scholarly journals Association Between -1607 1G/2G Polymorphism of MMP1 and Temporomandibular Joint Anterior Disc Displacement with Reduction

2020 ◽  
Vol 31 (2) ◽  
pp. 152-156
Author(s):  
Alberto Sierra Rosales ◽  
Eduardo Alberto Villaseñor Rodríguez ◽  
Christian Lorena López González ◽  
Edy David Rubio Arellano ◽  
Susan Andrea Gutiérrez Rubio ◽  
...  
Keyword(s):  
Temporomandibular Joint ◽  
Control Group ◽  
Disc Displacement ◽  
Western Mexico ◽  
Accelerated Degradation ◽  
Matrix Metalloproteinase 1 ◽  
Anterior Disc Displacement ◽  
The Matrix ◽  
Study Participants ◽  
Disc Displacement With Reduction

Abstract Anterior disc displacement with reduction (DDWR) is considered one of the most common disorders within the temporomandibular joint (TMJ), with a prevalence of 41% in adults. Matrix metalloproteinases play an important role in the degradation of the TMJ and the matrix metalloproteinase 1 (MMP1) 1607 1G/2G polymorphism increases the local expression of MMP1 thus leading to accelerated degradation of the extracellular matrix. The objective of this study was to evaluate the association between the 1607 1G/2G polymorphism of MMP1 gene and DDWR in a group of Mexican individuals from western Mexico. A total of 67 unrelated individuals, between the ages of 18 and 36 years, of both genders, were included in this study. Study participants with DDWR were required to meet the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD), while a second control group of 90 individuals without DDWR were also included. Both groups were required to have paternal and maternal ancestry (grandparents) of the same geographic and ethnic region. Genotypes were determined using the nested PCR technique. The 1G/2G polymorphism was found in 68.7%, followed by 2G/2G in 25.4% and 1G/1G in 6.0% of the cases group. While the prevalence in the control group was 55.5% for the 1G/2G polymorphism, 26.6% for 1G/1G and 17.7% for 2G/2G. An association was found between the 2G allele of the 1607 1G/2G polymorphism of MMP1 gene and the presence of DDWR in the patients of western Mexico.

scholarly journals Management of Internal Derangement of Temporomandibular Joint Disc Displacement with Reduction Using Two Different Lines of Treatment

2021 ◽  
Vol 24 (2) ◽  
pp. 8
Author(s):  
Mohamed Ahmed Helal ◽  
Shoroog Hassan Agou ◽  
Amr Bayoumi ◽  
Ahmed Imam ◽  
Ali Habiballah Hassan
Keyword(s):  
Range Of Motion ◽  
Temporomandibular Joint ◽  
Lower Cost ◽  
Internal Derangement ◽  
Disc Displacement ◽  
Temporomandibular Joint Disc ◽  
Non Invasive ◽  
Anterior Disc Displacement ◽  
Disc Displacement With Reduction

Objetive: This study was to compare the effectiveness of arthrocentesis versus the insertion of anterior repositioning splint (ARS) in improving the mandibular range of motion (MRM) for patients with the temporomandibular joint (TMJ) anterior disc displacement with reduction (ADDwR). Methods: 36 patients diagnosed as ADDwR were recruited and divided randomly into two groups. The first group (G1) was treated by arthrocentesis, and the second (G2) was treated using ARS. All patients were reexamined after six months. Results: Except that for protrusive movement, there were significant differences between the two groups for the percentage changes of the MRM as measured by the amount of pain free opening, unassisted opening, maximum assisted opening, right lateral and left lateral movements (p < 0.05). Conclusion: Within the context of the current study, the non-invasive, lower cost ARS, provided better results in improving the MRM when managing ADDwR cases.   Keywords Arthrocentesis; Anterior repositioning splint; TMD; Internal derangement; Anterior disc displacement; Mandibular range of motion.

scholarly journals Diagnostic reproducibility of temporomandibular joint using magnetic resonance imaging at 0.5 and 1.5 Tesla

