scholarly journals Ketamine-assisted psychotherapy for trauma-exposed patients in an outpatient setting: A clinical chart review study

2021 ◽  
Author(s):  
Alan K. Davis ◽  
Pratheek Mangini ◽  
Yitong Xin
Keyword(s):  
Chart Review ◽  
Trauma Exposure ◽  
The United States ◽  
Outpatient Setting ◽  
Medium Effect ◽  
Ptsd Symptoms ◽  
Medium Effect Size ◽  
Clinical Records ◽  
Symptom Measures ◽  
Clinical Chart

Abstract Trauma exposure across the lifespan produces risks for posttraumatic stress disorder (PTSD), depression, anxiety, as well as global disability in functioning. This retrospective clinical chart review is the first of its kind to assess the utility of sublingual ketamine-assisted body-centered psychotherapy in trauma-exposed patients in a real world clinic setting. De-identified clinical records data on self-reported symptom measures were retrospectively analyzed for patients (N = 18; M age = 45.22, SD = 12.90) entering ketamine-assisted psychotherapy treatment in an outpatient clinic between 2018 and 2020. Patients who completed six sessions of ketamine therapy reported meaningful (e.g., medium effect size) improvements in PTSD symptoms (P = 0.058; d = −0.48) and global disability in functioning (P = 0.050; d = −0.52) and statistically significant and meaningful improvements in depression (P = 0.019; d = −0.53). There were no improvements in anxiety symptoms. Sublingual ketamine-assisted psychotherapy was associated with heterogenous clinical utility among patients with trauma-exposure in an outpatient setting. This study was underpowered and unrepresentative of the population of ketamine patients in the United States. Replication of these findings is needed with larger and more diverse patient samples.

scholarly journals The new normal of web camera theft on campus during COVID-19 and the impact of anti-theft signage

Crime Science ◽  
2021 ◽  
Vol 10 (1) ◽  
Author(s):  
William A. Chernoff
Keyword(s):  
The United States ◽  
Public University ◽  
Medium Effect ◽  
Institutions Of Higher Education ◽  
Socially Responsible ◽  
Exact Test ◽  
Web Camera ◽  
Medium Effect Size ◽  
The Impact ◽  
To Receive

Abstract Objective The opportunity for web camera theft increased globally as institutions of higher education transitioned to remote learning during COVID-19. Given the thousands of cameras currently installed in classrooms, many with little protection, the present study tests the effectiveness of anti-theft signage for preventing camera theft. Methods Examined web camera theft at a southern, public university located in the United States of America by randomly assigning N = 104 classrooms to receive either anti-theft signage or no signage. Camera theft was analyzed using Blaker’s exact test. Results Classrooms not receiving anti-theft signage (control) were 3.42 times more likely to exhibit web camera theft than classrooms receiving anti-theft signage (medium effect size). Conclusions Using classrooms as the unit of analysis presents new opportunities for not only future crime prevention experiments, but also improving campus safety and security. Also, preventing web camera theft on campus is both fiscally and socially responsible, saving money and ensuring inclusivity for remote learners.

scholarly journals The Age-Related Performance Decline in Marathon Running: The Paradigm of the Berlin Marathon

2019 ◽  
Vol 16 (11) ◽  
pp. 2022 ◽  
Author(s):  
Pantelis T. Nikolaidis ◽  
José Ramón Alvero-Cruz ◽  
Elias Villiger ◽  
Thomas Rosemann ◽  
Beat Knechtle
Keyword(s):  
Effect Size ◽  
Age Groups ◽  
The United States ◽  
Medium Effect ◽  
Peak Performance ◽  
Marathon Running ◽  
Marathon Race ◽  
Age Related ◽  
Medium Effect Size ◽  
Performance Decline

