scholarly journals Effect of 0.15% sodium hialuronate and 0.5% carboxymethylcellulose on tear film breakup time in healthy dogs and in dogs with keratoconjunctivitis sicca

2018 ◽  
Vol 70 (5) ◽  
pp. 1388-1396
Author(s):  
G.M. Madruga ◽  
A.P. Ribeiro ◽  
T.B.S. Magalhães ◽  
L.A.S. Rondelli ◽  
F.H. Furlan
Keyword(s):  
Ocular Surface ◽  
Keratoconjunctivitis Sicca ◽  
Sodium Hyaluronate ◽  
Tear Film ◽  
Severe Form ◽  
Film Stability ◽  
Time Points ◽  
Healthy Dogs ◽  
Breakup Time ◽  
Goblet Cell Density

ABSTRACT This study aimed to evaluate the effect of the 0.15% sodium hyaluronate (SH) and of 0.5% carboxymethylcellulose (CMC) on tear film breakup time (TFBUT) in 10 healthy dogs and in 32 eyes of dogs with keratoconjunctivis sicca (KCS). In addition, the goblet cell density (GCD) of this population was quantified. TFBUT was assessed at baseline and at different time points following the instillation of SH and CMC. KCS was graded as mild, moderate, and severe. GCD were quantified from conjunctival biopsies. The number of GCD differed significantly between patients with mild and moderate KCS (P<0.01). TFBUT of healthy dogs increased only for 1 minute after treatment with SH (P<0.01). Regarding baseline and treatments, SH significantly increased TFBUT for up to 30 minutes on the ocular surface, in comparison to CMC, in all categories of KCS (P<0.01). TFBUT and GCD correlated positively when the healthy and diseased eyes were grouped (r=0.41, P=0.006). It can be concluded that in dogs with KCS, SH lasts longer periods on the ocular surface than CMC, but such agents does not increase TFBUT in healthy dogs. Additionally, tear film stability tends to reduce in a linear fashion from the mild to severe form of KCS.

scholarly journals New Possibilities of Tear Replacement Therapy in Patients with Dry Eye Syndrome of Various Origins

2019 ◽  
Vol 16 (2) ◽  
pp. 244-251
Author(s):  
V. V. Brzheskiy ◽  
S. Yu. Golubev ◽  
I. V. Brzheskaya ◽  
V. Yu. Popov
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Sodium Hyaluronate ◽  
Tear Film ◽  
Severe Form ◽  
Dry Eye Syndrome ◽  
Degenerative Changes ◽  
Ocular Surface Disease Index ◽  
Film Stability ◽  
Days Of Therapy

The artificial tears on the basis hyaluronic acid is primary importance today in dry eye syndrome (DES) treatment. In recent years, they have been supplemented Optinol® Express Moisture (0.21 %) and Optinol® Deep Moisture (0.4 %) differing concentrations of sodium hyaluronate and viscosity. The study is devoted to assessing the effectiveness of these drugs in the treatment of patients with dry eye syndrome (DES) of various etiology and severities.There were 73 volunteers with DES of various etiology: 21 — Sjogren’s syndrome, 24 — meibomian blepharitis, and 28 — perimenopause in the study. All patients were divided into 2 groups: 36 patients of the first group received instillations into conjunctival cavity of the Optinol® Express Moisture (0.21 %) and 37 patients of the second group — Optinol® Deep moistening (0.4 %).Starting from the first days of therapy, all patients had a decrease in the severity of subjective signs of DES, estimated by the value of the ocular surface disease index (OSDI). At the same time, tendency to stop of the degenerative changes in the epithelium of the ocular surface was established. It is characterized by a decrease in the degree of staining. The increasement of the tear film stability and an index of the tear meniscus was found in all patients. The dynamics of the controlled parameters increased, as the instillation of the drugs took place and by the 30th day of therapy. There were significant differences from the baseline values. At the same time, the Optinol® Express Moisture (0.21 %) was more effective (mainly in terms of subjective discomfort and the severity of degenerative changes in the epithelium of the ocular surface) in patients with mild and extremely severe form of the xerosis process.The drug Optinol® Deep Moisture (0.4 %) was more effective in patients with xerosis of moderate severity and severe by the same parameters. In the course of research, we have not observed any side effects of both drugs. It allows us to recommend the drugs Optinol® Express Moisture (0.21 %) and Optinol® Deep Moisture (0.4 %) to widespread clinical use in treating patients with DES of various etiology. 

scholarly journals Association among Blink Rate, Changes in Ocular Surface Temperature, Tear Film Stability, and Functional Visual Acuity in Patients after Cataract Surgery

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Takashi Itokawa ◽  
Yukinobu Okajima ◽  
Takashi Suzuki ◽  
Tatsuhiko Kobayashi ◽  
Yuto Tei ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Regression Analysis ◽  
Cataract Surgery ◽  
Ocular Surface ◽  
Tear Film ◽  
Blink Rate ◽  
Film Stability ◽  
Tear Film Stability ◽  
Functional Visual Acuity ◽  
Film Group

