scholarly journals TSH neurosecretory dysfunction (TSH-nd) in Down syndrome (DS): low risk of progression to Hashimoto's thyroiditis

2011 ◽  
Vol 55 (8) ◽  
pp. 628-631 ◽  
Author(s):  
Claudia Dutra Costantin Faria ◽  
Simone Ribeiro ◽  
Cristiane Kochi ◽  
Aryane Pereira Neves da Silva ◽  
Bruna Natalia Freire Ribeiro ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Hashimoto’S Thyroiditis ◽  
Low Risk ◽  
Hashimoto's Thyroiditis ◽  
Thyroid Antibodies ◽  
Free T4 ◽  
Risk Of Progression ◽  
Slight Elevation

INTRODUCTION: Patients with Down syndrome (DS) often have elevated TSH (hypothalamic origin), which is called TSH neurosecretory dysfunction (TSH-nd). In these cases, there is slight elevation in TSH (5-15 µUI/mL), with normal free T4 and negative thyroid antibodies (AB). OBJECTIVE: To recognize the risk of progression to Hashimoto's thyroiditis (HT). SUBJECTS AND METHODS: We retrospectively analyzed 40 DS patients (mean age = 4.5 years), followed up for 6.8 years. RESULTS: HT was diagnosed in 9/40 patients, three early in monitoring, and six during evolution. In 31/40 patients, TSH-nd diagnosis remained unchanged over the years, with maximum TSH values ranging from 5 to 15 µUI/mL. In this group, free T4 also remained normal and AB were negative. There was a significant TSH reduction (p = 0.017), and normal TSH concentrations (< 5.0 µUI/mL) were observed in 29/31 patients, in at least one moment. No patient had TSH > 15 µUI/mL. CONCLUSION: DS patients with TSH-nd present low risk of progression to HT (10% for females and 6% for males).

scholarly journals Metamorphic thyroid autoimmunity in Down Syndrome: from Hashimoto’s thyroiditis to Graves’ disease and beyond

2015 ◽  
Vol 41 (1) ◽  
Author(s):  
Tommaso Aversa ◽  
Mariella Valenzise ◽  
Mariacarolina Salerno ◽  
Andrea Corrias ◽  
Lorenzo Iughetti ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Hashimoto’S Thyroiditis ◽  
Thyroid Autoimmunity ◽  
Hashimoto's Thyroiditis ◽  
Graves Disease

scholarly journals SAT-478 A Case of Congenital Thyroid Hemi-Agenesis- Caution for Complications!

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Sabah Patel ◽  
Petra Krutilova ◽  
Janice L Gilden
Keyword(s):  
Thyroid Gland ◽  
Hashimoto’S Thyroiditis ◽  
Case Series ◽  
Cervical Lymphadenopathy ◽  
Left Lobe ◽  
Compensatory Hypertrophy ◽  
Hashimoto's Thyroiditis ◽  
Fetal Life ◽  
Free T4 ◽  
Risk Of Malignancy

Abstract Introduction: Congenital Thyroid hemi-agenesis is an uncommon clinical entity. We present a case highlighting the importance of awareness of this condition and the need to evaluate and manage co-existing hypothyroidism and risk of malignancy. Case: A 20 year old female known to have Hashimoto’s thyroiditis (non-adherent to levothyroxine), and hemi-agenesis of left lobe of thyroid gland, presented with right-sided thyroid enlargement. She was clinically euthyroid. Physical exam: enlarged right sided thyroid gland with palpable anterior cervical lymphadenopathy. Left lobe could not be palpated. TFTs were notable for TSH 4.98 uIU/ml (0.358-3.74) and Free T4 0.79 ng/dl (0.76-1.46) consistent with sub-clinical hypothyroidism while Anti TPO antibody was positive at 8332.8 U/mL (0 - 60). CBC negative for leukocytosis. US thyroid: left-sided thyroid agenesis with intact isthmus and enlargement of right lobe of the thyroid 7.7 cm x 1.6 cm x 2.6 cm with 2 sub-centimeter hypoechoic solid nodules and 2 enlarged lymph nodes 1.5 cm and 2.3 cm (not found in US thyroid 2 years ago) Levothyroxine was re-started. ENT evaluation determined that her lymphadenopathy was benign and consistent with Hashimoto’s thyroiditis. Subsequent TFTs improved. Discussion: Thyroid Gland embryogenesis occurs in the 4th week of fetal life. Subsequent abnormal bilobal differentiation of the thyroid gland is presumed to be the etiology of congenital hemi-agenesis. Its prevalence in several studies is estimated to be between 0.05-0.25%. It is symptomatic pre-dominantly in females and may have familial origin with vast majority of cases having left hemi-agenesis with intact isthmus. It is helpful to know that most symptomatic patients have compensatory hypertrophy of the remnant lobe. It is important to remember that compensatory enlargement of the remnant lobe in the setting of hypothyroidism may be a sign of insufficient endogenous thyroxine production and/or replacement. Although rarely symptomatic, hemi-thyroid remnant may need to be evaluated for co-existing hyperthyroidism, hypothyroidism, carcinoma and multinodular goiter among others, with hypothyroidism thought to be the most common. US thyroid is a useful modality to help guide the evaluation of patients with hemi-agenesis. Awareness of this congenital condition is key in preventing unnecessary evaluations and interventions. Non-resolving lymphadenopathy in Hashimoto’s thyroiditis must be evaluated for lymphoma, however, based on studies, no additional risk of malignancy was identified in patients with underlying thyroid hemi-agenesis. References: Y.H. Wu, R.O. Wein, B. Carter Thyroid hemiagenesis: a case series and review of the literature Am J Otolaryngol, 33 (3) (2012), pp. 299-302

