The value of risk factors in infertile men in the aspect of choice of assisted reproductive technologies to renew fertility in married couples

2016 ◽  
pp. 136-139
Author(s):  
Yu. N. Gurzhenko ◽  
◽  
A. O. Kutsenko ◽  
Keyword(s):  
Risk Factors ◽  
Male Infertility ◽  
Assisted Reproductive Technologies ◽  
Married Couples ◽  
Risk Groups ◽  
Reproductive Technologies ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Key Words Male Infertility ◽  
Personalized Approach

The objective: the rationalization of a personalized approach to the selection of the program art on the basis of the allocation of risk. Patients and methods. Were analyzed 180 couples with male factor infertility, which in 2012-2015, in the Institute of reproductive medicine (IRM) (Kiev) was held the program of intracytoplasmic sperm injection (ICSI) with the aim of restoring fertility. Examination and ICSI procedure is carried out in accordance with clinical protocols. Results. According to the results of analytical and synthetic analysis of primary documents (enhanced, adapted to the purpose of the work of the medical record) were identified risk factors (and their signs) for the development of male infertility and grouped by direction of impact. As a result, 25 of the 51 factors and their basis formed three groups: social (behavioral), biological/clinical and special medical. With the help of mathematical analysis it was determined the boundary values of the minimum and maximum of reliability of the negative result of the application of ART. Conclusion. It was proposed the predictive map for the determination of the probability of pregnancy in couples with male infertility problems with the application of ART. Was justified the separation of three risk groups to restore fertility in couples with male factor infertility using ART. Was based the principle of personalized approach to choosing the best program of art-based stratification of men at risk groups. Key words: male infertility, assisted reproductive technologies, risk factors, prognostic chart.

Approach to the Evaluation and Treatment of Venous Thromboembolism in Pregnancy

2021 ◽  
Author(s):  
Benjamin Brenner ◽  
Elvira Grandone ◽  
Alexander Makatsariya ◽  
Jamilya Khizroeva ◽  
Victoria Bitsadze ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Pregnant Women ◽  
Assisted Reproductive Technologies ◽  
Total Duration ◽  
Reproductive Technologies ◽  
Increased Risk ◽  
Prothrombotic Risk Factors ◽  
Personalized Approach ◽  
In Pregnancy

AbstractThrombosis in pregnancy is a major cause of maternal and fetal morbidity and mortality. Risk stratification of venous thromboembolism (VTE) during pregnancy is complex. The hypercoagulability observed in pregnant women can reduce bleeding during childbirth, but may cause thrombosis especially in the presence of additional prothrombotic risk factors such as antiphospholipid antibodies or genetic thrombophilic defects. The availability of large datasets allows for the identification of additional independent risk factors, including assisted reproductive technologies (ARTs), endometriosis, and recurrent pregnancy loss. Data on the risk of VTE linked to COVID-19 in pregnant women are very limited, but suggest that infected pregnant women have an increased risk of VTE. Current guidelines on the prevention and treatment of VTE in pregnancy are based on available, albeit limited, data and mainly present expert opinion. Low-molecular-weight heparins (LMWHs) are the mainstay of anticoagulation to be employed during pregnancy. Administration of LMWH for VTE treatment in pregnancy should be based on the personalized approach, taking into account a weight-based adjusted scheme. During gestation, due to physiological changes, in women at high risk of VTE, monitoring of anti-Xa activity is performed to ensure adequate LMWH dosing. As for the treatment duration for pregnant women with acute VTE, guidelines suggest that anticoagulation should be continued for at least 6 weeks postpartum for a minimum total duration of therapy of 3 months.

scholarly journals An Update on Semen Physiology, Technologies, and Selection Techniques for the Advancement of In Vitro Equine Embryo Production: Section I

Animals ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 3248
Author(s):  
Morgan F. Orsolini ◽  
Stuart A. Meyers ◽  
Pouya Dini
Keyword(s):  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Sperm Parameters ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Embryo Production ◽  
Normal Sperm ◽  
Production Section ◽  
Equine Industry

As the use of assisted reproductive technologies (ART) and in vitro embryo production (IVP) expand in the equine industry, it has become necessary to further our understanding of semen physiology as it applies to overall fertility. This segment of our two-section review will focus on normal sperm parameters, beginning with development and extending through the basic morphology of mature spermatozoa, as well as common issues with male factor infertility in IVP. Ultimately, the relevance of sperm parameters to overall male factor fertility in equine IVP will be assessed.

scholarly journals Male Infertility: Shining a Light on Lipids and Lipid-Modulating Enzymes in the Male Germline

