Altered coupling of default-mode, executive-control and salience networks in Internet gaming disorder

2017 ◽  
Vol 45 ◽  
pp. 114-120 ◽  
Author(s):  
J.T. Zhang ◽  
S.-S. Ma ◽  
C.-G. Yan ◽  
S. Zhang ◽  
L. Liu ◽  
...  
Keyword(s):  
Network Model ◽  
Executive Control ◽  
Large Scale ◽  
Right Hemisphere ◽  
Critical Role ◽  
Internet Gaming Disorder ◽  
Gaming Disorder ◽  
Neural Basis ◽  
Default Mode ◽  
Internet Gaming

AbstractBackground:Recently, a triple-network model suggested the abnormal interactions between the executive-control network (ECN), default-mode network (DMN) and salience network (SN) are important characteristics of addiction, in which the SN plays a critical role in allocating attentional resources toward the ECN and DMN. Although increasing studies have reported dysfunctions in these brain networks in Internet gaming disorder (IGD), interactions between these networks, particularly in the context of the triple-network model, have not been investigated in IGD. Thus, we aimed to assess alterations in the inter-network interactions of these large-scale networks in IGD, and to associate the alterations with IGD-related behaviors.Methods:DMN, ECN and SN were identified using group-level independent component analysis (gICA) in 39 individuals with IGD and 34 age and gender matched healthy controls (HCs). Then alterations in the SN-ECN and SN-DMN connectivity, as well as in the modulation of ECN versus DMN by SN, using a resource allocation index (RAI) developed and validated previously in nicotine addiction, were assessed. Further, associations between these altered network coupling and clinical assessments were also examined.Results:Compared with HCs, IGD had significantly increased SN-DMN connectivity and decreased RAI in right hemisphere (rRAI), and the rRAI in IGD was negatively associated with their scores of craving.Conclusions:These findings suggest that the deficient modulation of ECN versus DMN by SN might provide a mechanistic framework to better understand the neural basis of IGD and might provide novel evidence for the triple-network model in IGD.

scholarly journals Aberrant posterior superior temporal sulcus functional connectivity and executive dysfunction in adolescents with internet gaming disorder

2020 ◽  
Vol 9 (3) ◽  
pp. 589-597
Author(s):  
Junghan Lee ◽  
Deokjong Lee ◽  
Kee Namkoong ◽  
Young-Chul Jung
Keyword(s):  
Functional Connectivity ◽  
Default Mode Network ◽  
Large Scale ◽  
Internet Gaming Disorder ◽  
Executive Dysfunction ◽  
Brain Network ◽  
Salience Network ◽  
Gaming Disorder ◽  
Default Mode ◽  
Internet Gaming

AbstractBackground and aimsThe clinical significance of Internet gaming disorder (IGD) is spreading worldwide, but its underlying neural mechanism still remains unclear. Moreover, the prevalence of IGD seems to be the highest in adolescents whose brains are in development. This study investigated the functional connectivity between large-scale intrinsic networks including default mode network, executive control network, and salience network. We hypothesized that adolescents with IGD would demonstrate different functional connectivity patterns among large-scale intrinsic networks, implying neurodevelopmental alterations, which might be associated with executive dysfunction.MethodsThis study included 17 male adolescents with Internet gaming disorder, and 18 age-matched male adolescents as healthy controls. Functional connectivity was examined using seed-to-voxel analysis and seed-to-seed analysis, with the nodes of large-scale intrinsic networks used as region of interests. Group independent component analysis was performed to investigate spatially independent network.ResultsWe identified aberrant functional connectivity of salience network and default mode network with the left posterior superior temporal sulcus (pSTS) in adolescents with IGD. Furthermore, functional connectivity between salience network and pSTS correlated with proneness to Internet addiction and self-reported cognitive problems. Independent component analysis revealed that pSTS was involved in social brain network.Discussion and conclusionsThe results imply that aberrant functional connectivity of social brain network with default mode network and salience network was identified in IGD that may be associated with executive dysfunction. Our results suggest that inordinate social stimuli during excessive online gaming leads to altered connections among large-scale networks during neurodevelopment of adolescents.

