Acute Exposure of Uranyl Nitrate Causes Lipid Peroxidation and Histopathological Damage in Brain and Bone of Wistar Rat

2007 ◽  
Vol 26 (4) ◽  
pp. 255-261 ◽  
Author(s):  
Somnath Ghosh ◽  
Amit Kumar ◽  
Badri N. Pandey ◽  
Kaushala Prasad Mishra
Keyword(s):  
Lipid Peroxidation ◽  
Uranyl Nitrate ◽  
Wistar Rat ◽  
Acute Exposure

Phytochemical analysis and nephroprotective effect of cactus (Opuntia ficus-indica) cladodes on sodium dichromate-induced kidney injury in rats

2019 ◽  
Vol 44 (3) ◽  
pp. 239-247
Author(s):  
Mbarka Hfaiedh ◽  
Dalel Brahmi ◽  
Mohamed Nizar Zourgui ◽  
Lazhar Zourgui
Keyword(s):  
Lipid Peroxidation ◽  
Ascorbic Acid ◽  
Antioxidant Activities ◽  
Antioxidant Properties ◽  
Wistar Rat ◽  
Phytochemical Analysis ◽  
Sodium Dichromate ◽  
Opuntia Ficus Indica

Environmental and occupational exposure to chromium compounds, especially hexavalent chromium, is widely recognized as potentially nephrotoxic in humans and animals. The present study aimed to assess the efficacy of cactus (Opuntia ficus-indica) against sodium dichromate-induced nephrotoxicity, oxidative stress, and genotoxicity. Cactus cladodes extract (CCE) was phytochemically studied and tested in vitro for its potential antioxidant activities. Additionally, the preventive effect of CCE against sodium dichromate-induced renal dysfunction in a Wistar rat model (24 rats) was evaluated. For this purpose, CCE at a dose of 100 mg/kg was orally administered, followed by 10 mg/kg sodium dichromate (intraperitoneal injection). After 40 days of treatment, the rats were sacrificed, and the kidneys were excised for histological, lipid peroxidation, and antioxidant enzyme analyses. The phenol, flavonoid, tannin, ascorbic acid, and carotenoid contents of CCE were considered to be important. Our analyses showed that 1 mL of CCE was equivalent to 982.5 ± 1.79 μg of gallic acid, 294.37 ± 0.84 μg of rutin, 234.78 ± 0.24 μg of catechin, 204.34 ± 1.53 μg of ascorbic acid, and 3.14 ± 0.51 μg of β-carotene. In vivo, pretreatment with CCE was found to provide significant protection against sodium dichromate-induced nephrotoxicity by inhibiting lipid peroxidation, preserving normal antioxidant activities, and protecting renal tissues from lesions and DNA damage. The nephroprotective potential of CCE against sodium dichromate toxicity might be due to its antioxidant properties.

Effect of sodium metabisulfite on lipid peroxidation and enzyme activities in adult rat stomach and spleen

2017 ◽  
Vol 7 (1) ◽  
pp. 01-08
Author(s):  
Elkadi Fatima Zohra ◽  
Boufadi Mokhtaria Yasmina ◽  
Meziani Samira ◽  
Sarsar Fatima Zohra ◽  
Djebara Soraya ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Experimental Period ◽  
Wistar Rat ◽  
Redox Status ◽  
Control Group ◽  
Sodium Metabisulfite ◽  
Enzymatic Antioxidants ◽  
Gastric Tissue ◽  
Rat Stomach ◽  
Adult Rat

Sodium metabisulfite (NaMBS) has been used as an antioxidant and antimicrobial agent in a variety of drugs and foods. The aim of our study was to evaluate the effect of subchronic ingestion of NaMBS on lipid peroxidation, protein and enzymatic antioxidants in the gastric tissue and splenic Wistar rat. The rats were divided into four groups (n = 06 rats/group) as follows; Control (C), rats treated with 0.25% NaMBS (S0.25%), rats treated with 1% NaMBS (S1%) and rats treated with 4% NaMBS (S4%). NaMBS was administered to animals via drinking water. At the end of the experimental period, Malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxi-dase (GPx), catalase (CAT) and thiols were determined. Redox status assess-ment revealed that 1% and 4% NaMBS doses induced gastric and spleen lipid peroxidation in animals compared to the control group. On the other hand, activities of SOD, GPx, CAT and thiols were reduced in the S1% and S4% groups in the stomach and spleen compared to the controls. Slight changes were detected in the GPx and CAT in the stomach of S0.25% group compared to the control group. In conclusion, the subchronic consumption of NaMBS has an adverse effect on the spleen and stomach by inducing oxidative damage leading to an increase in lipid peroxidation, protein oxidation and alteration of enzyme activity antioxidant.

Antioxidant defenses and lipid peroxidation in the cerebral cortex and hippocampus following acute exposure to malathion and/or zinc chloride

Toxicology ◽  
2005 ◽  
Vol 207 (2) ◽  
pp. 283-291 ◽  
Author(s):  
Patrícia S. Brocardo ◽  
Pablo Pandolfo ◽  
Reinaldo N. Takahashi ◽  
Ana Lúcia S. Rodrigues ◽  
Alcir L. Dafre
Keyword(s):  
Lipid Peroxidation ◽  
Cerebral Cortex ◽  
Zinc Chloride ◽  
Acute Exposure ◽  
Antioxidant Defenses

scholarly journals Effect of Soyflour (Glycine max L.) Hepatoprotector Activity on Liver MDA Level in Male Wistar Rat Induced by Diazinon