The variation of marathon race time by age group has been used recently to model the decline of endurance with aging; however, paradigms of races (i.e., marathon running) examined so far have mostly been from the United States. Therefore, the aim of the present study was to examine the age of peak performance (APP) in a European race, the “Berlin Marathon”. Race times of 387,222 finishers (women, n = 93,022; men, n = 294,200) in this marathon race from 2008 to 2018 were examined. Men were faster by +1.10 km.h−1 (10.74 ± 1.84 km.h−1 versus 9.64 ± 1.46 km.h−1, p <0.001, η2 = 0.065, medium effect size) and older by +2.1 years (43.1 ± 10.0 years versus 41.0 ± 9.8 years, p < 0.001, η2 = 0.008, trivial effect size) than women. APP was 32 years in women and 34 years in men using 1-year age groups, and 30–34 years in women and 35–39 years in men using 5-year age groups. Women’s and men’s performance at 60–64 and 55–59 age groups, respectively, corresponded to ~90% of the running speed at APP. Based on these findings, it was concluded that although APP occurred earlier in women than men, the observed age-related differences indicated that the decline of endurance with aging might differ by sex.

Co-occurrence of PTSD and cardiovascular disease among ethnic/racial groups in the United States

2016 ◽  
Vol 33 (S1) ◽  
pp. S92-S92
Author(s):  
C. Vidal Mariño ◽  
R. Polo del Rio ◽  
M. Alegría ◽  
Y. Wang ◽  
R. Carmona
Keyword(s):  
Mental Health ◽  
Cardiovascular Disease ◽  
Traumatic Event ◽  
Trauma Exposure ◽  
The United States ◽  
Racial Groups ◽  
Ptsd Symptoms ◽  
Increased Risk ◽  
Competing Interest ◽  
Exposure To Trauma

IntroductionSome inconsistent evidence indicates experiences of trauma and the presence of symptoms of PTSD are associated with increased risk of cardiovascular diseases. This relation has rarely been explored with community samples including participants with PTSD symptoms or who fulfill criteria for PTSD disorders.ObjectivesWe identify those with a high number of PTSD symptoms and those fulfilling criteria for PTSD are more likely to have CVD than those without a PTSD syndrome or diagnosis. We examine rates of mental health access for those with PTSD and CVD.MethodsWe use Collaborative Psychiatric Epidemiology Surveys (CPES) to examine differences in trauma/PTSD prevalence and the association of prior trauma exposure and PTSD diagnoses with CVD (n = 13,286). CIDI was used to make psychiatric diagnoses and medical data was acquired regarding onset and severity of CVD.ResultsIndividuals with prior exposure to trauma and PTSD diagnoses had twice the likelihood of developing a cardiovascular disease as those without trauma exposure [OR = 1.77, 95% CI (1.0, 2.94)]. Having a PTSD diagnosis is a significant predictor of having a CVD for individuals who experienced a traumatic event.The probability of developing a CVD was higher when patients had prior diagnosis of substance abuse [OR = 1.36, 95% CI (1.11, 1.65)] or mental health disorders [OR = 1.43, 95% CI (1.10, 1.87) for depression; OR = 1.33, 95% CI (1.04, 1.69) for anxiety]. Men were almost twice as likely as women to be diagnosed with a CVD [OR = 1.67, 95% CI (1.37, 2.00)].ConclusionsExposure to trauma and the presence of PTSD symptoms are significantly associated with CVD.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Trauma exposure and PTSD symptoms among heavy-drinking college students

2008 ◽  
Author(s):  
Christopher J. Monahan ◽  
Meghan E. McDevitt-Murphy ◽  
James G. Murphy ◽  
Matthew P. Martens ◽  
Katherine L. Bracken ◽  
...  
Keyword(s):  
College Students ◽  
Trauma Exposure ◽  
Heavy Drinking ◽  
Ptsd Symptoms

SARS-CoV-2 and The Case for Empirical Treatment (Preprint)

2020 ◽  
Author(s):  
Richard P Bartlett ◽  
Alexandria Watkins
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
The United States ◽  
Type Ii Diabetes Mellitus ◽  
Outpatient Setting ◽  
Empirical Treatment ◽  
Residual Effects ◽  
Type Ii ◽  
West Texas

