scholarly journals The effect of functional limitations and fatigue on the quality of life in people with multiple sclerosis

2009 ◽  
Vol 67 (3b) ◽  
pp. 812-817 ◽  
Author(s):  
Leandro Alberto Calazans Nogueira ◽  
Felipe Resende Nóbrega ◽  
Kátia Nogueira Lopes ◽  
Luiz Claudio Santos Thuler ◽  
Regina Maria Papais Alvarenga
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Functional Limitations ◽  
Case Series ◽  
Lower Limbs ◽  
Case Series Study ◽  
Modified Ashworth Scale ◽  
Mild Disability ◽  
Fatigue Severity

The purpose of this study was to determine the effect of functional limitations and fatigue on the quality of life (QoL) in people with multiple sclerosis (MS). A descriptive case series study at Lagoa Hospital - Rio de Janeiro, Brazil was carried. The main outcome measurements were demographic variables, QoL (SF-36 v.1), disability (EDSS), motor function of the upper limb (Box & Blocks test), Tone (Modified Ashworth Scale), gait (Hauser ambulatory index) and fatigue (Fatigue Severity Scale). Sixty one patients fulfilled the study criteria. The mean age of patients was 39 years and 74% of patients were female. The most of cases presented mild disability (EDSS<3.5). A decrease was found in all domains of QoL. It was found association between physical functioning and the variables of EDSS, fatigue, lower limb tone and gait. Gait, disability, hypertonia of the lower limbs and fatigue negatively affected QoL in people with MS.

Comparing the effects of multi-session anodal trans-cranial direct current stimulation of primary motor and dorsolateral prefrontal cortices on fatigue and quality of life in patients with multiple sclerosis: a double-blind, randomized, sham-controlled trial

2020 ◽  
Vol 34 (8) ◽  
pp. 1103-1111
Author(s):  
Marzieh Mortezanejad ◽  
Fatemeh Ehsani ◽  
Nooshin Masoudian ◽  
Maryam Zoghi ◽  
Shapour Jaberzadeh
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Prefrontal Cortex ◽  
Direct Current ◽  
Dorsolateral Prefrontal Cortex ◽  
Fatigue Severity Scale ◽  
Severity Scale ◽  
Dorsolateral Prefrontal ◽  
Fatigue Severity

Objective: To compare the effects of anodal trans-cranial direct current stimulation (a-tDCS) over primary motor and dorsolateral prefrontal cortices on Fatigue Severity Scale and its lasting effect on fatigue reduction and improvement in quality of life in patients with multiple sclerosis. Design: A randomized, double-blinded, sham-controlled parallel clinical trial study. Setting: Neurological physiotherapy clinics. Subjects: Thirty-nine participants were randomly assigned to three groups: dorsolateral prefrontal cortex a-tDCS, primary motor a-tDCS (experimental groups) and sham a-tDCS. Finally, 36 participants completed the whole study ( n = 12 in each group). Interventions: Participants in the experimental groups received six-session a-tDCS (1.5 mA, 20 minutes) during two weeks (three sessions per week). The sham group received six sessions of 20-minute sham stimulation. Main measures: The Fatigue Severity Scale and quality of life were assessed before, immediately and four weeks after the intervention. Results: Findings indicated a significant reduction in the Fatigue Severity Scale and a significant increase in the quality of life in both experimental groups, immediately after the intervention ( P < 0.001), while Fatigue Severity Scale and quality of life changes were not significant in the sham a-tDCS group ( P > 0.05). In addition, improvement of the variables remained four weeks after the intervention in dorsolateral prefrontal cortex a-tDCS (mean differences (95% confidence interval): 0.03 (−0.63 to 0.68) as compared to primary motor (−0.62 (−0.11 to −1.14) and sham a-tDCS groups (−0.47 (−1.37 to 0.43)). Conclusion: Both primary motor and dorsolateral prefrontal cortex a-tDCS as compared to sham intervention can immediately improve fatigue and quality of life. However, the effects last up to four weeks only by the dorsolateral prefrontal cortex a-tDCS.

scholarly journals Prevalence of fatigue in patients with multiple sclerosis and its effect on the quality of life

2013 ◽  
Vol 04 (03) ◽  
pp. 278-282 ◽  
Author(s):  
Karthik Nagaraj ◽  
Arun B Taly ◽  
Anupam Gupta ◽  
Chandrajit Prasad ◽  
Rita Christopher
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
World Health ◽  
Fatigue Score ◽  
Duration Of Illness ◽  
Disability Status ◽  
Fatigue Severity ◽  
The Mean ◽  
Health Organization

