scholarly journals Kaposi’s sarcoma in Brazilian AIDS patients: a study of 144 cases

2000 ◽  
Vol 14 (4) ◽  
pp. 362-366 ◽  
Author(s):  
Esther G. BIRMAN ◽  
Fernando R. X. SILVEIRA ◽  
Luzia F. GODOY ◽  
Catalina R. COSTA
Keyword(s):  
Oral Mucosa ◽  
Kaposi's Sarcoma ◽  
Young Male ◽  
Kaposi’S Sarcoma ◽  
Skin Lesions ◽  
Bacterial Disease ◽  
Aids Patients ◽  
Main Site ◽  
Oral Neoplasms ◽  
Age Range

One hundred and forty-four Brazilian AIDS patients presenting with Kaposi’s sarcoma (KS) were evaluated with respect to the frequency of oral neoplasms and their clinical features. The majority of the patients were young male adults (age range: 21-40 years old), from which 11.1 % presented with oral KS (OKS) exclusively. Oral and skin lesions were associated in 25% of the cases, while only four patients showed association between oral and visceral KS; 49.3% of the cases were exclusively dermatological. The hard palate was the main site affected, followed by the oropharynx. The localization of KS was found to be similarly frequent in the tongue, gingiva and other sites of the oral mucosa. Candidosis was the prevailing fungal disease; in 20% of the cases it was restricted to the oral mucosa and in 80% it was systemic. No high frequency of paracoccidioidomicosis and cryptococcosis was detected. The prevailing bacterial disease was Tuberculosis and there was only one case of syphilis. Among the viral diseases, the most frequently detected was herpes simplex, followed by molusco contagiosum, condiloma acuminatum and cytomegaloviroses at lower frequencies. Pneumonia caused by Pneumocystes carinii and toxoplasmosis were also identified. The authors emphasise the importance of oral examination in HIV-infected patients bearing in mind several aspects related especially to KS, and stress the need for an interdisciplinary team in the management of these patients, in order to provide better quality of life as well as rapid diagnosis and treatment.

scholarly journals Results of chemotherapy in 30 AIDS patients with symptomatic pulmonary Kaposi's sarcoma.

Thorax ◽  
1994 ◽  
Vol 49 (10) ◽  
pp. 958-960 ◽  
Author(s):  
J L Cadranel ◽  
S Kammoun ◽  
S Chevret ◽  
A Parrot ◽  
M Denis ◽  
...  
Keyword(s):  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Aids Patients

Detection of human herpesvirus 8 DNA and antibodies to latent nuclear and lytic-phase antigens in serial samples from aids patients with Kaposi’s sarcoma

2000 ◽  
Vol 16 (3) ◽  
pp. 247-251 ◽  
Author(s):  
Lı́gia Camera Pierrotti ◽  
Laura Masami Sumita ◽  
Wilton Santos Freire ◽  
Hélio Hehl Caiaffa Filho ◽  
Vanda Akico Ueda Fick de Souza
Keyword(s):  
Kaposi's Sarcoma ◽  
Human Herpesvirus ◽  
Kaposi’S Sarcoma ◽  
Human Herpesvirus 8 ◽  
Aids Patients ◽  
Herpesvirus 8 ◽  
Serial Samples

scholarly journals Primary Gastrointestinal Kaposi’s Sarcoma in a Patient with Human Immunodeficiency Virus

2018 ◽  
Vol 11 (3) ◽  
pp. 638-647 ◽  
Author(s):  
Martin Ignacio Zapata Laguado ◽  
Jorge Enrique Aponte Monsalve ◽  
Jorge Hernan Santos ◽  
Javier Preciado ◽  
Andres Mosquera Zamudio ◽  
...  
Keyword(s):  
Gastrointestinal Bleeding ◽  
Kaposi's Sarcoma ◽  
Gastrointestinal Endoscopy ◽  
Rare Complication ◽  
Kaposi’S Sarcoma ◽  
Skin Lesions ◽  
Clinical Findings ◽  
Upper Gastrointestinal Endoscopy ◽  
Immunodeficiency Virus ◽  
Upper Gastrointestinal

Gastrointestinal bleeding in HIV patients secondary to coinfection by HHV8 and development of Kaposi’s sarcoma (KS) is a rare complication even if no skin lesions are detected on physical examination. This article indicates which patients might develop this type of clinical sign and also tries to recall that absence of skin lesions never rules out the presence of KS, especially if gastrointestinal involvement is documented. Gastrointestinal bleeding in terms of hematemesis has rarely been reported in the literature. We review some important clinical findings, diagnosis, and treatment approach. We present the case of an HIV patient who presented to the emergency department with hematemesis and gastrointestinal signs of KS on upper gastrointestinal endoscopy without any dermatological involvement.

