scholarly journals A SURVEY PAPER ON THE METHODS FOR CLASSIFYING THE BRAIN TUMOUR CELLS

2016 ◽  
Vol 05 (12) ◽  
pp. 73-75
Author(s):  
Sindhiya Devi.R .
Keyword(s):  
Brain Tumour ◽  
Tumour Cells ◽  
Survey Paper ◽  
The Brain

scholarly journals Brain tumours repurpose endogenous neuron to microglia signalling mechanisms to promote their own proliferation

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Kelda Chia ◽  
Marcus Keatinge ◽  
Julie Mazzolini ◽  
Dirk Sieger
Keyword(s):  
Brain Tumour ◽  
Brain Tumours ◽  
Atp Release ◽  
Live Imaging ◽  
Tumour Cells ◽  
Cellular Interactions ◽  
Neoplastic Cells ◽  
Highly Active ◽  
The Brain

Previously we described direct cellular interactions between microglia and AKT1+ brain tumour cells in zebrafish (Chia et al., 2018). However, it was unclear how these interactions were initiated: it was also not clear if they had an impact on the growth of tumour cells. Here, we show that neoplastic cells hijack mechanisms that are usually employed to direct microglial processes towards highly active neurons and injuries in the brain. We show that AKT1+ cells possess dynamically regulated high intracellular Ca2+ levels. Using a combination of live imaging, genetic and pharmacological tools, we show that these Ca2+ transients stimulate ATP-mediated interactions with microglia. Interfering with Ca2+ levels, inhibiting ATP release and CRISPR-mediated mutation of the p2ry12 locus abolishes these interactions. Finally, we show that reducing the number of microglial interactions significantly impairs the proliferation of neoplastic AKT1 cells. In conclusion, neoplastic cells repurpose the endogenous neuron to microglia signalling mechanism via P2ry12 activation to promote their own proliferation.

Severe Head Injury linked to Subsequent Development of Malignant Brain Tumour within a Short Period- A Case Report

2018 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Head Injury ◽  
Brain Tumour ◽  
Severe Head Injury ◽  
Case Reports ◽  
Subsequent Development ◽  
Malignant Brain Tumour ◽  
Tumour Development ◽  
Short Period ◽  
The Brain

There have been a few case reports of head injury leading to brain tumour development in the same region as the brain injury. Here we report a case where the patient suffered a severe head injury with contusion. He recovered clinically with conservative management. Follow up Computed Tomography scan of the brain a month later showed complete resolution of the lesion. He subsequently developed malignant brain tumour in the same region as the original contusion within a very short period of 15 months. Head injury patients need close follow up especially when severe. The link between severity of head injury and malignant brain tumour development needs further evaluation. Role of anti-inflammatory agents for prevention of post traumatic brain tumours needs further exploration.

scholarly journals Cancer Cell Invasion of Brain Tissue: Guided by a Prepattern?

2005 ◽  
Vol 6 (1) ◽  
pp. 21-31 ◽  
Author(s):  
Michael Wurzel ◽  
Carlo Schaller ◽  
Matthias Simon ◽  
Andreas Deutsch
Keyword(s):  
Lattice Gas ◽  
Individual Cell ◽  
Physical Structure ◽  
Tumour Cells ◽  
Malignant Cells ◽  
Malignant Brain Tumour ◽  
Tumour Bulk ◽  
Cell Motion ◽  
The Brain ◽  
Global Growth

The malignant brain tumourGlioblastoma multiforme(GBM) displays a highly invasive behaviour. Spreading of the malignant cells appears to be guided by the white matter fibre tracts within the brain. In order to understand the global growth process we introduce a lattice-gas cellular automaton model which describes the local interaction between individual malignant cells and their neighbourhood. We consider interactions between cells (brain cells and tumour cells) and between malignant cells and the fibre tracts in the brain, which are considered as a prepattern. The prepattern implies persistent individual cell motion along the fibre structure. Simulations with the model show that only the inclusion of the prepattern results in invading tumour and growing tumour islets in front of the expanding tumour bulk (i.e. the growth pattern observed in clinical practice). Our results imply that the infiltrative growth of GBMs is, in part, determined by the physical structure of the surrounding brain rather than by intrinsic properties of the tumour cells.

Production and characterization of monoclonal antibodies to human brain tumour cells

1988 ◽  
Vol 16 (3) ◽  
pp. 373-374
Author(s):  
ELIZABETH MORAN ◽  
RICHARD O'KENNEDY ◽  
JACK PHILLIPS ◽  
GEORGE KARR
Keyword(s):  
Monoclonal Antibodies ◽  
Human Brain ◽  
Brain Tumour ◽  
Tumour Cells

Children’s Brain Tumour Cells Produce RNA Particles with Incomplete Retrovirus Characteristics

Oncology ◽  
1982 ◽  
Vol 39 (3) ◽  
pp. 156-162 ◽  
Author(s):  
H.J. Thorne ◽  
D.G. Jose ◽  
F.C. Adams ◽  
R.J. Coelen ◽  
R.H. Whitehead ◽  
...  
Keyword(s):  
Brain Tumour ◽  
Tumour Cells

scholarly journals Single-cell resolution in high-resolution synchrotron X-ray CT imaging with gold nanoparticles

2013 ◽  
Vol 21 (1) ◽  
pp. 242-250 ◽  
Author(s):  
Elisabeth Schültke ◽  
Ralf Menk ◽  
Bernd Pinzer ◽  
Alberto Astolfo ◽  
Marco Stampanoni ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Single Cell ◽  
Brain Tumour ◽  
Ex Vivo ◽  
Small Animal ◽  
C6 Glioma Cells ◽  
X Ray ◽  
Local Tomography ◽  
The Brain

