Internet gaming disorder impacts gray matter structural covariance organization in the default mode network

2021 ◽  
Author(s):  
Shuaiyu Chen ◽  
Min Wang ◽  
Haohao Dong ◽  
Lingxiao Wang ◽  
Yuchao Jiang ◽  
...  
Keyword(s):  
Gray Matter ◽  
Default Mode Network ◽  
Internet Gaming Disorder ◽  
Gaming Disorder ◽  
Structural Covariance ◽  
Default Mode ◽  
Internet Gaming

scholarly journals Aberrant posterior superior temporal sulcus functional connectivity and executive dysfunction in adolescents with internet gaming disorder

2020 ◽  
Vol 9 (3) ◽  
pp. 589-597
Author(s):  
Junghan Lee ◽  
Deokjong Lee ◽  
Kee Namkoong ◽  
Young-Chul Jung
Keyword(s):  
Functional Connectivity ◽  
Default Mode Network ◽  
Large Scale ◽  
Internet Gaming Disorder ◽  
Executive Dysfunction ◽  
Brain Network ◽  
Salience Network ◽  
Gaming Disorder ◽  
Default Mode ◽  
Internet Gaming

AbstractBackground and aimsThe clinical significance of Internet gaming disorder (IGD) is spreading worldwide, but its underlying neural mechanism still remains unclear. Moreover, the prevalence of IGD seems to be the highest in adolescents whose brains are in development. This study investigated the functional connectivity between large-scale intrinsic networks including default mode network, executive control network, and salience network. We hypothesized that adolescents with IGD would demonstrate different functional connectivity patterns among large-scale intrinsic networks, implying neurodevelopmental alterations, which might be associated with executive dysfunction.MethodsThis study included 17 male adolescents with Internet gaming disorder, and 18 age-matched male adolescents as healthy controls. Functional connectivity was examined using seed-to-voxel analysis and seed-to-seed analysis, with the nodes of large-scale intrinsic networks used as region of interests. Group independent component analysis was performed to investigate spatially independent network.ResultsWe identified aberrant functional connectivity of salience network and default mode network with the left posterior superior temporal sulcus (pSTS) in adolescents with IGD. Furthermore, functional connectivity between salience network and pSTS correlated with proneness to Internet addiction and self-reported cognitive problems. Independent component analysis revealed that pSTS was involved in social brain network.Discussion and conclusionsThe results imply that aberrant functional connectivity of social brain network with default mode network and salience network was identified in IGD that may be associated with executive dysfunction. Our results suggest that inordinate social stimuli during excessive online gaming leads to altered connections among large-scale networks during neurodevelopment of adolescents.

Altered functional connectivity in default mode network in Internet gaming disorder with childhood ADHD

2017 ◽  
Vol 41 (S1) ◽  
pp. S346-S346
Author(s):  
Y.C. Jung ◽  
K. Namkoong
Keyword(s):  
Functional Connectivity ◽  
Executive Control ◽  
Default Mode Network ◽  
Internet Gaming Disorder ◽  
Brain Regions ◽  
Posterior Cingulate Cortex ◽  
Gaming Disorder ◽  
Default Mode ◽  
Childhood Adhd ◽  
Internet Gaming

ObjectiveInternet gaming disorder (IGD) is a type of behavioral addiction characterized by abnormal executive control, leading to loss of control over excessive gaming. Attention deficit and hyperactivity disorder (ADHD) is one of the most common comorbid disorders in IGD, involving delayed development of the executive control system, which could predispose individuals to gaming addiction. We investigated the influence of childhood ADHD on neural network features of IGD.MethodsResting-state functional magnetic resonance imaging analysis was performed on 44 young, male IGD subjects with and without childhood ADHD and 19 age-matched, healthy male controls. Posterior cingulate cortex (PCC)-seeded connectivity was evaluated to assess abnormalities in default mode network (DMN) connectivity, which is associated with deficits in executive control.ResultsIGD subjects without childhood ADHD showed expanded functional connectivity (FC) between DMN-related regions (PCC, medial prefrontal cortex, thalamus) compared with controls. These subjects also exhibited expanded FC between the PCC and brain regions implicated in salience processing (anterior insula, orbitofrontal cortex) compared with IGD subjects with childhood ADHD. IGD subjects with childhood ADHD showed expanded FC between the PCC and cerebellum (crus II), a region involved in executive control. The strength of connectivity between the PCC and cerebellum (crus II) was positively correlated with self-reporting scales reflecting impulsiveness.ConclusionIndividuals with IGD showed altered PCC-based FC, the characteristics of which might be dependent upon history of childhood ADHD. Our findings suggest that altered neural networks for executive control in ADHD would be a predisposition for developing IGD.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Orbitofrontal gray matter deficits as marker of Internet gaming disorder: converging evidence from a cross-sectional and prospective longitudinal design