Altered functional connectivity in default mode network in Internet gaming disorder with childhood ADHD

2017 ◽  
Vol 41 (S1) ◽  
pp. S346-S346
Author(s):  
Y.C. Jung ◽  
K. Namkoong
Keyword(s):  
Functional Connectivity ◽  
Executive Control ◽  
Default Mode Network ◽  
Internet Gaming Disorder ◽  
Brain Regions ◽  
Posterior Cingulate Cortex ◽  
Gaming Disorder ◽  
Default Mode ◽  
Childhood Adhd ◽  
Internet Gaming

ObjectiveInternet gaming disorder (IGD) is a type of behavioral addiction characterized by abnormal executive control, leading to loss of control over excessive gaming. Attention deficit and hyperactivity disorder (ADHD) is one of the most common comorbid disorders in IGD, involving delayed development of the executive control system, which could predispose individuals to gaming addiction. We investigated the influence of childhood ADHD on neural network features of IGD.MethodsResting-state functional magnetic resonance imaging analysis was performed on 44 young, male IGD subjects with and without childhood ADHD and 19 age-matched, healthy male controls. Posterior cingulate cortex (PCC)-seeded connectivity was evaluated to assess abnormalities in default mode network (DMN) connectivity, which is associated with deficits in executive control.ResultsIGD subjects without childhood ADHD showed expanded functional connectivity (FC) between DMN-related regions (PCC, medial prefrontal cortex, thalamus) compared with controls. These subjects also exhibited expanded FC between the PCC and brain regions implicated in salience processing (anterior insula, orbitofrontal cortex) compared with IGD subjects with childhood ADHD. IGD subjects with childhood ADHD showed expanded FC between the PCC and cerebellum (crus II), a region involved in executive control. The strength of connectivity between the PCC and cerebellum (crus II) was positively correlated with self-reporting scales reflecting impulsiveness.ConclusionIndividuals with IGD showed altered PCC-based FC, the characteristics of which might be dependent upon history of childhood ADHD. Our findings suggest that altered neural networks for executive control in ADHD would be a predisposition for developing IGD.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals The Clinical Utility of the Chen Internet Addiction Scale—Gaming Version, for Internet Gaming Disorder in the DSM-5 among Young Adults

2019 ◽  
Vol 16 (21) ◽  
pp. 4141 ◽  
Author(s):  
Chih-Hung Ko ◽  
Sue-Huei Chen ◽  
Chih-Hung Wang ◽  
Wen-Xiang Tsai ◽  
Ju-Yu Yen
Keyword(s):  
Internet Addiction ◽  
Large Scale ◽  
Internet Gaming Disorder ◽  
Cutoff Point ◽  
Gaming Disorder ◽  
Diagnostic And Statistical Manual ◽  
Dsm 5 ◽  
Internet Gaming ◽  
Cutoff Points ◽  
Optimal Screening

Objectives: The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) includes the diagnostic criteria for Internet gaming disorder (IGD). This study evaluated (1) the screening, diagnostic, and prevalence-estimated cutoff points of the Chen Internet Addiction Scale–Gaming Version (CIAS-G) for IGD in the DSM-5; and (2) the differences in the CIAS-G and subscale scores among individuals with IGD, regular gamers (RGs), and other control subjects. Methods: We recruited 69 participants with IGD, 69 RGs, and 69 healthy participants based on diagnostic interviews conducted by a psychiatrist according to DSM-5 IGD criteria. All participants completed the CIAS-G and were assessed using the clinical global impression scale. Results: The optimal screening and diagnostic cutoff points were 68 or more (sensitivity, 97.1%; specificity, 76.8%) and 72 or more (sensitivity, 85.5%; specificity, 87.0%) for IGD based on DSM-5 criteria, respectively. The 76 or more cutoff point had the highest number needed to misdiagnose and was the optimal prevalence estimated cutoff point. Conclusions: The screening cutoff point could be used to identify individuals with IGD for further diagnostic interviewing to confirm the diagnosis in the clinical setting or for two-stage epidemiological evaluation. The diagnostic cutoff point provides a provisional diagnosis of IGD when diagnostic interviewing is unavailable. The prevalence-estimated cutoff point could be used to estimate the prevalence of IGD in large-scale epidemiological investigations when further diagnostic interviewing is impractical. The clinical and epidemiological utility of CIAS-G warrants further study.

scholarly journals Neurophysiological Mechanisms of Resilience as a Protective Factor in Patients with Internet Gaming Disorder: A Resting-State EEG Coherence Study

2019 ◽  
Vol 8 (1) ◽  
pp. 49 ◽  
Author(s):  
Ji-Yoon Lee ◽  
Jung-Seok Choi ◽  
Jun Soo Kwon
Keyword(s):  
Resting State ◽  
Indirect Effects ◽  
Protective Factor ◽  
Right Hemisphere ◽  
Internet Gaming Disorder ◽  
Eeg Coherence ◽  
Gaming Disorder ◽  
Internet Gaming ◽  
The Right ◽  
Eeg Features

