scholarly journals Effect of Korean Red Ginseng on Artificial Sand Dust (ASD) Induced Allergic Lung Inflammation

2014 ◽  
Vol 20 (3) ◽  
pp. 173-179 ◽  
Author(s):  
Jung-Ha Kim ◽  
Tae-Jin Lee ◽  
Im Jee-Aee ◽  
Duk-Chul Lee
2008 ◽  
Vol 55 (3) ◽  
pp. 348-357 ◽  
Author(s):  
T. Ichinose ◽  
S. Yoshida ◽  
K. Hiyoshi ◽  
K. Sadakane ◽  
H. Takano ◽  
...  

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 2002
Author(s):  
Seung-Heon Shin ◽  
Mi-Kyung Ye ◽  
Dong-Won Lee ◽  
Byung-Jun Kang ◽  
Mi-Hyun Chae

Korean Red ginseng (KRG), commonly used in traditional medicine, has anti-inflammatory, anti- oxidative, and anti-tumorigenic properties. Asian sand dust (ASD) is known to aggravate upper and lower airway inflammatory responses. BEAS-2B cells were exposed to ASD with or without KRG or ginsenoside Rg3. Mucin 5AC (MUC5AC), MUC5B, and MUC8 mRNA and protein expression levels were determined using quantitative RT-PCR and enzyme-linked immunosorbent assay. Nuclear factor kappa B (NF-κB), activator protein 1, and mitogen-activated protein kinase expression and activity were determined using western blot analysis. ASD induced MUC5AC, MUC5B, and MUC8 mRNA and protein expression in BEAS-2B cells, which was significantly inhibited by KRG and Rg3. Although ASD-induced mucin expression was associated with NF-κB and p38 mitogen-activated protein kinase (MAPK) activity, KRG and Rg3 significantly suppressed only ASD-induced NF-κB expression and activity. KRG and Rg3 inhibited ASD-induced mucin gene expression and protein production from bronchial epithelial cells. These results suggest that KRG and Rg3 have potential for treating mucus-producing airway inflammatory diseases.


2018 ◽  
Author(s):  
Ahn Chul Woo ◽  
Kim Jung Hye ◽  
Kahui Park ◽  
Lee Sang Bae ◽  
Nam Ji Sun ◽  
...  

2009 ◽  
Vol 38 (9) ◽  
pp. 1153-1160 ◽  
Author(s):  
Jae-Young Cha ◽  
Jin-Chul Park ◽  
Hee-Young Ahn ◽  
Kyung-Eun Eom ◽  
Bo-Kyung Park ◽  
...  

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