Acute and Sub-acute Toxicity of Ganoderma applanatum (Pres.) Pat. Extract Mediated Silver Nanoparticles on Rat

Ganoderm applanatum is a polypore macrofungi and traditionally used as medicine rather than fodder. Silver nanoparticles mediated by G. applanatum extract were synthesized, characterized and toxicity impacts were investigated for their pharmacological and medicinal uses. The synthesized silver nanoparticles were of average 58.78 nm in diameter with -13.8 mV zetpotential, analysed by dynamic light scattering method. Fourier transform infrared spectroscopy analysis of synthesized nanoparticles confirmed the capping and stabilizing with mycochemicals, that showed transmittance at 3606 cm-1 corresponds to O-H stretch for phenol, 2430 cm-1 corresponds to N-H stretch for primary and secondary amines. 2000 mg kg-1, 200 mg kg-1 and 400 mg kg-1 doses of silver nanoparticles showed non-significant (p<0.05) increase in body weight and organ weight. Non-significant increase in RBC indices were observed and significant (p<0.05) increase in WBC count (7.28±0.41 × 103 µL-1 and 8.41±0.35 × 103 µL-1) at 200 mg kg-1 and 400 mg kg-1 doses of silver nanoparticles were observed. Thus, G. applanatum extract mediated silver nanoparticles can be used pharmacologically and medicinally due to their nontoxic effect.

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Effects of UV Radiation and pH of Tannic Acid Solution in the Synthesis of Silver Nanoparticles

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.911.110 ◽

2014 ◽

Vol 911 ◽

pp. 110-114

Author(s):

Kanitta Watcharaporn ◽

Mantana Opaprakasit ◽

Vimolvan Pimpan

Keyword(s):

Silver Nanoparticles ◽

Acid Solution ◽

Uv Radiation ◽

Tannic Acid ◽

Suitable Condition ◽

Scattering Method ◽

Dynamic Light Scattering Method ◽

Transmission Electron ◽

Uv Visible ◽

Tannic Acid Solution

The reductions of silver nitrate by tannic acid at various pH with and without UV radiation at room temperature were done in order to study the effects of UV radiation and pH of tannic acid solution in the synthesis of silver nanoparticles. The results from UV-Visible spectroscopy, dynamic light scattering method and transmission electron microscopy indicated that using UV radiation resulted in silver nanoparticles with smaller particles and narrower size distribution at every pH. The results also revealed that smallest particles without agglomeration were obtained when alkali condition was applied. Therefore, the suitable condition for synthesizing silver nanoparticles in this research was to use UV radiation and tannic acid solution having pH of 8.0.

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Structural Changes of the Lipid Model Systems in the Presence of Enzymes or Silver Nanoparticles

Biointerface Research in Applied Chemistry ◽

10.33263/briac116.1506815074 ◽

2021 ◽

Vol 11 (6) ◽

pp. 15068-15074

Keyword(s):

Surface Tension ◽

Silver Nanoparticles ◽

Structural Changes ◽

Particle Diameter ◽

Biological Membranes ◽

Egg Yolk ◽

Model Systems ◽

Scattering Method ◽

Dynamic Light Scattering Method ◽

Equilibrium Surface Tension

This work aimed to study the interaction of silver nanoparticles (AgNP) and lipases with models of biological membranes based on natural phospholipid and cholesterol. The crude phosphatidylcholine from egg yolk (PCe1) and synthetic cholesterol (Chol) were obtained from Sigma-Aldrich. Porcine pancreatic lipase (PPL) was obtained by purification from the hog pancreas. AgNP dispersion was prepared by the well-known citrate method. Measurement of surface tension (ST) was carried out using a BPA-1P device. The equilibrium surface tension (eST) was obtained by calculating the ST-time isotherms using the ADSA program. The particle sizes were determined by the dynamic light scattering method. An addition of AgNPs led to a pronounced decrease in both ST and eST (whereas almost no changes occurred by lipase addition), and AgNPs destructed the large lipid particles. The average lipid particle diameter values changed drastically, whereas the effective particle diameter values were almost the same by lipase addition. Thus, the interactions of AgNPs or lipase with the mixture of natural phospholipid and cholesterol have had entirely different features. These effects are interesting for modeling the interactions of inorganic and organic compounds with biological membranes.

