ECN and DMN. Although increasing studies have reported dysfunctions in these brain networks in Internet gaming disorder (IGD), interactions between these networks, particularly in the context of the triple-network model, have not been investigated in IGD. Thus, we aimed to assess alterations in the inter-network interactions of these large-scale networks in IGD, and to associate the alterations with IGD-related behaviors.Methods:DMN, ECN and SN were identified using group-level independent component analysis (gICA) in 39 individuals with IGD and 34 age and gender matched healthy controls (HCs). Then alterations in the SN-ECN and SN-DMN connectivity, as well as in the modulation of ECN versus DMN by SN, using a resource allocation index (RAI) developed and validated previously in nicotine addiction, were assessed. Further, associations between these altered network coupling and clinical assessments were also examined.Results:Compared with HCs, IGD had significantly increased SN-DMN connectivity and decreased RAI in right hemisphere (rRAI), and the rRAI in IGD was negatively associated with their scores of craving.Conclusions:These findings suggest that the deficient modulation of ECN versus DMN by SN might provide a mechanistic framework to better understand the neural basis of IGD and might provide novel evidence for the triple-network model in IGD.

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