Bioinspired Artificial Protein Materials: Self-Assembly and Order from Nano to Macroscale

2011 ◽  
Vol 1301 ◽  
Author(s):  
Min Dai ◽  
Jennifer S. Haghpanah ◽  
Carlo Yuvienco ◽  
Jin Kim Montclare
Keyword(s):  
Self Assembly ◽  
Matrix Protein ◽  
Coiled Coil ◽  
Supramolecular Assembly ◽  
Stimuli Responsive ◽  
Block Polymers ◽  
Self Assembling ◽  
Assembly Behavior ◽  
Protein Block

ABSTRACTWe describe the biosynthesis and characterization of protein materials comprised of two distinct self-assembling domains (SADs): elastin (E) found in tissue for its elastic properties and cartilage oligomeric matrix protein coiled-coil (COMPcc, C) predominantly locatedin joint and in bones. Based on earlier studies on protein block polymers comprised these two SADs, orientation and number of blocks play a crucial role in the overall stimuli-responsive supramolecular assembly behavior. Here we fabricate a range of EnC and CEn block polymers in which the E domain is systematically truncated to explore the effects of the E domain on the overall physicochemical behavior.

scholarly journals On the Aqueous Solution Behavior of C-Substituted 3,1,2-Ruthenadicarbadodecaboranes

Inorganics ◽  
2019 ◽  
Vol 7 (7) ◽  
pp. 91 ◽  
Author(s):  
Marta Gozzi ◽  
Benedikt Schwarze ◽  
Peter Coburger ◽  
Evamarie Hey-Hawkins
Keyword(s):  
Aqueous Solution ◽  
Aqueous Solutions ◽  
Self Assembly ◽  
Self Assembling ◽  
Vis Spectroscopy ◽  
Assembly Behavior ◽  
Biological Performance ◽  
Type 3

3,1,2-Ruthenadicarbadodecaborane complexes bearing the [C2B9H11]2− (dicarbollide) ligand are robust scaffolds, with exceptional thermal and chemical stability. Our previous work has shown that these complexes possess promising anti-tumor activities in vitro, and tend to form aggregates (or self-assemblies) in aqueous solutions. Here, we report on the synthesis and characterization of four ruthenium(II) complexes of the type [3-(η6-arene)-1,2-R2-3,1,2-RuC2B9H9], bearing either non-polar (R = Me (2–4)) or polar (R = CO2Me (7)) substituents at the cluster carbon atoms. The behavior in aqueous solution of complexes 2, 7 and the parent unsubstituted [3-(η6-p-cymene)-3,1,2-RuC2B9H11] (8) was investigated via UV-Vis spectroscopy, mass spectrometry and nanoparticle tracking analysis (NTA). All complexes showed spontaneous formation of self-assemblies (108–109 particles mL−1), at low micromolar concentration, with high polydispersity. For perspective applications in medicine, there is thus a strong need for further characterization of the spontaneous self-assembly behavior in aqueous solutions for the class of neutral metallacarboranes, with the ultimate scope of finding the optimal conditions for exploiting this self-assembling behavior for improved biological performance.

Sticky ends in a self-assembling ABA triblock copolymer: the role of ureas in stimuli-responsive hydrogels

2019 ◽  
Vol 4 (1) ◽  
pp. 91-102 ◽  
Author(s):  
Ryan T. Shafranek ◽  
Joel D. Leger ◽  
Song Zhang ◽  
Munira Khalil ◽  
Xiaodan Gu ◽  
...  
Keyword(s):  
Self Assembly ◽  
Viscoelastic Properties ◽  
Triblock Copolymer ◽  
Thermal Response ◽  
Stimuli Responsive ◽  
Self Assembling ◽  
Polymeric Hydrogels ◽  
Aba Triblock Copolymer ◽  
Responsive Hydrogels

Directed self-assembly in polymeric hydrogels allows tunability of thermal response and viscoelastic properties.

Self-assembly of Stimuli Responsive Coiled-coil Fibrous Hydrogels

Soft Matter ◽  
2021 ◽  
Author(s):  
Michael Meleties ◽  
Priya Katyal ◽  
Bonnie Lin ◽  
Dustin Britton ◽  
Jin Kim Montclare
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Self Assembly ◽  
Coiled Coil ◽  
Stimuli Responsive ◽  
Tunable Properties ◽  
Stimuli Sensitive ◽  
Biomedical Fields

Owing to their tunable properties, hydrogels comprised of stimuli sensitive polymers are one of the most appealing scaffolds with applications in tissue engineering, drug delivery and other biomedical fields. We...

