The Crown Size and Sexual Dimorphism of Permanent Teeth in Jordanian Cleft Lip and Palate Patients

2007 ◽  
Vol 44 (2) ◽  
pp. 155-162 ◽  
Author(s):  
Ma'amon A. Rawashdeh ◽  
Ikhlas Fawaz Bani Bakir
Keyword(s):  
Sexual Dimorphism ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Permanent Tooth ◽  
Permanent Teeth ◽  
Maxillary Incisor ◽  
Control Group ◽  
Tooth Size ◽  
And Control ◽  
Crown Size

Objective: To provide a detailed description of crown size dimensions in the permanent dentition of Jordanian cleft lip and palate patients and to compare the findings with those of other populations. Method: The mesiodistal crown diameters of the permanent teeth of 47 patients with unilateral cleft lip and palate (UCLP), 25 patients with bilateral cleft lip and palate (BCLP), and 74 controls were measured. Results: The cleft group (UCLP and BCLP patients) generally demonstrated a smaller tooth size for both the maxillary and mandibular arches than did the control group. A sexual dimorphism pattern with males having larger teeth than females was observed for controls and UCLP patients. More males with BCLP had smaller teeth than did females. In the maxilla, the UCLP cleft-side teeth showed the largest percentage (4%) of sexual dimorphism, whereas the BCLP teeth achieved the highest percentage (3.4%) in the mandible. The UCLP cleft-side maxillary lateral incisors (13.2%) and BCLP mandibular canines (6%) displayed greater sexual dimorphism in crown size than did any other tooth class. Conclusions: Tooth size reduction occurred across all permanent tooth types and among early and late-forming teeth in cleft patients compared with the controls. This reduction was more pronounced in the maxillary incisor field. Males with UCLP and control males had larger teeth than did females, whereas a reversal of the normal dimorphism pattern was observed in patients with BCLP.

Sri Lankan Cleft Lip and Palate Study Model Analysis: Clefts of the Secondary Palate

1993 ◽  
Vol 30 (2) ◽  
pp. 227-230 ◽  
Author(s):  
Andrew Mccance ◽  
David Roberts-Harry ◽  
Martyn Sherriff ◽  
Michael Mars ◽  
William J.B. Houston
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Model Analysis ◽  
Control Group ◽  
Tooth Size ◽  
Sri Lankan ◽  
Control Groups ◽  
Secondary Palate ◽  
Comparable Control ◽  
And Control

The study models of a group of adult Sri Lankan patients with clefts of the secondary palate were investigated. Tooth-size and arch-dimension comparisons were made with a comparable control group. Significant differences were found between the cleft and control groups in tooth sizes, chord lengths, and arch widths. The cleft group dimensions were generally smaller than those of the control group. Overjets were larger in the cleft group.

Comparison of Dental Caries Prevalence in Patients with Cleft Lip and/or Palate and Their Sibling Controls

2009 ◽  
Vol 46 (5) ◽  
pp. 529-531 ◽  
Author(s):  
Mahmoud Al-Dajani
Keyword(s):  
Dental Caries ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Maxillofacial Surgery ◽  
Permanent Teeth ◽  
Control Group ◽  
Oral And Maxillofacial Surgery ◽  
Caries Prevalence ◽  
Dmft Index ◽  
And Control

Objective: To evaluate the prevalence of dental caries in patients with cleft lip and/or palate and their cleft-free sibling controls. Methods: The two subject groups (patient and control) comprised 106 participants. The former group consisted of 53 patients with cleft lip and/or palate, aged 12 to 29 years, who visited the Oral and Maxillofacial Surgery Hospital at Damascus University of Syria. The control group consisted of the patients’ siblings who had no clefts, and they were sex matched to the patient group. Dental caries were examined clinically and were reported using the decayed, missing, and filled permanent teeth (DMFT) index. The DMFT scores were compared between the two groups. Results: The author found an overall association of dental caries with the presence of cleft lip and/or palate (odds ratio  =  2.52; 95% confidence interval  =  1.389–4.574; p < .05). The DMFT index scores were proportionally higher in patients with cleft lip and/or palate compared with the control group (p < .001). Conclusion: Subjects with cleft lip and palate are susceptible to dental caries independently of socioeconomic status.

