Self-assembly of Stimuli Responsive Coiled-coil Fibrous Hydrogels

The effects of cononsolvents on the synthesis of responsive particles via polymerisation-induced thermal self-assembly

Polymer Chemistry ◽

10.1039/d1py00396h ◽

2021 ◽

Author(s):

Marissa Morales-Moctezuma ◽

Sebastian G Spain

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Self Assembly ◽

Biomedical Applications

Nanogels have emerged as innovative platforms for numerous biomedical applications including gene and drug delivery, biosensors, imaging, and tissue engineering. Polymerisation-induced thermal self-assembly (PITSA) has been shown to be suitable...

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Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

Biomaterials Science ◽

10.1039/d0bm01406k ◽

2021 ◽

Vol 9 (1) ◽

pp. 38-50

Author(s):

Hien Phan ◽

Vincenzo Taresco ◽

Jacques Penelle ◽

Benoit Couturaud

Keyword(s):

Drug Delivery ◽

Block Copolymers ◽

Drug Release ◽

Self Assembly ◽

Drug Delivery Systems ◽

Amphiphilic Block Copolymers ◽

Stimuli Responsive ◽

Site Specific ◽

On Demand ◽

Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

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Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering

Applied Sciences ◽

10.3390/app112311369 ◽

2021 ◽

Vol 11 (23) ◽

pp. 11369

Author(s):

Ashni Arun ◽

Pratyusha Malrautu ◽

Anindita Laha ◽

Hongrong Luo ◽

Seeram Ramakrishna

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Drug Solubility ◽

Stimuli Responsive ◽

Preparation Methods ◽

Nanoparticle Preparation ◽

Responsive Behavior ◽

Reduced Toxicity

The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.

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Design and self-assembly of albumin nanoclusters as a dynamic-covalent targeting co-delivery and stimuli-responsive controlled release platform

Journal of Materials Chemistry B ◽

10.1039/c8tb01791c ◽

2018 ◽

Vol 6 (42) ◽

pp. 6817-6830 ◽

Cited By ~ 1

Author(s):

Wen Liu ◽

Jian Dai ◽

Wei Xue

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Tumor Microenvironment ◽

Self Assembly ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Stimuli Responsive ◽

Target Sites

Stimuli-responsive nanomaterial-based drug delivery systems that are able to actively target the tumor microenvironment, enhance intratumoral accumulation and release drugs at target sites are attractive therapeutic platforms at present.

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Morphology-tunable and pH-responsive supramolecular self-assemblies based on AB2-type host–guest-conjugated amphiphilic molecules for controlled drug delivery

Beilstein Journal of Organic Chemistry ◽

10.3762/bjoc.15.188 ◽

2019 ◽

Vol 15 ◽

pp. 1925-1932 ◽

Cited By ~ 3

Author(s):

Yang Bai ◽

Cai-ping Liu ◽

Di Chen ◽

Long-hai Zhuo ◽

Huai-tian Bu ◽

...

Keyword(s):

Drug Delivery ◽

Self Assembly ◽

Controlled Drug Delivery ◽

Transition Process ◽

Hydrodynamic Diameter ◽

Cancer Cell Proliferation ◽

Acidic Ph ◽

Stimuli Responsive ◽

Amphiphilic Molecules ◽

Acidic Conditions

Although stimuli-responsive supramolecular self-assemblies have been constructed, the controlled drug delivery induced by morphology transitions of these supramolecular self-assemblies on the basis of host–guest-conjugated monomers (HGCMs) are few reported. In this paper, the self-assembly behaviors of AB2-type HGCMs, e.g., β-cyclodextrin-benzimidazole2 (β-CD-BM2), were investigated at neutral and acidic pH conditions, respectively. Specifically, β-CD-BM2 first self-assembled into fan-shaped supramolecular self-assemblies with a hydrodynamic diameter of 163 nm at neutral pH, whereas they were further dissociated into spherical supramolecular self-assemblies with a size of 52 nm under acidic conditions. This morphology transition process was utilized to conduct a two-stage DOX delivery under neutral and acidic pH. Basic cell experiments demonstrated that the drug-loaded β-CD-BM2-based supramolecular self-assemblies with varied morphology could inhibit cancer cell proliferation, indicating their potential application in the field of drug delivery.

