Natural history of varicocele management in the era of assisted reproductive technologies (ART): lessons from a controlled trial of microsurgical varicocelectomy for male factor infertility

As the use of assisted reproductive technologies (ART) and in vitro embryo production (IVP) expand in the equine industry, it has become necessary to further our understanding of semen physiology as it applies to overall fertility. This segment of our two-section review will focus on normal sperm parameters, beginning with development and extending through the basic morphology of mature spermatozoa, as well as common issues with male factor infertility in IVP. Ultimately, the relevance of sperm parameters to overall male factor fertility in equine IVP will be assessed.

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The value of risk factors in infertile men in the aspect of choice of assisted reproductive technologies to renew fertility in married couples

HEALTH OF WOMAN ◽

10.15574/hw.2016.116.136 ◽

2016 ◽

pp. 136-139

Author(s):

Yu. N. Gurzhenko ◽

◽

A. O. Kutsenko ◽

Keyword(s):

Risk Factors ◽

Male Infertility ◽

Assisted Reproductive Technologies ◽

Married Couples ◽

Risk Groups ◽

Reproductive Technologies ◽

Male Factor Infertility ◽

Male Factor ◽

Key Words Male Infertility ◽

Personalized Approach

The objective: the rationalization of a personalized approach to the selection of the program art on the basis of the allocation of risk. Patients and methods. Were analyzed 180 couples with male factor infertility, which in 2012-2015, in the Institute of reproductive medicine (IRM) (Kiev) was held the program of intracytoplasmic sperm injection (ICSI) with the aim of restoring fertility. Examination and ICSI procedure is carried out in accordance with clinical protocols. Results. According to the results of analytical and synthetic analysis of primary documents (enhanced, adapted to the purpose of the work of the medical record) were identified risk factors (and their signs) for the development of male infertility and grouped by direction of impact. As a result, 25 of the 51 factors and their basis formed three groups: social (behavioral), biological/clinical and special medical. With the help of mathematical analysis it was determined the boundary values of the minimum and maximum of reliability of the negative result of the application of ART. Conclusion. It was proposed the predictive map for the determination of the probability of pregnancy in couples with male infertility problems with the application of ART. Was justified the separation of three risk groups to restore fertility in couples with male factor infertility using ART. Was based the principle of personalized approach to choosing the best program of art-based stratification of men at risk groups. Key words: male infertility, assisted reproductive technologies, risk factors, prognostic chart.

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Ways to reduce cesarean section under conditions typical urban maternity hospital

HEALTH OF WOMAN ◽

10.15574/hw.2017.119.50 ◽

2017 ◽

pp. 50-53

Author(s):

N.P. Goncharuk ◽

◽

N.R. Kovyda ◽

Keyword(s):

Cesarean Section ◽

Assisted Reproductive Technologies ◽

Reproductive Technologies ◽

Maternity Hospital ◽

High Risk Group ◽

Positive Trend ◽

Careful Study ◽

Male Factor ◽

Uncomplicated Pregnancy ◽

History Of

The objective: Study ways to reduce the frequency of cesarean section (CS) in a typical urban maternity hospital. Patients and methods. In the course of the study, the history of the delivery of women of a typical urban maternity home was studied and analyzed, the birth of which was completed by holding a COP for the period from 2001 to 2014. Results. According to the analysis, the number of births has steadily increased every year: from 2.082 in 2001 to 4.655 in 2014. However, during a careful study of the structure of labor during the study period, a wave-like increase in the percentage of CS was noted from 17% in 2001 to 21.25% in 2008, followed by a positive trend of its decline - to 17.8% in 2014. In the conditions of the study, the structure of the most common indications from the mother and the child for conducting operations of the COP was established. The leading place among the testimony from the mother was the scar on the uterus. This indicator increased from 6.6% in 2001 to 36.3% in 2014, that is, almost 5 times. So, in modern obstetrics, it remains an important problem to find ways to reduce the number of scars on the uterus as the main indication for CS operation. Conclusion. 1. The delivery of women with a vaginal scars on the uterus is a reserve for reducing the percentage of Caesarean section (CS), reducing blood loss, more physiological delivery, rapid post-natal adaptation of newborns, and restoring the woman in labor after the delivery. 2. Women with a pathological preliminar period constitute a high-risk group for the development of abnormalities of labor. Therefore, there is a need to create and implement algorithms for managing women with a pathological preliminar period. 3. In the presence of polyhydramnios or lack of water it is necessary to carry out careful monitoring of women in labor, to react promptly and immediately to changes in the nature of labor. 4. To reduce the number of abnormalities of labor, it is necessary to develop new criteria for the selection of candidates for rhodostimulation and the introduction of integrated approaches to assessing the «maturity» of the cervix. 5. The reserve for reducing the frequency of CS after ART is, of course, a group of patients whose cause of infertility is the male factor and the somatic anamnesis is not burdened and pregnancy is characterized by a favorable course, as well as patients younger than 30 with tubal peritoneal infertility in the history of Uncomplicated pregnancy. Key words: c-section, scar on the uterus, abnormal labor, assisted reproductive technologies.

