scholarly journals Ischemic myelopathy caused by fibrocartilaginous embolism in a horse

2018 ◽  
Vol 48 (2) ◽  
Author(s):  
Welden Panziera ◽  
Ronaldo Michel Bianchi ◽  
Paula Reis Pereira ◽  
Mariana Martins Flores ◽  
Monique Togni ◽  
...  

ABSTRACT: This report described clinical, epidemiological, and pathological aspects of ischemic myelopathy caused by fibrocartilaginous embolism (FCE) in a 10-year-old, mixed breed gelding. Clinically, the horse presented acute hind limbs paralysis, with a clinical course of approximately 24 hours. At necropsy, no gross lesions were observed. Cross-sections of the spinal cord revealed focally extensive areas of malacia from the T10 to L4 segments. Focally extensive areas of liquefactive necrosis involving the gray matter and adjacent white matter were observed on histologic sections. The lumen of multiple blood vessels in the periphery of the necrotic areas was occluded by fibrocartilaginous emboli that strongly stained with alcian blue. Clinical signs, gross necropsy, and histological findings observed in this case were identical to those described in the literature for ischemic myelopathy caused by FCE in the horse and other species.

2021 ◽  
Vol 49 ◽  
Author(s):  
Yanca Góes Dos Santos Soares ◽  
Draenne Micarla dos Santos Silva ◽  
Maria Jussara Rodrigues do Nascimento ◽  
Millena de Oliveira Firmino ◽  
Rodrigo Cruz Alves ◽  
...  

Background: Melanosis is a blackened pigmentation resulting from the accumulation of melanocytes in tissues that are not normally pigmented. This change in the color of the organs occurs due to the agglomeration of melanocytes originating from abnormal migration during embryogenesis and does not cause dysfunction to the affected organ. Although melanosis frequently occurs in several species and affects several organs such as the brain and spinal cord leptomeninges, involvement in the thalamus region is unusual. The objective of this work was to report two cases of thalamic melanosis in goats, determining the pathological and histochemical aspects that assist in the diagnosis of this condition.Cases: Two cases of thalamic melanosis in goats were diagnosed. In both cases, the animals had no nervous history disease and clinical signs. The cause of death in cases 1 and 2 was established based on anatomopathological findings and clinical signs being diagnosed with mycoplasmosis and asphyxia, respectively. After fixing and making cross-sections of the brain, a focal lengthy blackened area was observed on the thalamus surface in both cases. Microscopically, lesions in the brain were similar in both cases and exclusively affected the thalamus. These cells had abundant cytoplasm, well delimited with brownish granular pigment. The nuclei were difficult to visualize and in some cells, it was rounded, well-defined, morphologically compatible with melanocytes. Melanocytes were mainly distributed around neurons and often distended the perivascular space of multiple blood vessels. In Fontana Masson staining, the granules in the cytoplasm of these cells stained strongly black. The Prussian Blue, Periodic Acid- Schiff's, Von Kossa, and Giemsa stains were negative, and the pigment remained brown. In the unstained slides, assembled after the deparaffinization and clarification process, it was observed the permanence of cells with blackish-brown pigment in the cytoplasm. In immunohistochemistry, strong immunostaining of pigmented cells with the Anti-MelanA antibodies was observed in both cases.Discussion: The diagnosis of thalamic melanosis in goats was carried out based on the characteristic pathological findings, in which melanin pigments were demonstrated and identified through HE, Fontana-Masson staining, and unstained slides and confirmed by the IHC. The use of complementary histochemical techniques was fundamental for the classification of the pigment as melanin, demonstrating to be an accessible and reliable tool for the diagnosis of pathological processes that lead to the accumulation of pigments and or material in the tissues. The occurrence of melanin in the thalamus may be associated with a failure in the migration of melanoblasts, which would go to the optical pathways or to the thalamus. This erratic migration of melanoblasts can be explained by the fact that the forebrain is the embryogenic origin of the optic and diencephalon pathways. Macroscopically, thalamic melanosis must be differentiated mainly from neoplastic processes such as melanoma and hemangiosarcoma, pigmented fungus infections, Phalaris angusta poisoning, listeriosis, neurocutaneous melanosis, and neuromelanin. It was concluded that thalamic melanosis is an uncommon alteration in goats and although it has been diagnosed as an incidental necropsy finding, should be included in the differential diagnosis of diseases that affect the central nervous system, especially those that have a color change associated with the deposition of pigments in the tissues. Keywords: melanin, necropsy findings, pigment, thalamus.Descritores: melanina, achados de necropsia, pigmento, tálamo.Título: Melanose talâmica em caprinos. 


