scholarly journals Erectile dysfunction and testosterone levels prior to COVID-19 disease: What is the relationship?

2021 ◽  
Vol 93 (4) ◽  
pp. 460-464
Author(s):  
Kadir Karkin ◽  
Ergün Alma
Keyword(s):  
Intensive Care ◽  
Erectile Dysfunction ◽  
Testosterone Level ◽  
Premature Ejaculation ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Testosterone Levels ◽  
Disease Prognosis ◽  
Before And After ◽  
The Relationship

Objective: We aimed to investigate the relationship between COVID-19 and Erectile Dysfunction (ED) and the effect of serum testosterone level on the disease prognosis. Methods: Between April-December 2020, 70 patients who were admitted with a complaint of ED after having COVID-19 and whose serum testosterone level was checked for varicocele, premature ejaculation, and infertility reasons before COVID-19. The patients filled the International Index of Erectile Function (IIEF-5) and their testosterone level was checked. The questionnaire was arranged to assess the first month before COVID-19 and after COVID-19. Testosterone levels of the patients before and after COVID-19 were compared. The relationship between testosterone levels and hospitalization in the intensive care was evaluated.Results: It was revealed that testosterone levels and IIEF-5 scores after COVID-19 in all patients were statisticaly and significantly different compared to the period before COVID-19 (p < 0.05). Testosterone levels of patients in need of intensive care were significantly higher than those without any need of intensive care (p < 0.05).Conclusions: Our study has presented that COVID-19 may cause ED and high testosterone levels increase the rate of hospitalization in the intensive care by intensifying the disease.

scholarly journals COVID-19 may cause Erectile Dysfunction (ED) and the high level of testosterone is associated with poor prognosis

2021 ◽  
Author(s):  
kadir karkin ◽  
ergün alma ◽  
Hakan Erçil ◽  
keremhan gözükara ◽  
ferhat ortaoğlu ◽  
...  
Keyword(s):  
Intensive Care ◽  
Erectile Dysfunction ◽  
Testosterone Level ◽  
Age Groups ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Age Group ◽  
Testosterone Levels ◽  
High Level ◽  
The Relationship

We aimed to investigate the relationship between COVID-19 and Erectile Dysfunction (ED) and the effect of serum testosterone level on the disease prognosis. Between April-December 2020, 70 patients who admitted with a complaint of ED after having COVID-19 and whose serum testosterone level was checked for any reason before COVID-19. The patients filled the International Index of Erectile Function (IIEF-5) and their testosterone level was checked. This questionnaire was arranged to present the first month before COVID-19 and after COVID-19. The patients were registered as 20-40 age group 1, 40-60 age group 2 and 60 years and above group 3. Testosterone levels of the patients before and after COVID-19 were compared. The relationship between testosterone levels and hospitalization in the intensive care was evaluated. It was revealed that testosterone levels and IIEF-5 scores after COVID-19 in all three groups were statisticaly and significantly different compared to the period before COVID-19 (p <0.05). Testosterone levels of patients in need of intensive care were significantly higher than those without any need of intensive care (p <0.05). Our study has presented that COVID-19 may cause ED and high testosterone levels increase the rate of hospitalization in the intensive care by intensifying the disease. Keywords COVID-19, erectile dysfunction, testosterone What’s already known about this topic? The relationship between Erectile Dysfunction (ED) and COVID-19 develops due to vasculogenic and hormonal causes which were caused by the primary disease. What does this article add? We showed with this study that COVID-19 causes ED in all age groups, reduces testosterone levels seriously. Moreover, we also presented that the higher the testosterone levels during COVID-19, the more severe the disease progresses.

Impact of Varicocele and Varicocele Surgery on Semen Quality, Erectile Function and Serum Hormone Levels

2018 ◽  
Vol 1 (1) ◽  
pp. 129-136
Author(s):  
Badereddin Mohamad Al-Ali ◽  
Emma Persad ◽  
Andreas Lunacek ◽  
Christof Mrstik ◽  
Eugen Plas
Keyword(s):  
Testosterone Level ◽  
Erectile Function ◽  
Semen Quality ◽  
Semen Analysis ◽  
Serum Testosterone ◽  
T Test ◽  
Serum Testosterone Level ◽  
Testosterone Levels ◽  
Group 2 ◽  
Group 1

