The Serotonin Transporter Gene and Personality: Association of the 5-HTTLPR S Allele, Anxiety, Depression and Affective Temperaments

Az 5-HTTLPR-polimorfizmus kiemelt szerepet játszik a hangulatzavarok és a neuroticismus hátterében. Vizsgálatunk célja az 5-HTTLPR és a neuroticismus komponensei közül a szorongásra és a depresszióra való hajlam és az affektív labilitás összefüggésének vizsgálata volt pszichiátriailag egészséges populációban. A vizsgálat résztvevői a Spielberger-féle vonás- és állapotszorongás kérdőívet (STAI), a Zung-féle önértékelő depresszióskálát (ZSDS), valamint a TEMPS-A kérdőívet töltötték ki. Az 5-HTTLPR genotípust PCR segítségével határoztuk meg. A pontszámokat a különböző csoportokban ANOVA segítségével hasonlítottuk össze. Az s allélt hordozók szignifikánsan magasabb pontszámot kaptak a ZSDS és a STAI állapotszorongás-skálán, valamint a depresszív komponenst hordozó affektívtemperamentum-skálákon is. Eredményeink szerint a neuroticismus komponensei önállóan is összefüggést mutatnak az 5-HTTLPR-polimorfizmussal, ami a vonás egységességét támasztja alá. Eredményeink rámutatnak további kutatások szükségességére az egészséges populációban megfigyelhető vonások genetikai hátterének feltárásával kapcsolatban, mivel ezek a neuropszichiátriai betegségek endofenotípusaiként a jövőbeli kutatások alapvető építőkövei lehetnek.

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The 5HTTLPR polymorphism of the serotonin transporter gene is associated with affective temperaments as measured by TEMPS-A

Journal of Affective Disorders ◽

10.1016/j.jad.2005.12.048 ◽

2006 ◽

Vol 91 (2-3) ◽

pp. 125-131 ◽

Cited By ~ 99

Author(s):

Xenia Gonda ◽

Zoltan Rihmer ◽

Terezia Zsombok ◽

Gyorgy Bagdy ◽

Kareen K. Akiskal ◽

...

Keyword(s):

Serotonin Transporter ◽

Serotonin Transporter Gene ◽

Transporter Gene ◽

Affective Temperaments

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Family-Based Analysis of Serotonin Transporter Gene Polymorphisms in Migraine With and Without Aura

Cephalalgia ◽

10.1111/j.1468-2982.2007.01344.x ◽

2007 ◽

Vol 27 (7) ◽

pp. 773-780 ◽

Cited By ~ 8

Author(s):

AFK Karwautz ◽

S Campos de Sousa ◽

C Wöber ◽

G Wagner ◽

T Li ◽

...

Keyword(s):

Serotonin Transporter ◽

Twin Studies ◽

Serotonin Transporter Gene ◽

Transporter Gene ◽

Test Analysis ◽

Significant Heritability ◽

The Common ◽

S Allele ◽

Family Based ◽

Intron 2

Genetic epidemiological twin studies have demonstrated a significant heritability for migraine, with >60% of liability to migraine either with or without aura coming from additive genetic factors. Because of the essential role of serotonin in the pathophysiology and treatment of migraine, genes of the serotonin system are candidates for involvement in migraine. Consequently, we examined two functional VNTR polymorphisms in the serotonin transporter gene, the 5-HTTLPR and the intron 2 VNTR, in a sample of 212 family trios each with a proband with childhood migraine, 153 with migraine without aura (MoA) and 59 with migraine with aura (MA). For the first time, we used transmission disequilibrium test analysis with the program TDTPHASE to examine the transmission of these two markers and their haplotypes to offspring affected by migraine. We found no significant transmission distortion of any marker, with the common L allele of the 5-HTTLPR transmitted 170 times and not transmitted 178 times, and the S allele 130 vs. 122 times. Likewise, the common 12 allele of the intron 2 VNTR was transmitted 201 times and not transmitted 188 times, and the 10 allele 107 vs. 120 times. The markers were not associated with MoA and MA and none of the haplotypes was associated with overall migraine, MoA or MA. The 5-HTTLPR and the intron 2 VNTRs do not play a major role in susceptibility to migraine.