2018 ◽  
Vol 46 ◽  
pp. 5 ◽  
Author(s):  
Welden Panziera ◽  
Claiton Ismael Schwertz ◽  
Fernando Soares Da Silva ◽  
Paula Augusto Taunde ◽  
Saulo Petinatti Pavarini ◽  
...  

Background: Fluorine is a ubiquitous environmental element and fluoride poisoning in cattle is usually related to the ingestion of contaminated pastures or water, especially near industries, or mineral supplements with excessive amounts of this element. Cattle poisoning can be acute or chronic and is directly associated with the ingested dose and with the duration of exposure. The objective of this study is to report the epidemiological, clinical and anatomopathological aspects of anoutbreak of acute sodium fluorosilicate intoxication in cattle.Case: Six 1-year-old, castrated male, mixed breed beef calves from a lot of 60 were found dead without previous clinical signs being observed. The calves died after ingesting a white, odorless, finely granular substance found by the owner near a road that intersected the property. The product was in an open package and identified as sodium fluorosilicate. Of the sixdead calves, three were necropsied. Gross lesions were restricted to the digestive system and included varying degrees of hyperemia, hemorrhage, edema, and erosions in the pre-stomach and abomasum mucosae. The histological lesions observed in the three calves were characterized mainly by variable degenerative, necrotic and ulcerative changes in the epitheliallining of the forestomachs and abomasum. Partially (erosion) or totally (ulceration) bare lamina propria of forestomach papillae was covered by cellular debris and neutrophils. Multifocal lymphoid necrosis was seen in lymph nodes and spleen. Fluoride levels measured in the ruminal content of two necropsied calves were 55.2 and 9.17 mgF/kg of dry matter. Afterthe diagnosis and discontinued exposure of the calves to the fluoride product, deaths ceased.Discussion: The diagnosis of acute sodium fluorosilicate intoxication in cattle in this study was based on epidemiological, clinical, and anatomopathological findings, and in the determination of fluoride levels in ruminal content. The association of these data constitutes an important aid in suspecting and confirming the diagnosis of intoxication. The acute toxicity of fluoride, observed in the cattle of this study, is relatively rare. The intake of sodium fluorosilicate by cattle may have been favored by the absence of organoleptic properties of the product. The involvement of young cattle revealed an important epidemiological aspect of the condition, since cattle in this age group are the most predisposed to the intoxication due to their greater absorption capacity. The spontaneous ingestion of large amounts of sodium fluorosilicate by cattle of this study produced digestive morphological changes, characterized by variable hyperemia, hemorrhage, and necrosis in the forestomachs and abomasum. The proposed mechanism of lesions is associated with the acidic activity exerted by fluoride on the mucosa. Acute toxicosis must be differentiated from other conditions that cause acute digestive changes in ruminantssuch as Baccharis spp. poisoning, ruminal acidosis, arsenic poisoning and Baccharidastrum triplinervium intoxication. In these cases, the epidemiological and anatomopathological evidences are extremely important in the differentiation of each condition. Therefore, cattle practitioners should consider acute fluoride poisoning as a differential diagnosis in cattle presenting digestive signs or death without previous signs. Epidemiological, clinical, anatomopathological and the assessmentof fluoride levels are important for the accurate diagnosis of this toxicosis.Keywords: pathology, toxicology, diseases of cattle, digestive lesions, fluoride.


2018 ◽  
Vol 46 (1) ◽  
Author(s):  
Catarina Borges Cardoso ◽  
Sheila Canevese Rahal ◽  
Maria Jaqueline Mamprim ◽  
Hugo Salvador Oliveira ◽  
Alessandra Melchert ◽  
...  