Background: Resilience, an important protective factor against Internet gaming disorder (IGD), is the ability to recover from negative emotional experiences and constitutes a flexible adaptation to stress. Despite the importance of resilience in predicting IGD, little is known about the relationships between resilience and the neurophysiological features of IGD patients. Methods: We investigated these relationships using resting-state electroencephalography (EEG) coherence, by comparing IGD patients (n = 35) to healthy controls (n = 36). To identify the resilience-related EEG features, the IGD patients were divided into two groups based on the 50th percentile score on the Connor–Davidson Resilience Scale: IGD with low resilience (n = 16) and IGD with high resilience (n = 19). We analyzed differences in EEG coherence among groups for each fast frequency band. The conditional indirect effects of resilience were examined on the relationships between IGD and resilience-related EEG features through clinical symptoms. Results: IGD patients with low resilience had higher alpha coherence in the right hemisphere. Particularly, resilience moderated the indirect effects of IGD on alpha coherence in the right hemisphere through depressive symptoms and stress level. Conclusion: These neurophysiological findings regarding the mechanisms underlying resilience may help to establish effective preventive measures against IGD.

Group independent component analysis reveals alternation of right executive control network in Internet gaming disorder

CNS Spectrums ◽  
2017 ◽  
Vol 23 (5) ◽  
pp. 300-310 ◽  
Author(s):  
Lingxiao Wang ◽  
Yifen Zhang ◽  
Xiao Lin ◽  
Hongli Zhou ◽  
Xiaoxia Du ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Independent Component Analysis ◽  
Executive Control ◽  
Internet Gaming Disorder ◽  
Control Network ◽  
Gaming Disorder ◽  
Executive Control Network ◽  
Internet Gaming ◽  
The Right ◽  
Group Independent Component Analysis

ObjectivePrevious studies have demonstrated that individuals with Internet gaming disorder (IGD) showed attentional bias toward gaming-related cues and exhibited impaired executive functions. The purpose of this study was to explore the alternations in related functional brain networks underlying attentional bias in IGD subjects.MethodsEighteen IGD subjects and 19 healthy controls (HC) were scanned with functional magnetic resonance imaging while they were performing an addiction Stroop task. Networks of functional connectivity were identified using group independent component analysis (ICA).ResultsICA identified 4 functional networks that showed differences between the 2 groups, which were related to the right executive control network and visual related networks in our study. Within the right executive control network, in contrast to controls, IGD subjects showed increased functional connectivity in the temporal gyrus and frontal gyrus, and reduced functional connectivity in the posterior cingulate cortex, temporal gyrus, and frontal gyrus.ConclusionThese findings suggest that IGD is related to abnormal functional connectivity of the right executive control network, and may be described as addiction-related abnormally increased cognitive control processing and diminished response inhibition during an addiction Stroop task. The results suggest that IGD subjects show increased susceptibility towards gaming-related cues but weakened strength of inhibitory control.

scholarly journals Disrupted dynamic network reconfiguration of the executive and reward networks in internet gaming disorder: Why IGD subjects cannot control their gaming cravings

2021 ◽  
Author(s):  
Min Wang ◽  
Hui Zheng ◽  
Weiran Zhou ◽  
Bo Yang ◽  
Lingxiao Wang ◽  
...  
Keyword(s):  
Executive Control ◽  
Internet Gaming Disorder ◽  
Dynamic Network ◽  
Control Network ◽  
Gaming Disorder ◽  
Mediation Effects ◽  
Executive Control Network ◽  
Internet Gaming ◽  
The Right ◽  
Male Subjects

AbstractBackgroundStudies have shown that people with internet gaming disorder (IGD) show impaired executive control over their gaming cravings; however, the neural mechanisms underlying this process remain unknown. In addition, these conclusions were based on the hypothesis that brain networks were temporally stationary and neglected changes in cognitive processes.MethodsResting-state fMRI data were collected from 402 subjects (162 subjects with IGD and 240 recreational game users (RGUs)). The community structure (recruitment and integration) of the executive control network and the basal ganglia network (BGN, representing the reward network) of patients with IGD and healthy controls were analyzed and compared. Mediation effects were analyzed among the different networks.ResultsWhen compared to RGUs, subjects with IGD had a lower recruitment coefficient within the right executive control network (ECN). Further analysis showed that only male subjects had a lower recruitment coefficient. Mediation analysis showed that the integration coefficient of the right ECN mediated the relationship between the recruitment coefficients of both the right ECN and the BGN in RGUs.ConclusionsSubjects with IGD had a lower recruitment coefficient than RGUs, and this feature was only observed in male subjects, making them less efficient at impulse control. The meditation results suggest a top-down control mechanism of the ECN is missing in subjects with IGD. All of these findings could explain why subjects with IGD have impaired executive control over their gaming cravings.

Sign in / Sign up

Export Citation Format

Share Document