scholarly journals Presumed cytomegalovirus retinitis late after kidney transplant

2021 ◽  
Author(s):  
Filipa Silva ◽  
Klaus Nunes Ficher ◽  
Laila Viana ◽  
Inês Coelho ◽  
Juliana Toniato Rezende ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Kidney Transplant ◽  
Invasive Disease ◽  
Secondary Prophylaxis ◽  
Clinical Suspicion ◽  
Cmv Infection ◽  
Ocular Complications ◽  
Cmv Retinitis ◽  
Long Period ◽  
Rare Manifestation

Abstract Cytomegalovirus (CMV) retinitis is a rare manifestation of CMV invasive disease and potentially threatening to vision in immunocompromised individuals. Clinical suspicion is fundamental since it is an unusual entity with a progressive and often asymptomatic installation over a long period. The authors report a 70-year-old man with diabetic nephropathy who underwent a kidney transplant (KT) in August 2014 with good clinical evolution. No previous CMV infection or episodes of acute rejection were reported. Five years after transplant, he was admitted due to a reduced visual acuity of the left eye with seven days of evolution with associated hyperemia, without exudate. The ophthalmologic evaluation was compatible with acute necrosis of the retina and presumed associated with CMV infection. He had a progressive improvement after ganciclovir initiation. CMV retinitis is one of the most serious ocular complications in immune-suppressed individuals and can lead to irreversible blindness, and because of that, early diagnosis and treatment remains crucial in obtaining the best visual prognosis in affected patients. Secondary prophylaxis with ganciclovir is not consensual, neither is the safety of reintroducing the antimetabolite in these cases.

scholarly journals Acute Progressive Visual Loss in a Case of Acute Myeloid Leukemia: Challenges in the Utility of Molecular Tests in Early Diagnose of Cytomegalovirus Retinitis

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Ali Amanati ◽  
Nader Shakibazad ◽  
Bahman Pourabbas ◽  
Mohammad Hossein Nowroozzadeh ◽  
Soheila Zareifar ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Visual Loss ◽  
Viral Infections ◽  
Cmv Infection ◽  
Cmv Retinitis ◽  
Molecular Tests ◽  
Early Diagnose ◽  
Clinical Pictures ◽  
Acute Myeloid

Cytomegalovirus (CMV) retinitis is one of the rare but debilitating presentations of the CMV infection in children with leukemia. Herein, we report a 12-year-old boy with acute myeloid leukemia complicated by rapid progressive visual loss during relapse of leukemia. The definite diagnosis of CMV retinitis was made after vitreous aspiration. Despite prompt treatment and ophthalmologic intervention, he died because of AML relapse. Viral infections, especially cytomegalovirus infection, may present with vague clinical pictures during any time of chemotherapy, which may not be easily distinguishable from bacterial or fungal retinitis and also chemotherapy-induced retinopathies. Clinician should consider CMV retinitis in seropositive patients especially those without detectable viremia.

scholarly journals A rare case of cytomegalovirus presentation in a hemodialysis patient

2017 ◽  
Vol 4 (3) ◽  
pp. 79
Author(s):  
Liesbeth De Waele ◽  
Katrien Wierckx ◽  
Anne-Marie Bogaert
Keyword(s):  
Terminal Ileum ◽  
Hemodynamic Instability ◽  
Cmv Infection ◽  
Intravenous Ganciclovir ◽  
Diffuse Abdominal Pain ◽  
Rare Manifestation ◽  
End Stage ◽  
Gastro Intestinal Tract ◽  
Cmv Disease ◽  
Substantial Morbidity

Background: Cytomegalovirus (CMV) infection is a common viral infection in humans with a diverse manifestation, mostly dependent on the host. CMV infection in the immunocompetent host is generally asymptomatic or may present as a mononucleosis syndrome. Infection in immunocompromised patients cause substantial morbidity and mortality.Case representation: We report a rare manifestation of a CMV infection in a 87-year-old male with end-stage renal failure with dialysis dependency and diabetes who presents with diffuse abdominal pain and nausea. Further assessment with a CT scan of the abdomen showed a thickening of the wall of the preterminal ileum, suggestive of focal enteritis. Ileocolonoscopy showed a partial circular ulcerated mucosa of the preterminal ileum, biopsies showed ulcerations, etiology was unknown. A few days later he develops melena and anemia of 7.2 g/dl. Further exploration with gastroscopy was normal. A new colonoscopy showed no abnormalities; however the terminal ileum could not be visualized. An urgent laparotomy was performed because of hemodynamic instability and showed an ulcus of 7 cm with a thickened terminal ileum. An enterectomy of the inflammated part of the ileum was performed. Histopathology of the ulceration showed the presence of CMV inclusions in the vascular endothelium of the capillaires of the ileal segment. Serologic examination showed nonreactive CMV IgM antibodies and IgG antibodies were positive. PCR CMV showed 300 copies/ml (whole blood). Treatment with intravenous ganciclovir was started with good clinical and biochemical response.Conclusions: In the differential diagnosis CMV disease should be considered in any ulceration in the gastro-intestinal tract in the immunocompromised patient.