Purpose. To investigate the association among the ocular surface temperature (OST), tear film stability, functional visual acuity (FVA), and blink rate in patients after cataract surgery. Methods. We recruited 98 eyes of 69 patients (mean age, 73.7 ± 5.2 years) 1 month after phacoemulsification with implantation of acrylic intraocular lenses and assessed slit-lamp microscopy, corrected distance VA, FVA, noninvasive tear breakup time (NIBUT), and OST. We defined the changes in the OST from 0 to 10 seconds after eye opening as the ΔOST. We measured the FVA and blink rate using the FVA measurement system. We divided the patients into two groups based on tear film stability: stable tear film (NIBUT, >5.0 seconds) and unstable tear film (NIBUT, ≤5.0 seconds). We evaluated the differences between the two groups and the association between the blink rate and other clinical parameters. Results. The unstable tear film group (56 eyes) had significantly (p<0.0001, unpaired t-test) shorter NIBUTs than the stable tear film group (42 eyes). The ΔOSTs and blink rates were significantly (p<0.0001) higher in the unstable tear film group than in the stable group. Linear single regression analysis showed that the ΔOST (r = −0.430, p<0.0001), NIBUT (r = −0.392, p<0.0001), and gender (r = −0.370, p=0.0002) were correlated significantly with the blink rate. Multiple regression analysis showed that the ΔOST independently contributed to the blink rate. Conclusions. The frequency of blinks is associated with tear film stability in patients after cataract surgery. The blink rate may be useful for evaluating the tear film stability in clinical practice. The ΔOST should be an important contributing factor to the blink rate. [This trial is registered with UMIN000026970].

The ocular surface in children: A review of current knowledge and meta-analysis of tear film stability and tear secretion in children

2019 ◽  
Vol 17 (1) ◽  
pp. 28-39 ◽  
Author(s):  
Ngozi Charity Chidi-Egboka ◽  
Nancy E. Briggs ◽  
Isabelle Jalbert ◽  
Blanka Golebiowski
Keyword(s):  
Ocular Surface ◽  
Current Knowledge ◽  
Meta Analysis ◽  
Tear Film ◽  
Film Stability ◽  
Tear Secretion ◽  
Tear Film Stability

scholarly journals Association Between Ocular Surface Temperature and Tear Film Stability in Soft Contact Lens Wearers

2018 ◽  
Vol 59 (2) ◽  
pp. 771 ◽  
Author(s):  
Takashi Itokawa ◽  
Yukinobu Okajima ◽  
Takashi Suzuki ◽  
Koji Kakisu ◽  
Hiroko Iwashita ◽  
...  
Keyword(s):  
Surface Temperature ◽  
Contact Lens ◽  
Ocular Surface ◽  
Tear Film ◽  
Soft Contact ◽  
Film Stability ◽  
Soft Contact Lens ◽  
Tear Film Stability

scholarly journals Efficacy of carbomer sodium hyaluronate trehalose vs hyaluronic acid to improve tear film instability and ocular surface discomfort after cataract surgery

2019 ◽  
Vol Volume 13 ◽  
pp. 1157-1163 ◽  
Author(s):  
L Caretti ◽  
A La Gloria Valerio ◽  
R Piermarocchi ◽  
G Badin ◽  
G Verzola ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cataract Surgery ◽  
Ocular Surface ◽  
Sodium Hyaluronate ◽  
Tear Film ◽  
Film Instability

Correlation between Non-Invasive Tear Breakup Time and Invasive Tear Breakup Time for Dry Eye Syndrome Diagnosis

The Eye ◽  
2021 ◽  
Vol 23 (1) ◽  
pp. 15-22
Author(s):  
K. A. Mubarakova ◽  
S. A. Mukhanov ◽  
I. F. Saliyev ◽  
N. H. Habibullayeva
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Optical Power ◽  
Dry Eye Syndrome ◽  
Non Invasive ◽  
Syndrome Diagnosis ◽  
Breakup Time ◽  
Test Result ◽  
Schirmer I Test

Introduction: in today’s digital environment, dry eye complaints step forward in all age groups. Along with dry eye syndrome, the diagnosis of which is not complicated, there are other causes of dryness such as dysfunction of the tear film and Meibomian glands, etc. For the early detection of the above conditions, invasive diagnostic methods are mainly used.Aim: to compare Non-Invasive Tear Breakup Time (NITBUT) assessed with LacryDiag ocular surface analyzer to results of invasive tests for dry eye syndrome diagnosis to determine the possibility of a wider use of LacryDiag in practical ophthalmology. Materials and Methods: 50 patients with dry eye, burning and feeling of a foreign body complaints participated in this study. Mean age amounted to 28.85 ± 5.86 years. NITBUT was assessed with LacryDiag ocular surface analyzer. The data obtained was compared to the results of Invasive Tear Breakup Time (TBUT) – Norne test, and Schirmer I test.Results: both quantitative and qualitative values of tear film stability were analyzed in all participants. Based on results of the Schirmer I test, patients were divided into subgroups: where it was greater than 21 mm, between 11 and 20 mm, between 6 and 10 mm, and less than 5 mm/ The mean value of the Schirmer I test result amounted to 15.32 ± 6.05 mm/5 min, NITBUT amounted to 9.59 ± 4.37 s, while invasive TBUT amounted to 8.98 ± 3.79 s. It was found that invasive TBUT is in a strong direct correlation with NITBUT values (p <0.001, r = 0.554). No correlation was discovered between Schirmer I test results and TBUT (p = 0.15, r = 0.207) as well as between Schirmer I test result and NITBUT (p = 0.17, r =0.228). No correlation was found between the optical power of the cornea and the tear film structure abnormalities.Conclusion: a strong correlation was found between results of invasive and non-invasive methods of tear film breakup time assessment. No correlation was found between the optical power of the cornea and the tear film disruption. The non-invasive test was found to be an effective and objective method for diagnosing dry eye.

