General anesthesia has proved to be an ef- fective mean for treating patients in need of restorative and surgical treatment, when other methods have failed. Aim: The aim of this retrospective clinical-statistical study was to assess the characteristics, oral health management of special needs patients attending for DGA treatment at Agios Dimitrios General Hospital of Thessaloniki,. Patients and method: Medical files retrieved from 169 male and 129 female patients, from 5 to 63 years of age and 36,2% of them were children and adoles- cence.257 patients during a twelve year old period, from 01/01/2008 to 31/12/2019. Demographic, quantitative and qualitative data were obtained from patients’ files (e.g place of residence, gender, age, type of disability, comorbidity, amount and type of treatments provided and were analyzed by means of descriptive and comparative statistics.Results: 298 DGA treatments were performed to 169 males and 129 female patients, from 5 to 63 years of age and 63,8% of them were over 18 years old. 68,5% of the patients were mentally retarded, 17,8% were au- tistic, 7% had cerebral palsy, 3,5% suffered from vari- ous syndromes and 3,2% were patients with systemic diseases and other health issues. A total of 2787 treat- ments were provided, with higher prevalence of 49,8% for restorative treatments. Conclusions: In many patients with severe disability, DGA is the only treatment option. The number and the geographic distribution of dental departments of Greek NHS that provide DGA, does not guarantee the equal and unimpeded access of special needs patients. Therefore, implementation of organized oral preventive programs is necessary, along with investment on the appropriate infrastructure, that would allow the creation of additional dental departments providing DGA treatments within the NHS.