scholarly journals Notes from the Field: Ongoing Transmission of Candida auris in Health Care Facilities — United States, June 2016–May 2017

2017 ◽  
Vol 66 (19) ◽  
pp. 514-515 ◽  
Author(s):  
Sharon Tsay ◽  
Rory M. Welsh ◽  
Eleanor H. Adams ◽  
Nancy A. Chow ◽  
Lalitha Gade ◽  
...  
Keyword(s):  
United States ◽  
Health Care ◽  
Health Care Facilities ◽  
Candida Auris ◽  
Care Facilities

scholarly journals Service Delivery and Patient Outcomes in Ryan White HIV/AIDS Program–Funded and –Nonfunded Health Care Facilities in the United States

2015 ◽  
Vol 175 (10) ◽  
pp. 1650 ◽  
Author(s):  
John Weiser ◽  
Linda Beer ◽  
Emma L. Frazier ◽  
Roshni Patel ◽  
Antigone Dempsey ◽  
...  
Keyword(s):  
United States ◽  
Health Care ◽  
Service Delivery ◽  
Patient Outcomes ◽  
The United States ◽  
Health Care Facilities ◽  
Ryan White ◽  
Care Facilities ◽  
Aids Program ◽  
Hiv Aids

scholarly journals Three Unsuspected CT Diagnoses of COVID-19

2020 ◽  
Author(s):  
David Vu ◽  
Maryanne Ruggiero ◽  
Woo Sung Choi ◽  
Daniel Masri ◽  
Mark Flyer ◽  
...  
Keyword(s):  
United States ◽  
Health Care ◽  
Severe Acute Respiratory Syndrome ◽  
The United States ◽  
Health Care Facilities ◽  
Ground Glass ◽  
Imaging Findings ◽  
Adequate Supply ◽  
Imaging Characteristics ◽  
Care Facilities

Abstract PURPOSE: Coronavirus disease 2019 (COVID-19) is caused by a novel strain of coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has quickly spread around the globe. Health care facilities in the United States currently do not have an adequate supply of COVID-19 tests to meet the growing demand. Imaging findings for COVID-19 are nonspecific but include pulmonary parenchymal ground-glass opacities in a predominantly basal and peripheral distribution.METHODS: Three patients imaged for non-respiratory related symptoms with a portion of the lungs in the imaged field.RESULTS: Each patient had suspicious imaging findings for COVID-19, prompting the interpreting radiologist to suggest testing for COVID-19. All 3 patients turned out to be infected with COVID-19 and one patient is the first reported case of the coincident presentation of COVID-19 and an intraparenchymal hemorrhage.CONCLUSION: Using imaging characteristics of COVID-19 on abdominal or neck CT when a portion of the lungs is included, patients not initially suspected of COVID-19 infection can be quarantined earlier to limit exposure to others.

scholarly journals Survival, Persistence, and Isolation of the Emerging Multidrug-Resistant Pathogenic Yeast Candida auris on a Plastic Health Care Surface

2017 ◽  
Vol 55 (10) ◽  
pp. 2996-3005 ◽  
Author(s):  
Rory M. Welsh ◽  
Meghan L. Bentz ◽  
Alicia Shams ◽  
Hollis Houston ◽  
Amanda Lyons ◽  
...  
Keyword(s):  
Health Care ◽  
Multidrug Resistant ◽  
Health Care Facilities ◽  
Candida Auris ◽  
Pathogenic Yeast ◽  
Content Type ◽  
Health Care Settings ◽  
Care Facilities ◽  
Enrichment Protocol ◽  
Plastic Surfaces

ABSTRACTThe emerging multidrug-resistant pathogenic yeastCandida aurisrepresents a serious threat to global health. Unlike most otherCandidaspecies, this organism appears to be commonly transmitted within health care facilities and causes health care-associated outbreaks. To better understand the epidemiology of this emerging pathogen, we investigated the ability ofC. auristo persist on plastic surfaces common in health care settings compared with that ofCandida parapsilosis, a species known to colonize the skin and plastics. Specifically, we compiled comparative and quantitative data essential to understanding the vehicles of spread and the ability of both species to survive and persist on plastic surfaces under controlled conditions (25°C and 57% relative humidity), such as those found in health care settings. When a test suspension of 104cells was applied and dried on plastic surfaces,C. aurisremained viable for at least 14 days andC. parapsilosisfor at least 28 days, as measured by CFU. However, survival measured by esterase activity was higher forC. auristhanC. parapsilosisthroughout the 28-day study. Given the notable length of timeCandidaspecies survive and persist outside their host, we developed methods to more effectively cultureC. aurisfrom patients and their environment. Using our enrichment protocol, public health laboratories and researchers can now readily isolateC. aurisfrom complex microbial communities (such as patient skin, nasopharynx, and stool) as well as environmental biofilms, in order to better understand and preventC. auriscolonization and transmission.

scholarly journals Laboratory Analysis of an Outbreak of Candida auris in New York from 2016 to 2018: Impact and Lessons Learned

2019 ◽  
Vol 58 (4) ◽  
Author(s):  
YanChun Zhu ◽  
Brittany O’Brien ◽  
Lynn Leach ◽  
Alexandra Clarke ◽  
Marian Bates ◽  
...  
Keyword(s):  
Health Care ◽  
New York ◽  
Real Time ◽  
Real Time Pcr ◽  
Health Care Facilities ◽  
Clinical Isolates ◽  
Environmental Surveillance ◽  
Candida Auris ◽  
Content Type ◽  
Care Facilities

ABSTRACT Candida auris is a multidrug-resistant yeast which has emerged in health care facilities worldwide; however, little is known about identification methods, patient colonization, environmental survival, spread, and drug resistance. Colonization on both biotic (patients) and abiotic (health care objects) surfaces, along with travel, appear to be the major factors for the spread of this pathogen across the globe. In this investigation, we present laboratory findings from an ongoing C. auris outbreak in New York (NY) from August 2016 through 2018. A total of 540 clinical isolates, 11,035 patient surveillance specimens, and 3,672 environmental surveillance samples were analyzed. Laboratory methods included matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) for yeast isolate identification, real-time PCR for rapid surveillance sample screening, culture on selective/nonselective media for recovery of C. auris and other yeasts from surveillance samples, antifungal susceptibility testing to determine the C. auris resistance profile, and Sanger sequencing of the internal transcribed spacer (ITS) and D1/D2 regions of the ribosomal gene for C. auris genotyping. Results included (a) identification and confirmation of C. auris in 413 clinical isolates and 931 patient surveillance isolates as well as identification of 277 clinical cases and 350 colonized cases from 151 health care facilities, including 59 hospitals, 92 nursing homes, 1 long-term acute care hospital (LTACH), and 2 hospices, (b) successful utilization of an in-house developed C. auris real-time PCR assay for the rapid screening of patient and environmental surveillance samples, (c) demonstration of relatively heavier colonization of C. auris in nares than in the axilla/groin, and (d) predominance of the South Asia clade I with intrinsic resistance to fluconazole and elevated MIC to voriconazole (81%), amphotericin B (61%), flucytosine (5FC) (3%), and echinocandins (1%). These findings reflect greater regional prevalence and incidence of C. auris and the deployment of better detection tools in an unprecedented outbreak.

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