scholarly journals NON-ADHERENCE TO HEPATITIS C TREATMENT: A BRAZILIAN REPORT

2021 ◽  
Vol 58 (4) ◽  
pp. 456-460
Author(s):  
Claudia Alexandra Pontes IVANTES ◽  
Bernardo Carvalho da SILVA ◽  
Gabriel Gonçalves ACOSTA ◽  
Fabiane Beatriz Neves El TAWIL ◽  
Renato NISIHARA
Keyword(s):  
Public Health ◽  
Hepatitis C ◽  
Health System ◽  
Public Health System ◽  
Epidemiological Data ◽  
Hepatitis C Treatment ◽  
The Public ◽  
Direct Acting Antiviral ◽  
Private Medicine ◽  
Direct Acting

ABSTRACT BACKGROUND: In Brazil, since 2015, the treatment of hepatitis C is provided by SUS (Public Health System) with direct-acting antiviral (DAA). OBJECTIVE: To describe the rate of non-adherence patients to hepatitis C treatment by DAA, investigating the epidemiological data in a large database from Curitiba, Brazil. METHODS: Retrospective study with patients treated between January 2015 and June 2019. Patients were considered adherent when received all medication doses during their treatment. The following data were evaluated: gender, age, type of treatment, period of treatment, presence of diabetes or HIV, previous therapy, originated from SUS or private medicine, fibrosis grade and HCV genotype. RESULTS: 1248 patients (56.8% males) were studied and 102/1248 (8.2%) were non-adherent to treatment. Age or gender not influenced significantly; 10.2% patients from SUS and 3.7% individuals from private medicine were non-adherent (P<0.0001; OR=2.9; CI95%=1.6-9.1); 13.1% patients were co-infected with HIV and among them, 15.9% abandoned treatment. Individuals without co-infection presented 7.0% of non-adherence (P<0.0001; OR=2.5; CI=1.5-4.1). All the other variables showed no differences in the adhesion rate. CONCLUSION: Our study showed that 8.2% of patients were non-adherent to HCV treatment, and that patients from the Public Health System and co-infected with HIV were significantly less adherent.

scholarly journals Effectiveness of chronic hepatitis C treatment with direct-acting antivirals in the Public Health System in Brazil

2018 ◽  
Vol 22 (4) ◽  
pp. 317-322 ◽  
Author(s):  
Iandra Holzmann ◽  
Cristiane V. Tovo ◽  
Roseline Minmé ◽  
Mônica P. Leal ◽  
Michele P. Kliemann ◽  
...  
Keyword(s):  
Public Health ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Health System ◽  
Chronic Hepatitis C ◽  
Public Health System ◽  
Direct Acting Antivirals ◽  
Hepatitis C Treatment ◽  
The Public ◽  
Direct Acting

scholarly journals Costs for in hospital treatment of urinary lithiasis in the Brazilian public health system

2011 ◽  
Vol 9 (4) ◽  
pp. 518-522 ◽  
Author(s):  
Fernando Korkes ◽  
Jarques Lúcio da Silva II ◽  
Ita Pfeferman Heilberg
Keyword(s):  
Public Health ◽  
Hospital Admission ◽  
Health System ◽  
Hospital Admissions ◽  
Public Health System ◽  
Epidemiological Data ◽  
Hospital Treatment ◽  
The Public ◽  
Urinary Lithiasis ◽  
Mean Cost

ABSTRACT Objective: To estimate costs associated to hospital treatment of urinary lithiasis in the Brazilian public health system as well as to evaluate demographic and epidemiological data referred to hospital admissions in the Brazilian public health system (or unified health care system). Methods: Data from the Informatic Department of Brazilian public health system were obtained as referred to costs in hospital admissions for urinary lithiasis during 2010 and also epidemiological data from 1996 through 2010. Results: There were 69,039 hospital admissions for urinary lithiasis, totaling 0.61% of all hospital admissions in the Brazilian public health system. The mean cost of each of these hospital admissions was US$ 240,23 or R$ 423.42 having as result an overall cost of US$ 16,240,378.00 or R$ 29.232.682,56. Hospital admissions for urinary lithiasis in the Brazilian public health system increased 69% from 1996 to 2010 (43,176 versus 69,309; p < 0.001; OR = 1.69). The number of hospital admissions was 5% greater between December and March as compared to the period between June and September (35,290 versus 33,749; p < 0.001; OR = 1.10). For Caucasian patients the hospital admission was 75% greater as compared to black patients (63.2% versus 35.8%; p = 0.02; OR = 1,75). Conclusion: Hospital admission for urinary liyhiasis has an elevated impact on the public health system with a cost of US$ 16,2 or R$ 29.2 million per year. The number of hospital admissions was greater in hotter months than in cold ones and also in the last decade, mainly in Caucasian population. These data may be helpful for the organization and optimization of health programs in the public health system as referred to prevention and treatment of urinary lithiasis in Brazil.

scholarly journals The high cost patients on waiting list for the Liver Transplantation. main burdens and consequences for the Public Health System

2015 ◽  
Vol 18 (3) ◽  
pp. A224
Author(s):  
J.A. Turri ◽  
L.B. Haddad ◽  
W. Andrauss ◽  
L.A. D’Albuquerque ◽  
M.A. Diniz
Keyword(s):  
Public Health ◽  
Liver Transplantation ◽  
Health System ◽  
Public Health System ◽  
Waiting List ◽  
The Public

Development of a probabilistic model for quantitative risk assessment of COVID-19 in Brazil

2021 ◽  
pp. 2150069
Author(s):  
Paulo Gabriel Santos Campos de Siqueira ◽  
Alexandre Calumbi Antunes de Oliveira ◽  
Heitor Oliveira Duarte ◽  
Márcio das Chagas Moura
Keyword(s):  
Public Health ◽  
Risk Assessment ◽  
Health System ◽  
Probabilistic Model ◽  
Public Health System ◽  
The Other ◽  
Quantitative Risk Assessment ◽  
The Public ◽  
Business As Usual ◽  
Excessive Number

We have developed a probabilistic model to quantify the risks of COVID-19 explosion in Brazil, the epicenter of COVID-19 in Latin America. By explosion, we mean an excessive number of new infections that would overload the public health system. We made predictions from July 12th to Oct 10th, 2020 for various containment strategies, including business as usual, stay at home (SAH) for young and elderly, flight restrictions among regions, gradual resumption of business and the compulsory wearing of masks. They indicate that: if a SAH strategy were sustained, there would be a negligible risk of explosion and the public health system would not be overloaded. For the other containment strategies, the scenario that combines the gradual resumption of business with the mandatory wearing of masks would be the most effective, reducing risk to considerable category. Should this strategy is applied together with the investment in more Intensive Care Unit beds, risk could be reduced to negligible levels. A sensitivity analysis sustained that risks would be negligible if SAH measures were adopted thoroughly.

Cost-effectiveness and budget impact of interferon-free direct-acting antiviral-based regimens for hepatitis C treatment: the French case

2016 ◽  
Vol 23 (10) ◽  
pp. 767-779 ◽  
Author(s):  
S. Deuffic-Burban ◽  
D. Obach ◽  
V. Canva ◽  
S. Pol ◽  
F. Roudot-Thoraval ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Hepatitis C ◽  
Budget Impact ◽  
Hepatitis C Treatment ◽  
Direct Acting Antiviral ◽  
French Case ◽  
Direct Acting
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