Clinical manifestations of the dry eye syndrome for women in menopause

2014 ◽  
Vol 5 (2) ◽  
pp. 25-29
Author(s):  
Nataliya Nikolayevna Sadovnikova ◽  
Galiya Fettyakhovna Kutusheva
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Clinical Manifestations ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Menopausal Syndrome ◽  
Film Stability ◽  
Tear Film Stability ◽  
Functional Features ◽  
Subjective Discomfort

To assess the effect of menopausal syndrome manifestations in the manifestation of «dry eye» examined 63 women . All examined the condition of the ocular surface, tear film stability, severity of subjective discomfort . Revealed that the dry eye syndrome in postmenopausal women occurs predominantly in the mild and moderate forms, with the severity of clinical and functional features of dry eye syndrome significantly correlated with severity of menopausal symptoms .

scholarly journals The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Sevda Aydin Kurna ◽  
Semih Acikgoz ◽  
Ahmet Altun ◽  
Nurver Ozbay ◽  
Tomris Sengor ◽  
...  
Keyword(s):  
Prospective Study ◽  
Ocular Surface ◽  
Beta Blockers ◽  
Squamous Metaplasia ◽  
Tear Film ◽  
Eye Drops ◽  
Group 2 ◽  
A Prospective Study ◽  
Breakup Time ◽  
Corneal Staining

Purpose. The aim was to compare the effects of antiglaucoma eye drops on the tear functions and ocular surface.Method. Eighty-five eyes of 43 patients with glaucoma were included into this randomized prospective study. Timolol without preservative (1), timolol with benzododecinium bromide (2), latanoprost (3), bimatoprost (4), travoprost with benzalkonium chloride (5), and brimonidine with purite (6) were given to 6 groups. Schirmer I, tear film breakup time (TBUT), staining scores, and impression cytology samples were evaluated before and during 12-month-follow-up period.Results. At the end of 12 months, there was no detected change in Schirmer I and TBUT tests indicating dry eye. Corneal staining scores were higher in groups 1 and 2, while conjunctival staining scores were higher in group 6. Goblet cell count decreased in groups 1 and 5 in superior and inferior, group 2 in superior, and groups 3 and 6 in inferior conjunctiva. Squamous metaplasia grades showed a significant increase in groups 1 and 2 at 3rd, 6th, and 12th month controls (P<0.05).Conclusion. We observed nonserious impact on tear functions and ocular surface with antiglaucoma monotherapy. Beta blockers induced more damage on the ocular surface suggesting the role of the dosing and active substances beside preservatives.

scholarly journals Factors associated with ocular surface epithelial damage in patients with primary Sjögren’s syndrome

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ji Eun Kim ◽  
Na Rae Kim ◽  
Hee Seung Chin ◽  
Kyoung Yul Seo ◽  
Tae-im Kim ◽  
...  
Keyword(s):  
Ocular Surface ◽  
Tear Film ◽  
Meibomian Gland ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Laboratory Findings ◽  
Surface Parameters ◽  
Primary Sjögren's Syndrome ◽  
Epithelial Damage ◽  
Breakup Time

Abstract Background The aim of this study was to evaluate the effects of systemic parameters, laboratory findings, oral parameters, and other ocular surface parameters on ocular surface epithelial damage in patients with primary Sjögren’s syndrome (pSS). Methods A total of 82 dry eye disease (DED) patients with pSS were enrolled in this study. Ocular surface epithelial damage was measured by ocular staining score (OSS). Systemic parameters, laboratory findings including serologic markers, oral parameters, and other ocular surface parameters were collected. Other ocular surface parameter assessments such as the Schirmer’s test, fluorescein tear breakup time, meibomian gland examinations, noninvasive keratographic tear film break-up time measurements using the Keratograph® 5 M were performed, and the Ocular Surface Disease Index was determined. Results In a multivariate analysis, decreased age and increased duration of pSS were significantly related to increased logarithm-transformed OSS (β = -0.011, P = 0.043 and β = 0.003, P = 0.008). Among the ocular surface parameters, decreased fluorescein tear breakup time and increased MGD grade were significantly associated with increased logarithm-transformed OSS (β = -0.183, P < 0.001 and β = 0.192, P = 0.049). Conclusions Ocular surface epithelial damage in patients with pSS was associated with young age, long duration of disease, unstable tear film, and decreased meibomian gland function.

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