Clinical, histological and immunohistochemical findings in oral Kaposi's sarcoma in a series of Mexican AIDS patients. Comparative study

2009 ◽  
Vol 38 (4) ◽  
pp. 328-333 ◽  
Author(s):  
V. Ramírez-Amador ◽  
G. Martínez-Mata ◽  
I. González-Ramírez ◽  
G. Anaya-Saavedra ◽  
O. P. De Almeida
Keyword(s):  
Comparative Study ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Aids Patients

Amino acid residue at position 13 in HLA-DR beta chain plays a critical role in the development of Kaposi's sarcoma in AIDS patients

AIDS ◽  
2004 ◽  
Vol 18 (2) ◽  
pp. 199-204 ◽  
Author(s):  
Antoni Gayà ◽  
Anna Esteve ◽  
Jordi Casabona ◽  
Jeanette J McCarthy ◽  
Jaume Martorell ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Residue ◽  
Kaposi's Sarcoma ◽  
Critical Role ◽  
Kaposi’S Sarcoma ◽  
Beta Chain ◽  
Aids Patients ◽  
Hla Dr

scholarly journals Skin Lesions in Melanoma and Kaposi’s Sarcoma

2002 ◽  
Vol 20 (5) ◽  
pp. 1412-1415 ◽  
Author(s):  
Maria A. Pizzichetta ◽  
Vincenzo Canzonieri ◽  
Alessandro Gatti ◽  
Clelia de Giacomi ◽  
Giusto Trevisan ◽  
...  
Keyword(s):  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Skin Lesions

Cytomegalovirus and human herpesvirus 8 DNA detection in peripheral blood monocytic cells of AIDS patients: Correlations with the presence of Kaposi's sarcoma and CMV disease

2005 ◽  
Vol 76 (4) ◽  
pp. 541-546 ◽  
Author(s):  
Antoinette C. van der Kuyl ◽  
Abeltje M. Polstra ◽  
Remco van den Burg ◽  
Gerrit Jan Weverling ◽  
Jaap Goudsmit ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Kaposi's Sarcoma ◽  
Dna Detection ◽  
Human Herpesvirus ◽  
Kaposi’S Sarcoma ◽  
Human Herpesvirus 8 ◽  
Aids Patients ◽  
Monocytic Cells ◽  
Herpesvirus 8 ◽  
Cmv Disease

A Case of Kaposi’s Sarcoma in a HIV Negative Patient with CLL Treated with Rituximab

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 4970-4970
Author(s):  
Anuradha Avinash Belur ◽  
Arun Kumar Arumugam Raajasekar ◽  
Srikant Nannapaneni ◽  
Thandavababu Chelliah
Keyword(s):  
Kaposi's Sarcoma ◽  
Conflicts Of Interest ◽  
Kaposi Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Skin Lesions ◽  
Elisa Test ◽  
Lymphocytic Leukemia ◽  
Cell Mediated Immunity ◽  
Negative Patient ◽  
Hiv Negative

Abstract Case Description: - A 76 year old lady was diagnosed with Chronic Lymphocytic Leukemia (CLL) with 11 q deletion after she presented with generalized lymphadenopathy and anemia. She was treated with rituximab 375mg/m2 day1 and bendamustine 60mg/m2 on day 1 and day 2 and completed six cycles of treatment. After the sixth cycle she developed multiple itchy, papular lesions with bleeding on both lower extremities. She was evaluated multiple times by vascular surgery and dermatology without a definitive diagnosis. She underwent a biopsy with staining for HHV-8, CD31 and CD34 which was positive confirming the diagnosis of Kaposi sarcoma. ELISA test for HIV was negative. She was started on treatment with Doxorubicin 20 mg/m2every 3 weeks and with 3 cycles there was significant regression of the lesions. Discussion-: We describe a case of CLL which was initially started on treatment with rituximab and bendamustine. She tolerated the treatment well, but a few months later presented with skin lesions which on biopsy was diagnosed as Kaposi sarcoma. It is very uncommon for Kaposi sarcoma to develop in a HIV negative patient. This patient was immunocompromised with recent chemotherapy. Rituximab specifically depletes B cells and leads to impaired T cell mediated immunity. This case illustrates the importance of a high index of suspicion in patients treated with rituximab as it is used for a number of hematologic malignancies like leukemia, lymphoma as well as non-malignant conditions like autoimmune disorders. While infusion reactions and reactivation of hepatitis B are side effects physicians are aware of and cautious of while using rituximab, Kaposi’s Sarcoma remains a less known side effect. Awareness of this possibility is important in physicians prescribing rituximab. Footnotes * Asterisk with author names denotes non-ASH members. Disclosures No relevant conflicts of interest to declare.

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