ABSTRACTObjective: This prospective study was carried out to observe the prevalence of fatigue in patients with multiple sclerosis (MS) and its effect on quality-of-life (QoL). Study Design and Setting: Prospective observational study in a University Tertiary Research Hospital in India. Patients and Methods: A total of 31 patients (25 females) with definite MS according to McDonald ′s criteria presented in out-patient/admitted in the Department of Neurology (between February 2010 and December 2011) were included in the study. Disease severity was evaluated using the Kurtzke′s expanded disability status scale (EDSS). Fatigue was assessed using Krupp′s fatigue severity scale (FSS). QoL was assessed by the World Health Organization QoL-BREF questionnaire. Results: The mean age of patients was 30.1 ± 9.1 years. The mean age at first symptom was 25.23 ± 6.4 years. The mean number of relapses was 4.7 ± 3.6 in the patients. The mean duration of illness was 4.9 ± 4.4 years. The mean EDSS score was 3.5 ± 2.2. Mean fatigue score was 38.7 ± 18.5 (cut-off value 36 in FSS). The prevalence of fatigue in patients with MS was 58.1% (18/31). MS patients with fatigue were significantly more impaired (P < 0.05) on all QoL domains (i.e., physical, psychosocial, social, and environment) than MS patients without fatigue. Conclusion: Prevalence of fatigue was found to be high in the MS patients in the study. All four domains of QoL were significantly more impaired in the group with fatigue than in those without fatigue.

The Impact of Health Anxiety in Multiple Sclerosis: A Replication and Treatment Case Series

2017 ◽  
Vol 46 (2) ◽  
pp. 148-167 ◽  
Author(s):  
Neil Carrigan ◽  
Leon Dysch ◽  
Paul M. Salkovskis
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Physical Disability ◽  
Cognitive Behaviour Therapy ◽  
Health Anxiety ◽  
Case Series ◽  
Behaviour Therapy ◽  
Cognitive Behaviour ◽  
The Impact

Background: Multiple sclerosis (MS) is commonly associated with psychological complications. Previous research by Hayter and colleagues (2016) found that in patients with MS, health anxiety (HA) can account for part of the variance in quality of life (QoL) independent of physical and cognitive impairment caused by the disease. MS patients with HA perceived their intact physical and cognitive performance as impaired relative to those without HA and attributed the impairment to MS. These misperceptions might be useful targets in the treatment of HA in MS using cognitive behaviour therapy (CBT). Aims: Study 1 sought to replicate the main findings from Hayter et al. (2016). Study 2 examined the impact of HA-focused CBT in a case series. Method: In Study 1, twenty participants with MS were screened for HA and assigned to either a high or low HA group. They completed assessments of cognitive and physical functioning before rating their performance on these tasks, followed by measures of QoL, mood and physical disability. Four participants in the high HA group subsequently received six sessions of CBT using a consecutive AB case series in Study 2. Results: Study 1 replicated the main findings from the earlier study. In Study 2, three of the four patients who received treatment showed substantial improvements in HA and mood and all showed improvement in QoL. Conclusion: Given the high rates of HA in MS patients and its impact on QoL, this case series suggests that a brief CBT intervention could significantly improve patients’ wellbeing.

scholarly journals Gender associated differences in determinants of quality of life in patients with COPD: a case series study

2006 ◽  
Vol 4 (1) ◽  
Author(s):  
Juan P de Torres ◽  
Ciro Casanova ◽  
Concepción Hernández ◽  
Juan Abreu ◽  
Angela Montejo de Garcini ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Case Series ◽  
Case Series Study ◽  
Series Study

scholarly journals Funcionalidad y calidad de vida luego de la cirugía de escoliosis neuromuscular. [Functionality and quality of life after neuromuscular scoliosis surgery.]

2018 ◽  
Vol 83 (2) ◽  
pp. 101
Author(s):  
Patricia Carolina Curbelo Nova ◽  
Claudio Silveri ◽  
Alejandro Cuneo ◽  
Rodrigo Olivera
Keyword(s):  
Quality Of Life ◽  
Social Life ◽  
Case Series ◽  
Neuromuscular Scoliosis ◽  
Scoliosis Surgery ◽  
Retrospective Case ◽  
Calidad De Vida ◽  
Case Series Study ◽  
Degree Of Satisfaction

