scholarly journals Fatores associados à infecção por Staphylococcus aureus resistente à meticilina em unidade de terapia intensiva

2020 ◽  
Vol 73 (6) ◽  
Author(s):  
Silmara Meneguin ◽  
Erika Aparecida Torres ◽  
Camila Fernandes Pollo
Keyword(s):  
Staphylococcus Aureus ◽  
Length Of Stay ◽  
Protective Factor ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Control Group ◽  
Retrospective Case ◽  
Methicillin Resistant ◽  
Factors Associated ◽  
Aureus Infection ◽  
Significant Difference

ABSTRACT Objective: To identify factors associated with methicillin-resistant Staphylococcus aureus (MRSA) infection in adult patients admitted to the Intensive Care Unit (ICU), and to compare them with a control group. Methods: Retrospective case-control study carried out in an adult ICU, from January 2015 to June 2017, with 61 patients who developed methicillin-resistant Staphylococcus aureus infection and the same number of control patients. Results: Most participants were male 65 (60.6%), with a neurological diagnosis 43 (35.2%) and hypertensive 61 (50.0%). In the comparison of the groups, there was a statistically significant difference in relation to mechanical ventilation (p=0.0107), tracheostomy (p=0.0083), death (p=0.0401), urinary catheter (p=0.0420), length of stay (p<0.0001) and severity (p=0.0003). The main factors associated with methicillin-resistant Staphylococcus aureus infection were: severity (OR= 65.69; CI=3.726-4.808; p=0.0018), use of antimicrobials (OR= 0.047;CI=0.028-0.122;p=0.0024), length of stay (OR=1.19; CI=0.952-1.031; p=0.0285). Conclusion: methicillin-resistant Staphylococcus aureus infection is multifactorial and has been associated with length of stay and severity. Use of antimicrobials was a protective factor.

Risk factors associated with methicillin-resistant Staphylococcus aureus infection in patients admitted to the ED

2007 ◽  
Vol 25 (8) ◽  
pp. 880-886 ◽  
Author(s):  
Alain Viallon ◽  
Olivier Marjollet ◽  
Philippe Berthelot ◽  
Anne Carricajo ◽  
Stéphane Guyomarc'h ◽  
...  
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistant ◽  
Factors Associated ◽  
Aureus Infection

scholarly journals Risk factors associated with Methicillin-resistant Staphylococcus aureus infection in children

2015 ◽  
Vol 52 (1) ◽  
pp. 31-33 ◽  
Author(s):  
Kandasamy Senthilkumar ◽  
Niranjan Biswal ◽  
Sujatha Sistla
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistant ◽  
Factors Associated ◽  
Aureus Infection

scholarly journals Daptomycin versus Vancomycin in Treatment of Methicillin-Resistant Staphylococcus aureus Meningitis in an Experimental Rabbit Model

2013 ◽  
Vol 57 (3) ◽  
pp. 1556-1558 ◽  
Author(s):  
Selin Bardak-Ozcem ◽  
Tuncer Turhan ◽  
Oguz Resat Sipahi ◽  
Bilgin Arda ◽  
Husnu Pullukcu ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Rabbit Model ◽  
Antibacterial Activities ◽  
Control Group ◽  
Strain Atcc ◽  
Methicillin Resistant ◽  
Content Type ◽  
Treatment Groups ◽  
Significant Difference

ABSTRACTIn this study, we aimed to compare the antibacterial activities of daptomycin and vancomycin in the treatment of methicillin-resistantStaphylococcus aureus(MRSA) meningitis (induced by MRSA strain ATCC 43300) in an experimental rabbit meningitis model. After an 8-h period of treatment, bacterial counts decreased significantly in both treatment groups compared to the control group (P< 0.05). However, there was no statistically significant difference between treatment groups. Our results suggest that the antibacterial activity of daptomycin is similar to vancomycin for treatment in the experimental MRSA meningitis model in rabbits.

scholarly journals Antimicrobial in vitro Study of Cosmos caudatus H.B.K Leaves Extract Towards Methicillin-Resistant Staphylococcus aureus (MRSA)

