scholarly journals Involucrin in the differential diagnosis between linear psoriasis and inflammatory linear verrucous epidermal nevus: a report of one case

2013 ◽  
Vol 88 (4) ◽  
pp. 604-607 ◽  
Author(s):  
Flávia Regina Ferreira ◽  
Nilton Gioia Di Chiacchio ◽  
Márcia Lanzoni de Alvarenga ◽  
Samuel Henrique Mandelbaum
Keyword(s):  
Differential Diagnosis ◽  
Physical Examination ◽  
Clinical Manifestations ◽  
Clinical History ◽  
Epidermal Nevus ◽  
Linear Psoriasis

Inflammatory linear verrucous epidermal nevus is a variant of verrucous epidermal nevus, characterized by recurrent inflammatory phenomena. Despite well-established clinical manifestations, the differential diagnosis between inflammatory linear verrucous epidermal nevus and linear psoriasis remains difficult. Clinical history, physical examination and histopathology analysis may not be sufficient to confirm the diagnosis. We report the case of a 4-year-old girl in which the involucrin immunostaining was helpful in the diagnosis of inflammatory linear verrucous epidermal nevus. Our findings confirm that involucrin immunohistochemistry is a useful tool in such cases.

scholarly journals Linear Psoriasis- A rare case report

2016 ◽  
Vol 8 (1) ◽  
pp. 74
Author(s):  
Md. Mahabubur Rahaman ◽  
Md Rahmat Ullah Siddique ◽  
Md Aminul Islam ◽  
Md. Moksedur Rahman ◽  
Md. Zahed Parvez Barbhuiyan ◽  
...  
Keyword(s):  
Case Report ◽  
Physical Examination ◽  
Skin Biopsy ◽  
Rare Case ◽  
Clinical History ◽  
Rare Form ◽  
Epidermal Nevus ◽  
Linear Pattern ◽  
Rare Case Report ◽  
Linear Psoriasis

Linear psoriasis is a rare form of disease which is very difficult to differentiate from inflammatory linear verrucous epidermal nevus. Sometimes clinical history, physical examination and histopathology analysis may not be sufficient to confirm the diagnosis. We report a case of25 year-old male presented with a linear plaque covered with silvery scales on left upper extremity extending from tip of the index to mid forearm for last 2 years. A skin biopsy was consistent with psoriasis, and the unilateral distribution in a linear pattern led to a diagnosis of linear psoriasis, which is a rare variant of psoriasis. Although histopathologically it can be difficult to distinguish from inflammatory linear verrucous epidermal nevus (ILVEN), linear psoriasis presents in adulthood and responds to conventional topical antipsoriatic therapies.

scholarly journals Gradinego’s syndrome: atypical presentation

2018 ◽  
Vol 4 (2) ◽  
pp. 604
Author(s):  
Sumana C. V. ◽  
Suhel Hasan
Keyword(s):  
Differential Diagnosis ◽  
Physical Examination ◽  
Otitis Media ◽  
Nerve Palsy ◽  
Surgical Intervention ◽  
Clinical History ◽  
Atypical Presentation ◽  
Sixth Cranial Nerve ◽  
Gradenigo’S Syndrome ◽  
Periorbital Pain

Gradenigo’s syndrome was first described by Giuseppe Gradenigo in 1907 when he reported a triad of symptoms consisting of unilateral periorbital pain related to trigeminal nerve involvement, diplopia due to sixth cranial nerve palsy and persistent otorrhoea, associated with otitis media with petrositis. The classical syndrome related to otitis media has become very rare after the antibiotic era. Incomplete and atypical clinical features of Gradenigo’s syndrome have been described and non infectious causes may mimic this condition. We report a case of acute petrositis in a 19 year old boy with unilateral periorbital pain, diplopia (lateral rectus palsy) in the absence of ear discharge. Careful clinical history, physical examination, including neuroimaging, is necessary to make a differential diagnosis. Appropriate management requires antibiotic treatment and possible surgical intervention.

Abdominal Pain and Abdominal Mass

2018 ◽  
Author(s):  
Blake D. Babcock ◽  
Alexander E. Poor ◽  
Mohammad F. Shaikh ◽  
Wilbur B. Bowne
Keyword(s):  
Differential Diagnosis ◽  
Abdominal Pain ◽  
Physical Examination ◽  
Acute Abdominal Pain ◽  
Abdominal Mass ◽  
Gastroesophageal Junction ◽  
Percutaneous Biopsy ◽  
Clinical History ◽  
Diagnostic Process ◽  
Abdominal Masses