2017 ◽  
Vol 21 (3) ◽  
Author(s):  
Mathias Pante Fontana ◽  
Nádia Assein Arús ◽  
Mariana Boessio Vizzotto ◽  
Priscila Fernanda Da Silveira ◽  
Heloísa Emília Dias da Silveira ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Temporomandibular Joint ◽  
Soft Tissues ◽  
Shape Change ◽  
Disc Displacement ◽  
Resonance Imaging ◽  
Anterior Disc Displacement ◽  
Disc Displacement With Reduction ◽  
Good Agreement

Introduction: magnetic resonance imaging is described as the reference standard for the evaluation of temporomandibular joint soft tissues; however, the literature shows conflicting results regarding the reproducibility of this method. Objective: this study aimed to assess the reproducibility of temporomandibular joint diagnoses using magnetic resonance imaging at 0.5 and 1.5 Tesla. Methods: a trained observer analyzed 212 temporomandibular joint images (134 at 0.5T and 78 at 1.5T) and diagnosed the presence or absence of nine conditions. Results: overall agreement was over 80% in both magnetic resonance units, with no significant differences (P > 0.05). Images at 0.5T and 1.5T provided excellent reproducibility for anterior disc displacement without reduction (κ = 0.82 and 0.80, respectively), hypermobility (κ = 0.84 and 0.90), and hypomobility (κ = 0.80 and 0.95), while fair to moderate values were obtained for anterior disc displacement with reduction (κ = 0.48 and 0.42) and disc shape changes (κ = 0.45 and 0.37). Conclusion: magnetic resonance imaging diagnoses at 0.5T and 1.5T presented good agreement. However, the lowest reproducibility for anterior disc displacement with reduction and disc shape change reveals the difficulty to diagnose these disorders.

scholarly journals The Efficiency of Anterior Repositioning Splints in the Management of Pain Related to Temporomandibular Joint Disc Displacement with Reduction

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Malgorzata Pihut ◽  
Malgorzata Gorecka ◽  
Piotr Ceranowicz ◽  
Mieszko Wieckiewicz
Keyword(s):  
Temporomandibular Joint ◽  
Temporomandibular Disorders ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Masticatory Muscles ◽  
Control Group ◽  
Study Group ◽  
Disc Displacement ◽  
Temporomandibular Joint Disc ◽  
Disc Displacement With Reduction

Background and Objective. Intra-articular temporomandibular disorders are often related to pain in the area of the temporomandibular joint, ear, and temple. The aim of the study was to investigate the efficiency of anterior repositioning splints in decreasing pain related to temporomandibular joint disc displacement with reduction. Methods. The research material consisted of 112 patients, aged 24 to 45 years, of both genders, who reported for treatment at the Consulting Room of Temporomandibular Joint Dysfunctions at the Jagiellonian University in Cracow between 2014 and 2016 due to pain in the area of the temporomandibular joint(s) and noise(s) of temporomandibular joint(s) present during jaw movements with comorbid contracture of masticatory muscles. Subjects were examined according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) protocol and, after diagnosis of painful disc displacement with reduction and masticatory muscle contracture, they were assigned randomly to either the study or control groups (56 patients in each). In the study group, we used an anterior repositioning splint on the full lower arch for about 20 hours usage over a 4-month period. In the control group, a noninvasive therapy was applied using a biostimulation laser over 12 sessions performed every second day on the area of both temporomandibular joints with mouth open and while performing muscle self-exercises with a dominant protrusive position of the mandible. Pain intensity was evaluated using the Verbal Numerical Rating Scale (VNRS) immediately before the treatment and then after 4 and 16 weeks. The obtained data were analyzed using the Mann–Whitney U test p≤0.005. Results. The VNRS values reported during the final examination for the study group were significantly lower than for the control group p=0.0004. Conclusions. The anterior repositioning splint is an efficient tool in decreasing pain related to disc displacement with reduction. This trial is registered with Clinicaltrials.gov NCT03057262.