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Impact of Polymorphisms in the Serotonin Transporter Gene on Oscillatory Dynamics during Inhibition of Planned Movement in Children

Brain Sciences ◽

10.3390/brainsci9110311 ◽

2019 ◽

Vol 9 (11) ◽

pp. 311

Author(s):

Bocharov ◽

Savostyanov ◽

Tamozhnikov ◽

Saprigyn ◽

Proshina ◽

...

Keyword(s):

Serotonin Transporter ◽

Stop Signal ◽

Serotonin Transporter Gene ◽

Transporter Gene ◽

Gene Encoding ◽

Oscillatory Dynamics ◽

Prepotent Response ◽

Serotonin Transporter Polymorphism ◽

S Allele ◽

The Impact

The serotonin transporter plays an important role in serotonergic neuromodulation. It is known that polymorphisms in the serotonin transporter gene are linked to the dysregulation of emotions. In the current study, we aimed to investigate the impact of variation in the gene encoding serotonin transporter polymorphism on oscillatory dynamics during inhibition of planned movement in the stop signal paradigm. During performance the stop signal paradigm, electroencephalograms (EEGs) were recorded in 90 healthy Caucasian children (39 girls) from 7 to 12 years. Buccal epithelium probes were taken from all participants. The La, Lg, and S alleles of serotonin transporter-linked polymorphic region (5-HTTLPR) polymorphism were detected in the DNA samples using PCR. LaLa genotype carriers did not differ from LaS\LgS and LgS\LgLg\SS carriers in a number of successful inhibitions of a prepotent response. Carriers of LaLa exhibit higher alpha and beta event-related spectral perturbations (ERSP) in parietal and occipital cortices after the presentation of signal of inhibition of movement than LaS\LgS and LgS\LgLg\SS carriers. Results are consistent with current literature and confirm that S allele carriers are more predisposed to disturbances in cognitive control.

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Adaptive developmental plasticity in rhesus macaques: the serotonin transporter gene interacts with maternal care to affect juvenile social behaviour

Proceedings of The Royal Society B Biological Sciences ◽

10.1098/rspb.2018.0541 ◽

2018 ◽

Vol 285 (1881) ◽

pp. 20180541 ◽

Cited By ~ 8

Author(s):

Jesus E. Madrid ◽

Tara M. Mandalaywala ◽

Sean P. Coyne ◽

Jamie Ahloy-Dallaire ◽

Joseph P. Garner ◽

...

Keyword(s):

Serotonin Transporter ◽

Developmental Plasticity ◽

Rhesus Macaques ◽

Empirical Support ◽

Serotonin Transporter Gene ◽

Transporter Gene ◽

Loss Of Function ◽

S Allele ◽

Maternal Protection

Research has increasingly highlighted the role that developmental plasticity—the ability of a particular genotype to produce variable phenotypes in response to different early environments—plays as an adaptive mechanism. One of the most widely studied genetic contributors to developmental plasticity in humans and rhesus macaques is a serotonin transporter gene-linked polymorphic region (5-HTTLPR), which determines transcriptional efficiency of the serotonin transporter gene in vitro and modifies the availability of synaptic serotonin in these species. A majority of studies to date have shown that carriers of a loss-of-function variant of the 5-HTTLPR, the short (s) allele, develop a stress-reactive phenotype in response to adverse early environments compared with long (l) allele homozygotes, leading to the prevalent conceptualization of the s-allele as a vulnerability allele. However, this framework fails to address the independent evolution of these loss-of-function mutations in both humans and macaques as well as the high population prevalence of s-alleles in both species. Here we show in free-ranging rhesus macaques that s-allele carriers benefit more from supportive early social environments than l-allele homozygotes, such that s-allele carriers which receive higher levels of maternal protection during infancy demonstrate greater social competence later in life. These findings provide, to our knowledge, the first empirical support for the assertion that the s-allele grants high undirected biological sensitivity to context in primates and suggest a mechanism through which the 5-HTTLPR s-allele is maintained in primate populations.

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