Acute abdominal pain and abdominal mass are intimately connected; therefore, the diagnostic process for evaluating abdominal pain and abdominal masses is largely the same and has been preserved since ancient times. The primary goals in the management of patients with abdominal pain and/or abdominal mass are to establish a differential diagnosis by obtaining a clinical history, to refine the differential diagnosis with a physical examination and appropriate studies, and to determine the role of operative intervention in the treatment or refinement of the working diagnosis. This review describes the process of diagnosing abdominal pain, including taking a clinical history and performing a physical examination. Investigative studies, including laboratory tests, imaging, and pathology are reviewed. Management, including surgical treatment, is discussed. Tables describe intraperitoneal and extraperitoneal causes of acute abdominal pain, frequency of specific diagnoses in patients with acute abdominal pain, and common abdominal signs and findings noted on physical examination. Figures show abdominal pain in specific locations, a data sheet, the differential diagnosis of an abdominal mass by quadrant or region, characteristic patterns of abdominal pain, acute appendicitis with associated appendicolith, bilateral adrenal masses, adrenocortical carcinoma, retroperitoneal leiomyosarcoma, pancreatic mass, a sagittal ultrasonogram of the pancreas, ultrasonograms of the liver, a dark and well circumscribed abdominal mass, gastroesophageal junction adenocarcinoma, and percutaneous biopsy of a large abdominal mass. An algorithm outlines the assessment of acute abdominal pain and abdominal mass. This review contains 14 figures, 5 tables, and 143 references.

scholarly journals Unusual Clinical Manifestations of Chronic Discoid Lupus Erythematosus

2014 ◽  
Vol 6 (2) ◽  
pp. 69-72
Author(s):  
Ljubka Miteva ◽  
Valentina Broshtilova ◽  
Robert A. Schwartz
Keyword(s):  
Physical Examination ◽  
Alopecia Areata ◽  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Clinical History ◽  
Discoid Lupus Erythematosus ◽  
Histopathological Analysis ◽  
Scarring Alopecia ◽  
History Of ◽  
Scalp Lesions

Abstract A 22-year-old woman with a 3-year history of discoid lupus erythematosus presented with two circumscribed patches of non-scarring alopecia, clinically simulating alopecia areata. Histopathological analysis of scalp lesions revealed discoid lupus erythematosus. Based on the clinical history, physical examination, and histological and immunological findings, we distinguished our case from a true combination of alopecia areata and typical chronic discoid lupus erythematosus.

scholarly journals Clinical and histological challenge in the differential diagnosis of diffuse alopecia: female androgenetic alopecia, telogen effluvium and alopecia areata - part I

2012 ◽  
Vol 87 (5) ◽  
pp. 742-747 ◽  
Author(s):  
Betina Werner ◽  
Fabiane Mulinari-Brenner
Keyword(s):  
Physical Examination ◽  
Alopecia Areata ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Clinical History ◽  
Careful Analysis ◽  
Androgenetic Alopecia ◽  
Histological Changes ◽  
Female Pattern Hair Loss ◽  
Scalp Biopsy

Diffuse androgenetic alopecia (female pattern hair loss), telogen effluvium, and diffuse alopecia areata may have similar clinical manifestations. Subtle details on physical examination and dermoscopy of the scalp may help to identify those disorders. The authors present a practical discussion on how to approach the patient with diffuse alopecia, considering clinical history, physical examination, and dermoscopic findings. If the diagnosis remains unclear after a careful analysis of the clinical signs, a scalp biopsy may help to distinguish between the three diseases. In this first part of our study, an objective review of female androgenetic alopecia is presented and the most important histological changes are discussed.

Abdominal Pain and Abdominal Mass

2020 ◽  
Author(s):  
Madison M. Crutcher ◽  
Darshak S. Thosani ◽  
Mohammad F. Shaikh ◽  
Wilbur B. Bowne
Keyword(s):  
Differential Diagnosis ◽  
Abdominal Pain ◽  
Physical Examination ◽  
Acute Abdominal Pain ◽  
Abdominal Mass ◽  
Gastroesophageal Junction ◽  
Percutaneous Biopsy ◽  
Clinical History ◽  
Diagnostic Process ◽  
Abdominal Masses

Acute abdominal pain and abdominal mass are intimately connected; therefore, the diagnostic process for evaluating abdominal pain and abdominal masses is largely the same and has been preserved since ancient times. The primary goals in the management of patients with abdominal pain and/or abdominal mass are to establish a differential diagnosis by obtaining a clinical history, to refine the differential diagnosis with a physical examination and appropriate studies, and to determine the role of operative intervention in the treatment or refinement of the working diagnosis. This review describes the process of diagnosing abdominal pain, including taking a clinical history and performing a physical examination. Investigative studies, including laboratory tests, imaging, and pathology are reviewed. Management, including surgical treatment, is discussed. Tables describe intraperitoneal and extraperitoneal causes of acute abdominal pain, frequency of specific diagnoses in patients with acute abdominal pain, and common abdominal signs and findings noted on physical examination. Figures show abdominal pain in specific locations, a data sheet, the differential diagnosis of an abdominal mass by quadrant or region, characteristic patterns of abdominal pain, acute appendicitis with associated appendicolith, bilateral adrenal masses, adrenocortical carcinoma, retroperitoneal leiomyosarcoma, pancreatic mass, a sagittal ultrasonogram of the pancreas, ultrasonograms of the liver, a dark and well circumscribed abdominal mass, gastroesophageal junction adenocarcinoma, and percutaneous biopsy of a large abdominal mass. An algorithm outlines the assessment of acute abdominal pain and abdominal mass. This review contains 16 figures, 5 tables, and 164 references. Keywords:  anatomy, swellings, inflammatory, opioid, palpatation, PET, COVID 19

scholarly journals A case of seminoma presented with clinical manifestations of testicular torsion

