Sonographic features of benign common skin tumors

A 35-year-old male returned from vacation in Hawaii where he went scuba diving and snorkeling. While snorkeling, he stepped on a sea urchin and sustained injuries to the dorsal aspect of his right foot. He began to swim back to shore when he felt significant pain and began removing visible spines when he reached shore. He saw a physician in Hawaii who removed remaining spines and started a treatment regimen of cephalexin 500 mg QID. Patient followed up 2 weeks later with his home dermatologist for persistent granuloma and was given 15-day course of oral doxycycline 50 mg BID with near full recovery within 2 weeks. Even physicians practicing inland need to be aware of coastal injuries and reactions as they can mimic other common skin tumors such as keratoacanthomas.

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Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors

Scientific Reports ◽

10.1038/s41598-020-71700-9 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Wybke Klatt ◽

Susanne Wallner ◽

Christoph Brochhausen ◽

Judith A. Stolwijk ◽

Stephan Schreml

Keyword(s):

Skin Cancer ◽

Cell Carcinoma ◽

Expression Profiles ◽

Expression Patterns ◽

Skin Tumors ◽

Solid Cancer ◽

Tissue Samples ◽

Skin Cancers ◽

Common Skin

Abstract The proton-sensing GPCRs (pH-GPCRs) GPR4 (GPR19), TDAG8 (GPR65, T-cell death associated gene 8), OGR1 (GPR68, ovarian cancer GPCR1), and G2A (GPR132, G2 accumulation protein) are involved in sensing and transducing changes in extracellular pH (pHe). Extracellular acidification is a central hallmark of solid cancer. pH-GPCR function has been associated with cancer cell proliferation, adhesion, migration and metastasis, as well as with modulation of the immune system. Little is known about the expression levels and role of pH-GPCRs in skin cancer. To better understand the functions of pH-GPCRs in skin cancer in vivo, we examined the expression-profiles of GPR4, TDAG8, OGR1 and G2A in four common skin tumors, i.e. squamous cell carcinoma (SCC), malignant melanoma (MM), compound nevus cell nevi (NCN), basal cell carcinoma (BCC). We performed immunohistochemistry and immunofluorescence staining on paraffin-embedded tissue samples acquired from patients suffering from SCC, MM, NCN or BCC. We show the expression of pH-GPCRs in four common skin cancers. Different expression patterns in the investigated skin cancer types indicate that the different pH-GPCRs may have distinct functions in tumor progression and serve as novel therapeutic targets.

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Enhanced IL-18 expression in common skin tumors

Immunology Letters ◽

10.1016/s0165-2478(01)00278-4 ◽

2001 ◽

Vol 79 (3) ◽

pp. 215-219 ◽

Cited By ~ 53

Author(s):

H Park

Keyword(s):

Skin Tumors ◽

Common Skin

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The comparison of nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) with Ki67 proliferation marker expression in common skin tumors

Polish Journal of Pathology ◽

10.5114/pjp.2014.42669 ◽

2014 ◽

Vol 1 ◽

pp. 48-54 ◽

Cited By ~ 5

Author(s):

Krzysztof Zduniak ◽

Siddarth Agrawal ◽

Krzysztof Symonowicz ◽

Kamil Jurczyszyn ◽

Piotr Ziółkowski

Keyword(s):

Skin Tumors ◽

Proliferation Marker ◽

Cyclin Dependent Kinases ◽

Common Skin ◽

Marker Expression

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Molecular Detection of Bovine Papillomavirus DNA in the Placenta and Blood of Healthy Mares and Respective Foals

Veterinary Sciences ◽

10.3390/vetsci6010014 ◽

2019 ◽

Vol 6 (1) ◽

pp. 14 ◽

Cited By ~ 2

Author(s):

Federica Savini ◽

Laura Gallina ◽

Francesca Mazza ◽

Jole Mariella ◽

Carolina Castagnetti ◽

...

Keyword(s):

Vertical Transmission ◽

Molecular Detection ◽

Skin Neoplasms ◽

Skin Tumors ◽

Transmission Mechanism ◽

Bovine Papillomavirus ◽

Viral Dna ◽

Common Skin ◽

Characteristic Species ◽

Papillomavirus Dna

Despite the characteristic species specificity of Papillomaviruses (PVs), the bovine papillomavirus (BPV) types 1, 2, and—more rarely—13, can cross-infect equids, where they are involved in the pathogenesis of sarcoid neoplasms. Sarcoids are locally invasive fibroblastic skin tumors that represent the most common skin neoplasms in horses worldwide. The transmission mechanism of BPV is still controversial in horses. Thus far, direct and indirect routes have been implicated, while vertical transmission has been suggested after the detection of viral DNA in the semen of healthy stallions. Testing of the blood and placenta of non-sarcoid baring mares and their respective foals revealed that the equine placenta can harbor BPV DNA, leading us to speculate a possible prenatal vertical DNA transmission in equids.