2018 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Sofi Aliyatul Himah ◽  
Desie Dwi Wisudanti ◽  
Heni Fatmawati
Keyword(s):  
Lipid Peroxidation ◽  
Glycine Max ◽  
Pearson Correlation ◽  
Wistar Rat ◽  
Soy Flour ◽  
Strong Negative Correlation ◽  
Level Increase ◽  
Glycine Max L ◽  
Post Hoc ◽  
One Way Anova

Diazinon is metabolized in liver becomes diazoxon, an active metabolite form that can cause free radical raisingthat leads to lipid peroxidation. The result of lipid peroxidation is MDA. Soyflour has higher isoflavones than theother processed food of Glycine max L.This isoflavones donate its electron and hydrogen atom in lipidperoxidation so it can block the lipid peroxidation. The aim of this experiment is to investigate the effect of soyflour on MDA hepar level increase of male wistar rat induced by diazinon. The sample are divided into 5 groupswhich are Kn, K(-) group induced by diazinon 40mg/kgBW, K1, K2, K3 group given with soy flour 10%, 15%, and20% orally, then induced by diazinon 40 mg/kgBW. MDA liver measured on the day 34th with MDA-TBAmethode which has pink colour and measured by spectrofotometer. Average of liver MDA levels is Kn 6,35μg/mL; K(-) 9,23 μg/mL; K1 8,85 μg/mL; K2 7,88 μg/mL; K3 7,04 μg/mL. One way ANOVA and Post hoc LSDshowed significantly different (p<0,05). Pearson correlation showed strong negative correlation. Keywords: Diazinon, Diazoxon, MDA, Soyflour, Glycine max L., antioxidant

scholarly journals Hepatotoxic Manifestations of Arsenic Trioxide Loaded Poly (Lactide-co-Glycolide) Nanoparticles in Wistar Rat

2021 ◽  
Author(s):  
Yeshvandra Verma ◽  
Kavita Rana ◽  
Varsha Rani ◽  
Suresh VS Rana
Keyword(s):  
Lipid Peroxidation ◽  
Arsenic Trioxide ◽  
Human Health Risk ◽  
Wistar Rat ◽  
Point Of View ◽  
Glutathione S Transferase ◽  
Prime Concern ◽  
Different Types ◽  
Serum Transaminases ◽  
Mitochondrial Lipid

Abstract Present study reports on the hepatotoxic manifestations of arsenic trioxide loaded poly lactide-co-glycolide nanoparticles (As2O3-PLGA- NPs) in rats. As2O3-PLGA- NPs enhances the activity of serum transaminases. As2O3-PLGA-NPs are potential inducer of lipid peroxidation in mitochondria as well as microsomes. Mitochondrial lipid peroxidation was higher than the microsomal lipid peroxidation. CYP450 2E1 was lower in the liver of As2O3-PLGA- NPs treated rats in comparison to arsenic trioxide treated rats. GSH showed lower values than control rats and arsenic trioxide treated rats. Glutathione-S-transferase inhibited by arsenic trioxide, non significant increase was recorded in the liver of As2O3-PLGA- NPs treated rats. As2O3-PLGA- NPs readily accumulates in liver and induces peculiar histopathological changes viz. intracytoplasmic/intranuclear inclusions and apoptosis. Since As2O3-PLGA- NPs are being considered as a suitable chemo-preventive agent against different types of cancer, its toxicological properties are of prime concern from bio-safety point of view. Thus, present observations seem to be important from human health risk assessment point of view.

scholarly journals Hepatotoxic manifestations of arsenic trioxide loaded poly (lactide-co-glycolide) nanoparticles in wistar rat

2021 ◽  
Author(s):  
Yeshvandra Verma ◽  
Kavita Rana ◽  
Varsha Rani ◽  
S VS Rana
Keyword(s):  
Lipid Peroxidation ◽  
Arsenic Trioxide ◽  
Human Health Risk ◽  
Wistar Rat ◽  
Point Of View ◽  
Glutathione S Transferase ◽  
Prime Concern ◽  
Different Types ◽  
Serum Transaminases ◽  
Mitochondrial Lipid

Abstract Present study reports on the hepatotoxic manifestations of arsenic trioxide loaded poly lactide-co-glycolide nanoparticles (As2O3-PLGA- NPs) in rats. As2O3-PLGA- NPs enhances the activity of serum transaminases. As2O3-PLGA-NPs are potential inducer of lipid peroxidation in mitochondria as well as microsomes. Mitochondrial lipid peroxidation was higher than the microsomal lipid peroxidation. CYP450 2E1 was lower in the liver of As2O3-PLGA- NPs treated rats in comparison to arsenic trioxide treated rats. GSH showed lower values than control rats and arsenic trioxide treated rats. Glutathione-S-transferase inhibited by arsenic trioxide, non significant increase was recorded in the liver of As2O3-PLGA- NPs treated rats. As2O3-PLGA- NPs readily accumulates in liver and induces peculiar histopathological changes viz. intracytoplasmic/intranuclear inclusions and apoptosis. Since As2O3-PLGA- NPs are being considered as a suitable chemo-preventive agent against different types of cancer, its toxicological properties are of prime concern from bio-safety point of view. Thus, present observations seem to be important from human health risk assessment point of view.

Effects of benomyl and carbendazim on lipid peroxidation and antioxidant system in kidney of rats following acute exposure

2007 ◽  
Vol 172 ◽  
pp. S62-S63 ◽  
Author(s):  
Betul Catalgol ◽  
Sadik Catalgol ◽  
Buket Alpertunga
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant System ◽  
Acute Exposure
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