scholarly journals Diagnostic usefulness of the cytomegalovirus (CMV)-specific T cell-based assay for predicting CMV infection after kidney transplant

2020 ◽  
Vol 35 (2) ◽  
pp. 438-448 ◽  
Author(s):  
Taeeun Kim ◽  
Hyun-Jeong Lee ◽  
Sun-Mi Kim ◽  
Joo Hee Jung ◽  
Sung Shin ◽  
...  
Keyword(s):  
T Cell ◽  
Kidney Transplant ◽  
Cmv Infection ◽  
Diagnostic Usefulness

scholarly journals CD4+T cell levels are decreased during active CMV infection in kidney transplant recipients

2002 ◽  
Vol 34 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Sahar Essa ◽  
Alexander S Pacsa ◽  
Raj Raghupathy ◽  
Raja'a Al-Attiyah ◽  
Amany El-Shazly ◽  
...  
Keyword(s):  
T Cell ◽  
Kidney Transplant ◽  
Cd4 T Cell ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Cmv Infection

Ocular Complications

2019 ◽  
pp. 447-452
Author(s):  
James P. Dunn
Keyword(s):  
Risk Factors ◽  
Systemic Therapy ◽  
Treatment Options ◽  
Clinical Findings ◽  
Immune Recovery ◽  
Ocular Complications ◽  
Immune Recovery Uveitis ◽  
Cmv Retinitis ◽  
Symptoms And Signs

Upon completion of this chapter, the reader should be able to • Describe the symptoms and signs of cytomegalovirus (CMV) retinitis in patients with AIDS. • Describe treatment options for CMV retinitis and the need for systemic therapy whenever possible. • Identify risk factors, clinical findings, and treatment of immune recovery uveitis....

HIV: disorders of the eye

2019 ◽  
pp. 513-522
Keyword(s):  
Herpes Zoster ◽  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Opportunistic Infections ◽  
Acute Retinal Necrosis ◽  
Ocular Complications ◽  
Eye Infections ◽  
Cmv Retinitis ◽  
Ophthalmic Manifestations ◽  
Wide Availability

Although the incidence of ocular complications of HIV declined significantly with the wide availability of effective antiretroviral therapy, they are still important and require close collaboration between the HIV physician and the ophthalmologists. This chapter describes the ophthalmic manifestations of HIV infection, tabulated according to the anatomy of the eye. HIV-related conditions and opportunistic infections are described. Particular reference and details are given to important eye infections, such as CMV retinitis, ophthalmic herpes zoster, acute retinal necrosis, and progressive outer retinal necrosis.

Other Viral Uveitis Except for Herpes, Cytomegalovirus and Human Immunodeficiency Viruses

2019 ◽  
pp. 277-282
Keyword(s):  
Visual Acuity ◽  
Epstein Barr Virus ◽  
Ebola Virus ◽  
Viral Disease ◽  
Eye Disease ◽  
Ocular Complications ◽  
Barr Virus ◽  
Human Immunodeficiency Viruses ◽  
Epstein Barr ◽  
Rift Valley Virus

Viral uveitis may happen as isolated eye disease or as a part of systemic viral disease. Large ocular findings occur. Early diagnosis and treatment are important to prevent ocular complications that are threatened by visual acuity. In this review, we mention about other viral üveitis seen less frequently except for herpes, cytomegalovirus, and human immunodeficiency viruses including Epstein-Barr virus (EBV), measles (Rubeola), rubella (Rubella), arboviruses (Dang, Chikungunya, Rift Valley virus and West Nile virus [WNV]) and other rare causes Influenza, Koksaki, Ebola virus.

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