scholarly journals CHRONIC CONSUMPTION OF ALCOHOL ADVERSELY AFFECTS THE BONE OF YOUNG RATS

2019 ◽  
Vol 27 (6) ◽  
pp. 321-324 ◽  
Author(s):  
Rodrigo César Rosa ◽  
Wellington Francisco Rodrigues ◽  
Camila Botelho Miguel ◽  
Fabrizio Antonio Gomide Cardoso ◽  
Ana Paula Espindula ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Alcohol Consumption ◽  
Bone Mineral ◽  
Mechanical Resistance ◽  
Chronic Alcohol ◽  
Mineral Density ◽  
Chronic Alcohol Consumption ◽  
Tibial Length ◽  
Young Rats ◽  
Maximal Load

ABSTRACT Objective: To assess the effect of chronic alcohol consumption on the longitudinal growth of the tibia and bone quality parameters in young rats under an experimental setup. METHODS: The control (n=10) rats received only water. The ethanol (n=10) rats received ethyl alcohol at concentrations established in the protocol for the induction of chronic alcohol consumption. The blood samples were immediately collected via cardiac puncture and processed to evaluate the levels of alkaline phosphatase by automated spectrophotometry. Following blood sample collection, both tibias were dissected, and weighed; the tibial length was measured., and the samples were stored in a freezer for future analysis of the bone mineral content and mechanical resistance, known as maximal load and stiffness. RESULTS: Compromised bone health, with a 35.3% decrease in the serum alkaline phosphatase levels (p < 0.01), a 10% decrease in the tibial mass (p < 0.05), and a 5.3% decrease in the tibial length (p < 0.0001) were noted. Furthermore, a 10% decrease in the bone mineral density was observed (p < 0.01), which led to a 17.2% decrease in the maximum strength (p < 0.01) and 22.6% decrease in stiffness (p < 0.001). CONCLUSION: Chronic consumption of alcohol affected the bones of young rats, making them weaker and osteopenic. In addition, the long bones were shorter, suggesting interference with growth. Level of Evidence III, Case Control Study.

61 Bone Micro-Architecture, Mineral Density and Content in Rat Femurs After a Period of Chronic Alcohol Consumption

2009 ◽  
Vol 12 (1) ◽  
pp. 118
Author(s):  
D.B. Maurel ◽  
G.Y. Rochefort ◽  
N. Boisseau ◽  
C.L. Benhamou ◽  
C. Jaffré
Keyword(s):  
Alcohol Consumption ◽  
Chronic Alcohol ◽  
Mineral Density ◽  
Chronic Alcohol Consumption

Effects of One-Year Adjuvant Treatment with Tamoxifen on Bone Mineral Density in Postmenopausal Breast Cancer Women

1996 ◽  
Vol 82 (1) ◽  
pp. 65-67 ◽  
Author(s):  
Sandro Barni ◽  
Paolo Lissoni ◽  
Gabriele Tancini ◽  
Antonio Ardizzoia ◽  
Marina Cazzaniga
Keyword(s):  
Breast Cancer ◽  
Bone Mineral Density ◽  
Alkaline Phosphatase ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Adjuvant Treatment ◽  
Mineral Content ◽  
Postmenopausal Breast Cancer ◽  
Mineral Density ◽  
One Year

In this study, the authors have analyzed the possible effects of one-year adjuvant treatment with tamoxifen on bone mineral density in postmenopausal breast cancer women. Bone mineral content was studied by photon absorptiometry (I-125), whereas bone balance was analyzed indirectly by serum PTH, osteocalcin, calcitonin, calcium and alkaline phosphatase levels. Bone mineral content and serum bone-related substances were measured before starting treatment and after one year. Results were analyzed using Student's t test for paired data. No difference was found between the two measurements for bone mineral content, PTH, calcitonin, calcium and alkaline phosphatase levels. Measurements at entry and after one year of treatment showed a statistically significant difference ( P < 0.001) only for osteocalcin. In accordance with other authors, we can conclude that treatment with tamoxifen does not cause an increase in menopausal bone resorption. The finding that osteocalcin levels decreased after one year of therapy with tamoxifen is interesting, but further studies are necessary to clarify the role of such levels in predicting a turnover of bone balance towards osteoblastic activity.

scholarly journals Evaluation of association of fragility fracture and bone mineral density in Nepalese population

2013 ◽  
Vol 2 (2) ◽  
pp. 130-134
Author(s):  
Md. Farid Amanullah ◽  
BP Shrestha ◽  
GP Khanal ◽  
NK Karna ◽  
S Ansari ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Risk Factor ◽  
Alcohol Consumption ◽  
Bone Mineral ◽  
Fragility Fracture ◽  
High Energy ◽  
Medical Illness ◽  
Mineral Density ◽  
T Score ◽  
Study Results

Background: Fragility fractures are one of the major health problems. Many factors are associated with it some of which are modifiable and some are not. If we know the value of T-score at which fragility fracture occurs and associated factors responsible for fragility fracture than we will be able to control this burden to the society. The objective of this study is to determine association between fragility fracture and bone mineral density (BMD) using bone densitometry and to know the value of T-score at which fragility fracture occurs. Methods: Patients presenting to B.P. Koirala Institute of Health Sciences with fragility fracture of distal end of radius, fracture around hip and vertebral fractures were included in the study to know the value of T-score at which fragility fracture occurs and their associated risk factor. Patients less than 50 years of age, high energy trauma fracture and pathological fractures were excluded from the study. Results: We found that being multipara, smoking, alcohol consumption, post-hysterectomized patients and steroid intake had significant association with fragility fracture. There was no association with religion, geographic location, associated medical illness, age, sex, associated injury and site of injury. Conclusion: The patients with risk factor for fragility fracture like smoking, alcohol consumption, multipara women, post-hysterectomized women and those who are on long term steroid therapy should undergo BMD test and the value at -3.254 are prone to fragility fracture and should be treated accordingly. Nepal Journal of Medical Sciences | Volume 02 | Number 02 | July-December 2013 | Page 130-134 DOI: http://dx.doi.org/10.3126/njms.v2i2.8956

scholarly journals Chronic Alcohol Consumption Leads to a Tissue Specific Expression of Uncoupling Protein-2

2015 ◽  
Vol 12 (12) ◽  
pp. 995-999 ◽  
Author(s):  
Jan A. Graw ◽  
Clarissa von Haefen ◽  
Deniz Poyraz ◽  
Nadine Möbius ◽  
Marco Sifringer ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Uncoupling Protein ◽  
Uncoupling Protein 2 ◽  
Chronic Alcohol ◽  
Specific Expression ◽  
Chronic Alcohol Consumption ◽  
Tissue Specific ◽  
Tissue Specific Expression

Decreased Hepatotoxicity of Dimethylnitrosamine (DMN) Following Chronic Alcohol Consumption

1980 ◽  
pp. 237-243
Author(s):  
J. Gellert ◽  
F. Moreno ◽  
M. Haydn ◽  
H. Oldiges ◽  
H. Frenzel ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Chronic Alcohol ◽  
Chronic Alcohol Consumption
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