2017 ◽  
Vol 24 (1) ◽  
pp. 100-109 ◽  
Author(s):  
Feng Zhou ◽  
Christian Montag ◽  
Rayna Sariyska ◽  
Bernd Lachmann ◽  
Martin Reuter ◽  
...  
Keyword(s):  
Gray Matter ◽  
Longitudinal Design ◽  
Internet Gaming Disorder ◽  
Gaming Disorder ◽  
Cross Sectional ◽  
Internet Gaming ◽  
Prospective Longitudinal

scholarly journals The alteration of gray matter volume and cognitive control in adolescents with internet gaming disorder

2015 ◽  
Vol 9 ◽  
Author(s):  
Hongmei Wang ◽  
Chenwang Jin ◽  
Kai Yuan ◽  
Tahir Mehmood Shakir ◽  
Cuiping Mao ◽  
...  
Keyword(s):  
Cognitive Control ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Internet Gaming Disorder ◽  
Gaming Disorder ◽  
Matter Volume ◽  
Internet Gaming

Abnormal gray matter volume and impulsivity in young adults with Internet gaming disorder

2017 ◽  
Vol 23 (5) ◽  
pp. 1160-1167 ◽  
Author(s):  
Deokjong Lee ◽  
Kee Namkoong ◽  
Junghan Lee ◽  
Young-Chul Jung
Keyword(s):  
Young Adults ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Internet Gaming Disorder ◽  
Gaming Disorder ◽  
Matter Volume ◽  
Internet Gaming

Altered coupling of default-mode, executive-control and salience networks in Internet gaming disorder

2017 ◽  
Vol 45 ◽  
pp. 114-120 ◽  
Author(s):  
J.T. Zhang ◽  
S.-S. Ma ◽  
C.-G. Yan ◽  
S. Zhang ◽  
L. Liu ◽  
...  
Keyword(s):  
Network Model ◽  
Executive Control ◽  
Large Scale ◽  
Right Hemisphere ◽  
Critical Role ◽  
Internet Gaming Disorder ◽  
Gaming Disorder ◽  
Neural Basis ◽  
Default Mode ◽  
Internet Gaming

AbstractBackground:Recently, a triple-network model suggested the abnormal interactions between the executive-control network (ECN), default-mode network (DMN) and salience network (SN) are important characteristics of addiction, in which the SN plays a critical role in allocating attentional resources toward the ECN and DMN. Although increasing studies have reported dysfunctions in these brain networks in Internet gaming disorder (IGD), interactions between these networks, particularly in the context of the triple-network model, have not been investigated in IGD. Thus, we aimed to assess alterations in the inter-network interactions of these large-scale networks in IGD, and to associate the alterations with IGD-related behaviors.Methods:DMN, ECN and SN were identified using group-level independent component analysis (gICA) in 39 individuals with IGD and 34 age and gender matched healthy controls (HCs). Then alterations in the SN-ECN and SN-DMN connectivity, as well as in the modulation of ECN versus DMN by SN, using a resource allocation index (RAI) developed and validated previously in nicotine addiction, were assessed. Further, associations between these altered network coupling and clinical assessments were also examined.Results:Compared with HCs, IGD had significantly increased SN-DMN connectivity and decreased RAI in right hemisphere (rRAI), and the rRAI in IGD was negatively associated with their scores of craving.Conclusions:These findings suggest that the deficient modulation of ECN versus DMN by SN might provide a mechanistic framework to better understand the neural basis of IGD and might provide novel evidence for the triple-network model in IGD.

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