Introduction: Many studies suggest that varicoceles are associated with hypogonadism and varicocele repair can increase testosterone levels and improve erectile function.Aim: The aim of this retrospective study was to analyze the impact of varicocele and varicocele surgery on testosterone level, semen quality, and erectile function.Methods: Our study included 265 infertile males with a clinical varicocele. This group was divided into three groups: group 1 (193) patients who did not receive surgery, group 2 (72 patients) who were operated on according to the Palomo procedure and group 3 (28 patients), who acted as a control group without a varicocele. All patients completed the International Index of Erectile Function IIEF-5 (German version) and underwent semen analysis. Serum testosterone, follicle stimulating hormone (FSH), and luteinizing hormone (LH) were measured at inclusion into the study and after surgery.Main outcome measures: Changes in semen quality, erectile function, and serum hormones after surgery.Results: The IIEF-5 scores in groups 1 and 2 were 21.01 ± 2.2; and 21.74 ± 1 respectively, and the resulting t-test for equality of variance was significant (p < 0.0001). Total testosterone level in groups 1 and 2 were 3.16 ± 0.37 and 3 ± 0.01, respectively, and the resulting t-test for equality of variance was significant (p < 0.0001). The results of the semen analysis were better in group 2 (after surgery) (28.6%, p < 0.001) in comparison to group 1. Interestingly, pre-operative serum testosterone levels were lower in patients with later improvement of semen analysis (p = 0.05). Body mass index (p = 0.8), pre-operative serum FSH (p = 0.9), LH (p = 0.2), and nicotine consumption (p = 0.6) were similar in both the group that saw improvement and the group with no change in semen quality.Conclusion: Semen quality improved in 28.6% of patients after varicocele surgery. Erectile dysfunction (ED) improved after varicocele surgery. We report that lower pre-operative serum testosterone level might be a possible indicator for successful surgical outcome.

Serum testosterone level and overall survival in first-line abiraterone and enzalutamide for metastatic castration-resistant prostate cancer patients.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e17545-e17545
Author(s):  
Maysa Tamara Silveira Vilbert ◽  
Marcelle Goldner Cesca ◽  
Natasha Carvalho Pandolfi ◽  
Vinicius Fernando Calsavara ◽  
Bruno Cezar de Mendonça Uchôa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Overall Survival ◽  
Testosterone Level ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Castration Resistant Prostate Cancer ◽  
First Line ◽  
Testosterone Levels ◽  
Castration Resistant ◽  
Low Serum

e17545 Background: Androgen receptor-targeted agents Abiraterone and Enzalutamide (Abi/Ez) prolonged overall survival in metastatic castration resistant prostate cancer (mCRPC). Patients with very-low serum testosterone levels seem to have less benefit from these therapies as well as more aggressive prostate cancer. Methods: A retrospective observational cohort study was conducted to evaluate whether a serum testosterone measured at time of start first-line therapy with Abi/Ez is related to overall survival (OS) and time-to-treatment failure (TTF) in mCRPC patients. Kaplan-Meier survival estimates and Cox-regression models were used for time-to-event analyses. The best cut-off for testosterone was defined using Log-rank statistics (Lausen and Schumacher). X² test and Mann-Whitney U-test were applied to compare categorical and continuous variables, respectively. Logistic regression was used to assess characteristics related to serum testosterone levels. Statistical significance was fixed at 0.05. Results: From May 2012 to February 2017, 100 patients were assessed. Median follow-up was 27.8 months (range 2.23 to 68.26). Pts with a high testosterone level ( > 28.2; n = 20) achieved a significantly higher OS (median 66.0 vs 31.9 mo, testosterone > 28.2 HR: 0.206, 95% CI 0.074 to 0.571, p = 0.002) and TTF (median 30.6 vs 11.8 mo, testosterone > 28.2 HR: 0.408, 95%CI 0.219 to 0.762, p = 0.005) than pts with a low serum testosterone level ( < 28.2; n = 80), regardless of receiving therapy with either Abi (n = 69) or Ez (n = 31). Pts with a higher testosterone level were younger (median 67.7 vs 73.6 years; p = 0.026), had a higher body mass index (BMI) (28.5 vs 25.9, p = 0.023) and a lower PSA at start Abi/Ez (12 vs 26, p = 0.031) than pts with lower values. Age (OR 0.93, 95%CI 0.8 to 0.9, p = 0.021), BMI (OR 1.21, 95%CI 1.1 to 1.4, p = 0.006) and baseline PSA (OR 1.2, 95%CI 1.03 to 1.4, p = 0.020) were significantly associated with testosterone > 28.2. After 4 months of Abi/Ez treatment, PSA decrease > 50% of baseline was seen more frequently in high testosterone levels group than in low testosterone levels pts (90% vs 57.5% of pts, respectively, p = 0.007). Conclusions: Pts with high levels of testosterone ( > 28.2) achieved a better OS and TTF when treated with Abi/Ez in first-line mCRPC than those with low levels. Testosterone can be considered a prognostic and predictive biomarker in this scenario, and could be used in treatment decision for this population.

