Altered functional connectivity in default mode network in Internet gaming disorder with childhood ADHD

2017 ◽  
Vol 41 (S1) ◽  
pp. S346-S346
Author(s):  
Y.C. Jung ◽  
K. Namkoong
Keyword(s):  
Functional Connectivity ◽  
Executive Control ◽  
Default Mode Network ◽  
Internet Gaming Disorder ◽  
Brain Regions ◽  
Posterior Cingulate Cortex ◽  
Gaming Disorder ◽  
Default Mode ◽  
Childhood Adhd ◽  
Internet Gaming

ObjectiveInternet gaming disorder (IGD) is a type of behavioral addiction characterized by abnormal executive control, leading to loss of control over excessive gaming. Attention deficit and hyperactivity disorder (ADHD) is one of the most common comorbid disorders in IGD, involving delayed development of the executive control system, which could predispose individuals to gaming addiction. We investigated the influence of childhood ADHD on neural network features of IGD.MethodsResting-state functional magnetic resonance imaging analysis was performed on 44 young, male IGD subjects with and without childhood ADHD and 19 age-matched, healthy male controls. Posterior cingulate cortex (PCC)-seeded connectivity was evaluated to assess abnormalities in default mode network (DMN) connectivity, which is associated with deficits in executive control.ResultsIGD subjects without childhood ADHD showed expanded functional connectivity (FC) between DMN-related regions (PCC, medial prefrontal cortex, thalamus) compared with controls. These subjects also exhibited expanded FC between the PCC and brain regions implicated in salience processing (anterior insula, orbitofrontal cortex) compared with IGD subjects with childhood ADHD. IGD subjects with childhood ADHD showed expanded FC between the PCC and cerebellum (crus II), a region involved in executive control. The strength of connectivity between the PCC and cerebellum (crus II) was positively correlated with self-reporting scales reflecting impulsiveness.ConclusionIndividuals with IGD showed altered PCC-based FC, the characteristics of which might be dependent upon history of childhood ADHD. Our findings suggest that altered neural networks for executive control in ADHD would be a predisposition for developing IGD.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Aberrant posterior superior temporal sulcus functional connectivity and executive dysfunction in adolescents with internet gaming disorder

2020 ◽  
Vol 9 (3) ◽  
pp. 589-597
Author(s):  
Junghan Lee ◽  
Deokjong Lee ◽  
Kee Namkoong ◽  
Young-Chul Jung
Keyword(s):  
Functional Connectivity ◽  
Default Mode Network ◽  
Large Scale ◽  
Internet Gaming Disorder ◽  
Executive Dysfunction ◽  
Brain Network ◽  
Salience Network ◽  
Gaming Disorder ◽  
Default Mode ◽  
Internet Gaming

AbstractBackground and aimsThe clinical significance of Internet gaming disorder (IGD) is spreading worldwide, but its underlying neural mechanism still remains unclear. Moreover, the prevalence of IGD seems to be the highest in adolescents whose brains are in development. This study investigated the functional connectivity between large-scale intrinsic networks including default mode network, executive control network, and salience network. We hypothesized that adolescents with IGD would demonstrate different functional connectivity patterns among large-scale intrinsic networks, implying neurodevelopmental alterations, which might be associated with executive dysfunction.MethodsThis study included 17 male adolescents with Internet gaming disorder, and 18 age-matched male adolescents as healthy controls. Functional connectivity was examined using seed-to-voxel analysis and seed-to-seed analysis, with the nodes of large-scale intrinsic networks used as region of interests. Group independent component analysis was performed to investigate spatially independent network.ResultsWe identified aberrant functional connectivity of salience network and default mode network with the left posterior superior temporal sulcus (pSTS) in adolescents with IGD. Furthermore, functional connectivity between salience network and pSTS correlated with proneness to Internet addiction and self-reported cognitive problems. Independent component analysis revealed that pSTS was involved in social brain network.Discussion and conclusionsThe results imply that aberrant functional connectivity of social brain network with default mode network and salience network was identified in IGD that may be associated with executive dysfunction. Our results suggest that inordinate social stimuli during excessive online gaming leads to altered connections among large-scale networks during neurodevelopment of adolescents.

scholarly journals Maladaptive Self-Focused Attention and Default Mode Network Connectivity: A Transdiagnostic Investigation Across Social Anxiety and Body Dysmorphic Disorders