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Reaction of arylmethylenemalonaldehydes with some nucleophiles

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19872699 ◽

1987 ◽

Vol 52 (11) ◽

pp. 2699-2709 ◽

Cited By ~ 3

Author(s):

Dalimil Dvořák ◽

Zdeněk Arnold

Keyword(s):

Inorganic Anions ◽

Secondary Amines ◽

Tertiary Amines ◽

Primary And Secondary Amines ◽

Dipolar Structure

Reaction of arylmethylenemalonaldehydes with tributylphosphine and tertiary amines affords compounds of dipolar structure whereas reaction with primary and secondary amines leads to 1,4-addition products. Salts of nucleophilic inorganic anions add to arylmethylenemalonaldehydes under formation of salts of substituted malonaldehydes.

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Some 1-substitution derivatives of 4-aryl-2,3-dihalogeno-1-naphthols

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19840110 ◽

1984 ◽

Vol 49 (1) ◽

pp. 110-121 ◽

Cited By ~ 1

Author(s):

Jiří Křepelka ◽

Drahuše Vlčková ◽

Milan Mělka

Keyword(s):

Thionyl Chloride ◽

Oxirane Ring ◽

Secondary Amines ◽

Two Phase ◽

Lytic Effect ◽

Primary And Secondary Amines ◽

Phase Medium ◽

Chloro Derivatives ◽

Derivatives Of

Alkylation of derivatives of 4-aryl-1-naphthols (I-V) by 2,3-epoxypropyl chloride in methanolic sodium hydroxide gave epoxy derivatives VI, VIII, IX, XI and XII, apart from products of cleavage of the oxirane ring, VII and X. Analogous alkylation of compounds I, IV and V by 2-(N,N-diethylamino)ethyl chloride hydrochloride in a two-phase medium afforded basic ethers XIII to XV. The cleavage of the oxirane ring in compound VI by the action of primary and secondary amines, piperidine and substituted piperazines led to compounds XVI-XXIV. Reaction of thionyl chloride with compounds XXI, XXII and XXIV gave chloro derivatives XXV-XXVII.Exposure of compound XXII to 4-methylbenzenesulfonyl chloride produced compound XXVIII, retaining the secondary alcoholic group. In an antineoplastic screening in vivo none of the compounds prepared had an appreciable activity. Compound XVII, being an analogue of propranolol, was used in the test of isoproterenolic tachycardia, and showed a beta-lytic effect comparable with that of propranol.

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Microwave-assisted green synthesis of silver nanoparticles using dried extracts of Chlorella vulgaris and antibacterial activity studies

Green Processing and Synthesis ◽

10.1515/gps-2020-0024 ◽

2020 ◽

Vol 9 (1) ◽

pp. 283-293

Author(s):

Milad Torabfam ◽

Meral Yüce

Keyword(s):

Silver Nanoparticles ◽

Green Synthesis ◽

Chlorella Vulgaris ◽

Metallic Nanoparticles ◽

Nitrate Solution ◽

Spherical Shape ◽

Silver Nitrate Solution ◽

Spectroscopy Analysis ◽

Bacterial Diseases ◽

Serovar Typhimurium

AbstractGreen synthesis of metallic nanoparticles (NPs) is acquiring considerable attention due to its environmental and economic superiorities over other methods. This study describes the practical synthesis of silver nanoparticles (AgNPs) through the reduction of silver nitrate solution using an algal source, Chlorella vulgaris, as the reducing as well as the stabilizing agent. The energy required for this synthesis was supplied by microwave radiation. The ultraviolet-visible spectroscopy exhibited a single peak related to the surface plasmon absorbance of AgNPs at 431 nm. The AgNPs with high stability (a zeta potential of −17 mV), hydrodynamic size distribution of 1–50 nm, and mostly spherical shape were obtained through a 10 min process. Fourier transform infrared spectroscopy analysis revealed that several functional groups, including carbonyl groups of C. vulgaris, play a significant role in the formation of functional NPs. Antibacterial features of the produced AgNPs were verified against those of Salmonella enterica subsp. enterica serovar typhimurium and Staphylococcus aureus, demonstrating a considerable growth inhibition at increasing concentrations of the NPs. As a result, the formed AgNPs can be used as a promising agent against bacterial diseases.

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