2020 ◽  
Vol 9 (2) ◽  
pp. 327 ◽  
Author(s):  
Jessica L.H. Walters ◽  
Bart M. Gadella ◽  
Jessie M. Sutherland ◽  
Brett Nixon ◽  
Elizabeth G. Bromfield
Keyword(s):  
Male Infertility ◽  
Assisted Reproductive Technologies ◽  
Membrane Lipids ◽  
Treatment Options ◽  
Reproductive Technologies ◽  
Male Factor ◽  
Male Germline ◽  
Efficacious Treatment ◽  
Cellular Dysfunction ◽  
The Impact

Despite the prevalence of male factor infertility, most cases are defined as idiopathic, thus limiting treatment options and driving increased rates of recourse to assisted reproductive technologies (ARTs). Regrettably, our current armory of ARTs does not constitute therapeutic treatments for male infertility, thus highlighting an urgent need for novel intervention strategies. In our attempts to fill this void, we have come to appreciate that the production of pathological levels of oxygen radicals within the male germline are a defining etiology of many idiopathic infertility cases. Indeed, an imbalance of reactive oxygen species can precipitate a cascade of deleterious sequelae, beginning with the peroxidation of membrane lipids and culminating in cellular dysfunction and death. Here, we shine light on the importance of lipid homeostasis, and the impact of lipid stress in the demise of the male germ cell. We also seek to highlight the utility of emerging lipidomic technologies to enhance our understanding of the diverse roles that lipids play in sperm function, and to identify biomarkers capable of tracking infertility in patient cohorts. Such information should improve our fundamental understanding of the mechanistic causes of male infertility and find application in the development of efficacious treatment options.

Insemination by husband’s sperm: fertility renewal in married couples with male infertility

2016 ◽  
pp. 159-163
Author(s):  
Yu.N. Gurzhenko ◽  
◽  
А.О. Кutsenko ◽  
Keyword(s):  
Male Infertility ◽  
Key Words ◽  
Causal Relationship ◽  
Linear Dependence ◽  
Reproductive Medicine ◽  
Married Couples ◽  
Male Factor ◽  
Key Words Male Infertility ◽  
Total State ◽  
Infertile Couples

The objective: analysis of the results in the resumption of fertility of infertile couples with male factor with a program of insemination with husband's sperm. Patients and methods. There are analyzed the results of achievement of genital function in 140 married couples with man’s infertility who in 2013–2015 underwent the program of insemination by man’s sperm at the Institute of Reproductive Medicine (Kyiv). Results. It has been stated that the pregnancy number and births after 3 attempts (420 cycles) with 3–5 month interval was reached in 17.0±1.8% and 15.0±1.8% of cases, respectively. There was confirmed the linear dependence between the fact of renewal of fertility and such factor as an age of a woman, duration of absence of native pregnancy, response of ovular function on stimulation. There was objectivized the influence on the result of readings of a spectrogram: the kind of pathospermia, the concentration of spermatozoons which is in the inverse dependence on the presence of predictors and determinants aggravating the total state of a man, and also the percent of actively movable fractions of sperms. Conclusions. Confirmed a causal relationship the result with such factors as age of women, duration of occurrence of natural pregnancy, ovulatory response to the stimulation. However, it is crucial to objectively brought the semen: patospermia, concentration of sperm and percentage of actively motile fractions thereof, as well as overall health of men. Key words: male infertility factor, insemination by man’s sperm, result.

Infertility and the Military Male

2019 ◽  
Vol 37 (01) ◽  
pp. 005-011
Author(s):  
Amanda B. Reed-Maldonado ◽  
Kristin C. Madden
Keyword(s):  
Male Infertility ◽  
Military Service ◽  
Clinical Investigation ◽  
Male Factor Infertility ◽  
Military Population ◽  
Male Factor ◽  
Scientific Publications ◽  
Military Service Members ◽  
Infertile Couples ◽  
The Military

AbstractMale infertility is a condition that affects approximately 50% of infertile couples and about 30% of those couples have only male factor infertility identified. There has been speculation that male military service members may have an even greater lifetime prevalence of infertility as compared to the general population, but very few scientific publications focus on male factor infertility in the military population specifically. This review will discuss many of the unique considerations regarding male infertility in the military and highlight future opportunities for research. The military/federal health system has the potential to serve as a leader in both the delivery of health care for male factor infertility and in the clinical investigation into the etiologies of and treatments for male factor infertility.

Sign in / Sign up

Export Citation Format

Share Document