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Expression of Proton-Sensitive GPR31, GPR151, TASK1 and TASK3 in Common Skin Tumors

Cells ◽

10.3390/cells11010027 ◽

2021 ◽

Vol 11 (1) ◽

pp. 27

Author(s):

Antonia Förch ◽

Susanne Wallner ◽

Florian Zeman ◽

Tobias Ettl ◽

Christoph Brochhausen ◽

...

Keyword(s):

Expression Profiles ◽

Expression Patterns ◽

Skin Tumors ◽

Tissue Samples ◽

Basal Cell Carcinomas ◽

Common Skin ◽

G Protein Coupled ◽

Nevus Cell ◽

Lower Expression

TWIK-related acid-sensitive potassium channels TASK1 and TASK3, as well as the G-protein-coupled receptors GPR31 and GPR151, are proton-sensitive membrane proteins. They can be activated or inhibited by low extracellular pH (pHe), which is a hallmark of the tumor microenvironment in solid tumors. However, the role of these channels in the development of skin tumors is still unclear. In this study, we investigated the expression profiles of TASK1, TASK3, GPR31 and GPR151 in squamous cell carcinomas (SCCs), basal cell carcinomas (BCCs), nevus cell nevi (NCN), and malignant melanomas (MMs). We performed immunohistochemistry using paraffin-embedded tissue samples from patients and found that most skin tumors express TASK1/3 and GPR31/151. The results show that BCCs are often negative for GPR31/151 as well as for TASK1/3, while nearly all SCCs express these markers. MMs and NCN show similar expression patterns. However, some tumors show a decreasing TASK1/3 expression in deeper dermal tumor tissue, while GPCRs were expressed more evenly. The lower frequency of GPR31/151 and TSAK1/3 expression in BCCs when compared to SCCs is a novel histological feature distinguishing these two entities. Moreover, BCCs also show lower expression of GPR31/151 and TASK1/3 as compared to NCN and MMs.

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Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors

International Journal of Molecular Sciences ◽

10.3390/ijms22116024 ◽

2021 ◽

Vol 22 (11) ◽

pp. 6024

Author(s):

Kirsten Ackermann ◽

Susanne Wallner ◽

Christoph Brochhausen ◽

Stephan Schreml

Keyword(s):

Cell Carcinoma ◽

Transient Receptor Potential ◽

Expression Profiles ◽

Receptor Potential ◽

Skin Tumors ◽

Transient Receptor Potential Vanilloid ◽

Tissue Samples ◽

Acid Sensing Ion Channels ◽

Common Skin ◽

Transient Receptor

The acid-sensing ion channels ASIC1 and ASIC2, as well as the transient receptor potential vanilloid channels TRPV1 and TRPV4, are proton-gated cation channels that can be activated by low extracellular pH (pHe), which is a hallmark of the tumor microenvironment in solid tumors. However, the role of these channels in the development of skin tumors is still unclear. In this study, we investigated the expression profiles of ASIC1, ASIC2, TRPV1 and TRPV4 in malignant melanoma (MM), squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and in nevus cell nevi (NCN). We conducted immunohistochemistry using paraffin-embedded tissue samples from patients and found that most skin tumors express ASIC1/2 and TRPV1/4. Striking results were that BCCs are often negative for ASIC2, while nearly all SCCs express this marker. Epidermal MM sometimes seem to lack ASIC1 in contrast to NCN. Dermal portions of MM show strong expression of TRPV1 more frequently than dermal NCN portions. Some NCN show a decreasing ASIC1/2 expression in deeper dermal tumor tissue, while MM seem to not lose ASIC1/2 in deeper dermal portions. ASIC1, ASIC2, TRPV1 and TRPV4 in skin tumors might be involved in tumor progression, thus being potential diagnostic and therapeutic targets.

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Common Skin Tumors of the Head and Neck

Pathology of the Head and Neck ◽

10.1007/978-3-662-49672-5_15 ◽

2016 ◽

pp. 673-751 ◽

Cited By ~ 1

Author(s):

Daniela Massi ◽

Boštjan Luzar ◽

Llucia Alos

Keyword(s):

Head And Neck ◽

Skin Tumors ◽

Common Skin

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Occult Basal Cell Carcinoma Arising in Seborrheic Keratosis

Case Reports in Dermatology ◽

10.1159/000497067 ◽

2019 ◽

Vol 11 (1) ◽

pp. 48-51 ◽

Cited By ~ 2

Author(s):

Yuichi Kurihara ◽

Masutaka Furue

Keyword(s):

Clinical Practice ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Skin Tumors ◽

Daily Clinical Practice ◽

Seborrheic Keratosis ◽

Common Skin

Both seborrheic keratosis and basal cell carcinoma are common skin tumors in daily clinical practice. However, the coexistence of seborrheic keratosis and basal cell carcinoma is rare. In this report, we present a case of occult microscopic basal cell carcinoma arising in a lesion of seborrheic keratosis. This case indicates that the basal cell carcinoma could arise from seborrheic keratosis and might help to clarify the origin of basal cell carcinoma.

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