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Re-imagining Reproduction: Unsettling Metaphors in the History of Imperial Science and Commercial Surrogacy in India

Somatechnics ◽

10.3366/soma.2015.0149 ◽

2015 ◽

Vol 5 (1) ◽

pp. 88-103 ◽

Cited By ~ 14

Author(s):

Kalindi Vora

Keyword(s):

Assisted Reproductive Technologies ◽

Reproductive Technologies ◽

The Body ◽

Body Parts ◽

Colonial History ◽

Women's Bodies ◽

Commercial Surrogacy ◽

Art Practices ◽

History Of ◽

Travel Industry

This paper provides an analysis of how cultural notions of the body and kinship conveyed through Western medical technologies and practices in Assisted Reproductive Technologies (ART) bring together India's colonial history and its economic development through outsourcing, globalisation and instrumentalised notions of the reproductive body in transnational commercial surrogacy. Essential to this industry is the concept of the disembodied uterus that has arisen in scientific and medical practice, which allows for the logic of the ‘gestational carrier’ as a functional role in ART practices, and therefore in transnational medical fertility travel to India. Highlighting the instrumentalisation of the uterus as an alienable component of a body and subject – and therefore of women's bodies in surrogacy – helps elucidate some of the material and political stakes that accompany the growth of the fertility travel industry in India, where histories of privilege and difference converge. I conclude that the metaphors we use to structure our understanding of bodies and body parts impact how we imagine appropriate roles for people and their bodies in ways that are still deeply entangled with imperial histories of science, and these histories shape the contemporary disparities found in access to medical and legal protections among participants in transnational surrogacy arrangements.

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In vitro fertilisation (IVF) versus intracytoplasmic sperm injection (ICSI) in patients without severe male factor infertility: study protocol for the randomised, controlled, multicentre trial INVICSI

BMJ Open ◽

10.1136/bmjopen-2021-051058 ◽

2021 ◽

Vol 11 (6) ◽

pp. e051058

Author(s):

Sine Berntsen ◽

Bugge Nøhr ◽

Marie Louise Grøndahl ◽

Morten Rønn Petersen ◽

Lars Franch Andersen ◽

...

Keyword(s):

Live Birth ◽

Intracytoplasmic Sperm Injection ◽

Controlled Trial ◽

Male Partner ◽

In Vitro Fertilisation ◽

Male Factor Infertility ◽

Male Factor ◽

Fertilisation Rate ◽

Randomised Controlled

IntroductionOver the last decades, the use of intracytoplasmic sperm injection (ICSI) has increased, even among patients without male factor infertility. The increase has happened even though there is no evidence to support that ICSI results in higher live birth rates compared with conventional in vitro fertilisation (IVF) in cases with nonmale factor infertility. The lack of robust evidence on an advantage of using ICSI over conventional IVF in these patients is problematic since ICSI is more invasive, complex and requires additional resources, time and effort. Therefore, the primary objective of the IVF versus ICSI (INVICSI) study is to determine whether ICSI is superior to standard IVF in patients without severe male factor infertility. The primary outcome measure is first live birth from fresh and frozen-thawed transfers after one stimulated cycle. Secondary outcomes include fertilisation rate, ongoing pregnancy rate, birth weight and congenital anomalies.Methods and analysisThis is a two-armed, multicentre, randomised, controlled trial. In total, 824 couples/women with infertility without severe male factor will be recruited and allocated randomly into two groups (IVF or ICSI) in a 1:1 ratio. Participants will be randomised in variable block sizes and stratified by trial site and age. The main inclusion criteria are (1) no prior IVF/ICSI treatment, (2) male partner sperm with an expected count of minimum 2 million progressive motile spermatozoa following density gradient purification on the day of oocyte pick up and (3) age of the woman between 18 and 42 years.Ethics and disseminationThe study will be performed in accordance with the ethical principles in the Helsinki Declaration. The study is approved by the Scientific Ethical Committee of the Capital Region of Denmark. Study findings will be presented, irrespectively of results at international conferences and submitted for publication in peer-reviewed journals.Trial registration numberNCT04128904. Pre-results.

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Features of psychoemotional condition and stress-assosiatate hormons bioproduction in pregnant women after application of assisted reproductive technologies

HEALTH OF WOMAN ◽

10.15574/hw.2018.132.121 ◽

2018 ◽

pp. 118-121

Author(s):

L.M. Vygivska ◽

◽

I.A. Usevych ◽

I.V. Maidannyk ◽

V.F. Oleshko ◽

...