Prevalence and Risk Factors of Testosterone Deficiency in Aging Thai Male Outpatients

2021 ◽  
Vol 104 (6) ◽  
pp. 921-926
Keyword(s):  
Risk Factors ◽  
Erectile Dysfunction ◽  
Potential Risk ◽  
Testosterone Level ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Total Testosterone ◽  
Testosterone Deficiency ◽  
Factors Associated ◽  
Potential Risk Factors

Background: Testosterone deficiency in men, characterized by a reduced concentration of serum testosterone, causes a constellation of signs and symptoms that may include decreased libido, erectile dysfunction, increased body fat, fatigue, and psychological problem. Testosterone deficiency in adult men is often overlooked, because they ignore their symptoms or attribute them to alternate causes, including aging and underlying diseases that made them lose the opportunity for treatment. The present study aimed to describe the prevalence of testosterone deficiency and to study potential risk factors associated with testosterone deficiency among Thai men in Phramongutklao Hospital. Objective: To determine the prevalence of testosterone deficiency and potential risk factors associated with testosterone deficiency in Thai men. Materials and Methods: Thai male older than 40 years old who visited in urological outpatient unit at Phramongkutklao Hospital between July and October 2018 were included. Demographic data, medical information, and the androgen deficiency in the aging male (ADAM) questionnaires were collected. The participants having symptoms of testosterone deficiency from ADAM questionnaires were requested to measure serum total testosterone levels and were repeated if serum testosterone level was less than 300 ng/dL. Results: Data from 156 men were collected. The mean age of the participants was 67±8.73 years. Prevalence of testosterone deficiency was 5.8%. Obesity, waist circumference at or greater than 90 cm, diabetes mellitus, and dyslipidemia were identified as risk factors of testosterone deficiency. There was an association between three symptoms of ADAM questionnaires, which were decreased libido, erectile dysfunction, and decreased enjoyment of life, with testosterone deficiency. Conclusion: Prevalence of testosterone deficiency among Thai men at Phramongkutklao Hospital is about 5.8%. Clarification of the underlying causes for the changes in testosterone level may provide helpful information so that preventive action can be taken. Low libido, erectile dysfunction, and decreased enjoyment of life may be specific symptoms of testosterone deficiency and should be the questions to ask the suspected patients. Keywords: Testosterone deficiency; Total testosterone; Prevalence; ADAM questionnaires

scholarly journals Prepubertal Serum Testosterone Concentration In Vembur Rams At Different Rearing System

2017 ◽  
Vol 12 (4) ◽  
Author(s):  
R. Selvakkumar ◽  
T. Sivakumar ◽  
S. Ganesh Kumar ◽  
P. Anuradha
Keyword(s):  
Field Condition ◽  
Testosterone Level ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Testosterone Concentration ◽  
Testosterone Levels ◽  
Ram Lambs ◽  
Age At Puberty

The present investigation was carried out to study the prepubertal testosterone pattern and age at puberty in Vembur rams reared under farm and farmers field condition. A total number of 8 Vembur ram lambs each from farm and farmers field were selected. The measurement of testosterone was performed by Radioimmunoassay (RIA). The serum testosterone level from 6th to 20th month of age ranged from 0.132 ± 0.04 to 3.823 ng/ml in semi intensively maintained farm males and 0.138±0.04 to 3.456±0.17 ng/ml in animals maintained at farmer’s holdings. The serum testosterone levels were crossing the concentration of 2.5 ng/ml at the age of 17 to 18th weeks and successful mounting, intromission and ejaculation were noticed after this age.

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