Feasibility of Platelet Indices As Possible Biomarkers in Evaluation of Initial Vascular Risks in Diabetes Mellitus: Correlation of Platelet Dysfunction Indices With Hematopoietic and Biochemical Biomarkers in Non-diabetic Subjects

2015 ◽  
Vol 2015 (1) ◽  
pp. 8-21
Author(s):  
Sabiha Ashraf ◽  
◽  
Rajiv Ranjan ◽  
Harender Singh ◽  
Madhur Kudesia ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Platelet Dysfunction ◽  
Biochemical Biomarkers ◽  
Platelet Indices

Evaluation of platelet indices in complicated and non-complicated patients of diabetes mellitus

2019 ◽  
Vol 10 (3) ◽  
pp. 180-183
Author(s):  
Shruti K Katkoria ◽  
◽  
Rohit V Bhalara ◽  
Gauravi A Dhruva ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Platelet Indices

scholarly journals Platelet indices in type 2 diabetes mellitus and their association with microvascular complications

2019 ◽  
Vol 9 (1) ◽  
pp. 23-28
Author(s):  
Ravindra M. Kshirsagar ◽  
◽  
Shilpa Deoke ◽  
Shamim Akhtar ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Microvascular Complications ◽  
Platelet Indices

scholarly journals Mean Platelet Volume (MPV): New diagnostic indices for co-morbidity of Tuberculosis and Diabetes Mellitus

2020 ◽  
Author(s):  
feifan xu ◽  
shengyan qu ◽  
lin Wang ◽  
Yongwei Qin
Keyword(s):  
Diabetes Mellitus ◽  
Differential Diagnosis ◽  
Blood Glucose ◽  
Sensitivity And Specificity ◽  
Mean Platelet Volume ◽  
Fasting Blood Glucose ◽  
Platelet Volume ◽  
Distribution Width ◽  
Platelet Indices ◽  
Co Morbidity

Abstract Background: Tuberculosis (TB) and type 2 diabetes mellitus (DM) are global health diseases with high morbidity and mortality. Few studies have focused on platelet indices in TB-DM coinfection patients. The objective of this work was to analyze the platelet indices in TB, DM and TB-DM patients to assess the predictive value of the platelet index for the risk of these diseases.Methods: In total, 246 patients admitted to our hospital were distributed into three groups (113 TB, 59 DM and 74 TB+DM). A total of 133 individuals were also recruited as healthy controls (HC). Platelet indices, namely, platelet count (PC), mean platelet volume (MPV), plateletcrit (PCT) and platelet distribution width (PDW), were compared among the four groups, and the relationship with inflammatory markers was explored by using statistical software.Results: Our study discovered that MPV and PCT were significantly downregulated in TB+DM patients (9.95±1.25 fL, 0.20±0.05%, P<0.0001, P=0.0121, separately) compared with DM individuals (10.92±1.17 fL, 0.22±0.04%). Moreover, the changes in MPV were significantly higher in TB+DM patients (9.95±1.25 fL, P=0.0041) than in TB patients (9.42±1.01 fL). No differences were found in PLT and PDW among the four groups (P>0.05). The sensitivity and specificity of MPV in the differential diagnosis of DM patients vs TB+DM patients were 64.9% and 66.1% (P<0.0001), respectively, and the sensitivity and specificity of MPV between TB patients and TB+DM patients was 60.8% and 66.4%, respectively (P=0.003). MPV improved the diagnosis sensitivity when it was combined with clinical parameters, such as fasting blood glucose in DM and Mycobacterium tuberculosis culture result in TB (76.3% vs 64.9%, 72.6% vs 60.8%, P<0.0001, P=0.001, respectively). In addition, the sensitivity and specificity of PCT in the differential diagnosis of DM patients vs TB+DM patients were 69.5% and 59.4%, respectively (P=0.008). PCT improved the diagnosis sensitivity when combined with fasting blood glucose in DM (72.9% vs 64.9%, P=0.004). In addition, MPV was linked to CRP (C-reactive protein) [Ed1] and ESR (erythrocyte sedimentation rate) in the TB+DM patients (r = 0.3203, P =0.0054, r = 0.2504, P=0.0307) but PCT was not (r = 0.1905, r = 0.008675, P>0.05, respectively).Conclusions: Our research shows that MPV and PCT might be good clinical laboratory markers to distinguish TB+DM patients from TB or DM individuals, thus providing support for earlier clinical diagnosis, prevention, and therapy.When defining abbreviations and acronyms, please be consistent in whether it is the abbreviated or spelled-out form that appears in parentheses. Some journals request a specific style, so please review the journal's guidelines.

scholarly journals ANALYSIS PLATELET INDICES IN PATIENT TYPE 2 DIABETES MELLITUS WITH VASCULAR COMPLICATION

2019 ◽  
Vol 26 (1) ◽  
pp. 102
Author(s):  
Nelly Tolla Taggara
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Clinical Pathology ◽  
Vascular Complication ◽  
P Value ◽  
Distribution Width ◽  
Patient Type ◽  
Platelet Indices

