scholarly journals Retraction Note to: A research on the relationship between ejaculation and serum testosterone level in men

Author(s):  
Ming Jiang ◽  
Xin Jiang ◽  
Qiang Zou ◽  
Jin-wen Shen
2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Junxiao Liang ◽  
Qiaohua Peng ◽  
Xinyun Yang ◽  
Chunbo Yang

Abstract Background This study aimed to investigate the relationship between total serum testosterone level (TT) and metabolic syndrome (MetS) among adult female population. Subgroup analysis further stratified the population by menopausal status to address the potential hormonal difference in postmenopausal women. Methods A total of 1966 participants from the National Health and Nutrition Examination Survey (NHANES) 2011–2012 cycle was included for analysis in this study. MetS was defined based on the National Cholesterol Education Program Adult Treatment Panel III guidelines. Serum TT was collected during the physical examination of the NHANES program and divided into quartiles (Q) in this analysis. Menopausal status was determined based on NHANES Reproductive Health Questionnaire. Logistic regression models were applied for analysis. Results The odds of MetS in Q2: 12.99–19.38 ng/mL (OR = 0.641, 95%CI 0.493–0.835, P < 0.01), Q3: 19.39–28.38 ng/mL (OR = 0.476, 95%CI 0.362–0.626, P < 0.001), and Q4: ≥28.40 ng/mL (OR = 0.390, 95%CI 0.294–0.517, P < 0.001) were statistically lower compared to the reference Q1: <12.99 ng/mL. For the postmenopausal group, a significantly lower odds of MetS was observed in the Q2 (OR = 0.689, 95%CI 0.486–0.977, P < 0.05) and Q4 (OR = 0.606, 95%CI 0.399–0.922, P < 0.05), while the odds of Q3 (OR = 0.439, 95%CI 0.248–0.779, P < 0.01) and Q4 (OR = 0.464, 95%CI 0.261–0.825, P < 0.01) were significantly lower than the reference Q1 in the premenopausal group. Conclusions Elevated TT levels are associated with incremental reductions in the odds of metabolic syndrome among adult females. Although, serum testosterone level is associated with the occurrence of metabolic syndrome in both the postmenopausal and the premenopausal group, the patterns of the relationship are different.


Author(s):  
kadir karkin ◽  
ergün alma ◽  
Hakan Erçil ◽  
keremhan gözükara ◽  
ferhat ortaoğlu ◽  
...  

We aimed to investigate the relationship between COVID-19 and Erectile Dysfunction (ED) and the effect of serum testosterone level on the disease prognosis. Between April-December 2020, 70 patients who admitted with a complaint of ED after having COVID-19 and whose serum testosterone level was checked for any reason before COVID-19. The patients filled the International Index of Erectile Function (IIEF-5) and their testosterone level was checked. This questionnaire was arranged to present the first month before COVID-19 and after COVID-19. The patients were registered as 20-40 age group 1, 40-60 age group 2 and 60 years and above group 3. Testosterone levels of the patients before and after COVID-19 were compared. The relationship between testosterone levels and hospitalization in the intensive care was evaluated. It was revealed that testosterone levels and IIEF-5 scores after COVID-19 in all three groups were statisticaly and significantly different compared to the period before COVID-19 (p <0.05). Testosterone levels of patients in need of intensive care were significantly higher than those without any need of intensive care (p <0.05). Our study has presented that COVID-19 may cause ED and high testosterone levels increase the rate of hospitalization in the intensive care by intensifying the disease. Keywords COVID-19, erectile dysfunction, testosterone What’s already known about this topic? The relationship between Erectile Dysfunction (ED) and COVID-19 develops due to vasculogenic and hormonal causes which were caused by the primary disease. What does this article add? We showed with this study that COVID-19 causes ED in all age groups, reduces testosterone levels seriously. Moreover, we also presented that the higher the testosterone levels during COVID-19, the more severe the disease progresses.


2021 ◽  
Vol 93 (4) ◽  
pp. 460-464
Author(s):  
Kadir Karkin ◽  
Ergün Alma

Objective: We aimed to investigate the relationship between COVID-19 and Erectile Dysfunction (ED) and the effect of serum testosterone level on the disease prognosis. Methods: Between April-December 2020, 70 patients who were admitted with a complaint of ED after having COVID-19 and whose serum testosterone level was checked for varicocele, premature ejaculation, and infertility reasons before COVID-19. The patients filled the International Index of Erectile Function (IIEF-5) and their testosterone level was checked. The questionnaire was arranged to assess the first month before COVID-19 and after COVID-19. Testosterone levels of the patients before and after COVID-19 were compared. The relationship between testosterone levels and hospitalization in the intensive care was evaluated.Results: It was revealed that testosterone levels and IIEF-5 scores after COVID-19 in all patients were statisticaly and significantly different compared to the period before COVID-19 (p < 0.05). Testosterone levels of patients in need of intensive care were significantly higher than those without any need of intensive care (p < 0.05).Conclusions: Our study has presented that COVID-19 may cause ED and high testosterone levels increase the rate of hospitalization in the intensive care by intensifying the disease.


2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Meng Zuo ◽  
Guotao Liao ◽  
Wenqian Zhang ◽  
Dan Xu ◽  
Juan Lu ◽  
...  

Abstract Objective PCOS is a heterogeneous endocrine disorder with both reproductive and metabolic abnormalities. At present, PCOS has been confirmed to have a certain genetic background. Compared with healthy women, the vast majority of PCOS patients have hyperandrogenemia, and this excessive androgen exposure during pregnancy may affect the development of female fetuses. The aim of the current study was to investigate the effect of adiponectin intervention during early pregnancy of obese mice with PCOS on the metabolic phenotype of adult female offspring. Methods After the PCOS model was established, C57BL/6J mice were divided into maternal-control, maternal-PCOS, and maternal-PCOS + APN groups. DHEA-induced PCOS mice were supplemented with adiponectin (10 mg/kg/day) in the early pregnancy in order to eliminate adverse hormone exposure and then traced for endocrine indicators in their adult female offspring, which were observed for metabolism syndrome or endocrine disturbance and exhibited the main effects of APN. To further explore the underlying mechanism, the relative expressions of phosphorylated AMPK, PI3K, and Akt were detected in the ovaries of offspring mice. Results The serum testosterone level of the maternal-PCOS + APN group in early pregnancy was significantly lower than that of the maternal-PCOS group (p < 0.01). The serum testosterone level in the offspring-PCOS + APN group was significantly lower than in the offspring-PCOS group (p <0.05), the diestrus time characterized by massive granulocyte aggregation in the estrus cycle was significantly shorter than in the offspring-PCOS group (p<0.05), and the phenotypes of PCOS-like reproductive disorders and metabolic disorders, such as obesity, insulin resistance, impaired glucose tolerance, and hyperlipidemia, were also significantly improved in the offspring-PCOS + APN group (p < 0.05). Compared with the control group, the expression levels of phosphorylated AMPK, PI3K, and Akt in the offspring-PCOS group were significantly decreased (p < 0.05), while those in the offspring-PCOS + APN group were significantly increased (p < 0.05). Conclusions APN intervention in early pregnancy significantly reduced the adverse effects of maternal obesity and high androgen levels during pregnancy on female offspring and corrected the PCOS-like endocrine phenotype and metabolic disorders of adult female offspring. This effect may be caused by the activation of the AMPK/PI3K-Akt signaling pathway in PCOS offspring mice.


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