UNSTRUCTURED Background: This is an outpatient case study that examines two patients in the United States with unique cases that involve oncology, hypertension, Type II Diabetes Mellitus, and Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), also known as COVID-19. This case study involves two patients in the outpatient setting - treated via telemedicine, with laboratory-confirmed SARS-CoV-2 infection in the West Texas region between March 29th, 2020, and May 14th, 2020. Case Report: The first patient is a 63-year-old female, non-smoker, who is diagnosed with Waldenstrom’s Macroglobulinemia (2012) and Primary Cutaneous Marginal Zone Lymphoma (2020) and the second patient is a 38-year-old male, non-smoker, who has the following comorbidities: Type II Diabetes Mellitus (DM), hypertension, and gout. Both patients were empirically started on budesonide 0.5mg nebulizer twice daily, clarithromycin (Biaxin) 500mg tab twice daily for ten days, Zinc 50mg tab twice daily, and aspirin 81mg tab daily. Both patients have fully recovered with no residual effects. Conclusion: The goal is to call attention to the success of proactive, early empirical treatment, combining a classic corticosteroid (budesonide) administered via a nebulizer and an oral macrolide antibiotic known as clarithromycin (Biaxin).

scholarly journals AB0994 NEW ALTERNATIVE IN THE TREATMENT OF PATIENT WITH MUTATION OF GEN LACC1

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1790.2-1790
Author(s):  
R. M. Alcobendas ◽  
C. Quintana ◽  
J. Arostegui ◽  
C. Udaondo ◽  
S. Murias Loza ◽  
...  
Keyword(s):  
Chart Review ◽  
Loss Of Function ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Inflammatory Parameters ◽  
Whole Exome ◽  
Multiple Treatments ◽  
Clinical Chart ◽  
Clinical Worsening

Background:Few patients have been described in the literature with mutations in the Lacasa Domain containing one (LACC1) gene. Its clinical presentation usually associates sustained systemic inflammation associated with chronic polyarticular erosive arthritis. Until now, there have been multiple treatments described to try to control the disease, however, they are generally unsuccessful in the long term.Objectives:Describe the clinical course of a patient as well as the different treatments usedMethods:Clinical chart reviewResults:Female 18-year-old born from a consanguineous Moroccan couple. Mother, brother and sister with similar conditions. She started at 3 years with fever, anemia, intense elevation of acute phase reactants and symmetric polyarthritis (knees, elbows, carps, shoulders, hands and ankles). Subsequent whole exome sequencing identified c.128_129delGT mutation in the LACC1/FAMIN gene. During the course of her illness, she has received treatment with oral, intravenous and infiltrated corticosteroid, methotrexate and etanercept, without getting adequate control of the disease. In 2016, she started treatment with tocilizumab (8 mg / kg every two weeks), obtaining an acceptable control of the disease (requiring periodic infiltrations every 2-3 months due to persistent arthritis). Nonetheless, in April 2019, she consulted for clinical worsening of the arthritis and laboratory test (C reactive protein 99.7 mg / L, erythrosedimentation rate 53 mm / h, leukocytes 13,500/µL and neutrophils 10,930/µL). At that time, she discontinued therapy with tocilizumab and started tofacitinib 5 mg every 12 hours with good evolution. Since its introduction, it has not required joint infiltration again and the inflammatory parameters (persistently elevated previously) have normalized.Conclusion:The jak kinasa inhibitors may be a treatment option in those patients with bad response to conventional therapy.References:[1]Rabionet R, Remesal A, Mensa-Vilaró A, Murías S, Alcobendas R, González-Roca E, Ruiz-Ortiz E, Antón J, Iglesias E, Modesto C, Comas D, Puig A, Drechsel O, Ossowski S, Yagüe J, Merino R, Estivill X, Arostegui JI. Biallelic loss-of-function LACC1/FAMIN Mutations Presenting as Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis. Sci Rep. 2019 Mar 14;9(1):4579Disclosure of Interests:None declared

scholarly journals An Egocentric Network Contact Tracing Experiment: Testing Different Procedures to Elicit Contacts and Places

