scholarly journals Ketogenic diet for the treatment of refractory epilepsy: a 10 year experience in children

2007 ◽  
Vol 65 (2b) ◽  
pp. 381-384 ◽  
Author(s):  
Alessandra Freitas ◽  
José Albino da Paz ◽  
Erasmo Barbante Casella ◽  
Maria Joaquina Marques-Dias
Keyword(s):  
Adverse Effects ◽  
Ketogenic Diet ◽  
Seizure Control ◽  
Refractory Epilepsy ◽  
High Fat ◽  
Low Carbohydrate Diet ◽  
Age Related ◽  
Low Carbohydrate ◽  
Generalized Epilepsy ◽  
The University

Ketogenic diet (KD) is a high fat and low carbohydrate diet, which controls refractory epilepsy. We analyzed the KD effects on 54 children of the Children's Institute of the University of São Paulo. Efficacy, tolerability, and adverse effects were studied. Response to KD was effective (E) if seizure control was >75%, good (G) when 50-75%. When possible, we correlated the results with the epileptic syndrome and patient's age. By the second month on diet, 57.4% of the patients had E response and 31.4% G results. At the 6th month, 63.8% had E response and 25.5% G. At the 12th month, 71.8% had E and 25.6% G. At the 24th month, 62.1% had E and 37.9% G. Antiepileptic drugs have been reduced, and generalized epilepsy was the most sensitive. Age-related differences were not observed. Adverse effects were rarely observed. In conclusion, KD proved to be an effective treatment for refractory epilepsy.

scholarly journals Ketogenic Diet in Epileptic Encephalopathies

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Suvasini Sharma ◽  
Manjari Tripathi
Keyword(s):  
Ketogenic Diet ◽  
Refractory Epilepsy ◽  
Dravet Syndrome ◽  
High Fat ◽  
Carbohydrate Diet ◽  
Epileptic Encephalopathies ◽  
Low Carbohydrate Diet ◽  
Ohtahara Syndrome ◽  
Low Carbohydrate ◽  
Atonic Seizures

The ketogenic diet is a medically supervised high-fat, low-carbohydrate diet that has been found useful in patients with refractory epilepsy. It has been shown to be effective in treating multiple seizure types and epilepsy syndromes. In this paper, we review the use of the ketogenic diet in epileptic encephalopathies such as Ohtahara syndrome, West syndrome, Dravet syndrome, epilepsy with myoclonic atonic seizures, and Lennox-Gastaut syndrome.

scholarly journals Ketogenic Diet-Induced Severe Ketoacidosis in a Lactating Woman: A Case Report and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Benedicta Nneoma Nnodum ◽  
Eziafa Oduah ◽  
David Albert ◽  
Mark Pettus
Keyword(s):  
Ketogenic Diet ◽  
Case Reports ◽  
High Fat ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Lactating Mothers ◽  
Low Carbohydrate ◽  
Life Threatening ◽  
Clinically Significant ◽  
Prompt Diagnosis

The ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that leads to nutritional ketosis and weight loss. It is known to induce ketosis but is not an established cause of clinically significant ketoacidosis. Lactation ketoacidosis is well established in bovine literature but remains a rare phenomenon in humans. Here we present a life-threatening case of severe ketoacidosis in a nondiabetic lactating mother on a strict ketogenic diet. We review the available case reports of lactation ketoacidosis in humans and the mechanisms thereof. Although ketogenic diet has been shown to be safe in nonpregnant individuals, the safety of this diet in lactating mothers is not known. Health professionals and mothers should be made aware of the potential risk associated with a strict ketogenic diet when combined with lactation. Prompt diagnosis and immediate treatment cannot be overemphasized. To our knowledge, this is the first reported case of life-threatening lactation ketoacidosis associated with ketogenic diet while consuming an adequate number of calories per day.

scholarly journals Long-Term Ketogenic Diet Induces Metabolic Acidosis, Anemia, and Oxidative Stress in Healthy Wistar Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Aryadi Arsyad ◽  
Irfan Idris ◽  
Andi A. Rasyid ◽  
Rezky A. Usman ◽  
Kiki R. Faradillah ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Metabolic Acidosis ◽  
Ketogenic Diet ◽  
Wistar Rats ◽  
Blood Gas ◽  
High Fat ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate

Background. Ketogenic diet has been used as supportive therapy in a range of conditions including epilepsy, diabetes mellitus, and cancer. Objective. This study aimed to investigate the effects of long-term consumption of ketogenic diet on blood gas, hematological profiles, organ functions, and superoxide dismutase level in a rat model. Materials and Methods. Fifteen male Wistar rats were divided into control (n = 8) and ketogenic (n = 7) groups. Controls received standard diet contained 52.20% of carbohydrates, 7.00% fat, and 15.25% protein; meanwhile, the ketogenic group received a high-fat-low-carbohydrate diet which contained 5.66% of carbohydrate, 86.19% fat, and 8.15% protein. All rats were caged individually and received 30g of either standard or high-fat-low-carbohydrate pellets. The experiment was carried out for 60 days before the blood samples were taken and analyzed to obtain blood gas, cell counts, organ biomarkers, and plasma antioxidant superoxide dismutase (SOD) levels. Results. The rats subjected to ketogenic diet experienced a marked decrease in body weight, blood sugar, and increased blood ketones (p<0.05). The average blood pH was 7.36 ± 0.02 and base excess was −5.57 ± 2.39 mOsm/L, which were significantly lower than controls (p<0.05). Hematological analysis showed significantly lower erythrocyte, hemoglobin, and hematocrit levels. No significant changes were found in alanine aminotransferase, aspartate aminotransferase, urea, and creatinine levels, indicating normal liver and kidney functions. Nevertheless, plasma SOD level significantly reduced with ketogenic diet. Conclusion. Long-term ketogenic diet induces metabolic acidosis, anemia, and reduced antioxidant enzyme level in rats following 60 days of consuming high-fat-low-carbohydrate diet.

scholarly journals Popular Diets: Ketogenic Diet

EDIS ◽  
2020 ◽  
Vol 2020 (5) ◽  
Author(s):  
Kelsey Gemmill ◽  
Daniela Rivero-Mendoza ◽  
Wendy J. Dahl
Keyword(s):  
Social Media ◽  
Weight Loss ◽  
Ketogenic Diet ◽  
Human Nutrition ◽  
Food Science ◽  
High Fat ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
The Past ◽  
Low Carbohydrate

The ketogenic diet is a high-fat, very low carbohydrate diet. The first documented use of the ketogenic diet was in 1921 to treat epilepsy in children. In the past few years, the ketogenic diet has resurged in popularity as a potential means for weight loss. The ketogenic diet has become popular due to celebrity endorsement and social media influences. This new 4-page publication of the UF/IFAS Food Science and Human Nutrition Department explains the concepts behind this diet, explores the available menu, and examines whether this diet is safe and effective. Written by Kelsey Gemmill, Daniela Rivero-Mendoza, and Wendy Dahl.https://edis.ifas.ufl.edu/fs403

scholarly journals The use of a formula-based ketogenic diet in children with refractory epilepsy

2017 ◽  
Vol 75 (4) ◽  
pp. 234-237 ◽  
Author(s):  
Letícia Pereira de Brito Sampaio ◽  
Cristina Takakura ◽  
Maria Luiza Giraldes de Manreza
Keyword(s):  
Adverse Events ◽  
Ketogenic Diet ◽  
Seizure Frequency ◽  
Refractory Epilepsy ◽  
Protein Diet ◽  
High Fat ◽  
Low Carbohydrate ◽  
Nonpharmacologic Treatment ◽  
Long Time ◽  
Restricted Protein Diet

ABSTRACT The ketogenic diet (KD) is a nonpharmacologic treatment that has been used for refractory epilepsy since 1921. The KD is a high-fat, low-carbohydrate, and restricted protein diet, which is calculated and weighed for each individual patient. Introducing and maintaining the diet for a long time remains a challenge. In this study, we evaluated the acceptability, tolerance, and efficacy of a formula-based KD in 10 children with refractory epilepsy. The ketogenic formula tested herein caused only mild KD-related adverse events and adequate adherence. Moreover, 60% of patients had more than 50% seizure frequency reduction and 10% were seizure-free.

scholarly journals Ketogenic Diet for Refractory Childhood Epilepsy: Beyond Seizures Control, the Experience of a Portuguese Pediatric Centre