Background: The avascular necrosis of the femoral head is a development disease caused by ischemic necrosis, which is mainly observed in young dogs. The etiology of the disease remains controversial. The diagnosis requires imaging exams such as MRI and radiographs. Thus, the aim of the current study was to retrospectively assess a population of dogs with avascular necrosis of the femoral head in order to feature the disease, as well as to analyze the radiographic appearance of the lesion at the moment of patient consultation.Materials, Methods & Results: The signalment factors of dogs (breed, gender, age and body mass), the affected hind limb, the radiographic appearance of the lesion, the clinical signs at the moment of patient consultation, the time of occurrence and the type of treatment were evaluated. The disease was radiographically classified according to the previously described items. Forty-three cases of avascular necrosis of the femoral head were identified, 97.67% presented lameness and pain during palpation of the hip joint; and 54.34%, were 1 week to 4 months old. Females represented 58.13% of the sample, and 65.11% of them weighed from 2.6 to 4.9 kg. Based on the radiographic classification, 4.34% were Grade 1; 32.60%, Grade 2; 8.69%, Grade 3; 19.56%, Grade 4; and 34.78%, Grade 5. The femoral head and neck ostectomy was performed in 42 hind limbs (91.30%); 42.85% of the dogs reached total functional recovery and 26.19% required physiotherapy and rehabilitation.Discussion: The present sample was composed of 25 dogs, which were 6-to-11-month old at the moment of patient consultation, but 17 dogs were 12-to-36-month old at this time; only one dog was older than 36 months. It may be associated with the non-recognition of clinical signs by the owners, rather than with the late-onset form of the disease. With respect to the breed, pinscher, Yorkshire, poodle, Lhasa apso, pug were most frequently observed. However, 7 dogs were crossbreed. Such group differed from that of a review involving 188 cases encompassing West Highland white terrier, Cairn terrier and poodle as the most commonly affected breeds. No sex predilection was found in a study comprising 188 cases, but in another study comprising 14 dogs, female predilection was observed. Likewise, the females represented 58.13% of cases in the present study; and 41.86% of the participants were male. The mean body mass of the dogs in the current study was 4.33 kg, which matches the small breed dogs, which are most affected by the disease. Clinical signs of non-weightbearing lameness or an intermittent subtle lameness are common in the avascular necrosis of the femoral head. Lameness of the affected hind limb was observed in 69.76% of the cases in the present study, but 2.32% showed no lameness. Occasionally, the avascular necrosis of the femoral head is bilaterally found in 12% to 16.5% of the cases. Only 3 out of the 43 cases assessed in the present study were bilateral. Since the lesions were more frequent in Grades 2 and 5, there is less chance of success through the conservative treatment. Thus, the femoral head and neck ostectomy was the surgical procedure performed in 42 hind limbs. The procedure is used to provide pain relief and to reduce the signs of lameness. In conclusion, the population assessed in the present study was composed of small size dogs, mean body mass 4.33 kg, no sex predilection, mostly presenting unilateral lesions and higher Grade 2 and Grade 5 radiographic lesion frequency.Keywords: radiographic, joint, canine, hip.


Author(s):  
Gilberto Gonçalves Facco ◽  
Eloty Justina Schleder ◽  
Natalia Yoshioka de Vidis ◽  
Maristela Halverson ◽  
Rosemary Matias ◽  
...  

This study aimed to carry out morphoanatomical, histochemical and phytochemical analysis of leaves and stems of Tetrapterys multiglandulosa Cav. (Malpighiaceae), a native plant responsible for abortion and sudden death in beef cattle. Plant specimens underwent anatomical study, in which leaves and stems were dried and ground with aqueous and ethanol extracts subjected to histochemical and phytochemical analysis. Anatomical observation of vegetative organs detected the presence of simple columnar cells in the adaxial epidermis, palisade mesophyll, parenchyma with a layer of cells and paracitic type stomata. Stem cross-sections presented circular section, single layer (uniseriate) epidermis with thick cuticle and Malpighi’s trichomes, the phelogen was in differentiation. The cortex showed angular collenchyma, parenchyma with exogenous channels and druse shaped calcium oxalate crystals. Phytochemical tests of aqueous and ethanol extracts of leaves and stems indicated the presence of phenolic compounds, tannins, flavonoids, saponins, alkaloids and cardiotonic heterosides. Potentially phytotoxic secondary metabolites evidenced in the leaves and stems, including saponins and cardiotonic heterosides were correlated with clinical signs observed in intoxicated animals.


