Intestinal helminth coinfection is associated with mucosal lesions and poor response to therapy in American tegumentary leishmaniasis

Acta Tropica ◽  
2016 ◽  
Vol 154 ◽  
pp. 42-49 ◽  
Author(s):  
Rilza Beatriz G. Azeredo-Coutinho ◽  
Maria Inês Pimentel ◽  
Graziela Maria Zanini ◽  
Maria F. Madeira ◽  
Jamyra Iglesias Cataldo ◽  
...  
Keyword(s):  
Poor Response ◽  
Response To Therapy ◽  
Intestinal Helminth ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis ◽  
Mucosal Lesions

scholarly journals Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Carolina de O Mendes-Aguiar ◽  
Camilla Lopes-Siqueira ◽  
Fabrício Pettito-Assis ◽  
Márcia Pereira-Oliveira ◽  
Manoel Paes de Oliveira-Neto ◽  
...  
Keyword(s):  
Growth Factor ◽  
Inflammatory Process ◽  
Healing Process ◽  
Response To Therapy ◽  
Leishmania Infection ◽  
Histopathological Analysis ◽  
Insulin Like Growth Factor ◽  
Tegumentary Leishmaniasis ◽  
Igf I ◽  
American Tegumentary Leishmaniasis

Background. Cytokines and growth factors involved in the tissue inflammatory process influence the outcome of Leishmania infection. Insulin-like growth factor (IGF-I) constitutively present in the skin may participate in the inflammatory process and parasite-host interaction. Previous work has shown that preincubation of Leishmania (Leishmania) amazonensis with recombinant IGF-I induces accelerated lesion development. However, in human cutaneous leishmaniasis (CL) pathogenesis, it is more relevant to the persistent inflammatory process than progressive parasite proliferation. In this context, we aimed to investigate whether IGF-I was present in the CL lesions and if this factor may influence the lesions’ development acting on parasite growth and/or on the inflammatory/healing process. Methodology. Fifty-one CL patients’ skin lesion samples from endemic area of L. (Viannia) braziliensis infection were submitted to histopathological analysis and searched for Leishmania and IGF-I expression by immunohistochemistry. Results. In human CL lesions, IGF-I was observed preferentially in the late lesion (more than 90 days), and the percentage of positive area for IGF-I was positively correlated with duration of illness ( r = 0.42 , P < 0.05 ). IGF-I was highly expressed in the inflammatory infiltrate of CL lesions from patients evolving with good response to therapy ( 2.8 % ± 2.1 % ; median = 2.1 % ; n = 18 ) than poor responders ( 1.3 % ± 1.1 % ; median: 1.05%; n = 6 ; P < 0.05 ). Conclusions. It is the first time that IGF-I was detected in lesions of infectious cutaneous disease, specifically in American tegumentary leishmaniasis. IGF-I was related to chronicity and good response to treatment. We may relate this finding to the efficient anti-inflammatory response and the known action of IGF-I in wound repair. The present data highlight the importance of searching nonspecific factors besides adaptive immune elements in the study of leishmaniasis’ pathogenesis.

Clinical features and therapeutic response in adult and pediatric patients with American tegumentary leishmaniasis in Rio de Janeiro

2019 ◽  
Author(s):  
Tatiana C R Senna ◽  
Maria Inês F Pimentel ◽  
Liliane F A Oliveira ◽  
Marcelo R Lyra ◽  
Mauricio N Saheki ◽  
...  
Keyword(s):  
Clinical Features ◽  
Rio De Janeiro ◽  
Pediatric Patients ◽  
Therapeutic Response ◽  
Age Groups ◽  
Healing Time ◽  
The Body ◽  
Reference Centre ◽  
Tegumentary Leishmaniasis ◽  
American Tegumentary Leishmaniasis

Abstract Background American tegumentary leishmaniasis (ATL) is a neglected disease with wide territorial distribution. Knowledge is scarce in children and adolescents. This study aims to compare the clinical features and response to antimony treatment in pediatric and adult patients with cutaneous leishmaniasis. Methods A retrospective cohort study was performed with 659 patients who attended a reference centre in Rio de Janeiro, Brazil, from 2000 to 2015. The pediatric cohort consisted of 131 (20%) patients and the adult cohort consisted of 528 (80%) patients. Results The epidemiological profile, antimony therapeutic response and incidence of adverse events (AE) were different in the pediatric cohort compared with the adult cohort. Mucosal form was less frequent in the pediatric cohort (RR:0.49, p=0.011). Lesions in the head, neck and trunk were more frequent in the pediatric cohort (RR:1.49, p=0.043). The effectiveness of antimony treatment was superior in the pediatric cohort (88.3% vs 76.6%) with a shorter healing time (RR:0.49, p=0.009). Pediatric patients had lower proportions of moderate to severe AE compared with adults (RR:0.45, p=0.027). Clinical AE predominated in the adult cohort (RR:0.40, p=0.000) and laboratory AE in the pediatric cohort (RR:1.50, p=0.023). Conclusions This study adds to the body of knowledge on differences that exist between different age groups in ATL.

