White matter hyperintensities, executive function and global cognitive performance in vascular mild cognitive impairment

Vascular mild cognitive impairment (VaMCI) represents an early symptomatic stage of vascular cognitive impairment and might be associated to fronto-executive dysfunction.MethodsTwenty-six individuals (age: 73.11±7.90 years; 65.4% female; schooling: 9.84±3.61 years) were selected through neuropsychological assessment and neuroimaging. Clinical and neuroimaging data of VaMCI individuals (n=15) were compared to normal controls (NC, n=11) and correlated with Fazekas scale.ResultsVaMCI performed significantly worse than NC in Trail-Making Test (TMT) B, errors in TMT B, difference TMT B-A and Cambridge Cognitive Examination (CAMCOG) final scores. Correlations were found among scores in modified Fazekas scale and performances in TMT B (time to complete and errors), difference TMT B-A and CAMCOG total score.ConclusionExtension of white matter hyperintensities might be correlated to poorer global cognition and impairments in a set of fronto-executive functions, such as cognitive speed, set shifting and inhibitory control in VaMCI.

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Correlation between instrumental activities of daily living and white matter hyperintensities in amnestic mild cognitive impairment: results of a cross-sectional study

Neurological Sciences ◽

10.1007/s10072-012-1120-z ◽

2012 ◽

Vol 34 (5) ◽

pp. 715-721 ◽

Cited By ~ 4

Author(s):

Bora Yoon ◽

Yong S. Shim ◽

Yong-Duk Kim ◽

Kee Ook Lee ◽

Sang-Jun Na ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

White Matter ◽

Activities Of Daily Living ◽

Daily Living ◽

White Matter Hyperintensities ◽

Cross Sectional Study ◽

Amnestic Mild Cognitive Impairment ◽

Sectional Study ◽

Cross Sectional

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P3-083: The clinical, behavioral and cognitive correlates to the proportional impact of white matter hyperintensities in the patients with amnestic mild cognitive impairment in Korea

Alzheimer s & Dementia ◽

10.1016/j.jalz.2011.05.1523 ◽

2011 ◽

Vol 7 ◽

pp. S540-S540

Author(s):

Bon Ku ◽

Park Key Chung ◽

Duk Na

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

White Matter ◽

White Matter Hyperintensities ◽

Amnestic Mild Cognitive Impairment ◽

Cognitive Correlates

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Mild cognitive impairment, poor episodic memory, and late-life depression are associated with cerebral cortical thinning and increased white matter hyperintensities

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2014.00306 ◽

2014 ◽

Vol 6 ◽

Cited By ~ 36

Author(s):

Motonobu Fujishima ◽

Norihide Maikusa ◽

Kei Nakamura ◽

Masahiro Nakatsuka ◽

Hiroshi Matsuda ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

White Matter ◽

Episodic Memory ◽

White Matter Hyperintensities ◽

Late Life ◽

Late Life Depression ◽

Cortical Thinning

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Abstract TP442: Periventricular Not Deep White Matter Hyperintensities Are Associated With Vascular Cognitive Impairment

Stroke ◽

10.1161/str.48.suppl_1.tp442 ◽

2017 ◽

Vol 48 (suppl_1) ◽

Author(s):

Yan Chen ◽

Renyuan Liu ◽

Shuwei Qiu ◽

Yun Xu

Keyword(s):

Regression Analysis ◽

Cognitive Impairment ◽

White Matter ◽

Linear Regression ◽

Cognitive Performance ◽

White Matter Hyperintensities ◽

Rating Scale ◽

Linear Regression Analysis ◽

Vascular Cognitive Impairment ◽

Cerebral White Matter

Introduction: Cerebral White matter hyperintensities(WMH) are frequent findings on MRI scan. They are well known to correlate with vascular cognitive impairment(VCI). However, controversies still remain about the relationship between WMH locations and cognitive function across studies. Hypothesis: Periventricular WMHs(PWH) rather than deep WMHs(DWH) are associated with cognitive decline in VCI. Methods: Fifty-nine subjects with WMHs on MRI were divided into three groups, normal control(NC), mild cognitive impairment(MCI) and vascular dementia(VaD), according to clinical manifestation and neuropsychological performance. WMH volumes were evaluated by Fazekas rating scale and segmental volumetric. Correlations between cognitive performance and WMH volumes were determined in virtue of Spearman correlation analysis. Receiver operator characteristic (ROC) curves were generated to define the classification cut-off value of WMH volumes for distinguishing VCI versus normal controls. Multiple linear regression analysis was used to predict cognitive performance with WMH volumes and locations after adjusting for sex ,age and education level. Results: Cognitive capacities were gradually declined from NC through MCI to VaD patients while WMH volumes and Fazekas scores altered oppositely. Both PWH and DWH volumes and Fazekas scores were correlated with cognitive performance, and moreover, WMH volumes were correlated with Fazekas scores. ROC analysis showed a cut-off value of PWH rather than DWH to distinguish VCI from NC(AUC=0.745 and 0.635, p =0.001 and 0.076, respectively). Linear regression analysis demonstrated that only PWH volumes were associated with cognitive performance( p < 0.001). Conclusion: Our study demonstrate that PWHs are independent predictors for vascular contribution in white matter lesions and suggest clinicians that PWH should be emphasized on evaluating vascular cognitive impairment related with white matter load.

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