Secondary Dentition Characteristics in Children With Nonsyndromic Unilateral Cleft Lip and Palate

2018 ◽  
Vol 55 (4) ◽  
pp. 582-589 ◽  
Author(s):  
Elaine Li Yen Tan ◽  
Meaw Charm Kuek ◽  
Hung Chew Wong ◽  
Serene Ai Kiang Ong ◽  
Mimi Yow
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Permanent Teeth ◽  
Tooth Size ◽  
Dental Anomalies ◽  
Supernumerary Teeth ◽  
High Prevalence ◽  
Dental Records ◽  
Congenitally Missing ◽  
Maxillary Region

Objective: Children with cleft lip and palate are reported to be commonly associated with higher prevalence of dental anomalies such as hypodontia, supernumeraries, and abnormalities in tooth size, shape, and position. This study investigated the prevalence of dental anomalies in a longitudinal cohort of children with unilateral cleft lip and palate (UCLP). Design: The study was a retrospective analysis of radiographs, study models, and treatment notes. Patients: Sixty patients with repaired UCLP aged 13 years old with complete dental records dating from 5 years of age were included. Methods: Study casts, dental panoramic, anterior maxillary occlusal, and periapical radiographs of the patients were examined for cleft-sidedness, congenitally missing permanent teeth, supernumerary teeth, microdontic, and macrodontic teeth in the anterior maxillary region, presence of malformed permanent cleft-sided lateral incisor and its morphology (peg-shaped, conical shaped, canine-formed), positions of the permanent lateral incisors relative to the cleft side and presence of rotated cleft-sided central incisors. Results: Of the 60 patients studied, 63.3% had hypodontia, 21.7% had supernumerary teeth, 69.6% had microdontia, and 12.5% had macrodontia. All of the cleft-sided permanent lateral incisors had associated anomalies, with a large proportion (43.1%) missing; and when present in 31 subjects, the majority (90.3%) was positioned distal to the cleft. Most of the cleft-sided permanent central incisors were rotated if present, and prevalent at 86.7%. Conclusion: A high prevalence of dental anomalies was observed in this sample of children with UCLP.

scholarly journals Three-dimensional Evaluation of Mandibular Volume in Patients with Cleft Lip and Palate During the Deciduous Dentition Period

2019 ◽  
Vol 90 (1) ◽  
pp. 85-91 ◽  
Author(s):  
Abhishekhi Shrestha ◽  
Masahiro Takahashi ◽  
Tetsutaro Yamaguchi ◽  
Mohamed Adel ◽  
Mayu Furuhata ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Three Dimensional ◽  
Pairwise Comparison ◽  
Craniofacial Morphology ◽  
Analysis Of Covariance ◽  
Control Group ◽  
Deciduous Dentition ◽  
Post Hoc ◽  
And Control

ABSTRACT Objectives To examine the relationship between mandibular volume and craniofacial morphology in patients with cleft lip and palate using cone beam computed tomography (CBCT) and to compare these findings with control (noncleft) patients undergoing CBCT for other purposes during the deciduous dentition period. Materials and Methods Eighty-four patients were categorized into the unilateral cleft lip and alveolus (UCLA) group (n = 25; mean age, 4.60 ± 0.40 years), unilateral cleft lip and palate (UCLP) group (n = 23; mean age, 4.52 ± 0.39 years), bilateral cleft lip and palate (BCLP) group (n = 22; mean age, 4.54 ± 0.37 years), and control group without cleft (n = 14; mean age, 5.19 ± 0.52 years). Mandibular volume and craniofacial cephalometric measurements were obtained using CBCT. All measurements were assessed by analysis of covariance (ANCOVA) using Bonferroni post hoc pairwise comparison tests. Results ANCOVA revealed no statistically significant differences in mandibular volume among the groups. SNA° and ANB° were significantly larger in the UCLA and BCLP groups than in the control group. SN-MP° was smallest in the UCLA group. Co-A in the UCLP group was shorter than in the UCLA and BCLP groups. Go-Gn was shortest in the UCLP and BCLP groups compared with the control group. Conclusions Three-dimensional evaluation of craniofacial morphology using CBCT can provide valuable information on malocclusion and other dentoskeletal problems among patients with CLP.

scholarly journals Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Nonsyndromic Cleft Lip and/or Palate

2015 ◽  
Vol 26 (6) ◽  
pp. 561-565 ◽  
Author(s):  
Márcia Waltrick-Zambuzzi ◽  
Patricia Nivoloni Tannure ◽  
Thays Cristine dos Santos Vieira ◽  
Leonardo Santos Antunes ◽  
Fábio Lourenço Romano ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Taqman Assay ◽  
Control Group ◽  
Chi Square ◽  
Polymorphic Genotype ◽  
Chi Square Test ◽  
Hardy Weinberg Equilibrium ◽  
Cobalamin Metabolism ◽  
And Control

