scholarly journals Squamous cell carcinoma of the esophagus and multiple primary tumors of the upper aerodigestive tract

1999 ◽  
Vol 36 (4) ◽  
pp. 195-200 ◽  
Author(s):  
Ulysses RIBEIRO Jr. ◽  
Ivan CECCONELLO ◽  
Adriana Vaz SAFATLE-RIBEIRO ◽  
Bruno ZILBERSTEIN ◽  
Henrique Walter PINOTTI
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Aerodigestive Tract ◽  
Second Primary ◽  
Upper Aerodigestive Tract ◽  
Primary Tumors ◽  
Carcinoma Of The Esophagus ◽  
Multiple Primary Tumors ◽  
Multiple Primary

Squamous cell carcinoma of the esophagus is frequently associated with other, synchronous or metachronous tumors, in the upper aerodigestive tract. All 264 patients with squamous cell carcinoma of the esophagus, treated in the Gastrointestinal Surgery, Esophagus section, of the "Hospital das Clínicas" (São Paulo University Medical School, Brazil), between 1979 and 1989 were analyzed retrospectively with regards to the occurrence of multiple primary tumors in the upper aerodigestive tract. Multiple primary tumors were encountered in 10 (3.8%) patients. All patients were male and the mean age at the time of the first primary was 52.2 years. Tobacco smoke and alcohol were the principal carcinogens in these patients (n = 10). The sites of the tumors were: larynx (n = 4), tongue (n = 4), lung (n = 2), and oral cavity (n = 1). Two simultaneous, three synchronous and five metachronous multiple primary carcinomas were detected. The esophagus was the second primary tumor in nine patients. The mean overall survival after the diagnosis of the second primary was 2.8 months (SD = 0.89). Inquiry regarding other malignancies, associated with panendoscopy should be carry out prior to the treatment of the first primary to diagnose simultaneous or synchronous primary tumors, and careful follow-up should be performed after treatment of the first primary to detect new tumors in these high-risk patients.

Risk of multiple primary tumors following oral squamous-cell carcinoma

1994 ◽  
Vol 56 (3) ◽  
pp. 320-323 ◽  
Author(s):  
Andreas Jovanoic ◽  
Ignaz G. H. van der Tol ◽  
Engelbert A. J. M. Schulten ◽  
Pieter J. Kostense ◽  
Nico de Vries ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Tumors ◽  
Multiple Primary Tumors ◽  
Multiple Primary

Increased mutagen sensitivity in head-and-neck squamous-cell carcinoma patients, particularly those with multiple primary tumors

1994 ◽  
Vol 56 (6) ◽  
pp. 816-819 ◽  
Author(s):  
Jacqueline Cloos ◽  
Boudewijn J. M. Braakhuis ◽  
Ivar Steen ◽  
Marcel P. Copper ◽  
Nico De Vries ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Primary Tumors ◽  
Multiple Primary Tumors ◽  
Mutagen Sensitivity ◽  
Multiple Primary

Survival of second and multiple primary tumors in patients with oral cavity squamous cell carcinoma in the betel quid chewing area

Oral Oncology ◽  
2007 ◽  
Vol 43 (8) ◽  
pp. 811-819 ◽  
Author(s):  
Chun-Ta Liao ◽  
Chung-Jan Kang ◽  
Joseph Tung-Chieh Chang ◽  
Hung-Ming Wang ◽  
Shu-Hang Ng ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Betel Quid ◽  
Primary Tumors ◽  
Multiple Primary Tumors ◽  
Betel Quid Chewing ◽  
Multiple Primary

scholarly journals Evolution of patients with squamous cell carcinoma of upper aerodigestive tract

2003 ◽  
Vol 121 (4) ◽  
pp. 155-158 ◽  
Author(s):  
Ali Amar ◽  
Sergio Altino Franzi ◽  
Abrão Rapoport
Keyword(s):  
Squamous Cell Carcinoma ◽  
Surgical Treatment ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Stage Iv ◽  
Aerodigestive Tract ◽  
Post Treatment ◽  
Second Primary ◽  
Upper Aerodigestive Tract ◽  
Cross Sectional

CONTEXT: Local and regional recurrences are frequent in patients with squamous cell carcinoma of the upper aerodigestive tract and early diagnosis is important for salvage treatment. OBJECTIVE: To identify the period of highest risk for the development of recurrences after surgical treatment of squamous cell carcinoma of the upper aerodigestive tract, in spite of radical therapy, in order to plan the follow-up for these patients. TYPE OF STUDY: Cross-sectional, descriptive. SETTING: Department of Head and Neck Surgery/Otorhinolaryngology, Heliópolis Hospital (Hosphel), São Paulo, Brazil. PARTICIPANTS: A review was made of the hospital records of 889 patients with squamous cell carcinoma of the upper aerodigestive tract surgically treated between October 1977 and December 1996: 364 had oral cavity tumors, 107 had tumors of the oropharynx, 152 of the hypopharynx and 266, larynx tumors. The disease was stage I in 14 patients, stage II in 117, stage III in 352, stage IV in 397 and 9 patients were not staged. MAIN MEASUREMENTS: The interval between treatment and recurrence of disease was evaluated. The results were expressed as medians, quartiles (25% to 75%) and percentiles (10% to 90%). The annual incidence of recurrences and second tumors was calculated. RESULTS: Seventy-four percent of the recurrences were diagnosed within 18 months post-treatment. The local and regional recurrences and distant metastases showed medians of 270, 210 and 435 postoperative days respectively. The incidence of a second primary tumor varied from 2 to 3.1% a year. CONCLUSION: The majority of recurrences occurred within 18 months after the initial surgical treatment. The incidence of a second tumor remained stable after the first post-treatment year.