1984 ◽  
Vol 5 (2) ◽  
pp. 71-74 ◽  
Author(s):  
Inge Gurevich ◽  
Patricia Tafuro ◽  
Sharon P. Krystofiak ◽  
Robert D. Kalter ◽  
Burke A. Cunha

AbstractDuring a ten-month period from September 1981 to July 1982 three episodes of pseudobacteremia due to Bacillus species occurred at this 550-bed institution. The first involved eight isolates, the second 11, and the third seven isolates of the organism, all with the same antibiogram.The patients involved did not exhibit clinical signs of septicemia, and in only one case was more than one specimen per patient positive when multiple blood samples were obtained. Occasional blood cultures of Bacillus species identified in between clusters revealed a different antibiogram.Extensive epidemiologic investigation of patient locations, phlebotomists, and time of cultures yielded no common source. Components involved in the transport and processing of blood cultures, including the radiometric blood culture processor, were also sampled but without recovery of the organism. After the last episode, a layer of dust was noted inside the machine, and culture of this dust grew Bacillus spp. with the same antibiogram as those found in the blood cultures. The filter from an air conditioning unit in close proximity to the machine grew several species of Bacillus.It is presumed that Bacillus spores in the dust were introduced into the blood culture bottles following the heat sterilization of the gas sampling (inoculation/removal) needles.Modification of the cover of the machine was undertaken to prevent access of dust bearing microbes to the inside of the machine. In addition, maintenance now includes regular disinfection/cleaning of the “floor” of the machine, and more frequent changes of the air conditioner filter.


2017 ◽  
Vol 37 (6) ◽  
pp. 561-569
Author(s):  
Paulo V. Peixoto ◽  
Krishna D. Oliveira ◽  
Ticiana N. França ◽  
David Driemeier ◽  
Marcos D. Duarte ◽  
...  

ABSTRACT: Following a case of iatrogenic selenium poisoning in a young pig, an experimental study was carry out. Sodium selenite was orally and parenterally administered to 13 pigs that were subdivided into three groups (G1, G2 and G3). The animals in groups G1 and G3 received sodium selenite intramuscularly (IM), G1 received a comercial formula, and G3 received sodium selenite mixed with distilled water at different dosages, and those in group G2 were fed commercial sodium selenite. Acute and subacute poisoning was observed in both groups, although the onset of clinical signs was slower in group G2. Only one pig (in group G1) that had received the highest dose showed a peracute course. Apathy, anorexia, dyspnea, vomiting, muscular tremors, proprioceptive deficit, ataxia and paresis of the hind limbs progressing to the front limbs evolving to tetraplegia were observed. Postmortem findings differed whether the animals received the injected (G1 and G3) or oral (G2) sodium selenite. The liver was moderately atrophic in some animals of G2. Some of the animals in groups G1 and G3 presented with lung edema. One pig in G3 had yellowish-brown areas in the ventral horns of the cervical intumescences of the spinal cord. The most important histological changes were present in the ventral horns of the cervical and lumbar intumescences of the spinal cord. In one animal, changes were present in the brainstem and mesencephalon. The initial lesion was a perivascular and astrocyte edema that progressing to lysis and death of astrocytes and neurons. In the chronic stage of the lesions, there were extensive areas of liquefaction necrosis with perivascular lymphocytic and histiocytic infiltration and occasional eosinophils. It seems that disruption of the blood-brain barrier due to astrocyte edema is the most likely mechanism of CNS lesion.


2014 ◽  
Vol 34 (9) ◽  
pp. 845-850 ◽  
Author(s):  
José Diomedes Barbosa ◽  
Danillo Henrique S. Lima ◽  
Alessandra S. Belo-Reis ◽  
Cleyton P. Pinheiro ◽  
Melina G.S. Sousa ◽  
...  

A retrospective study of the epidemiological and clinic-pathological aspects of cattle and buffaloes with degenerative joint disease (DJD) was conducted in the state of Pará, Brazil. From 1999 to 2014, eleven cattle and 24 buffaloes were evaluated. All the treated animals with suspected DJD underwent a clinical examination of the musculoskeletal system. In seven cattle and eight buffaloes with clinical signs of the disease postmortem examination was performed. The common clinical signs observed in both species were chronic lameness, stiff gait, postural changes, audible crackles in the affected limb, prolonged recumbency, difficulty in getting up and progressive weight loss. The lesions observed at necropsy were: irregular articular surfaces, erosion of the articular cartilage and the underlying bone tissue, and proliferation of the periarticular bone tissue with formation of osteophytes. The most affected joints in cattle and buffaloes wereof the hind limb. In buffaloes, the main predisposing factor to the onset of DJD was phosphorus deficiency. In cattle, defects of the anatomical conformation of the hind limbs, chronic trauma due to the activities performed, such as semen collection, and advanced age possibly contributed to the emergence of the disease.