scholarly journals Randomized Controlled Trial on Physical Therapy for TMJ Closed Lock

2012 ◽  
Vol 91 (4) ◽  
pp. 364-369 ◽  
Author(s):  
B. Craane ◽  
P.U. Dijkstra ◽  
K. Stappaerts ◽  
A. De Laat
Keyword(s):  
Physical Therapy ◽  
Temporomandibular Joint ◽  
Therapy Group ◽  
Controlled Trial ◽  
Control Group ◽  
Disc Displacement ◽  
Oral Habits ◽  
Year Effect ◽  
Anterior Disc Displacement ◽  
Closed Lock

This study evaluated the one-year effect of physical therapy on pain and mandibular dysfunction associated with anterior disc displacement without reduction of the temporomandibular joint (closed lock). Forty-nine individuals were randomly assigned to either a physical therapy group [n = 23, mean age (SD) 34.7 (14.0) yrs] or a control group [n = 26, mean age 38.5 (15.1) yrs]. At baseline and after 3, 6, 12, 26, and 52 wks, pain and mandibular function were evaluated. All patients received extensive information about avoiding parafunctions and oral habits on all evaluation days. The physical therapy group received, in a 6-week period, 9 sessions of physical therapy, including joint mobilization, exercises, and massage, and the information on avoiding parafunctions and oral habits was repeated each time. All pain variables decreased, and all function variables increased significantly over time for both groups. The interaction between time and treatment group was not significant. Hence, physical therapy had no significant additional effect in patients with anterior disc displacement, without reduction, of the temporomandibular joint ( ClinicalTrials.gov number, CT01475630).

scholarly journals A comparative study of the effects of the anterior disc displacement with reduction and without reduction on the components of the temporomandibular joint by using magnetic resonance imaging – A Retrospective study

2021 ◽  
pp. 73-85
Author(s):  
Shunmugavelu KARTHIK ◽  
◽  
Dimple M VASWANI ◽  
Shanmugam ARASU ◽  
Raghavelu Narendran MUGUNDAN ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Temporomandibular Joint ◽  
Joint Space ◽  
Disc Displacement ◽  
Resonance Imaging ◽  
Range Of Movement ◽  
Anterior Disc Displacement ◽  
Closed Position ◽  
Disc Displacement With Reduction

Background: Internal derangement of the temporomandibular joint (TMJ) results in anterior disc displacement with reduction (ADDR), the disc is ante- riorly displaced in the closed position whereas in the opened position the disc returns to its normal location. In anterior disc displacement without reduction (AD- DWR), the disc is anteriorly displaced in the closed po- sition but does not return to its original location in the opened position. Here we studied and compared the effects of the ADDR and the ADDWR on the components of the TMJ by using the magnetic resonance imaging technique (MRI). Methods and materials: From the archival MRI records, 214 joints from 107 patients were included. The selec- tion criteria for the patients complaints as TMJ pain, clicking, limited mouth opening, headache, jaw tenderness and difficulty in eating. MRI records with sequences Proton Density (PD), PD FAT SAT and T2* gradient in the closed position and T2* gradient echo in the opened position. Data analysis and frequency distribution of explanatory variables by disc position in the open state was performed using chi-square test Results: Statistically significant differences were observed between the variables such as the joint space (closed position), disc morphology (closed position) and range of movement (opened position) among the ADDR and the ADDWR. In ADDWR, 20.3% demonstrated narrowed joint space and 1.6% with widened joint space, while in ADDR, 2.5% of joints had narrowed joint space and 0% widened joint space. Same was observed with abnormal disc morphology and rang of movement. Conclusion: The disc deformity is more in ADDWR compared to ADDR which can be seen as an alteration in the signal intensity. The malaligned disc could lead to the narrowing of the joint space and decreased range of movement in the ADDWR affected individuals.

scholarly journals Pain Management Associated with Posttraumatic Unilateral Temporomandibular Joint Anterior Disc Displacement: A Case Report and Literature Review