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Coupling Hydrophilic Amine-Containing Molecules to the Backbone of Poly(ε-Caprolactone)

Australian Journal of Chemistry ◽

10.1071/ch06144 ◽

2006 ◽

Vol 59 (8) ◽

pp. 534 ◽

Cited By ~ 14

Author(s):

Emma L. Prime ◽

Justin J. Cooper-White ◽

Greg G. Qiao

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Functional Groups ◽

Biodegradable Polymer ◽

Model Compound ◽

Side Chains ◽

Reactive Polymer ◽

Specific Reactivity ◽

Biomedical Fields

A poly(ϵ-caprolactone) (PCL) based biodegradable polymer containing robust, amine-reactive side chains has been successfully synthesized. The specific reactivity of the side chains allows for the coupling of unmodified amine-containing molecules such as poly(l-lysine) (PLL) to PCL to occur in the presence of other unprotected functional groups. The reactivity of this polymer has been demonstrated through successful coupling of both benzylamine (a model compound) and PLL. This novel amine-reactive polymer could have numerous applications in biomedical fields such as tissue engineering and drug delivery.

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Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery

International Journal of Molecular Sciences ◽

10.3390/ijms21134724 ◽

2020 ◽

Vol 21 (13) ◽

pp. 4724 ◽

Cited By ~ 1

Author(s):

Sofia Municoy ◽

María I. Álvarez Echazú ◽

Pablo E. Antezana ◽

Juan M. Galdopórpora ◽

Christian Olivetti ◽

...

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Smart Materials ◽

Controlled Drug Release ◽

Stimuli Responsive ◽

Responsive Materials ◽

Stimuli Responsive Polymers ◽

Responsive Polymers ◽

Stimuli Response ◽

Materials Used

Smart or stimuli-responsive materials are an emerging class of materials used for tissue engineering and drug delivery. A variety of stimuli (including temperature, pH, redox-state, light, and magnet fields) are being investigated for their potential to change a material’s properties, interactions, structure, and/or dimensions. The specificity of stimuli response, and ability to respond to endogenous cues inherently present in living systems provide possibilities to develop novel tissue engineering and drug delivery strategies (for example materials composed of stimuli responsive polymers that self-assemble or undergo phase transitions or morphology transformations). Herein, smart materials as controlled drug release vehicles for tissue engineering are described, highlighting their potential for the delivery of precise quantities of drugs at specific locations and times promoting the controlled repair or remodeling of tissues.

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Nanostructured Calcium-based Biomaterials and their Application in Drug Delivery

Current Medicinal Chemistry ◽

10.2174/0929867326666190222193357 ◽

2020 ◽

Vol 27 (31) ◽

pp. 5189-5212 ◽

Cited By ~ 1

Author(s):

Li-Juan Yi ◽

Jun-Feng Li ◽

Ming-Guo Ma ◽

Ying-Jie Zhu

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Bone Repair ◽

Antibacterial Agents ◽

Recent Progress ◽

Review Article ◽

Future Perspectives ◽

Comprehensive Review ◽

The Past ◽

Biomedical Fields

In the past several decades, various types of nanostructured biomaterials have been developed. These nanostructured biomaterials have promising applications in biomedical fields such as bone repair, tissue engineering, drug delivery, gene delivery, antibacterial agents, and bioimaging. Nanostructured biomaterials with high biocompatibility, including calcium phosphate, hydroxyapatite, and calcium silicate, are ideal candidates for drug delivery. This review article is not intended to offer a comprehensive review of the nanostructured biomaterials and their application in drug delivery but rather presents a brief summary of the recent progress in this field. Our recent endeavors in the research of nanostructured biomaterials for drug delivery are also summarized. Special attention is paid to the synthesis and properties of nanostructured biomaterials and their application in drug delivery with the use of typical examples. Finally, we discuss the problems and future perspectives of nanostructured biomaterials in the drug delivery field.

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