2021 ◽  
Vol 18 (4) ◽  
pp. 1466
Author(s):  
Andrew Pilny ◽  
C. Joseph Huber
Keyword(s):  
Social Network ◽  
Infectious Diseases ◽  
Effect Size ◽  
Survey Methods ◽  
Contact Tracing ◽  
Medium Effect ◽  
Physiological Variables ◽  
Medium Effect Size ◽  
Egocentric Network ◽  
Survey Instruments

Contact tracing is one of the oldest social network health interventions used to reduce the diffusion of various infectious diseases. However, some infectious diseases like COVID-19 amass at such a great scope that traditional methods of conducting contact tracing (e.g., face-to-face interviews) remain difficult to implement, pointing to the need to develop reliable and valid survey approaches. The purpose of this research is to test the effectiveness of three different egocentric survey methods for extracting contact tracing data: (1) a baseline approach, (2) a retrieval cue approach, and (3) a context-based approach. A sample of 397 college students were randomized into one condition each. They were prompted to anonymously provide contacts and populated places visited from the past four days depending on what condition they were given. After controlling for various demographic, social identity, psychological, and physiological variables, participants in the context-based condition were significantly more likely to recall more contacts (medium effect size) and places (large effect size) than the other two conditions. Theoretically, the research supports suggestions by field theory that assume network recall can be significantly improved by activating relevant activity foci. Practically, the research contributes to the development of innovative social network data collection methods for contract tracing survey instruments.

scholarly journals 142. Implementing an Antimicrobial Stewardship Program in the Outpatient Setting

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S82-S82
Author(s):  
Travis B Nielsen ◽  
Maressa Santarossa ◽  
Beatrice D Probst ◽  
Laurie Labuszewski ◽  
Jenna Lopez ◽  
...  
Keyword(s):  
Primary Care ◽  
Antimicrobial Stewardship ◽  
Inappropriate Prescribing ◽  
The United States ◽  
Outpatient Setting ◽  
Urgent Care ◽  
Antibiotic Prescribing ◽  
Antimicrobial Stewardship Program ◽  
Post Intervention ◽  
Stewardship Program

Abstract Background Antimicrobial-resistant infections lead to increased morbidity, mortality, and healthcare costs. Among the most facile modifiable risk factors for developing resistance is inappropriate prescribing. The CDC estimates that 47 million (or ≥30% of) outpatient antibiotic prescriptions in the United States are unnecessary. This has provided impetus for expanding our antimicrobial stewardship program (ASP) into the outpatient setting. Initial goals included the following: continuous evaluation and reporting of antibiotic prescribing compliance; minimize underuse of antibiotics from delayed diagnoses and misdiagnoses; ensure proper drug, dose, and duration; improve the percentage of appropriate prescriptions. Methods To achieve these goals, we first sent a baseline survey to outpatient prescribers, assessing their understanding of stewardship and antimicrobial resistance. Questions were modeled from the Illinois Department of Public Health (IDPH) Precious Drugs & Scary Bugs Campaign. The survey was sent to prescribers at 19 primary care and three immediate/urgent care clinics. Compliance rates for prescribing habits were subsequently tracked via electronic health records and reported to prescribers in accordance with IRB approval. Results Prescribers were highly knowledgeable about what constitutes appropriate prescribing, with verified compliance rates highly concordant with self-reported rates. However, 74% of respondents reported intense pressure from patients to inappropriately prescribe antimicrobials. Compliance rates have been tracked since December 2018 and comparing pre- with post-intervention rates shows improvement in primary care since reporting rates to prescribers in August 2019. Conclusion Reporting compliance rates has been helpful in avoiding inappropriate antimicrobial therapy. However, the survey data reinforce the importance of behavioral interventions to bolster ASP efficacy in the outpatient setting. Going forward, posters modeled off of the IDPH template will be conspicuously exhibited in exam rooms, indicating institutional commitment to the enumerated ASP guidelines. Future studies will allow for comparison of pre- and post-intervention knowledge and prescriber compliance. Disclosures All Authors: No reported disclosures

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