2018 ◽  
Vol 2018 ◽  
pp. 1-7
Author(s):  
Arturo Garrocho-Rangel ◽  
Andrea Gómez-González ◽  
Adriana Torre-Delgadillo ◽  
Socorro Ruiz-Rodríguez ◽  
Amaury Pozos-Guillén
Keyword(s):  
Temporomandibular Joint ◽  
Cervical Vertebrae ◽  
Signs And Symptoms ◽  
Temporomandibular Joint Disorders ◽  
Diagnostic Process ◽  
Disc Displacement ◽  
Occlusal Splints ◽  
Anterior Disc Displacement ◽  
Pediatric Dentists ◽  
Disc Displacement With Reduction

The aim of the present article is to review the etiological risk factors and the general and oral management of anterior disc displacement with reduction caused by a chin trauma, and to describe the diagnostic process and the treatment provided to an affected 7-year-old girl. The patient also experienced frequent and severe cephaleas, which may be related to cervical vertebrae deviation. The patient was successfully treated with an intraoral occlusal splint and analgesics. Pediatric dentists must always be aware of the early signs and symptoms of temporomandibular joint disorders in their patients, especially in cases of orofacial trauma history, with the aim of providing an opportune resolution and preventing its progression later in life. Occlusal splints are strongly recommended for the treatment of anterior disc displacement with reduction in children and adolescents.

scholarly journals Association of Estrogen Receptor 1 and Tumor Necrosis Factor α Polymorphisms with Temporomandibular Joint Anterior Disc Displacement without Reduction

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Bartosz Dalewski ◽  
Agata Kamińska ◽  
Katarzyna Białkowska ◽  
Anna Jakubowska ◽  
Ewa Sobolewska
Keyword(s):  
Temporomandibular Joint ◽  
Temporomandibular Joint Disorders ◽  
Control Group ◽  
Disc Displacement ◽  
Anterior Disc Displacement ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

Objectives. The aim of this study was to investigate the role of ESR1 rs1643821 and TNF-α rs1800629 as potential genetic factors regulating anterior disc displacement without reduction-mediated inflammatory pathway. Background. The temporomandibular joint is a complex synovial joint that allows mandibular movement in three directions. Although temporomandibular disorders are widespread, limited data is available on the biochemical characteristics of the displaced disc and quality of the surrounding soft tissue. Changes in degenerative tissue provoke disc displacement which involves secretion of inflammatory markers and sequential conversion of fibroblast-like cells into chondrocyte-like cells. Due to the high occurrence in female adolescents, the potential role of sex hormones in temporomandibular joint disorders has been speculated. Furthermore, anterior disc displacement without reduction severely affects the quality of life. Methods. 124 Caucasian patients with a history of at least one anterior disc displacement without reduction within 3 months were enrolled. Anterior disc displacement without reduction was diagnosed based on clinical examination, diagnostic criteria (DC)/TMD, and cone-beam computed tomography/magnetic resonance imaging (CBCT/MRI). The control group consisted of 126 patients with no temporomandibular joint disorders. Genotyping of two single nucleotide polymorphisms, estrogen receptor 1 (ESR1) rs1643821, and tumor necrosis factor α (TNF-α) rs1800629 was performed. Results. ESR1 rs1643821 showed significant P values (using chi-square analysis) revealing the difference in anterior disc displacement without reduction frequencies while TNF-α rs1800629 polymorphism was found to be statistically insignificant when compared to the control group. Furthermore, patients with a genotype of ESR1 rs1643821 showed a decreased probability ( OR = 0.412 ) against anterior disc displacement without reduction when compared to the GG genotype ( OR = 1 ). Conclusion. ESR1 rs1643821 with A allele frequency was lower in patients with anterior disc displacement without reduction compared to the control group. Thus, the rs1643821 variant is significantly associated with susceptibility to the anterior disc displacement without a reduction in European Caucasians. Conversely, TNF-α rs1800629 was a statistically insignificant factor against anterior disc displacement without reduction when compared to the control group.

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