2015 ◽  
pp. 1
Author(s):  
Zahrah Febianti
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Antimicrobial Effect ◽  
Control Group ◽  
Dilution Method ◽  
Minimal Bactericidal Concentration ◽  
Methicillin Resistant ◽  
Cosmos Caudatus ◽  
Significant Difference

Cosmos caudatus H.B.K leaves is known to have many active substances with antimicrobial effect such as saponin, flavonoid, poliphenol, volatile oil, costunolide, and 4,4’-bipyridin. This research is conducted to prove the antimicrobial effect of Cosmos caudatus leaves extract on gram positive Methicillin-Resistant Staphylococcus aureus (MRSA) in vitro. The sample of this research is served by Microbiology Laboratorium of Brawijaya University. An experimental study with tube dilution method was carried out. The treated groups are groups of bacteria treated with Cosmos caudatus leaves extract with a range concentrations of 14%; 12%; 10%; 8%; and 6%. The control group is groups treated with 0% extract. The result indicates that the MIC (Minimal Inhibitory Concentration) can not be observed due to the extract’s turbid green colour. The MBC (Minimal Bactericidal Concentration) is 14% for MRSA. Data analysis with CI=95% shows a significant difference of effects on the number of MRSA colonies growth (Anova, p = 0,000) with the change of extract concentrations. The correlation regression test shows a strong association between the extract concentration and the number of colonies growth (Correlation, r = -0,754, p=0,000). Cosmos caudatus leaves extract has antimicrobial effect on MRSA.Keywords : Cosmos caudatus leaves estract, Methicillin-Resistant Staphylococcus aureus (MRSA), antimicrobial.

scholarly journals Combination of Quinupristin-Dalfopristin and Gentamicin against Methicillin-Resistant Staphylococcus aureus: Experimental Rabbit Endocarditis Study

2002 ◽  
Vol 46 (7) ◽  
pp. 2174-2178 ◽  
Author(s):  
Eric Batard ◽  
Cedric Jacqueline ◽  
David Boutoille ◽  
Antoine Hamel ◽  
Henri B. Drugeon ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Control Group ◽  
Resistant Variant ◽  
Once Daily ◽  
Methicillin Resistant ◽  
Treatment Groups ◽  
Intravenous Injections ◽  
Significant Difference ◽  
Time Kill

ABSTRACT The combination of quinupristin-dalfopristin (Q-D) and gentamicin was tested against two strains of gentamicin- and dalfopristin-susceptible methicillin-resistant Staphylococcus aureus (MRSA). One strain was susceptible to macrolides, lincosamides, and streptogramin B type antibiotics (MLSB), and the other was constitutively resistant to these antibiotics by virtue of the ermA gene. The checkerboard method and time-kill curves showed that the combination of Q-D and gentamicin was indifferent. A rabbit endocarditis model simulated the pharmacokinetics achieved in humans receiving intravenous injections of Q-D (7.5 mg/kg of body weight three times a day) and gentamicin (3 mg/kg once daily). For the MLSB-susceptible strain, a 4-day regimen reduced mean bacterial titers (MBT) in vegetations from 8.5 ± 0.8 log CFU/g (control group) to 4.1 ± 2.6 (gentamicin), 3.0 ± 0.9 (Q-D), and 2.6 ± 0.5 log CFU/g (Q-D plus gentamicin). For the strain constitutively resistant to MLSB, a 4-day regimen reduced MBT in vegetations from 8.7 ± 0.9 log CFU/g (control group) to 5.0 ± 2.2 (gentamicin), 5.2 ± 2.2 (Q-D), and 5.1 ± 2.4 log CFU/g (Q-D plus gentamicin). The differences between control and treatment groups were significant for both strains (P < 0.0001), although there was no significant difference between treatment groups. No resistant variant was isolated from vegetations, and no significant difference in MBT in vegetations of treatment groups after 1-day regimens was observed. This experimental study found no additive benefit in combining Q-D and gentamicin against dalfopristin- and gentamicin-susceptible MRSA.

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