Gold nanoparticles are excellent intracellular markers in X-ray imaging. Having shown previously the suitability of gold nanoparticles to detect small groups of cells with the synchrotron-based computed tomography (CT) technique bothex vivoandin vivo, it is now demonstrated that even single-cell resolution can be obtained in the brain at leastex vivo. Working in a small animal model of malignant brain tumour, the image quality obtained with different imaging modalities was compared. To generate the brain tumour, 1 × 105C6 glioma cells were loaded with gold nanoparticles and implanted in the right cerebral hemisphere of an adult rat. Raw data were acquired with absorption X-ray CT followed by a local tomography technique based on synchrotron X-ray absorption yielding single-cell resolution. The reconstructed synchrotron X-ray images were compared with images obtained by small animal magnetic resonance imaging. The presence of gold nanoparticles in the tumour tissue was verified in histological sections.

Gliomatosis Cerebri: A Brain Tumour Which is too Difficult to Treat?

1998 ◽  
Vol 43 (3) ◽  
pp. 84-86 ◽  
Author(s):  
D. Choi ◽  
U. Schulz ◽  
K. Seex
Keyword(s):  
Brain Tumour ◽  
Clinical Symptoms ◽  
Ct Scanning ◽  
Mass Effect ◽  
World Health Organisation ◽  
Gliomatosis Cerebri ◽  
World Health ◽  
Low Grade ◽  
The Brain ◽  
Diffuse Brain

Gliomatosis cerebri is a rare form of primary diffuse brain tumour first described by Nevin in 1938.1 It was originally considered to be a post-mortem diagnosis before Troost et al reported a clinically diagnosed case in 1987.2 However antemortem diagnosis remains difficult due to vague clinical symptoms and often non-specific findings on CT scanning. Gliomatosis cerebri has been classified by the World Health Organisation as an infiltrative tumoural process, which involves at least two, and usually three, lobes of the brain.3 Magnetic resonance (MR) imaging shows a diffuse infiltrative process with possible mass effect but no necrosis. histology is usually of a low grade astrocytic neoplasm which seemingly infiltrates out of proportion to the degree of anaplasia. We report two patients who presented over the past year, whose clinical and radiological features prompted a preoperative diagnosis of gliomatosis cerebri, confirmed by biopsy.

scholarly journals Using surgical and oncology workload to plan brain tumour trial recruitment in England

2019 ◽  
Vol 21 (Supplement_4) ◽  
pp. iv11-iv12
Author(s):  
Kerlann Le Calvez ◽  
Peter Treasure ◽  
Matt Williams
Keyword(s):  
Clinical Trials ◽  
Brain Tumour ◽  
Brain Tumours ◽  
Adult Patients ◽  
Trial Recruitment ◽  
Trade Off ◽  
Primary Brain Tumour ◽  
Rational Planning ◽  
The Brain ◽  
Over Time

Abstract Introduction Access to clinical trials is a common request for patients with brain tumours. However, opening clinical trials requires additional work per centre opened. We have previously shown that surgical and oncology workload varies between centres, and fluctuates over time. There is a trade-off between offering access to clinical trials and increasing costs associated with opening trials in centres that treat few patients. Methods We used two separate datasets from England covering 3 years – one for neurosurgical workload and one for radiotherapy. We only included adult patients and calculated cumulative proportions of the malignant primary brain tumour population (C71) by number of centres. We investigated stability by checking how many patients would have to be added/ removed from a centre to change their rank. Results There were 7061 surgical and 5060 radiotherapy patients. To capture 25% of patients, we would need to open trials in 4 surgical/5 radiotherapy centres; for 50%, 9 surgical/ 13 radiotherapy centres; for 75%, 16 surgical/ 24 radiotherapy centres. Centre rank was fluid: adding 16 surgical/9 radiotherapy patients would change the rank of a centre. Discussion These are the first data to allow for rational planning of trials in brain tumour patients. We have shown that we can reach 75% of the brain tumour population by opening trials in ~50% of surgical and radiotherapy centres. Centre rank alters over year, so we should be cautious about being too prescriptive. Nonetheless, these data should allow some rational planning of trial centre inclusion.

scholarly journals Epithelioid and spindle-cell haemangioendothelioma in the brain of a dog: a case report

2018 ◽  
Vol 63 (No. 4) ◽  
pp. 193-197 ◽  
Author(s):  
T. Yaman ◽  
A. Uyar ◽  
OF Keles ◽  
Z. Yener
Keyword(s):  
Endothelial Cells ◽  
Blood Cells ◽  
Spindle Cell ◽  
Clinical Symptoms ◽  
Brain Parenchyma ◽  
Tumour Cells ◽  
Macroscopic Findings ◽  
The Right ◽  
The Brain ◽  
Cut Surface

A 9.5-year-old male Belgian malinois dog died after showing clinical symptoms that included fatigue, anorexia and dyspnoea. Necropsy revealed macroscopic findings in the brain and other organs. A solitary, brown-red-coloured mass, approximately 0.5 cm thick and 1.5 × 2 cm in diameter, was detected on the right side of the medulla oblongata, pons and cerebellum. The cut surface showed no invasion of the brain parenchyma. Histologically, the neoplasm was characterised by proliferation of endothelial cells, which showed epithelioid and spindle cell features. Some tumour cells had intracytoplasmic lumen formations containing red blood cells. The nuclei of the tumour cells were large and vesicular. In immunohistochemical experiments the tumour cells stained positive for factor VIII-related antigen, CD31 and CD34. A description is provided of the features of this epithelioid and spindle-cell haemangioendothelioma (EHE) that originated from vessels of the meninges in the subarachnoid space.

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