<p><strong>Objetivo</strong></p><p>El objetivo de nuestro trabajo es estudiar las complicaciones de la cirugía en las escoliosis neuromusculares operadas en nuestro centro, así como la funcionalidad y calidad de vida de los pacientes luego del tratamiento quirúrgico.</p><p><strong>Métodos</strong></p><p>Se realizó un estudio retrospectivo, tipo serie de casos. Se revisó la historia clínica y se entrevistó a paciente y cuidador principal. Se valoró los resultados luego de la cirugía en cuanto a las complicaciones, funcionabilidad, calidad de vida y grado de satisfacción de los cuidadores.</p><p><strong>Resultados</strong></p><p>Obtuvimos un 26,7% de complicaciones, debidas a infección y alteraciones hemodinámicas. En cuanto a la funcionabilidad y calidad de vida de estos pacientes obtuvimos resultados positivos, siendo más significativos en cuanto a la capacidad de estar sentado y las actividades de la vida diaria.</p><p><strong>Conclusiones</strong></p><p>La cirugía de los pacientes con  escoliosis neuromuscular mejora la capacidad y el equilibrio de estar sentado, favoreciendo con esto la capacidad digestiva, respiratoria y de vida social del paciente. Si bien se trata de cirugías con altos indices de complicaciones muestra indices elevados de satisfacción por parte de los cuidadores.</p><p> </p><p> </p><p><strong>Abstract</strong></p><p><strong></strong><br /><strong>Introduction</strong>: The objective of this study was to evaluate surgical complications in patients with scoliosis operated on in our Center, as well as their functionality and quality of life after surgical treatment.</p><p><br /><strong>Methods</strong>: A retrospective case series study was carried out. Medical history was reviewed and the patient and primary caregiver were interviewed. Results after surgery were assessed for complications, function, quality of life and caregivers´ degree of satisfaction.</p><p><br /><strong>Results</strong>: Complication rate was 26.7%, due to infection and hemodynamic alterations. Positive results were obtained regarding function and quality of life of these patients, being more significant in terms of the ability to be seated and activities of daily living.</p><p><br /><strong>Conclusions</strong>: Surgery of patients with neuromuscular scoliosis improves the capacity and balance of sitting, favoring digestive, respiratory and social life capacity. Although rate of complications is high, satisfaction rates on the part of the caregivers are elevated.</p>

scholarly journals Correlation between Seizure Characteristics and Quality of Life in Epilepsy Patients

2018 ◽  
Vol 9 (6) ◽  
pp. 1-6
Author(s):  
Rizaldy Taslim Pinzon ◽  
Rosa De Lima Renita Sanyasi ◽  
Jesisca Tandora ◽  
Andre Dharmawan Wijono ◽  
Fransiscus Buwana
Keyword(s):  
Quality Of Life ◽  
Social Role ◽  
Bodily Pain ◽  
Case Series ◽  
Health Perception ◽  
Role Functioning ◽  
Case Series Study ◽  
Pain Subscale ◽  
Emotional Role

Background: Epilepsy is one of the most common neurological disorder and characterized by recurrent seizures caused by abnormal electrical activity in the brain. Epilepsy is both a medical diagnosis and a social label that can negatively impact quality of life (QoL).Aims and Objective: This study aimed to evaluate the correlation between characteristics of seizure and QoL among epilepsy patients.Materials and Methods: This is a case series study conducted at Bethesda Hospital, Yogyakarta. Subjects answer 8 questions in the SF-8 questionnaire by choosing one from several alternative answers. Sub-scale assessed in this questionnaire including general health perception (GH), physical functioning (PF), physical role functioning (RP), bodily pain (BP), vitality (VT), social role function (SF), mental health (MH), and emotional role functioning (RE). Each answer will be score and processed in a program from Optum™. The final results will be summarized into physical component (PCS) and mental component (MCS).Results: Total of the subjects were 27. Subjects were dominated by male, age< 60 years. The highest score is on the bodily pain subscale (mean: 50.00 ± 8.0739), wherease the lowest score is on global health perception (mean: 43.95 ± 7.1970). Overall, subjects in this study have a better mental status than physical status (47.14 ± 10.2093 vs 46.90 ± 7.9418). Type of seizure (PCS p: 0.794; MCS p:0.093), duration of epilepsy(PCS p: 0.832; MCS p: 0.856), history of epileptic status (PCS p: 0.141; MCS p: 0.951), the presence of neurological deficit (PCS p: 0.140; MCS p: 0.283), frequency of seizure before treatment (PCS p: 0.648; MCS p: 0.213), frequency of seizure after treatment (PCS p: 0.249; MCS p: 0.407), and frequency of seizure within the last 1 year were not significant to influence the QoL (PCS p:0.978; MCS p: 0.513).Conclusion: There is no significant characteristics of seizure that influence the QoL.Asian Journal of Medical Sciences Vol.9(6) 2018 1-6

Self-reported quality of life of patients with multiple sclerosis with mild disability

2016 ◽  
Vol 53 (3) ◽  
pp. 161 ◽  
Author(s):  
Ali Shalash ◽  
Safeya Effat ◽  
Hanan Azzam ◽  
Seham Elkatan ◽  
Hanan Elrassas
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Mild Disability
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