scholarly journals Interferon-gamma Expression Profile as Diagnostic Signatures of Unexplained Infertility in Female Patients Suffer from Hashimoto's Thyroiditis

2021 ◽  
Author(s):  
Nearmeen M. Rashad ◽  
Reham Mohamed El Shabrawy ◽  
Ahmed M. Radwan ◽  
Reem M. Allam ◽  
Rehab S. Abdul-Maksoud ◽  
...  
Keyword(s):  
Gene Expression ◽  
Serum Level ◽  
Interferon Gamma ◽  
Expression Profile ◽  
Hashimoto’S Thyroiditis ◽  
Unexplained Infertility ◽  
Hashimoto's Thyroiditis ◽  
Free T4 ◽  
Female Patients ◽  
Ifn Γ

Diagnosis of unexplained infertility (UEI) is made by exclusion and a relatively common problem that affects couples worldwide. Unfortunately, it is a not uncommon for females to suffer from Hashimoto's thyroiditis (HT). Interferon-gamma (IFN- γ) has a central key role in HT and in the ability to conceive. We aimed to estimate serum IFN- γ level and its expression profile in Egyptian women with HT and assess their possible association with UEI. In this study, we examined 120 women with HT. We evaluated fertility in all patients; female patients who suffer from UEI were detected. Diagnosis of HT was based on the clinical data and the laboratory measures, enzyme-linked immunosorbent assay was used to measure serum IFN- γ, and the expression of IFN-γ messenger ribonucleic acid (mRNA) was assayed by real-time polymerase chain reaction (PCR). According to the results of this study, 37.5 % of the studied females who suffered from HT were diagnosed with UEI. The serum level of IFN-γ and its gene expression showed a significant positive correlation with thyroid-stimulating hormone (TSH) and thyroid autoantibodies. However, a negative correlation was found with anti-müllerian hormone (AMH), free T4 (FT3), and free T4 (FT4). Analysis by linear regression revealed that TSH and FT3 were associated with serum level of IFN-γ; while FT3 was associated with IFN-γ gene expression. We concluded that both are valued markers in diagnosing UEI in female patients suffering from HT.

The Effect of Steroid Therapy on Riedel's Thyroiditis

1968 ◽  
Vol 13 (1) ◽  
pp. 13-16 ◽  
Author(s):  
J. A. Thomson ◽  
I. M. D. Jackson ◽  
W. P. Duguid
Keyword(s):  
Family History ◽  
Hashimoto’S Thyroiditis ◽  
Therapeutic Response ◽  
Serum Levels ◽  
Clinical State ◽  
Hashimoto's Thyroiditis ◽  
Thyroid Antibodies ◽  
Riedel’S Thyroiditis ◽  
History Of ◽  
Riedel's Thyroiditis

A patient is described who passed from a clinical state consistent with Hashimoto's thyroiditis to Riedel's thyroiditis over a period of 6 months. Serum levels of thyroid antibodies were high and there was a family history of Hashimoto's thyroiditis. A good therapeutic response to steroids was observed but these were without effect in a further patient with Riedel's thyroiditis of 10 years' duration. It is suggested that Riedel's thyroiditis is an uncommon variant of Hashimoto's thyroiditis.