The aim of this study was to evaluate the association of the polymorphisms in TCN2 (rs1801198) gene and in MTRR (rs1801394) gene with nonsyndromic cleft lip and/or palate (NSCL/P) in a Brazilian population. Genomic DNA was extracted from buccal cells. The polymorphisms in TCN2 (rs1801198) and MTRR (rs1801394) genes were genotyped by carrying out real-time PCR and Taqman assay. Chi-square test was used to determine the association between genotype and allele frequencies with NSCL/P and NSCL/P subgroups (cleft lip only, cleft lip and palate, and cleft palate only). Eight hundred and sixty seven unrelated individuals (401 cases with NSCL/P and 466 individuals without cleft) were evaluated. Genotype distributions of TCN2 and MTRR polymorphisms were in Hardy-Weinberg equilibrium. The TCN2 polymorphic genotype GG was identified in 16.7% of the NSCL/P group and in 14.1% of the non-cleft group (p>0.05). Similarly, the frequency of MTRR genotype (GG) was similar in NSCL/P group (15.5%) and control group (17.8%) (p>0.05). Multivariate analysis showed an association between MTRR and the subgroup that the mother smoked during pregnancy (p=0.039). Our findings did not demonstrate an association between TCN2 polymorphisms and NSCL/P, however suggests an association between MTRR and NSCL/P etiology

scholarly journals Odontological analysis of Polish children with unilateral cleft lip and palate

2019 ◽  
Vol 82 (1) ◽  
pp. 91-104
Author(s):  
Piotr Sękowski ◽  
Elżbieta Żądzińska ◽  
Elżbieta Pawłowska ◽  
Aneta Sitek ◽  
Bogusław Antoszewski
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Shape Index ◽  
Permanent Teeth ◽  
Tooth Size ◽  
Prenatal Factors ◽  
Crown Shape ◽  
Cleft Lip Palate ◽  
And Performance ◽  
Healthy Participants

Abstract Tooth size, being the effect of interaction of genetic and prenatal factors, could be of importance in interpreting the multifactor causes of cleft lip/palate. Publications indicating decreased tooth parameters, no dental differences, or larger dimensions of teeth in cleft lip/palate patients. Researchers report mostly mesiodistal (MD) measurements of maxillary (affected) teeth. There is a lack of data for buccolingual (BL) diameters. Both MD and BL parameters have influence on the planning and performance of orthodontic treatment. The aim of this paper was to assess differences in mesiodistal and buccolingual tooth dimensions in Polish children with unilateral cleft lip and palate (UCLP) in comparison to patients without oral clefts. A total of 1883 permanent teeth, 1182 teeth of UCLP patients and 701 teeth of healthy participants were analyzed. Tooth diameters were performed using an orthodontic cast of dentition with a digital odontometer. The greatest anomalies were found in both maxillary canines and consisted of their reduced mesiodistal dimension and increased buccolingual dimension, resulting in a pathologically high crown shape index (BL/MD). Conclusion can be drawn that unilateral cleft lip and palate is a condition that causes morphological disturbances of varying severity in most mandibular and maxillary teeth both on the cleft and non-cleft sides.

scholarly journals Nasal Aesthetic Evaluation Following Pre-Surgical Naso-Alveolar Molding Application: A Single-Blinded Cohort Retrospective Study in Indonesia

2021 ◽  
Vol 8 (1) ◽  
pp. 38-46
Author(s):  
Kristaninta Bangun ◽  
Chaula Luthfia Sukasah ◽  
Jenisa Amanda Sandiarini Kamayana ◽  
Adi Basuki ◽  
Jessica Halim ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Dome Height ◽  
Control Group ◽  
Aesthetic Unit ◽  
History Of ◽  
Palate Repair ◽  
Prior Application ◽  
And Control