2021 ◽  
Author(s):  
Angela Fang ◽  
Bengi Baran ◽  
Clare C Beatty ◽  
Jennifer Mosley ◽  
Jamie D Feusner ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Social Anxiety ◽  
Default Mode Network ◽  
Brain Regions ◽  
Posterior Cingulate Cortex ◽  
Focused Attention ◽  
Neural Basis ◽  
Default Mode ◽  
Body Dysmorphic Disorders ◽  
Primary Body

Abstract Maladaptive self-focused attention (SFA) is a bias toward internal thoughts, feelings, and physical states. Despite its role as a core maintaining factor of symptoms in cognitive theories of social anxiety and body dysmorphic disorders, studies have not examined its neural basis. In this study, we hypothesized that maladaptive SFA would be associated with hyperconnectivity in the default mode network (DMN) in self-focused patients with these disorders. Thirty patients with primary social anxiety disorder or primary body dysmorphic disorder, and 28 healthy individuals were eligible and scanned. Eligibility was determined by scoring greater than 1SD or below 1SD of the Public Self-Consciousness Scale normative mean, respectively, for each group. Seed-to-voxel functional connectivity was computed using a DMN posterior cingulate cortex (PCC) seed. There was no evidence of increased DMN functional connectivity in patients compared to controls. Patients (regardless of diagnosis) showed reduced functional connectivity of the PCC with several brain regions, including the bilateral superior parietal lobule (SPL), compared to controls, which was inversely correlated with maladaptive SFA but not associated with social anxiety, body dysmorphic, or depression severity, or rumination. Abnormal PCC-SPL connectivity may represent a transdiagnostic neural marker of SFA that reflects difficulty shifting between internal versus external attention.

Group independent component analysis reveals alternation of right executive control network in Internet gaming disorder

CNS Spectrums ◽  
2017 ◽  
Vol 23 (5) ◽  
pp. 300-310 ◽  
Author(s):  
Lingxiao Wang ◽  
Yifen Zhang ◽  
Xiao Lin ◽  
Hongli Zhou ◽  
Xiaoxia Du ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Independent Component Analysis ◽  
Executive Control ◽  
Internet Gaming Disorder ◽  
Control Network ◽  
Gaming Disorder ◽  
Executive Control Network ◽  
Internet Gaming ◽  
The Right ◽  
Group Independent Component Analysis

ObjectivePrevious studies have demonstrated that individuals with Internet gaming disorder (IGD) showed attentional bias toward gaming-related cues and exhibited impaired executive functions. The purpose of this study was to explore the alternations in related functional brain networks underlying attentional bias in IGD subjects.MethodsEighteen IGD subjects and 19 healthy controls (HC) were scanned with functional magnetic resonance imaging while they were performing an addiction Stroop task. Networks of functional connectivity were identified using group independent component analysis (ICA).ResultsICA identified 4 functional networks that showed differences between the 2 groups, which were related to the right executive control network and visual related networks in our study. Within the right executive control network, in contrast to controls, IGD subjects showed increased functional connectivity in the temporal gyrus and frontal gyrus, and reduced functional connectivity in the posterior cingulate cortex, temporal gyrus, and frontal gyrus.ConclusionThese findings suggest that IGD is related to abnormal functional connectivity of the right executive control network, and may be described as addiction-related abnormally increased cognitive control processing and diminished response inhibition during an addiction Stroop task. The results suggest that IGD subjects show increased susceptibility towards gaming-related cues but weakened strength of inhibitory control.

Altered coupling of default-mode, executive-control and salience networks in Internet gaming disorder

2017 ◽  
Vol 45 ◽  
pp. 114-120 ◽  
Author(s):  
J.T. Zhang ◽  
S.-S. Ma ◽  
C.-G. Yan ◽  
S. Zhang ◽  
L. Liu ◽  
...  
Keyword(s):  
Network Model ◽  
Executive Control ◽  
Large Scale ◽  
Right Hemisphere ◽  
Critical Role ◽  
Internet Gaming Disorder ◽  
Gaming Disorder ◽  
Neural Basis ◽  
Default Mode ◽  
Internet Gaming