scholarly journals Thyroid Function and Structure Are Affected in Childhood Obesity

2008 ◽  
Vol 93 (12) ◽  
pp. 4749-4754 ◽  
Author(s):  
Giorgio Radetti ◽  
Wolfgang Kleon ◽  
Fabio Buzi ◽  
Claudio Crivellaro ◽  
Lucia Pappalardo ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Obese Children ◽  
Free T4 ◽  
Free T3 ◽  
Antithyroid Antibodies ◽  
Normal Ultrasound ◽  
Group B ◽  
Ultrasound Group

Objective: Alterations in thyroid function are reported in obesity, although no relevant data exist on the thyroid structure of these patients and the frequency of autoimmunity. The aim of our study was to evaluate the involvement of the thyroid gland in a large group of obese children. Design: This was a cross-sectional study. Methods: The study was conducted between March 2004 and December 2007 in 186 overweight and obese children. In all subjects, serum free T3, free T4, TSH, antithyroid antibodies, and a thyroid ultrasound were assessed. A total ot 40 healthy children matched for age and of normal weight for height served as controls. Results: A total of 23 children (12.4%) showed antithyroid antibodies and an ultrasound pattern suggestive of Hashimoto’s thyroiditis (group A). Of them, 20 (10.8%) showed antithyroid antibodies and normal ultrasound (group B). A total of 70 subjects (37.6%) showed absent antithyroid antibodies and an ultrasound pattern suggestive of Hashimoto’s thyroiditis (group C), and 73 children (39.2%) showed no thyroid antibodies with normal ultrasound (group D). TSH was higher in groups A and C compared with groups B and C, and controls (P &lt; 0.05). Mean free T4 was lower in group B (P &lt; 0.05) than in controls, whereas free T3 was higher in group C than in controls (P &lt; 0.05). TSH and body mass index sd scores were significantly correlated in group C (P &lt; 0.001), and TSH was also significantly associated with the degree of thyroid structure alterations (P &lt; 0.05). Conclusion: Obese children frequently show alterations of thyroid structure and function that are not completely explained by the presence of an autoimmune involvement.

scholarly journals The Recovery of Thyroid Function in Low-Risk Papillary Thyroid Cancer After Lobectomy: A 3-Year Follow-Up Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Yi Dou ◽  
Yingji Chen ◽  
Daixing Hu ◽  
Xinliang Su
Keyword(s):  
Risk Factors ◽  
Thyroid Function ◽  
Hashimoto’S Thyroiditis ◽  
Low Risk ◽  
Hashimoto's Thyroiditis ◽  
First Year ◽  
Papillary Thyroid ◽  
Normal Thyroid ◽  
Normal Thyroid Function

PurposeManagement strategies after lobectomy for low-risk papillary thyroid carcinoma (PTC) are controversial. This study aimed to identify the proportion of patients among low-risk PTC patients who do not require hormone replacement therapy and to evaluate the risk factors for postoperative hypothyroidism after lobectomy.Patients and MethodsThe records of 190 PTC patients who underwent thyroid lobectomy from January 2017 to December 2018 were retrospectively reviewed. Clinicopathological characteristics and follow-up data were collected. Univariate and multivariate analyses were performed to identify the risk factors associated with postoperative hypothyroidism and the recovery of thyroid function.ResultsIn summary, 74.21% of patients (141/190) had normal thyroid function without levothyroxine supplementation, while 40.53% (77/190) developed temporary or permanent hypothyroidism. Multivariate analysis indicated that higher preoperative thyroid-stimulating hormone (TSH) levels (&gt;2.62 mIU/L), Hashimoto’s thyroiditis (HT), and right lobectomy were associated with hypothyroidism (all P&lt;0.05). The Area Under Curve (AUC) by logistic analysis was 0.829. Twenty-eight (28/77, 36.4%) patients recovered to the euthyroid state in the first year after surgery, and this recovery was significantly associated with preoperative TSH level. Forty-nine (49/77, 63.6%) patients developed persistent hypothyroidism. The thyroid function of most patients (11/28, 39.3%) recovered in the third month after surgery.ConclusionPatients with a lower level of preoperative TSH, with left lobectomy and without Hashimoto’s thyroiditis had a higher chance of normal thyroid function within the first year after lobectomy. The recovery of thyroid function was associated with the level of preoperative TSH.

Sign in / Sign up

Export Citation Format

Share Document