Panendoscopy for Second Primaries in Head and Neck Cancer

1981 ◽  
Vol 90 (5) ◽  
pp. 460-464 ◽  
Author(s):  
Robert H. Maisel ◽  
Hubert Vermeersch
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Direct Laryngoscopy ◽  
Aerodigestive Tract ◽  
Barium Swallow ◽  
Second Primary ◽  
Upper Aerodigestive Tract ◽  
Primary Tumors ◽  
X Ray ◽  
Chest X Ray

Four hundred patients with biopsy-proven squamous cell carcinoma of the upper aerodigestive tract were studied for evidence of a synchronous second primary tumor. The protocol of study included in most cases direct laryngoscopy, metal tube bronchoscopy, and esophagoscopy. Chest x-ray studies were performed on all patients and many had barium swallow x-ray studies. Asymptomatic second head and neck primary tumors were found only in the vallecula and esophagus among this series of patients. Metachronous second primary tumors were presented as early as one month after the original endoscopy and were located in areas which had been carefully examined by endoscopy and appeared asymptomatic to the examining physician at the time of the original evaluation. Based on this series of patients, we recommend careful indirect laryngoscopy and oral examination, direct laryngoscopy and esophagoscopy as well as a barium swallow for patients with clinically suspicious mucosal lesion of the upper aerodigestive tract. In view of our failure to discover a single lung carcinoma which was not evident from chest x-ray studies, we recommend bronchoscopy, which adds some morbidity to the endoscopic procedure, not be included unless a specific clinical suspicion is entertained. However, because of the important treatment implications which follow the diagnosis of a new squamous cell carcinoma of the upper aerodigestive tract, we feel it is imperative that the entire esophagus be evaluated in the course of the pretreatment exploration of the patient. Although few esophageal tumors were discovered, their implications in terms of surgical resection and debilitation without much likelihood of long-term patient survival has encouraged us to continue the above described procedure.

Multiple primary cancers associated with squamous cell carcinoma of the esophagus

2019 ◽  
Vol 91 (3) ◽  
pp. 1-4
Author(s):  
Daria Dranka-Bojarowska ◽  
Adam Lewiński
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Diagnostic Procedures ◽  
Multiple Primary Cancers ◽  
Primary Tumors ◽  
Carcinoma Of The Esophagus ◽  
Increased Risk ◽  
Multiple Primary

Treatment of squamous cell carcinoma is associated with an increased risk of other primary malignancies, mainly within the head and neck, as well as in the oesophageal gastric graft. More frequent recognition of multiple primary cancers associated with esophageal cancer, both synchronous and metachronous, is associated with longer follow-up after radical cancer treatment for esophageal cancer and high quality diagnostic procedures, both before and after surgery. The paper reviews the available literature and describes the molecular basis of the formation of multiple primary tumors associated with squamous cell carcinoma of the esophagus.

Significance of Positive Bronchial Cytology in Presence of Squamous Cell Carcinoma of Upper Aerodigestive Tract

1981 ◽  
Vol 90 (5) ◽  
pp. 454-456 ◽  
Author(s):  
Jonas T. Johnson ◽  
Joseph Turner ◽  
Andrew Dekker ◽  
Eugene N. Myers
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Squamous Cell ◽  
False Positive ◽  
Tracheobronchial Tree ◽  
Aerodigestive Tract ◽  
Second Primary ◽  
Upper Aerodigestive Tract ◽  
Second Primary Neoplasms

The otolaryngologic literature reflects the high incidence of second primary neoplasms found in patients with a squamous cell carcinoma of the upper aerodigestive tract. Most commonly the second tumor is bronchogenic in origin. Routine panendoscopy (direct laryngoscopy, bronchoscopy, esophagoscopy) has been recommended in patients presenting with a squamous cell carcinoma primary in the upper aerodigestive tract. We have questioned the usefulness of obtaining bronchial washings during bronchoscopy in a patient who has an established primary in the upper aerodigestive tract. Perhaps false-positives would occur due to desquamation of tumor cells into the tracheobronchial tree. The authors address the incidence of false-positive washings encountered in a prospective evaluation of bronchial cytology encountered in 100 consecutive patients with primary squamous cell carcinoma of the upper aerodigestive tract who do not have primary bronchogenic carcinoma. A single false-positive (1 %) was encountered. It is concluded that epithelial carcinoma of the larynx and upper aerodigestive tract rarely shed identifiable tumor cells into the tracheobronchial tree. When malignant cells are found with bronchial washings, every effort should be made to localize a second primary tumor in the lung.

scholarly journals Bazex Syndrome

2013 ◽  
Vol 88 (6 suppl 1) ◽  
pp. 209-211 ◽  
Author(s):  
Ismael Alves Rodrigues Júnior ◽  
Letícia Trivellato Gresta ◽  
Rafaela Carolina Cruz ◽  
Giselly Gomes Carvalho ◽  
Melissa Heringer Chamon Barros Quintão Moreira
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Manifestations ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Cutaneous Lesions ◽  
Carcinoma Of The Esophagus ◽  
Rare Syndrome

Acrokeratosis Paraneoplastica or Bazex syndrome is a dermatologic manifestation usually associated with the diagnosis of squamous cell carcinoma of the upper aerodigestive tract. We report a case with exuberant clinical manifestations, exemplifying the typical cutaneous lesions in this rare syndrome, in a patient with squamous cell carcinoma of the esophagus.

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