Introduction: As a major facial aesthetic unit, the nose is one of the significant features in cleft lip and palate repair. The use of a naso-alveolar molding (NAM) device was known to help narrow the cleft gap and improve nasal aesthetics. This study aims to evaluate post-operative nasal morphology in unilateral cleft lip and palate patients who had used presurgical NAM, particularly in an established craniofacial centre in one of developing countries. Methods: A cohort retrospective study was conducted at Cleft Craniofacial Centre, Cipto Mangunkusumo Hospital Indonesia, comparing the nasal symmetry in unilateral cleft lip patients with and without prior application of NAM (NAM and control group), twelve months following primary cheiloplasty. Differences between the cleft and normal side were assessed using standard basilar view photographs based on five points nasal measurements. Results: A total of twelve patients were enrolled, six with a history of NAM application and six without (control). Overall nasal measurements confirmed a lower mean of differences in the NAM group compared to the control, showing statistically significant results in nostril height, nasal dome height, and columellar height (p <0.05). Conclusion: This study provides an insight that cleft lip patients with a history of NAM application had superior nasal symmetry compared to patients without presurgical NAM application 1-year post-cheiloplasty. Presurgical NAM application is recommended for patients with unilateral cleft lip and palate.

scholarly journals Cleft Candidate Genes and Their Products in Human Unilateral Cleft Lip Tissue

Diseases ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 26
Author(s):  
Mārtiņš Vaivads ◽  
Ilze Akota ◽  
Māra Pilmane
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Control Group ◽  
Strong Correlations ◽  
Control Groups ◽  
Morphological Studies ◽  
Affected Tissue ◽  
Pathological Material ◽  
And Control

Cleft lip and palate are common congenital pathologies that affect the human population worldwide. The formation of cleft lip is associated with multiple genes and their coded proteins, which regulate the development of craniofacial region, but the exact role of these factors is not always clear. The use of morphological studies for evaluation of human cleft-affected tissue has been limited because of insufficiency of available pathological material. The aim of this study was to detect and compare the immunohistochemical expression of cleft candidate gene coded proteins (DLX4, MSX2, HOXB3, SHH, PAX7, SOX3, WNT3A, and FOXE1) in the non-syndromic unilateral cleft lip patient tissue and control group tissue. A semiquantitative counting method was used to evaluate the tissue in biotin-streptavidin-stained slides. Statistically significant differences between the patient and control groups were found for the number of immunoreactive structures for SHH (p = 0.019) and FOXE1 (p = 0.011) in the connective tissue and SOX3 (p = 0.012) in the epithelium. Multiple statistically significant very strong and strong correlations were found between the immunoreactives in cleft-affected tissue. These significant differences and various correlations indicate that multiple morphopathogenetic pathways are possibly involved in unilateral cleft lip pathogenesis. Therefore, we further discuss these possible interactions.

Evaluation of the cervical vertebral anomalies in patients with cleft lip and palate in Aegean region of Turkey

2020 ◽  
pp. 1-9
Author(s):  
Ege Dogan ◽  
Gulen Ozses Ergican ◽  
Servet Dogan
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Control Group ◽  
Posterior Arch ◽  
Bilateral Cleft Lip ◽  
Bilateral Condition ◽  
Group A ◽  
Vertebral Anomalies ◽  
Group B ◽  
And Control

Abstract Objective: To identify the cervical vertebral anomalies in patients with cleft lip and palate, and to compare unilateral and bilateral cleft lip and palate. Methods: The retrospective cohort study was conducted in 2018 at Department of Orthodontics, Ege University, Izmir, Turkey, and comprised non-deteriorated lateral cephalometric radiographs of non-syndromic patients which showed the entire cervical spine. The radiographs were divided into two groups, with group A having those of patients with cleft lip and palate exposure, and control group B having those with non-exposure.  Within group A, unilateral and bilateral cleft lip and palate cases were compared. Data was analysed using SPSS 22. Results: Of the 220 subjects, 110(50%) were in group A with a mean age of 15±6.3 years, and 110(50%) were in group B with a mean age of 15±2.1 years. Within group A, 56(50.9%) subjects had unilateral and 54(49.1%) had bilateral cleft lip and palate. Cervical vertebral anomalies were found in 71(64.5%) patients and 45(40.9%) controls (p<0.001). Among those with bilateral condition, it was found in 41(75.9%) and in unilateral 56(56.6%) (p<0.05). Occipitalisation was 21(38.9%) in bilateral and 4(7.1%) in unilateral cases (p<0.001). Fusion was higher in bilateral patients 16(63%) compared to 23(41.1%) unilateral (p<0.05). Posterior arch deficiencies were found in 30(27.3%) patients in group A and 18(16.4%) controls in group B (p<0.05). Fusion was seen in 57(51.8%) group A patients and 33(30%) group B controls (p<0.001). Conclusion: Cervical vertebral anomalies were mostly found in patients with cleft lip and palate. Continuous....

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