ANALYSIS PLATELET INDICES IN PATIENT TYPE 2 DIABETES MELLITUS WITH VASCULAR COMPLICATION      Nelly1, Suci Aprianti2 ,Darmawaty ER31Medical Doctor Specialist Education Program of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo hospital, Makassar2Departement of Clinical Pathology, Faculty of Medicine, Hasanuddin University3Departement of Clinical Pathology, Faculty of Medicine, Hasanuddin University /Dr. Wahidin Sudirohusodo Hospital, Makassar ABSTRACT Introduction :Type 2 Diabetes Mellitus(T2DM) is an endocrin disease that is marked by hyperglycemic condition due to a decrease increase in insulin secretion and insulin resistance or both. Indonesia is the 7th country with the highest incidence of diabetes mellitus in the world. Progression of the disease is slow and cause vascular endothelial damage. The increase  of platelet indices is suspected to be an indications   of vascular complicationsObjective :To evaluate the  platelet indices in diabetics patients with complication and correlate these indices with GDP and HbA1c. Materials and methods :We analyzed platelet indices and biochemical data of patients seen in outpatients by clinicans of  wahidin soedirohusodo hospitals. 120 patients with type 2 diabetes mellitus were included with 64 patients vascular complication and 56 patients without complication.Result :We observed an increase in mean platelet volume (MPV): 9,96 + 1.99vs 8.87 + 1.35(p-value: 0,001) ;in platelet distribution width (PDW): 15.29 + 3.45 vs 12.36 + 2.819(p-value: 0,000; without increase  plateletcrit (PCT); 0.28 + 0.14 vs 0.25 + 0.12 (p-value: 0.168). we observed  a correlation between FBG with PDW (P=0.044).Conclusion :The study findings point to the significant differences in platelet indices (MPV and PDW) in patients with T2DM with complication and without complication, suggesting the presence of platelet in diabetics type 2 patients more reactive and aggregatable  in this group of individuals. These suggest that platelet evaluation may be useful in the early detection of long term complication in diabetics patients.Keyword :T2DM, platelet indices, complication vascular   

scholarly journals Platelet indices in type 1 diabetes mellitus

2019 ◽  
Vol 2 (2) ◽  
pp. 69-75
Author(s):  
Mehmet Inanir ◽  
Isa Sincer ◽  
Yilmaz Gunes
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Platelet Indices

scholarly journals THE EFFECT OF METFORMIN AND GLIMEPIRIDE ON PLATELET COUNT AND INDICES AMONG DIABETIC PATIENTS WERE ATTENDING JABER ABU ALIZ DIABETIC CENTER IN KHARTOUM STATE

2021 ◽  
Vol 10 (1) ◽  
pp. 93-98
Author(s):  
Hussein Abker Hussein ◽  
Fatima-Elzhra Ahmed Elmagzoub ◽  
Dalia Mohammed Babikir ◽  
Mouna Adel Samaan
Keyword(s):  
Diabetes Mellitus ◽  
Platelet Count ◽  
Hba1c Level ◽  
Venous Blood ◽  
Large Cell ◽  
Control Group ◽  
Diabetic Patients ◽  
Distribution Width ◽  
Accelerated Atherosclerosis ◽  
Platelet Indices

Diabetes mellitus (DM) is a global pandemic, Platelets have crucial role in accelerated atherosclerosis and thrombosis which characterize DM. Aim The aim of the study was to detect the effect of two major oral hypoglycemic drugs (Metformin and Glimepiride) on platelet count and indices{ MPV (Mean platelet volume), PLCR (platelet large cell ratio),PDW (platelet distribution width)}.Beside, to studythe effects of variation induration of the drug, dose of drug, HbA1C level and associated complications. Material and methods A case control study was performed 146subjects 50 were using metformin, 46 were using Glimepiride in addition to 50 apparently healthy non-diabetic matching for age and sex subjects have been tested as control group. EDTA anti-coagulated venous blood samples has been taken from eachsubject , platelet count and indices were measured using automatic blood counter (Sysmex KX-21N) and HbA1C was Measured using Ichroma II . Statistics was performed by SPSS (version 22). Results The results showed that both types of treatment (Metformin, Glimepiride)have reduced the platelets indices but the reduction in Glimepiride was insignificant except in PDW when comparedwith controls. Also both treatments have no effect on platelet count and there was insignificant variation between different doses of metformin and Glimepiride.Glimepiride diabetic patients from 15 to 20 yearshave increased platelet count in contrast to patients whom used glimepiride for less than 15 years.there was increased platelet count and decreased platelet indices in patients with foot ulcers whom using glimepiride than patients without complications. Also increased platelet indices in patients with HbA1C level less than 6% in contrast to those with HbA1C more than 7%. Conclusion It is concluded that both types of drugsreduce platelet indices. Glimepiride have a good prognostic effect on the Pro-thrombotic state and accelerated atherosclerosis which is associated with type 2 study population because the platelet indices were insignificant compared withcontrols. Keywords: Diabetes Mellitus, Metformin, Glimepiride, platelet count and indices

Platelet indices and glucose control in type 1 and type 2 diabetes mellitus: A case-control study

2017 ◽  
Vol 27 (10) ◽  
pp. 902-909 ◽  
Author(s):  
F. Zaccardi ◽  
B. Rocca ◽  
A. Rizzi ◽  
A. Ciminello ◽  
L. Teofili ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glucose Control ◽  
Case Control Study ◽  
Case Control ◽  
Platelet Indices ◽  
Control Study
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