Trithiazolyl-1,3,5-triazines bearing decyloxybenzene moieties: synthesis, photophysical and electrochemical properties, and self-assembly behavior

2018 ◽  
Vol 16 (19) ◽  
pp. 3584-3595 ◽  
Author(s):  
Shin-ichiro Kato ◽  
Satoshi Jin ◽  
Terutaka Kimura ◽  
Naoki Yoshikawa ◽  
Daiki Nara ◽  
...  
Keyword(s):  
Electrochemical Properties ◽  
Self Assembly ◽  
Self Assembling ◽  
Assembly Behavior

We synthesized the first members of trithiazolyl-1,3,5-triazines that combine attractive photophysical and self-assembling properties.

scholarly journals pH- and concentration-dependent supramolecular self-assembly of a naturally occurring octapeptide

2020 ◽  
Vol 16 ◽  
pp. 2017-2025
Author(s):  
Goutam Ghosh ◽  
Gustavo Fernández
Keyword(s):  
Self Assembly ◽  
Ph Value ◽  
Secondary Structures ◽  
Random Coil ◽  
Conformational Transformation ◽  
Stimuli Responsive ◽  
Responsive Materials ◽  
Force Microscopy ◽  
Assembly Behavior ◽  
Novel Drug

Peptide-based biopolymers represent highly promising biocompatible materials with multiple applications, such as tailored drug delivery, tissue engineering and regeneration, and as stimuli-responsive materials. Herein, we report the pH- and concentration-dependent self-assembly and conformational transformation of the newly synthesized octapeptide PEP-1. At pH 7.4, PEP-1 forms β-sheet-rich secondary structures into fractal-like morphologies, as verified by circular dichroism (CD), Fourier-transform infrared (FTIR) spectroscopy, thioflavin T (ThT) fluorescence spectroscopy assay, and atomic force microscopy (AFM). Upon changing the pH value (using pH 5.5 and 13.0), PEP-1 forms different types of secondary structures and resulting morphologies due to electrostatic repulsion between charged amino acids. PEP-1 can also form helical or random-coil secondary structures at a relatively low concentration. The obtained pH-sensitive self-assembly behavior of the target octapeptide is expected to contribute to the development of novel drug nanocarrier assemblies.

The influence of side-chain conformations on the phase behavior of bottlebrush block polymers

Soft Matter ◽  
2020 ◽  
Vol 16 (34) ◽  
pp. 8047-8056
Author(s):  
Yuguo Chen ◽  
Xinghua Zhang ◽  
Ying Jiang
Keyword(s):  
Self Assembly ◽  
Side Chain ◽  
Chain Model ◽  
Block Polymers ◽  
Consistent Field ◽  
Self Consistent Field ◽  
Self Consistent Field Theory ◽  
Assembly Behavior ◽  
Wormlike Chain Model ◽  
Chain Conformations

A self-consistent field theory based on the wormlike chain model is implemented in the investigation of the self-assembly behavior of bottlebrush block polymers in the formation of a lamellar phase.

scholarly journals Dual self-assembly of supramolecular peptide nanotubes to provide stabilisation in water

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Julia Y. Rho ◽  
Henry Cox ◽  
Edward D. H. Mansfield ◽  
Sean H. Ellacott ◽  
Raoul Peltier ◽  
...  
Keyword(s):  
Self Assembly ◽  
Supramolecular Assembly ◽  
Ordered Structures ◽  
Peptide Bonds ◽  
Self Assembling ◽  
Peptide Hydrogen ◽  
Aqueous Conditions ◽  
Β Sheet ◽  
Peptide Core ◽  
Hydrogen Bonded

Abstract Self-assembling peptides have the ability to spontaneously aggregate into large ordered structures. The reversibility of the peptide hydrogen bonded supramolecular assembly make them tunable to a host of different applications, although it leaves them highly dynamic and prone to disassembly at the low concentration needed for biological applications. Here we demonstrate that a secondary hydrophobic interaction, near the peptide core, can stabilise the highly dynamic peptide bonds, without losing the vital solubility of the systems in aqueous conditions. This hierarchical self-assembly process can be used to stabilise a range of different β-sheet hydrogen bonded architectures.

scholarly journals Structural Characterization of an LPA1 Second Extracellular Loop Mimetic with a Self-Assembling Coiled-Coil Folding Constraint

2013 ◽  
Vol 14 (2) ◽  
pp. 2788-2807 ◽  
Author(s):  
John Young ◽  
Benjamin Clayton ◽  
Alexandra Kikonyogo ◽  
Truc-Chi Pham ◽  
Abby Parrill
Keyword(s):  
Structural Characterization ◽  
Coiled Coil ◽  
Extracellular Loop ◽  
Self Assembling
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