A Study of the Mass Transport Resistance of Glucose Across Rat Capsular Membranes

1987 ◽  
Vol 110 ◽  
Author(s):  
C. L. Freeman ◽  
K. G. Mayhan ◽  
G. J. Picha ◽  
C. K. Colton

The interaction between a polymer or other foreign surface and soft tissue is determined by a variety of materials and tissue factors. After failing to engulf the foreign body, the classical response is to wall it off. First the site is invaded by macrophages and giant cells and then fibrous connective tissue is laid down. This fibrous connective tissue gradually replaces the cellular matrix and forms the capsule. The composition is mostly collagen and mucopolysaccharides with few cells in the mature capsule. It contains 75–80% water.When the implant surface represents a sensor and the transport of low molecular weight species across the capsule is necessary for meaningful measurement and response time, the mass transport resistance of the capsule may become a critical factor. This study represents an initial attempt to characterize the diffusion of glucose through fibrous capsules grown around silicone elastomer implants in a rat. Specifically, the study was designed to develop techniques to measure mass transport properties of tissue capsules, to use these techniques to determine effective glucose transport properties at two weeks, four weeks, and ten weeks after implant; and, to use these results along with histological examinations to gain an understanding of the factors which influence mass transport.

Author(s):  
J.R. Scott ◽  
R.B. Marshall ◽  
D.K. Roberts

Interstitial calcinosis and tumoral calcinosis lesions were studied ultrastructurally and with the use of enzyme cytochemistry. Technics for alkaline phosphatase, acid phosphatase, atpase and aryl sulfatase were utilized after removal of calcium salts with EDTA.Granular elements were seen in both lesions. These granules were seen to lie in cystic spaces of the lesions (Figure 1). Also seen were aggregates of these granules which had apparently calcified (Figure 2). The lesion of tumoral calcinosis had many multinuclear giant cells present peripheral to the cystic spaces with macrophages contributing to the cell population. The lesions all had a pseudocapsule of fibrous connective tissue and “active” connective tissue cells were seen near the cystic space.


2007 ◽  
Vol 361-363 ◽  
pp. 1269-1272 ◽  
Author(s):  
Monica Calasans-Maia ◽  
Antonella M. Rossi ◽  
Eliane Pedra Dias ◽  
Silvia R. A. Santos ◽  
Fabio Áscoli ◽  
...  

The study was carried out aiming the evaluation of the effect of hydroxyapatite (HA) and zinc-substituted hydroxyapatite (ZnHA) on osseous repair of rabbit’s tibia. For the study, 15 adult animals, weighing around 2.5 and 3.0 Kg, sourced by the Fluminense Federal University Animal Lab were acquired. Two perforations were created in each tibia and filled with cylinders (2x6 mm) of HA (group 1, right) or ZnHA (group 2, left). The animals were killed after 7, 14, and 28 days for evaluating the histological aspects of the interface site and bone repair. No sign of inflammatory reaction surrounding the cylinders area were observed, neither giant cells. Osteogenesis was evidently accelerated in all healing periods for the ZnHA group in regards to the HA group. Randomly dispersed areas of neoformed bone among wide areas of fibrous connective tissue was observed in the HA group. We conclude that both biomaterials are biocompatible, but zinc-containg HA enhanced and accelerated the osteogenesis in relation to HA.


1975 ◽  
Vol 54 (3) ◽  
pp. 561-566 ◽  
Author(s):  
F.J. Ceravolo ◽  
J.A. Molinari ◽  
A. Baumhammers

Ivory rod implants were found to be biologically unacceptable in rabbit mandibles. Fibrous connective-tissue capsules containing numerous multinucleated giant cells formed around the implants. Resorption of the ivory was also apparent. In addition, osteoid deposition and ankylosis at the experimental sites were not evident.


1993 ◽  
Vol 55 (1) ◽  
pp. 55-60
Author(s):  
Toshihide AKASAKA ◽  
Yuko IMAMURA ◽  
Yasuki MORI ◽  
Satoshi MAYAMA ◽  
Saiichi KON

2013 ◽  
Vol 19 (1-3) ◽  
pp. 22-28 ◽  
Author(s):  
Zaira Lipani ◽  
Maria R. Catalano ◽  
Patrizia Rossi ◽  
Paola Paoli ◽  
Graziella Malandrino

1987 ◽  
Vol 101 (9) ◽  
pp. 897-904 ◽  
Author(s):  
Etsuo Yamamoto ◽  
Michitaka Iwanaga

AbstractSoft-tissue reaction to ceramic ossicular replacement prostheses (CORP) has been evaluated histologically in rabbits and humans. One week after implantation, severe inflammatory and foreign body reaction was observed in the fibrous connective tissue surrounding the prosthesis. Though some inflammatory response was seen after one month, after three months the CORP was surrounded by a layer of fibrous connective tissue without any foreigh body giant cell, histiocyte or inflammatory cell infiltration. Our satisfactory clinical results in humans without placing a cartilage between the CORP and the fascia graft may be due to the excellent softtissue compatibility of CORP, as demonstrated in this study.


2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Ramalingam Suganya ◽  
Narasimhan Malathi ◽  
Subramani Vijaya Nirmala ◽  
Chinnaswami Ravindran ◽  
Harikrishnan Thamizhchelvan

Choristomas are rare entities which are aggregates of microscopically normal cells or tissues in aberrant locations. They are a “heterotopic” rest of cells, as they appear as a tumor-like mass. Herein we report a case of cartilaginous choristoma in a 54-year-old male who presented with a swelling on right lower gingiva. The histopathological examination revealed features of a well circumscribed mass of mature cartilage in a dense fibrous connective tissue stroma.


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