2019 ◽  
Vol 32 (12) ◽  
pp. 760 ◽  
Author(s):  
Inês Romão Luz ◽  
Cristina Pereira ◽  
Paula Garcia ◽  
Fátima Ferreira ◽  
Ana Faria ◽  
...  
Keyword(s):  
Antiepileptic Drugs ◽  
Ketogenic Diet ◽  
Seizure Control ◽  
Median Number ◽  
Childhood Epilepsy ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate ◽  
The Mean ◽  
Clinical Records ◽  
Control Behaviour

Introduction: Ketogenic diet is a low carbohydrate diet, which can be used as a treatment for refractory childhood epilepsy. The first aim of this study was to evaluate its efficacy, in patients receiving ketogenic diet for at least three months, on epilepsy control, behaviour and awareness. The secondary aims were to evaluate the variation in the number of antiepileptic drugs, reasons for discontinuing the diet and adverse effects.Material and Methods: Retrospective analysis of clinical records of patients who underwent ketogenic diet for refractory epilepsy, from October 2007 to January 2018, in a tertiary pediatric hospital.Results: In the twenty-nine eligible patients, the mean age of initiation was 7.9 years-old (+/– 5.6). Of those, 18 had a ≥ 50% reduction of seizure activity, 19 a marked behaviour improvement and 18 improved awareness. The median number of antiepileptic drugs remained equal for the 15 patients who completed 18 months of treatment (three drugs). The main reason for discontinuing ketogenic diet was a familiar decision. The main adverse effects were hypercholesterolemia (n = 23) and hypertriglyceridemia (n = 21).Discussion: Results were comparable to those of other cohorts, namely age of initiation, proportion of patients completing ketogenic diet, most frequent reasons for stopping and significant improvement of alertness and behavior.Conclusion: Beyond seizure control, patients experienced a marked improvement in behavior and awareness. It is necessary to develop strategies to increase the adherence of families to the diet.

Amelioration of clinical course and demyelination in the cuprizone mouse model in relation to ketogenic diet

2020 ◽  
Vol 11 (6) ◽  
pp. 5647-5663 ◽  
Author(s):  
Ning Zhang ◽  
Chunhong Liu ◽  
Ruiyan Zhang ◽  
Li Jin ◽  
Xiaohan Yin ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ketogenic Diet ◽  
Clinical Course ◽  
High Fat ◽  
Carbohydrate Diet ◽  
Neuroprotective Effects ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate

Ketogenic diet (KD) is defined as a high-fat, low-carbohydrate diet with appropriate amounts of protein, which has broad neuroprotective effects.

scholarly journals An 8-Week, Low Carbohydrate, High Fat, Ketogenic Diet Enhanced Exhaustive Exercise Capacity in Mice Part 2: Effect on Fatigue Recovery, Post-Exercise Biomarkers and Anti-Oxidation Capacity

Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1339 ◽  
Author(s):  
Qingyi Huang ◽  
Sihui Ma ◽  
Takaki Tominaga ◽  
Katsuhiko Suzuki ◽  
Chunhong Liu
Keyword(s):  
Open Field ◽  
Ketogenic Diet ◽  
The Body ◽  
Exhaustive Exercise ◽  
Blood Biomarkers ◽  
High Fat ◽  
Post Exercise ◽  
Low Carbohydrate Diet ◽  
Low Carbohydrate ◽  
Fatigue Recovery

A low-carbohydrate, high-fat ketogenic diet (KD) is a nutritional approach ensuring that the body utilizes lipids. In our previous study, we found that an eight-week ketogenic high-fat, low-carbohydrate diet increased the capacity of endurance exercise in mice without aggravated muscle injury, despite the decrease of absolute muscle volume. The potential mechanism is most possibly to be enhanced capacity to mobilize and utilize fat. In the present study, we investigated whether a ketogenic diet influences post-exercise recovery by measuring blood biomarkers, muscle and liver oxidative state as well as fatigue recovery 24 h post exercise by employing an open-field locomotion test. Several biochemistry markers indicating exercise-induced injury after exhaustive exercise were improved by KD, followed by a 24-h rest with free feed access, including lactate. No aggravated hepatic oxidative damage was observed, whereas muscular oxidative stress was increased by KD. Accelerated recovery induced by exhaustive exercise was also observed from blood biomarkers of injury. For fatigue recovery, lactate concentration, a marker often employed as exhaustion index was lowered by KD, whereas an open field test showed that KD application contributed to increased locomotion after exhaustive exercise, followed by a 24-h rest. These results suggest that KD has the potential to be used as a fatigue-preventing and/or recovery-promoting diet approach in endurance athletes.

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