Recombinant antigens for specific and sensitive serodiagnosis of Latin American tegumentary leishmaniasis

Author(s):  
Y. Montoya ◽  
C. Leon ◽  
M. Talledo ◽  
O. Nolasco ◽  
C. Padilla ◽  
...  
Author(s):  
Tatiana C R Senna ◽  
Maria Inês F Pimentel ◽  
Liliane F A Oliveira ◽  
Marcelo R Lyra ◽  
Mauricio N Saheki ◽  
...  

Abstract Background American tegumentary leishmaniasis (ATL) is a neglected disease with wide territorial distribution. Knowledge is scarce in children and adolescents. This study aims to compare the clinical features and response to antimony treatment in pediatric and adult patients with cutaneous leishmaniasis. Methods A retrospective cohort study was performed with 659 patients who attended a reference centre in Rio de Janeiro, Brazil, from 2000 to 2015. The pediatric cohort consisted of 131 (20%) patients and the adult cohort consisted of 528 (80%) patients. Results The epidemiological profile, antimony therapeutic response and incidence of adverse events (AE) were different in the pediatric cohort compared with the adult cohort. Mucosal form was less frequent in the pediatric cohort (RR:0.49, p=0.011). Lesions in the head, neck and trunk were more frequent in the pediatric cohort (RR:1.49, p=0.043). The effectiveness of antimony treatment was superior in the pediatric cohort (88.3% vs 76.6%) with a shorter healing time (RR:0.49, p=0.009). Pediatric patients had lower proportions of moderate to severe AE compared with adults (RR:0.45, p=0.027). Clinical AE predominated in the adult cohort (RR:0.40, p=0.000) and laboratory AE in the pediatric cohort (RR:1.50, p=0.023). Conclusions This study adds to the body of knowledge on differences that exist between different age groups in ATL.


2013 ◽  
Vol 55 (6) ◽  
pp. 407-410 ◽  
Author(s):  
Simone Cristina Castanho Sabaini de Melo ◽  
Wilsandrei Cella ◽  
Rubens Massafera ◽  
Natalia Maria Maciel Guerra Silva ◽  
Reinaldo Marqui ◽  
...  

SUMMARY This study reports the fauna and frequency of sandflies in domestic animal shelters, residences and other ecotopes in rural areas of the municipality of Bandeirantes, Paraná State. Sandflies were collected twice in eight rural villages by using Falcon traps from 8pm to 6am in 2008. In these localities 4,790 sandflies were collected, which were represented by ten sandfly species, prevailing of Nyssomyia neivai and Nyssomyia whitmani species. It was observed that animal shelters are the domestic ecotopes where there is the greatest frequency of these insects. The localities where the collections were made had the environmental characteristics that allow the persistence of transmission of parasites from the American tegumentary leishmaniasis. Although the fauna and the behavior of sandflies species are similar in different localities, the method of controlling these insects should be adjusted to the environmental characteristics of each one of the most diverse endemic areas of American tegumentary leishmaniasis in the municipalities of Paraná State.


2008 ◽  
Vol 24 (12) ◽  
pp. 2969-2978 ◽  
Author(s):  
Thieres Marassati das Virgens ◽  
Claudiney Biral dos Santos ◽  
Israel de Souza Pinto ◽  
Kleber Silveira da Silva ◽  
Fernanda Cristina Leal ◽  
...  

American tegumentary leishmaniasis is endemic to the Espírito Santo State, Brazil, where it is widely distributed. The composition of the phlebotomine sand fly fauna in an American tegumentary leishmaniasis focus was determined by monthly sampling, using Shannon light traps in an Atlantic Forest reserve and adjacent habitat that had been modified by human activity. Seasonal fluctuations in numbers of the most abundant species were also monitored from June 2004 to May 2006. Of the 6,176 specimens collected, 47.4% were captured in the forest and 52.6% in the disturbed habitat. Although Lutzomyia davisi (60.8%) predominated in specimens from the forest, those captured near human dwellings consisted almost entirely of Lu. choti (72%) and Lu. intermedia (24.3%). All three species occurred throughout the year. Based on our findings, Lu. intermedia probably acts as the principal domestic Leishmania vector in the study area.


2012 ◽  
Vol 45 (5) ◽  
pp. 597-600 ◽  
Author(s):  
Doracy Silva Diniz ◽  
Alexandre Sylvio Vieira Costa ◽  
Patrícia Maria Fonseca Escalda

INTRODUCTION: Governador Valadares is an endemic area of American tegumentary leishmaniasis (ATL). The detection rate was 15.36 per 100,000 habitants from 2001 to 2006 (Miranda, 2008). This study aimed to analyze the effects of age on the frequency of adverse reactions caused by antimony in the treatment of ATL in the City of Governador Valadares, State of Minas Gerais, Brazil, during 2009. METHODS: Data were collected from the forms of the Information System for Notifiable Diseases, and from charts, questionnaires, and home visits to patients. RESULTS: The study included 40 patients, 26 (65%) of whom were males. Individuals over the age of 50 had a 66% higher rate of adverse effects than subjects who were 50 years old or less (CI 95%, 1.14-2.41). The average age of individuals who reported some type of adverse effect was 44.11 years (SD = 20.14), while the average age of the group that did not report any adverse effect was of 25.46 years (SD = 18.37; p < 0.01). Clinical healing was 67.5%, and 10% of patients discontinued the treatment. CONCLUSIONS: In the treatment of ATL, the age of patients should be considered, because most adverse reactions occur in individuals over 50 years of age. For this reason, the drug should be used with restriction in these cases.


2017 ◽  
Vol 216 (7) ◽  
pp. 877-886 ◽  
Author(s):  
Ruwandi Kariyawasam ◽  
Jugvinder Grewal ◽  
Rachel Lau ◽  
Andrew Purssell ◽  
Braulio M Valencia ◽  
...  

2009 ◽  
Vol 23 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Luiza C. Reis ◽  
Maria Edilenza F. Brito ◽  
Marina A. Souza ◽  
Angela C.R. Medeiros ◽  
Claudio J. Silva ◽  
...  

Acta Tropica ◽  
2005 ◽  
Vol 95 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Marília Brasil Xavier ◽  
Fernando Tobias Silveira ◽  
Sâmia Demachki ◽  
Márcia Milene Rodrigues Ferreira ◽  
José Luiz Martins do Nascimento

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