Effect of Sharpey's Fibers on the Stress Distribution in the Anulus Fibrosus of an Intervertebral Disc Subjected to Compression

Author(s):  
Sébastien Demers ◽  
Abdel-Hakim Bouzid ◽  
Sylvie Nadeau
Author(s):  
John M. Peloquin ◽  
Jonathon H. Yoder ◽  
Nathan T. Jacobs ◽  
Sung M. Moon ◽  
Alexander C. Wright ◽  
...  

Degeneration of the intervertebral disc (IVD) is implicated in low back pain, which is a costly and prevalent disease. Since the IVD is a mechanically active organ, it is important to consider its mechanical behavior as one factor in the degenerate pathology. Strain can be measured directly by imaging methods, but the stress distribution within the disc must be calculated. The stress distribution for a particular strain state is dependent on the IVD’s material properties and its geometry. While the material properties of the tissues comprising IVD have been extensively studied, its three-dimensional geometry remains incompletely characterized. Prior whole-disc models have been constructed from single IVDs. While this approach ensures that the geometry has a physiological basis, it is uncertain the degree to which results from a single IVD shape can be generalized to the entire population.


Spine ◽  
2007 ◽  
Vol 32 (25) ◽  
pp. E734-E740 ◽  
Author(s):  
Hiroki Yasuoka ◽  
Takashi Asazuma ◽  
Kuniaki Nakanishi ◽  
Yasuo Yoshihara ◽  
Atsushi Sugihara ◽  
...  

1989 ◽  
Vol 6 (2) ◽  
pp. 223
Author(s):  
Hyun Kug Shin ◽  
Jae Chang Lee ◽  
Myun Hwan Ahn ◽  
Jong Chul Ahn ◽  
Joo Chul Ihn

2019 ◽  
Vol 252 ◽  
pp. 07006 ◽  
Author(s):  
Robert Karpiński ◽  
Łukasz Jaworski ◽  
Józef Jonak ◽  
Przemysław Krakowski

The aim of this article was to present the results of a preliminary study on the stress distribution in the lumbar intervertebral disc [IVD] under loads induced during daily activities. Basic anatomy, biomechanical analysis of the vertebra and intervertebral disc were introduced. The third and fourth lumbar vertebrae were chosen for the study because they carry considerably higher loads, especially while standing or sitting. The static mechanical analyses using the finite element method (FEM) were conducted for four standard loads reflecting patient’s positions: recumbent, standing, sitting and standing with additional loads, and three models: an intervertebral disc with an inner nucleus pulposus and two prosthetic intervertebral discs, with or without an artificial nucleus. The FEM analysis was performed in the SolidWorks Simulation module on reverse-engineered 3D models of vertebrae and the intervertebral disc, based on a series of computed tomography [CT] scans of the patient’s spine, which had been properly processed in Materialise Mimics software and exported to CAD files. The model of the fourth intervertebral disc, placed between third and fourth vertebra, had been additionally modified to include its inner core, the nucleus pulposus.


2009 ◽  
Vol 10 (6) ◽  
pp. 522-530 ◽  
Author(s):  
Huina Zhang ◽  
Frank La Marca ◽  
Scott J. Hollister ◽  
Steven A. Goldstein ◽  
Chia-Ying Lin

Object The goal in this study was to develop a convenient, less-invasive animal model to monitor progression of intervertebral disc (IVD) degeneration for future testing of new treatments for disc degeneration. Methods Level 5/6 and 7/8 IVDs of rat caudal spine were stabbed laterally with 18- or 21-gauge hypodermic needles to a depth of 5 mm from the subcutaneous surface with the aid of fluoroscopy. In vivo MR imaging studies were performed at 4, 8, and 12 weeks postsurgery to monitor progression of IVD degeneration. Histological analysis including H & E and safranin O staining, and immunohistochemical studies of collagen type II and bone morphogenetic protein receptor type II (BMPRII) were assessed at 12 weeks postsurgery. Results The 18- and 21-gauge needle–stabbed discs illustrated decreases in both the T2 density and MR imaging index starting at 4 weeks, with no evidence of spontaneous recovery by 12 weeks. Histological staining demonstrated a decreased nucleus pulposus (NP) area, and the NP–anulus fibrosus border became unclear during the progression of disc degeneration. Similar patterns of degenerative signs were also shown in both safranin O– and collagen type II–stained sections. The BMPRII immunohistochemical analysis of stabbed discs demonstrated an increase in BMPRII expression in the remaining NP cells and became stronger in anulus fibrosus with the severity of disc degeneration. Conclusions After introducing an 18- or 21-gauge needle into the NP area of discs in the rat tail, the stabbed disc showed signs of degeneration in terms of MR imaging and histological outcome measurements. Changes in BMPRII expression in this animal model provide an insight for the effectiveness of delivering BMPs into the region responsible for chondrogenesis for disc repair. This convenient, less-invasive, reproducible, and cost-effective model may be a useful choice for testing novel treatments for disc degeneration.


Spine ◽  
2002 ◽  
Vol 27 (20) ◽  
pp. 2212-2219 ◽  
Author(s):  
Gabriella Cs-Szabo ◽  
Deborah Ragasa-San Juan ◽  
Vani Turumella ◽  
Koichi Masuda ◽  
Eugene J-M.A. Thonar ◽  
...  

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