2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Carl L. Kay ◽  
Matthew J. Rendo ◽  
Paul Gonzales ◽  
Sead G. Beganovic ◽  
Magdalena Czader

Hemophagocytic lymphohistiocytosis (HLH) is a rare, hyperinflammatory syndrome characterized by clinical signs and symptoms of extreme inflammation. In adults, HLH is typically a complication of infections, autoimmune diseases, and malignancies. While the disease is often fatal, classic management of HLH revolves around early diagnosis and initiation of protocolized therapy. We present a case of a previously healthy 56-year-old female who developed distributive shock requiring intubation, vasopressors, and continuous venovenous hemofiltration. In the setting of multiple infectious syndromes, severe cytopenias, and rising direct hyperbilirubinemia, her diagnosis of HLH was confirmed. Therapy was initiated with dexamethasone and two doses of reduced-intensity etoposide based on the patient’s clinical course. Over the next few weeks, she continued to improve on dexamethasone monotherapy and has maintained remission up to the present with complete resolution of her cytopenias and return of baseline renal function. Our case highlights the variability in the management of probable infection-associated HLH (IHLH) with a good patient outcome. We demonstrate the potential to treat IHLH with partial protocols and minimal chemotherapeutics.


2021 ◽  
Vol 4 (3) ◽  
pp. 1109-1116
Author(s):  
Nguyen Thi Thu Hang ◽  
Truong Quang Lam ◽  
Dao Le Anh ◽  
Nguyen Thi Hoa ◽  
Nguyen Thi Lan ◽  
...  

This study aimed to diagnose swine dysentery (SD) caused by Brachyspira hyodysenteriae in pigs by the PCR method in Vietnam. Of the 250 samples, 29 isolates of B. hyodysenteriae (11.60%) were identified by PCR in seven provinces of Northern Vietnam, and the infection rate differed from region to region. From the positive cases of B. hyodysenteriae, we analyzed B. hyodysenteriae infected cases according to the ages of the pigs, farm sizes, and veterinary hygiene practices to get more information about the disease in Vietnam. The results showed that the positive B. hyodysenteriae samples were commonly seen in post-weaning pigs (32.14%) in households (20.73%) with poor hygiene (24.69%). Clinical signs of SD included high fever (100%); anorexia (100%); watery, bloody diarrhea, usually gray to brown in color (100%); and weight loss (86.42%). Gross lesions of SD were limited to the large intestine were described as having a fibrinous, blood-flecked membrane covering the mucosa (93.75%), swollen with hemorrhaged colon and cecum (75.00%), and mesenteric lymph nodes (81.25%).


Author(s):  
Amalia Marina NEAGU ◽  
Ecaterina DIAC ◽  
Andrei Razvan CODEA ◽  
Andras NAGY ◽  
Adrian OROS ◽  
...  

Veterinary toxicology is a common field in veterinary medicine, being a science closely related to other clinical and para clinical disciplines. The multitude of toxics and the ability of each organism to respond differently to them, non-specific clinical signs and an inadequate anamnesis can often put the clinician in difficulty when seeking to diagnose. The aim of the study was to highlight the incidence of pet poisoning cases, over a period of 10 years of time at the emergency clinic, faculty of Veterinary Medicine Cluj-Napoca. An epidemiological study was performed with the help of the emergency clinic archive, where the files of the intoxicated patients were selected. The data were centralized in the Microsoft Office Excel. The results obtained revealed the sum of 256 cases of pet poisoning in the last ten years (0.611% of the number of cases registered during this period), of which the predominantly affected species was the dog of mixed breed. Also, within the most common poisonings, the ones with ethylene glycol and anticoagulants rodenticides were observed. In the present study a correlation was established between breed, age, sex and the most frequent incidence of poisoning, common toxins and the connection between the periods of the year.


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