Keyword(s):

Pregnant Women ◽

Emotional State ◽

Assisted Reproductive Technologies ◽

Past History ◽

Reproductive Technologies ◽

Main Group ◽

Psychological Status ◽

Perinatal Complications ◽

History Of ◽

High Level

The article represents the results of a prospective clinical and paraclinical examination of women with a history of infertility, pregnancy in which occurred as a result of the assisted reproductive technologies application. The objective: was to study the dynamics of pregnancy features of the psycho - emotional state and the concentration of stress-associated hormones in the serum of pregnant women after the application of assisted reproductive technologies in order to improve the tactics of antenatal care and prevention of obstetric and perinatal complications. Materials and methods. The main group consisted of 80 pregnant women with endocrine infertility, in which pregnancy occurred as a result of therapeutic cycles of ART, control – 50 first-pregnant women with spontaneous fertilization, taken in an arbitrary order of clinical, statistical and laboratory and instrumental studies. In pregnant women of the study groups, in order to determine the psycho emotional state in the screening mode, a clinical interview was conducted by filling out questionnaires that contained the Spilberger test questions in modification of Y.L. Hanina and «Test of relationof pregnant» by the method of I.V. Dobryakova. In the dynamics of pregnancy, the concentration of prolactin (PRL) and cortisol (K) was determined by the enzyme immunoassay on the Reader-MSR-1000 apparatus using test systems manufactured by Hema-Medicament (Russia). Results. Pregnant women with infertility in past history were characterized by a state of chronic stress. According to the results of the Spielberger test in modification Y .L. Hanina every second pregnant of main group had a high level of reactive and every fourth personal anxiety. Almost 90.0% of pregnant women after art are characterized by the presence of pathological PKGD, among which an alarming and depressive type was registered in every sixth and twelfth pregnant woman, respectively. The obtained data are confirmed by the results of the study of the level of K and PRL. For women with a history of infertility and pregnancy, which is the result of therapeutic cycles of ART, inherent in increasing concentrations of stress-associated hormones – cortisol and prolactin, which is one of the reasons for the complicated course of pregnancy and requires reasonable pathogenetic correction. Conclusion. For women who are pregnant as a result of the use of therapeutic cycles of art characterized by a high level of personal and reactive anxiety and PKGD, which confirm the presence of neuropsychiatric and afferent disorders. Increasing the concentration of stress-associated hormones is one of the causes of complicated pregnancy and requires a reasonable pathogenetic correction. Key words: pregnancy, infertility, assisted reproductive technologies, psychological status, cortisol, prolactin.

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FACTORS THAT DETERMINE THE OUTCOME OF PREGNANCY AND HEALTH OF CHILDREN BORN TO WOMEN WITH GENITOURINARY SYSTEM DISEASES USING ASSISTED REPRODUCTIVE TECHNOLOGIES

PEDIATRIA Journal named after G N SPERANSKY ◽

10.24110/0031-403x-2021-100-1-52-59 ◽

2021 ◽

Vol 100 (1) ◽

pp. 52-59

Author(s):

A.N. Plaksina ◽

◽

O.P. Kovtun ◽

S.L. Sinotova ◽

O.V. Limanovskaya ◽

...

Keyword(s):

Assisted Reproductive Technologies ◽

Risk Group ◽

Perinatal Period ◽

Reproductive Technologies ◽

Parasitic Diseases ◽

Genitourinary System ◽

System P ◽

History Of ◽

External Causes ◽

Mental And Behavioral Disorders

Objective of the research: identification of risk factors that potentially affect the outcomes of pregnancies achieved by assisted reproductive technologies (ART), with an assessment of the health status of children born to women with genitourinary system (GUS) diseases. Materials and methods: a retrospective uncontrolled non-randomized multicenter study of 821 women and 836 children under the age of 3 years. Results: gynecological history of women has little effect on pregnancy outcomes achieved by ART (Matthews coefficient <0,2). Children born to mothers with GUS diseases are statistically significantly more likely to have some infectious and parasitic diseases (p=0,0002), mental and behavioral disorders (p=0,009), diseases of the nervous system (p=0,031), respiratory system (p=0,009), oral cavity, salivary glands and digestion (p=0,002), musculoskeletal system and connective tissue (p=0,001), genitourinary system (p=0,009), certain conditions arising in the perinatal period (p=0,009), as well as trauma, poisoning, and some other consequences of external causes (p=0,009) than children from mothers without GUS diseases. Conclusion: children born by ART from women with GUS pathology are a risk group for the development of diseases in early age.

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