AbstractBackground:Recently, a triple-network model suggested the abnormal interactions between the executive-control network (ECN), default-mode network (DMN) and salience network (SN) are important characteristics of addiction, in which the SN plays a critical role in allocating attentional resources toward the ECN and DMN. Although increasing studies have reported dysfunctions in these brain networks in Internet gaming disorder (IGD), interactions between these networks, particularly in the context of the triple-network model, have not been investigated in IGD. Thus, we aimed to assess alterations in the inter-network interactions of these large-scale networks in IGD, and to associate the alterations with IGD-related behaviors.Methods:DMN, ECN and SN were identified using group-level independent component analysis (gICA) in 39 individuals with IGD and 34 age and gender matched healthy controls (HCs). Then alterations in the SN-ECN and SN-DMN connectivity, as well as in the modulation of ECN versus DMN by SN, using a resource allocation index (RAI) developed and validated previously in nicotine addiction, were assessed. Further, associations between these altered network coupling and clinical assessments were also examined.Results:Compared with HCs, IGD had significantly increased SN-DMN connectivity and decreased RAI in right hemisphere (rRAI), and the rRAI in IGD was negatively associated with their scores of craving.Conclusions:These findings suggest that the deficient modulation of ECN versus DMN by SN might provide a mechanistic framework to better understand the neural basis of IGD and might provide novel evidence for the triple-network model in IGD.

scholarly journals Relationship between Resting-State Alpha Coherence and Cognitive Control in Individuals with Internet Gaming Disorder: A Multimodal Approach Based on Resting-State Electroencephalography and Event-Related Potentials

2021 ◽  
Vol 11 (12) ◽  
pp. 1635
Author(s):  
Minkyung Park ◽  
So Young Yoo ◽  
Ji-Yoon Lee ◽  
Ja Wook Koo ◽  
Ung Gu Kang ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Internet Gaming Disorder ◽  
Event Related Potentials ◽  
Brain Regions ◽  
Event Related Potential ◽  
Gaming Disorder ◽  
Addictive Disorders ◽  
Internet Gaming ◽  
Related Potentials

The human brain is constantly active, even at rest. Alpha coherence is an electroencephalography (EEG) rhythm that regulates functional connectivity between different brain regions. However, the relationships between resting-state alpha coherence and N2/P3 components associated with response inhibition and cognitive processes have not been investigated in addictive disorders. The present study investigated the relationships between alpha coherence during the resting state and N2/P3 components of event-related potentials during the Go/Nogo task in healthy controls (HCs) and patients with Internet gaming disorder (IGD). A total of 64 young adults (HC: n = 31; IGD: n = 33) participated in this study. Alpha coherence values at left fronto-central and bilateral centro-temporal electrode sites were significantly correlated with P3 latency in HCs, whereas inverse correlations were observed in patients with IGD. Furthermore, significant differences were observed in the correlation values between the groups. Our results suggest that patients with IGD lack dynamic interactions of functional connectivity between the fronto-centro-temporal regions during the resting state and the event-related potential (ERP) index during cognitive tasks. The findings of this study may have important implications for understanding the neurophysiological mechanisms linking resting-state EEG and task-related ERPs underlying IGD.

scholarly journals Dysfunctional default mode network and executive control network in people with Internet gaming disorder: Independent component analysis under a probability discounting task

2016 ◽  
Vol 34 ◽  
pp. 36-42 ◽  
Author(s):  
L Wang ◽  
L Wu ◽  
X Lin ◽  
Y Zhang ◽  
H Zhou ◽  
...  
Keyword(s):  
Reaction Time ◽  
Independent Component Analysis ◽  
Executive Control ◽  
Default Mode Network ◽  
Internet Gaming Disorder ◽  
Probability Discounting ◽  
Control Network ◽  
Gaming Disorder ◽  
Executive Control Network ◽  
Internet Gaming

AbstractBackgroundThe present study identified the neural mechanism of risky decision-making in Internet gaming disorder (IGD) under a probability discounting task.MethodsIndependent component analysis was used on the functional magnetic resonance imaging data from 19 IGD subjects (22.2 ± 3.08 years) and 21 healthy controls (HC, 22.8 ± 3.5 years).ResultsFor the behavioral results, IGD subjects prefer the risky to the fixed options and showed shorter reaction time compared to HC. For the imaging results, the IGD subjects showed higher task-related activity in default mode network (DMN) and less engagement in the executive control network (ECN) than HC when making the risky decisions. Also, we found the activities of DMN correlate negatively with the reaction time and the ECN correlate positively with the probability discounting rates.ConclusionsThe results suggest that people with IGD show altered modulation in DMN and deficit in executive control function, which might be the reason for why the IGD subjects continue to play online games despite the potential negative consequences.

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