New frontiers in endovascular therapies for locally advanced hepatocellular carcinoma

Abstract Hepatocellular carcinoma is the most common primary malignant liver tumour and is a leading cause of death worldwide. Despite the advent of screening programmes, most cases of hepatocellular carcinoma are diagnosed late (in an advanced stage) which precludes curative treatments such as surgery and ablation. Therefore, intra-arterial locoregional treatments now play a central role in the management of advanced hepatocellular carcinoma, such treatments ranging from trans-arterial chemo-embolisation to the more recently developed trans-arterial radio-embolisation technique. In this essay, we discuss the state of the art of intra-arterial treatment for locally advanced hepatocellular carcinoma and the future directions for such treatment.

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En bloc transdiaphragmatic lung resection for locally advanced hepatocellular carcinoma: a case report

Journal of Surgical Case Reports ◽

10.1093/jscr/rjaa084 ◽

2020 ◽

Vol 2020 (6) ◽

Author(s):

Kit-fai Lee ◽

Randolph H L Wong ◽

Howard H W Leung ◽

Eugene Y J Lo ◽

Charing C N Chong ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Locally Advanced ◽

Left Lung ◽

Lower Lobe ◽

Uneventful Recovery ◽

Advanced Hepatocellular Carcinoma ◽

Right Hepatectomy ◽

En Bloc ◽

Liver Recurrence ◽

Lung Base

Abstract A 56-year-old man presented with an 11-cm hepatocellular carcinoma (HCC) at segment 7 of liver. To induce left liver hypertrophy, a sequential transarterial chemoembolization (TACE) and portal vein embolization before right hepatectomy were adopted. However, the tumor further increased in size despite TACE and invaded through the diaphragm to the right lung base. Anterior approach right hepatectomy with en bloc wedge resection of the involved right lower lobe of lung by endovascular staplers via transdiaphragmatic approach was performed. The diaphragmatic defect was closed with Goretex mesh. Patient made an uneventful recovery. Pathology confirmed a 12.5 cm poorly differentiated HCC invading through diaphragm to lung. During follow-up, patient developed a 6 cm recurrence at left lung base 17 months after surgery for which he received sorafenib therapy. However, the lung mass further increased in size with new liver recurrence at segment 3 despite treatment. He succumbed 2 years and 3 months after surgery.

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Adaptation Approaches in Unsupervised Learning: A Survey of the State-of-the-Art and Future Directions

Lecture Notes in Computer Science - Image Analysis and Recognition ◽

10.1007/978-3-319-41501-7_1 ◽

2016 ◽

pp. 3-11 ◽

Cited By ~ 1

Author(s):

JunHong Wang ◽

YunQian Miao ◽

Alaa Khamis ◽

Fakhri Karray ◽

Jiye Liang

Keyword(s):

Unsupervised Learning ◽

State Of The Art ◽

The State ◽

Future Directions

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Modelling Reintroduced Populations: The State of the Art and Future Directions

Reintroduction Biology ◽

10.1002/9781444355833.ch6 ◽

2012 ◽

pp. 165-222 ◽

Cited By ~ 26

Author(s):

Doug P. Armstrong ◽

Michelle H. Reynolds

Keyword(s):

State Of The Art ◽

The State ◽

Future Directions

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Host–Based Intrusion Detection Systems

Architectures and Protocols for Secure Information Technology Infrastructures - Advances in Information Security, Privacy, and Ethics ◽

10.4018/978-1-4666-4514-1.ch007 ◽

2014 ◽

pp. 184-213

Author(s):

Vít Bukač ◽

Vashek Matyáš

Keyword(s):

Intrusion Detection ◽

Detection Method ◽

State Of The Art ◽

Research Trends ◽

The State ◽

Intrusion Detection Systems ◽

Future Directions ◽

Detection Systems ◽

Research Findings ◽

Art Research

In this chapter, the reader explores both the founding ideas and the state-of-the-art research on host-based intrusion detection systems. HIDSs are categorized by their intrusion detection method. Each category is thoroughly investigated, and its limitations and benefits are discussed. Seminal research findings and ideas are presented and supplied with comments. Separate sections are devoted to the protection against tampering and to the HIDS evasion techniques that are employed by attackers. Existing research trends are highlighted, and possible future directions are suggested.

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Multidisciplinary Treatment of Advanced Hepatocellular Carcinoma

Case Reports in Gastroenterology ◽

10.1159/000506185 ◽

2020 ◽

Vol 14 (1) ◽

pp. 98-102

Author(s):

Zhe Yang ◽

Bulat Abdrakhimov ◽

Shuo Wang ◽

Qin-Fen Xie ◽

Shu-Sen Zheng

Keyword(s):

Hepatocellular Carcinoma ◽

Overall Survival ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Pulmonary Resection ◽

Multidisciplinary Treatment ◽

Advanced Hepatocellular Carcinoma ◽

Advanced Stage ◽

Receive Treatment

Current strategy for treatment of hepatocellular carcinoma (HCC) based on Barcelona-Clinic Liver Cancer (BCLC) criteria dictates that patients with advanced-stage HCC are to only receive treatment with tyrosine kinase inhibitors. However, they prolong overall survival just by slightly more than 6 months. In this article, we present a patient with HCC diagnosed at an advanced stage who received multidisciplinary treatment consisting of transarterial chemoembolization, hepatic resection, pulmonary resection, radiofrequency ablation, tyrosine kinase inhibitors, and radiotherapy, and has survived for more than 2 years since diagnosis and counting.

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