scholarly journals PHLEBOTOMINE SANDFLIES IN RURAL LOCATIONS IN THE STATE OF PARANA, SOUTHERN BRAZIL

2013 ◽  
Vol 55 (6) ◽  
pp. 407-410 ◽  
Author(s):  
Simone Cristina Castanho Sabaini de Melo ◽  
Wilsandrei Cella ◽  
Rubens Massafera ◽  
Natalia Maria Maciel Guerra Silva ◽  
Reinaldo Marqui ◽  
...  
Keyword(s):  
Rural Areas ◽  
Domestic Animal ◽  
The State ◽  
Southern Brazil ◽  
Environmental Characteristics ◽  
Animal Shelters ◽  
Rural Villages ◽  
Tegumentary Leishmaniasis ◽  
Phlebotomine Sandflies ◽  
American Tegumentary Leishmaniasis

SUMMARY This study reports the fauna and frequency of sandflies in domestic animal shelters, residences and other ecotopes in rural areas of the municipality of Bandeirantes, Paraná State. Sandflies were collected twice in eight rural villages by using Falcon traps from 8pm to 6am in 2008. In these localities 4,790 sandflies were collected, which were represented by ten sandfly species, prevailing of Nyssomyia neivai and Nyssomyia whitmani species. It was observed that animal shelters are the domestic ecotopes where there is the greatest frequency of these insects. The localities where the collections were made had the environmental characteristics that allow the persistence of transmission of parasites from the American tegumentary leishmaniasis. Although the fauna and the behavior of sandflies species are similar in different localities, the method of controlling these insects should be adjusted to the environmental characteristics of each one of the most diverse endemic areas of American tegumentary leishmaniasis in the municipalities of Paraná State.

scholarly journals Phlebotomine sand flies (Diptera, Psychodidae) in an American tegumentary leishmaniasis transmission area in northern Espírito Santo State, Brazil

2008 ◽  
Vol 24 (12) ◽  
pp. 2969-2978 ◽  
Author(s):  
Thieres Marassati das Virgens ◽  
Claudiney Biral dos Santos ◽  
Israel de Souza Pinto ◽  
Kleber Silveira da Silva ◽  
Fernanda Cristina Leal ◽  
...  
Keyword(s):  
Abundant Species ◽  
Sand Fly ◽  
Seasonal Fluctuations ◽  
Forest Reserve ◽  
Phlebotomine Sand Flies ◽  
Espírito Santo ◽  
Tegumentary Leishmaniasis ◽  
Transmission Area ◽  
American Tegumentary Leishmaniasis ◽  
Espirito Santo

American tegumentary leishmaniasis is endemic to the Espírito Santo State, Brazil, where it is widely distributed. The composition of the phlebotomine sand fly fauna in an American tegumentary leishmaniasis focus was determined by monthly sampling, using Shannon light traps in an Atlantic Forest reserve and adjacent habitat that had been modified by human activity. Seasonal fluctuations in numbers of the most abundant species were also monitored from June 2004 to May 2006. Of the 6,176 specimens collected, 47.4% were captured in the forest and 52.6% in the disturbed habitat. Although Lutzomyia davisi (60.8%) predominated in specimens from the forest, those captured near human dwellings consisted almost entirely of Lu. choti (72%) and Lu. intermedia (24.3%). All three species occurred throughout the year. Based on our findings, Lu. intermedia probably acts as the principal domestic Leishmania vector in the study area.

Dysregulation of miR‐125b predicts poor response to therapy in pediatric acute lymphoblastic leukemia

2018 ◽  
Vol 120 (5) ◽  
pp. 7428-7438 ◽  
Author(s):  
Nashwa El‐Khazragy ◽  
Amal Ali Elshimy ◽  
Safaa Shawky Hassan ◽  
Safa Matbouly ◽  
Gehan Safwat ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Poor Response ◽  
Response To Therapy ◽  
Pediatric Acute Lymphoblastic Leukemia
Sign in / Sign up

Export Citation Format

Share Document