scholarly journals Aluminum as a risk factor for Alzheimer's disease

2008 ◽  
Vol 16 (1) ◽  
pp. 151-157 ◽  
Author(s):  
Pricilla Costa Ferreira ◽  
Kamila de Almeida Piai ◽  
Angela Maria Magosso Takayanagui ◽  
Susana Inés Segura-Muñoz
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Alzheimer Disease ◽  
Scientific Evidence ◽  
Long Term Effects ◽  
Aluminum Exposure ◽  
The World

The purpose of the study was to condense existing scientific evidence about the relation between aluminum (Al) exposure and risk for the development of Alzheimer's Disease (AD), evaluating its long-term effects on the population's health. A systematic literature review was carried out in two databases, MEDLINE and LILACS, between 1990 and 2005, using the uniterms: "Aluminum exposure and Alzheimer Disease" and "Aluminum and risk for Alzheimer Disease". After application of the Relevance Test, 34 studies were selected, among which 68% established a relation between Al and AD, 23.5% were inconclusive and 8.5% did not establish a relation between Al and AD. Results showed that Al is associated to several neurophysiologic processes that are responsible for the characteristic degeneration of AD. In spite of existing polemics all over the world about the role of Al as a risk factor for AD, in recent years, scientific evidence has demonstrated that Al is associated with the development of AD.

Long-term Effects of Galantamine Treatment on Brain Functional Activities as Measured by PET in Alzheimer's Disease Patients

2011 ◽  
Vol 24 (1) ◽  
pp. 109-123 ◽  
Author(s):  
Connor Keller ◽  
Ahmadul Kadir ◽  
Anton Forsberg ◽  
Omar Porras ◽  
Agneta Nordberg
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Long Term Effects ◽  
Functional Activities

Long-term effects of rivastigmine in moderately severe Alzheimer's disease

2002 ◽  
Vol 26 (4) ◽  
pp. 705-712 ◽  
Author(s):  
P.Murali Doraiswamy ◽  
K.Ranga Rama Krishnan ◽  
Ravi Anand ◽  
Hyesung Sohn ◽  
Jacquiline Danyluk ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Long Term Effects

scholarly journals Nonviral Abeta DNA vaccine therapy against Alzheimer's disease: Long-term effects and safety

2006 ◽  
Vol 103 (25) ◽  
pp. 9619-9624 ◽  
Author(s):  
Y. Okura ◽  
A. Miyakoshi ◽  
K. Kohyama ◽  
I.-K. Park ◽  
M. Staufenbiel ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Dna Vaccine ◽  
Vaccine Therapy ◽  
Long Term Effects

Air Pollution as Risk Factor for Mental Disorders: In Search for a Possible Link with Alzheimer’s Disease and Schizophrenia

2021 ◽  
Author(s):  
Luigi Attademo ◽  
Francesco Bernardini
Keyword(s):  
Mental Health ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Air Pollution ◽  
Risk Factor ◽  
Air Pollutants ◽  
Epidemiological Studies ◽  
Increased Risk ◽  
The Central Nervous System

As a global problem that has increasingly been causing worldwide concern, air pollution poses a significant and serious environmental risk to health. Risks of cardiovascular and respiratory diseases, as well as various types of cancer, have been consistently associated with the exposure to air pollutants. More recently, various studies have also shown that the central nervous system is also attacked by air pollution. Air pollution appears to be strongly associated with a higher risk of cognitive defects, neurodevelopmental (e.g., schizophrenia) and neurodegenerative (e.g., Alzheimer’s disease) disorders. Subjects with schizophrenia, as well as subjects with Alzheimer’s disease, experience a variety of neuropsychological deficits and cognitive impairments. This determines an adverse effect on social and professional functioning, and it contributes to the long-term disease burden. However, no final conclusions have been drawn on the matter of the direct relationship between schizophrenia and Alzheimer’s disease. In recent years, the topic of urbanicity and mental health has become increasingly important. Urban exposure to environmental toxins and pollution is currently described as a reliable risk factor for schizophrenia and other psychoses, and it has been demonstrated more and more how exposure to air pollutants is associated with increased risk of dementia. Pathways by which air pollution can target and damage the brain, leading to an increased risk for developing schizophrenia and Alzheimer’s disease, are multiple and complex. Results from epidemiological studies suggest potential associations, but are still insufficient to confirm causality. Further studies are needed in order to verify this hypothesis. And if confirmed, the clinical implications could be of substantial relevance for both public and mental health.

scholarly journals Long-term effects of intracranial islet grafting on cognitive functioning in a rat metabolic model of sporadic Alzheimer's disease-like dementia

PLoS ONE ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. e0227879
Author(s):  
Konstantin Bloch ◽  
Shay Henry Hornfeld ◽  
Shira Dar ◽  
Alexey Vanichkin ◽  
Irit Gil-Ad ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Functioning ◽  
Metabolic Model ◽  
Long Term Effects ◽  
Sporadic Alzheimer’S Disease

scholarly journals Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia

2014 ◽  
Vol 35 (2) ◽  
pp. 444.e1-444.e4 ◽  
Author(s):  
Agustín Ruiz ◽  
Oriol Dols-Icardo ◽  
María J. Bullido ◽  
Pau Pastor ◽  
Eloy Rodríguez-Rodríguez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Frontotemporal Dementia

Effects of life review program on emotional well-being of Korean elderly with Alzheimer’s disease

2008 ◽  
Vol 7 (2) ◽  
pp. 35
Author(s):  
Yongho Lee, PhD, CTRS ◽  
Carla E. S. Tabourne, PhD ◽  
Jaesub Yoon, PhD
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Aging Process ◽  
Well Being ◽  
Self Esteem ◽  
Life Review ◽  
Therapeutic Recreation ◽  
Long Term Effects ◽  
Korean Elderly

Emotional well-being is an important aspect of health for individuals with Alzheimer's disease, and self-esteem, depression, and life satisfaction have been identified as factors that comprise emotional well-being. As individuals undergo physical and psychological change associated with aging process, they tend to review their lives to achieve a sense of well-being in an effort to compensate for loss due to aging process. It evidences in the literature that the life review program (LRP) is an effective therapeutic recreation intervention to increase emotional well-being of elders with Alzheimer’s disease. With 17 Korean elders with Alzheimer’s disease, the findings of the current study showed some significant effects on Korean elderly with Alzheimer's disease in their emotional well-being. Although long-term effects of the LRP were questionable, the LRP was effective to make a therapeutic change in emotional well-being of Korean elderly with Alzheimer's disease.

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