2017 ◽  
Vol 89 (3) ◽  
pp. 236
Author(s):  
Aytac Sahin ◽  
Caglar Yildirim ◽  
Serkan Akan ◽  
Ozgur Haki Yuksel ◽  
Ahmet Urkmez
Keyword(s):  
Differential Diagnosis ◽  
Physical Examination ◽  
Clinical Picture ◽  
Laboratory Tests ◽  
Testicular Torsion ◽  
Clinical Manifestations ◽  
Testicular Tumor ◽  
Imaging Modalities ◽  
Acute Scrotum ◽  
Testicular Tumors

Testicular tumors rarely manifest themselves with clinical picture of testicular torsion. In this presentation of ours, we reported a 30-year-old patient whose post-orchiectomy histopathology report revealed the presence of seminoma. The patient consulted us with acute scrotum whose physical examination and Doppler ultrasonographic findings showed testicular torsion. Though rarely seen patients, in cases who consulted with acute scrotum, the possibility of testicular tumor should not be discarded. For the establishment of differential diagnosis detailed anamnesis and physical examination findings should be supported with laboratory tests and imaging modalities.

scholarly journals Peripheral blood smear pathologist tool

2020 ◽  
Vol 8 (1) ◽  
pp. 10-11
Author(s):  
Menka Kapil ◽  
Rateesh Sareen ◽  
GN Gupta
Keyword(s):  
Differential Diagnosis ◽  
Physical Examination ◽  
Peripheral Blood ◽  
Blood Smear ◽  
Clinical History ◽  
Peripheral Blood Smear ◽  
Microscopic Evaluation

Microscopic evaluation of a peripheral blood smear is one of the most valuable test for the diagnosis and differential diagnosis of disease inclusive of clinical history and physical examination. Despite advances in haematology automation and application of molecular techniquesits diagnostic relevance is enormous.

scholarly journals Widely Spread Unilateral Inflammatory Linear Verrucous Epidermal Nevus (ILVEN)

2018 ◽  
Vol 10 (2) ◽  
pp. 169-174
Author(s):  
Kayo Tanita ◽  
Taku Fujimura ◽  
Yota Sato ◽  
Chunbing Lyu ◽  
Setsuya Aiba
Keyword(s):  
Carbon Dioxide ◽  
Differential Diagnosis ◽  
Proinflammatory Cytokines ◽  
Immunohistochemical Staining ◽  
Psoriasis Vulgaris ◽  
Epidermal Nevus ◽  
Gas Laser ◽  
Carbon Dioxide Gas ◽  
Linear Psoriasis

Inflammatory linear verrucous epidermal nevus (ILVEN) is an epidermal nevus that clinically and histologically mimics linear psoriasis. The pathogenesis of psoriasis has been widely investigated, with recent studies focusing especially on targeting proinflammatory cytokines such as IL-17A, TNFα, IL-23, and IL-12, while little is known about ILVEN. Since the treatment for ILVEN varies widely from the administration of topical ointment for psoriasis to invasive methods such as carbon dioxide gas laser, the differential diagnosis between ILVEN and psoriasis is necessary. In this report, we describe a case of widely spread unilateral ILVEN that clinically and histologically mimicked psoriasis vulgaris and could be diagnosed by immunohistochemical staining focused on the IL-36γ/IL-17A axis.

A glance on dystonias, how to recognize and handle them

2019 ◽  
pp. 22-29
Author(s):  
F. N. Mercan ◽  
E. Bayram ◽  
M. C. Akbostanci
Keyword(s):  
Differential Diagnosis ◽  
Movement Disorder ◽  
Age Of Onset ◽  
Clinical Manifestations ◽  
Body Part ◽  
Classification Model ◽  
Treatment Choices ◽  
Muscle Groups

Dystonia refers to an involuntary, repetitive, sustained, painful and twisting movements of the affected body part. This movement disorder was first described in 1911 by Hermain Oppenheim, and many studies have been conducted to understand the mechanism, the diagnosis and the treatment of dystonia ever since. However, there are still many unexplained aspects of this phenomenon. Dystonia is diagnosed by clinical manifestations, and various classifications are recommended for the diagnosis and the treatment. Anatomic classification, which is based on the muscle groups involved, is the most helpful classification model to plan the course of the treatment. Dystonias can also be classified based on the age of onset and the cause. These dystonic syndromes can be present without an identified etiology or they can be clinical manifestations of a neurodegenerative or neurometabolic disease. In this review we summarized the differential diagnosis, definition, classifications, possible mechanisms and treatment choices of dystonia.

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